126172005: Estradiol (substance)

SNOMED CT Concept\Substance\...

\Substance categorized by disposition\Substance with molecular messenger mechanism of action (substance)\Hormone\Sex hormone\Substance with estrogen receptor agonist mechanism of action (substance)\Estradiol
\Substance categorized by disposition\Substance with molecular messenger mechanism of action (substance)\Hormone\Steroid hormone\Estradiol
\Substance categorized by disposition\Receptor agonist\Substance with estrogen receptor agonist mechanism of action (substance)\Estradiol

\Drug or medicament (substance)\Hormone\...

\Sex hormone\Substance with estrogen receptor agonist mechanism of action (substance)\Estradiol

\Steroid hormone\Estradiol

\Substance categorised by structure\Chemical\Chemical categorized by structure\Organic compound\Organic cyclic compound\Polycyclic compound\Steroid (substance)\...

\Estrane\Estradiol and/or estradiol derivative\Estradiol

\Steroid hormone\Estradiol

Status: current, Not sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jan 2002. Module: SNOMED CT core

Descriptions:

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
Estradiol	Is a	Estrane	false	Inferred relationship	Existential restriction modifier (core metadata concept)
Estradiol	Is a	Estradiol and/or estradiol derivative	true	Inferred relationship	Existential restriction modifier (core metadata concept)
Estradiol	Is a	estrogeno	false	Inferred relationship	Existential restriction modifier (core metadata concept)
Estradiol	Has disposition	Estrogen	false	Inferred relationship	Existential restriction modifier (core metadata concept)
Estradiol	Has disposition	Gonadal hormone	false	Inferred relationship	Existential restriction modifier (core metadata concept)
Estradiol	Is a	Substance with estrogen receptor agonist mechanism of action (substance)	true	Inferred relationship	Existential restriction modifier (core metadata concept)
Estradiol	Has disposition	Estrogen receptor agonist	true	Inferred relationship	Existential restriction modifier (core metadata concept)
Estradiol	Is a	Steroid hormone	true	Inferred relationship	Existential restriction modifier (core metadata concept)

