255641001: Caffeine (substance)

SNOMED CT Concept\Substance\...

\Substance categorized by disposition\Substance with effector mechanism of action (substance)\Enzyme inhibitor\Substance with hydrolase inhibitor mechanism of action (substance)\Phosphodiesterase inhibitor\Caffeine

\Substance categorised by structure\Chemical\Chemical categorized by structure\...

\Nitrogen and/or nitrogen compound (substance)\Nitrogen compound\Organic nitrogen compound\Purine and/or purine derivative\Xanthine and/or xanthine derivative (substance)\Xanthine derivative (substance)\Methyl xanthine\Caffeine

\Substance categorized functionally\Phytochemical\Caffeine

\Material (substance)\Natural material\Organic natural material\Plant material (substance)\Phytochemical\Caffeine

\Biological substance\Organic natural material\Plant material (substance)\Phytochemical\Caffeine

Status: current, Not sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jan 2002. Module: SNOMED CT core

Descriptions:

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
Caffeine	Is a	Phytochemical	true	Inferred relationship	Existential restriction modifier (core metadata concept)
Caffeine	Is a	Xanthine	false	Inferred relationship	Existential restriction modifier (core metadata concept)
Caffeine	Is a	Central nervous system agent (substance)	false	Inferred relationship	Existential restriction modifier (core metadata concept)
Caffeine	Is a	allergène médicamenteux	false	Inferred relationship	Existential restriction modifier (core metadata concept)
Caffeine	Is a	Methyl xanthine	true	Inferred relationship	Existential restriction modifier (core metadata concept)
Caffeine	Is a	Central respiratory stimulant	false	Inferred relationship	Existential restriction modifier (core metadata concept)
Caffeine	Is a	Phosphodiesterase inhibitor	true	Inferred relationship	Existential restriction modifier (core metadata concept)
Caffeine	Has disposition	Phosphodiesterase inhibitor (disposition)	true	Inferred relationship	Existential restriction modifier (core metadata concept)
Caffeine	Is a	Enzyme inhibitor	false	Inferred relationship	Existential restriction modifier (core metadata concept)
Caffeine	Is a	Psychostimulant	true	Inferred relationship	Existential restriction modifier (core metadata concept)