Inbound Relationships	Type	Active	Source	Characteristic	Refinability	Group
Topical estradiol allergy	Causative agent (attribute)	False	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Allergy to estradiol	Causative agent (attribute)	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Oral estradiol allergy	Causative agent (attribute)	False	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Estradiol implant allergy	Causative agent (attribute)	False	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Estradiol enanthate (substance)	Is a	False	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)
Albumin bound estradiol (substance)	Is a	False	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)
Bioavailable estradiol (substance)	Is a	False	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)
Estradiol 1 mg oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Estradiol 1 mg oral tablet	Has basis of strength substance (attribute)	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely estradiol 2 milligram/1 each conventional release oral tablet (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely estradiol 2 milligram/1 each conventional release oral tablet (clinical drug)	Has basis of strength substance (attribute)	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Estradiol 2 mg and norethisterone acetate 1 mg oral tablet	Has basis of strength substance (attribute)	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Estradiol+norethisterone acetate 1mg/0.5mg tablet (substance)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Estradiol+norethisterone acetate 1mg/0.5mg tablet (substance)	Has basis of strength substance (attribute)	False	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Estradiol 1.5 mg oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Estradiol 1.5 mg oral tablet	Has basis of strength substance (attribute)	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely estradiol 500 microgram/1 each conventional release oral tablet (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely estradiol 500 microgram/1 each conventional release oral tablet (clinical drug)	Has basis of strength substance (attribute)	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Estradiol 4 mg oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Estradiol 4 mg oral tablet	Has basis of strength substance (attribute)	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely drospirenone 500 microgram and estradiol 1 milligram/1 each conventional release oral tablet (clinical drug)	Has basis of strength substance (attribute)	False	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Estradiol 2 mg and norethisterone acetate 1 mg oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Estradiol 2 mg and norethisterone acetate 1 mg oral tablet	Has basis of strength substance (attribute)	False	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely drospirenone 2 milligram and estradiol 1 milligram/1 each conventional release oral tablet (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely drospirenone 2 milligram and estradiol 1 milligram/1 each conventional release oral tablet (clinical drug)	Has basis of strength substance (attribute)	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Estradiol 500 microgram and norethisterone acetate 100 microgram oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Estradiol 500 microgram and norethisterone acetate 100 microgram oral tablet	Has basis of strength substance (attribute)	False	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely drospirenone 500 microgram and estradiol 1 milligram/1 each conventional release oral tablet (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely drospirenone 500 microgram and estradiol 1 milligram/1 each conventional release oral tablet (clinical drug)	Has basis of strength substance (attribute)	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Albumin bound estradiol (substance)	Is modification of (attribute)	False	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)
Estradiol cypionate	Is modification of (attribute)	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)
Estradiol acetate (substance)	Is modification of (attribute)	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)
Estradiol hemihydrate (substance)	Is modification of (attribute)	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)
Estradiol enanthate (substance)	Is modification of (attribute)	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)
Free estradiol	Is modification of (attribute)	False	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)
Bioavailable estradiol (substance)	Is modification of (attribute)	False	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)
Estradiol benzoate	Is modification of (attribute)	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)
Estradiol valerate	Is modification of (attribute)	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)
Ethinylestradiol (substance)	Is modification of (attribute)	False	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)
Estradiol 4 mg oral tablet	Has precise active ingredient	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Estradiol 500 microgram and norethisterone acetate 100 microgram oral tablet	Has precise active ingredient	False	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Estradiol 1.5 mg oral tablet	Has precise active ingredient	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Estradiol 1 mg oral tablet	Has precise active ingredient	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely estradiol 2 milligram/1 each conventional release oral tablet (clinical drug)	Has precise active ingredient	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely estradiol 500 microgram/1 each conventional release oral tablet (clinical drug)	Has precise active ingredient	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Estradiol+norethisterone acetate 1mg/0.5mg tablet (substance)	Has precise active ingredient	False	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing drospirenone and estradiol in oral dose form (medicinal product form)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely drospirenone 2 milligram and estradiol 1 milligram/1 each conventional release oral tablet (clinical drug)	Has precise active ingredient	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely drospirenone 500 microgram and estradiol 1 milligram/1 each conventional release oral tablet (clinical drug)	Has precise active ingredient	False	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Estradiol 2 mg and norethisterone acetate 1 mg oral tablet	Has precise active ingredient	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Product containing estradiol in transdermal dose form (medicinal product form)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Estradiol 2.083 microgram/hour and norethisterone acetate 10.417 microgram/hour prolonged-release transdermal patch	Has basis of strength substance (attribute)	False	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Estradiol 2.083 microgram/hour and norethisterone acetate 10.417 microgram/hour prolonged-release transdermal patch	Has precise active ingredient	False	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely estradiol 3.125 microgram/1 hour prolonged-release transdermal patch (clinical drug)	Has basis of strength substance (attribute)	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely estradiol 3.125 microgram/1 hour prolonged-release transdermal patch (clinical drug)	Has precise active ingredient	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Estradiol 1.042 microgram/hour prolonged-release transdermal patch	Has basis of strength substance (attribute)	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Estradiol 1.042 microgram/hour prolonged-release transdermal patch	Has precise active ingredient	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Estradiol 1.563 microgram/hour prolonged-release transdermal patch	Has basis of strength substance (attribute)	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Estradiol 1.563 microgram/hour prolonged-release transdermal patch	Has precise active ingredient	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely estradiol 1.667 microgram/1 hour prolonged-release transdermal patch (clinical drug)	Has precise active ingredient	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely estradiol 1.667 microgram/1 hour prolonged-release transdermal patch (clinical drug)	Has basis of strength substance (attribute)	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Estradiol 2.083 microgram/hour prolonged-release transdermal patch	Has basis of strength substance (attribute)	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Estradiol 2.083 microgram/hour prolonged-release transdermal patch	Has precise active ingredient	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely estradiol 3.333 microgram/1 hour prolonged-release transdermal patch (clinical drug)	Has precise active ingredient	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely estradiol 3.333 microgram/1 hour prolonged-release transdermal patch (clinical drug)	Has basis of strength substance (attribute)	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely estradiol 4.167 microgram/1 hour prolonged-release transdermal patch (clinical drug)	Has precise active ingredient	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely estradiol 4.167 microgram/1 hour prolonged-release transdermal patch (clinical drug)	Has basis of strength substance (attribute)	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Estradiol 2.083 microgram/hour and norethisterone acetate 7.083 microgram/hour prolonged-release transdermal patch	Has precise active ingredient	False	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Estradiol 2.083 microgram/hour and norethisterone acetate 7.083 microgram/hour prolonged-release transdermal patch	Has basis of strength substance (attribute)	False	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Estradiol- and medroxyprogesterone-containing product	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Estradiol-containing product in cutaneous dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing estradiol and levonorgestrel in transdermal dose form (medicinal product form)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Estradiol- and medroxyprogesterone-containing product in oral dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Estradiol- and norethisterone-containing product in oral dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Product containing estradiol and norethisterone in transdermal dose form (medicinal product form)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Product containing only drospirenone and estradiol (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing only estradiol (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing only estradiol and levonorgestrel (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Estradiol and medroxyprogesterone only product	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Estradiol and norethisterone only product	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Product containing only estradiol and norgestrel (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Product containing only dydrogesterone and estradiol (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Estradiol and levonorgestrel only product in transdermal dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Product containing only estradiol and medroxyprogesterone in oral dose form (medicinal product form)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Product containing only estradiol and norethisterone in transdermal dose form (medicinal product form)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Product containing only estradiol in cutaneous dose form (medicinal product form)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing only estradiol in nasal dose form (medicinal product form)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Estradiol only product in oral dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing only estradiol in parenteral dose form (medicinal product form)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Estradiol only product in transdermal dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Estradiol and norethisterone only product in oral dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Drospirenone and estradiol only product in oral dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing only estradiol in vaginal dose form (medicinal product form)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely estradiol 25 microgram/1 each conventional release vaginal tablet (clinical drug)	Has precise active ingredient	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely estradiol 25 microgram/1 each conventional release vaginal tablet (clinical drug)	Has basis of strength substance (attribute)	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely estradiol 312.5 nanogram/1 hour prolonged-release vaginal ring (clinical drug)	Has basis of strength substance (attribute)	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely estradiol 312.5 nanogram/1 hour prolonged-release vaginal ring (clinical drug)	Has precise active ingredient	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely estradiol 2.083 microgram/1 hour prolonged-release vaginal ring (clinical drug)	Has precise active ingredient	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely estradiol 2.083 microgram/1 hour prolonged-release vaginal ring (clinical drug)	Has basis of strength substance (attribute)	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Estradiol 4.167 microgram/hour prolonged-release vaginal ring	Has basis of strength substance (attribute)	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Estradiol 4.167 microgram/hour prolonged-release vaginal ring	Has precise active ingredient	True	Estradiol	Inferred relationship	Existential restriction modifier (core metadata concept)	1

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Id	Description	Lang	Type	Status	Case?	Module
24201011	Estradiol	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
730100013	Estradiol (substance)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
3721927018	17-beta estradiol	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
3722984013	E2 - estradiol	en	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT core
24201011	Estradiol	en	Synonym (core metadata concept)	Active	Only initial character case insensitive (core metadata concept)	SNOMED CT core
24201011	Estradiol	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
473635011	Oestradiol	en	Synonym (core metadata concept)	Active	Only initial character case insensitive (core metadata concept)	SNOMED CT core
473635011	Oestradiol	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
730100013	Estradiol (substance)	en	Fully specified name	Active	Only initial character case insensitive (core metadata concept)	SNOMED CT core
730100013	Estradiol (substance)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
1215921017	E2 - Oestradiol	en	Synonym (core metadata concept)	Active	Only initial character case insensitive (core metadata concept)	SNOMED CT core
1215922012	17-Beta oestradiol	en	Synonym (core metadata concept)	Active	Only initial character case insensitive (core metadata concept)	SNOMED CT core
1217424016	17-Beta estradiol	en	Synonym (core metadata concept)	Active	Only initial character case insensitive (core metadata concept)	SNOMED CT core
1217425015	E2 - Estradiol	en	Synonym (core metadata concept)	Active	Only initial character case insensitive (core metadata concept)	SNOMED CT core
3721927018	17-beta estradiol	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
3722984013	E2 - estradiol	en	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT core
49321000195112	estradiolo	it	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
63461000195117	Estradiol	de	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
234641000195118	Östradiol	de	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
234651000195115	E2 - Estradiol	de	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
234661000195117	E>2< - Estradiol	de	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
32701000188116	estradiol	fr	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
861191000172113	oestradiol	fr	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
32701000188116	estradiol	fr	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
861191000172113	oestradiol	fr	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
49321000195112	estradiolo	it	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
63461000195117	Estradiol	de	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
234641000195118	Östradiol	de	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
234651000195115	E2 - Estradiol	de	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
234661000195117	E>2< - Estradiol	de	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module