Inbound Relationships	Type	Active	Source	Characteristic	Refinability	Group
Caffeine and sodium benzoate injection solution vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Accidental caffeine poisoning	Causative agent (attribute)	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Intentional caffeine poisoning	Causative agent (attribute)	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
intoxication par la caféine d'intention indéterminée	Causative agent (attribute)	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Caffeine overdose	Causative agent (attribute)	True	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Accidental caffeine overdose	Causative agent (attribute)	True	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Intentional caffeine overdose	Causative agent (attribute)	True	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	1
surdose de caféine d'intention indéterminée	Causative agent (attribute)	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Caffeine-related disorder	Causative agent (attribute)	True	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Caffeine-induced organic mental disorder	Causative agent (attribute)	True	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Plasma caffeine measurement	Component	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Serum caffeine measurement	Component	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Caffeine solution	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Caffeine 5mg/mL injection solution 2mL vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Caffeine citrate 20mg/mL injection (product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Caffeine citrate 20mg solution	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Caffeine 30 mg and dihydrocodeine tartrate 16 mg and paracetamol 356.4 mg oral capsule	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Product containing precisely aspirin 325 milligram and butalbital 50 milligram and caffeine 40 milligram/1 each conventional release oral capsule (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Aspirin + butalbital + caffeine 325mg/50mg/40mg tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Product containing precisely aspirin 356.4 milligram and caffeine 30 milligram and dihydrocodeine tartrate 16 milligram/1 each conventional release oral capsule (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Aspirin 385 mg and caffeine 30 mg and orphenadrine citrate 25 mg oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Aspirin 428 mg and caffeine 30 mg and orphenadrine citrate 25 mg oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Product containing precisely caffeine 60 milligram and dihydrocodeine tartrate 32 milligram and paracetamol 712.8 milligram/1 each conventional release oral tablet (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Product containing precisely aspirin 770 milligram and caffeine 60 milligram and orphenadrine citrate 50 milligram/1 each conventional release oral tablet (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Aspirin 856 mg and caffeine 60 mg and orphenadrine citrate 50 mg oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Aspirin 389 mg and caffeine 32.4 mg and dextropropoxyphene hydrochloride 65 mg oral capsule	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Product containing precisely caffeine 100 milligram and isometheptene mucate 65 milligram and paracetamol 325 milligram/1 each conventional release oral capsule (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Caffeine + ergotamine tartrate 100mg/1mg tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Caffeine + ergotamine tartrate 100mg/2mg (product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Acetaminophen+butalbital+caffeine 325mg/50mg/40mg capsule	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Product containing precisely butalbital 50 milligram and caffeine 40 milligram and paracetamol 325 milligram/1 each conventional release oral tablet (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Product containing precisely butalbital 50 milligram and caffeine 40 milligram and paracetamol 500 milligram/1 each conventional release oral capsule (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Acetaminophen+butalbital+caffeine 500mg/50mg/40mg tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Caffeine measurement	Component	True	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Aspirin + caffeine + orphenadrine citrate tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Oral caffeine (product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing caffeine in rectal dose form (medicinal product form)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing caffeine in parenteral dose form (medicinal product form)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Sleep disorder caused by caffeine (disorder)	Causative agent (attribute)	True	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Poisoning by caffeine	Causative agent (attribute)	True	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Caffeine-induced anxiety disorder	Causative agent (attribute)	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Caffeine intoxication	Causative agent (attribute)	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Product containing caffeine (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Caffeine withdrawal	Causative agent (attribute)	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Butalbital 50 mg and caffeine 40 mg and codeine phosphate 30 mg and paracetamol 325 mg oral capsule	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Product containing precisely aspirin 325 milligram and butalbital 50 milligram and caffeine 40 milligram and codeine phosphate 30 milligram/1 each conventional release oral capsule (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Product containing aspirin and butalbital and caffeine and codeine phosphate	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Product containing caffeine and isometheptene mucate and paracetamol	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Product containing aspirin and caffeine and propoxyphene hydrochloride	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Product containing aspirin and caffeine and dihydrocodeine tartrate	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Caffeine + ergotamine tartrate	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Caffeine- and sodium benzoate-containing product	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Product containing butalbital and caffeine and paracetamol (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Aspirin + caffeine + orphenadrine citrate	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Product containing butalbital and caffeine and codeine phosphate and paracetamol	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Product containing aspirin and butalbital and caffeine (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely caffeine 100 milligram and ergotamine tartrate 1 milligram/1 each conventional release oral tablet (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Ergotamine tartrate+caffeine 2mg/100mg suppository (substance)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Product containing caffeine and dihydrocodeine tartrate and paracetamol	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Aspirin- and caffeine- and cinnamedrine-containing product	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing aspirin and caffeine and orphenadrine (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing caffeine and paracetamol and salicylamide (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Product containing buffered aspirin and caffeine (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Aspirin- and caffeine- and paracetamol-containing product	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing aspirin and caffeine (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely aspirin 389 milligram and caffeine 32.4 milligram and dextropropoxyphene hydrochloride 32 milligram/1 each conventional release oral capsule (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Product containing precisely aspirin 250 milligram and caffeine 65 milligram and paracetamol 250 milligram/1 each conventional release oral tablet (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Ergotamine + caffeine	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Caffeine citrate (substance)	Is a	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Intentional caffeine poisoning	Causative agent (attribute)	True	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	1
[X]Adverse reaction to caffeine	Causative agent (attribute)	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Caffeine 65 mg and paracetamol 500 mg oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Product containing precisely caffeine 30 milligram and paracetamol 450 milligram/1 each conventional release oral tablet (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Caffeine 25 mg and paracetamol 450 mg oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Caffeine- and paracetamol-containing product	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Paracetamol+caffeine 500mg/65mg soluble tablet (substance)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Accidental poisoning by caffeine	Causative agent (attribute)	True	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Adverse reaction to caffeine	Causative agent (attribute)	True	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Allergy to caffeine	Causative agent (attribute)	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Product containing caffeine and ergotamine (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Ammonium chloride- and caffeine-containing product	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Caffeine+glucose (product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Fioricet with codeine 325mg/50mg/40mg/30mg capsule	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)
Caffeine dependence (disorder)	Causative agent (attribute)	True	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Allergy to caffeine	Causative agent (attribute)	True	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Harmful pattern of use of caffeine (disorder)	Causative agent (attribute)	True	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely aspirin 325 milligram and butalbital 50 milligram and caffeine 40 milligram and codeine phosphate 30 milligram/1 each conventional release oral capsule (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	4
Product containing precisely aspirin 325 milligram and butalbital 50 milligram and caffeine 40 milligram and codeine phosphate 30 milligram/1 each conventional release oral capsule (clinical drug)	Has basis of strength substance (attribute)	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	4
Product containing precisely aspirin 325 milligram and butalbital 50 milligram and caffeine 40 milligram/1 each conventional release oral capsule (clinical drug)	Has basis of strength substance (attribute)	True	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Aspirin 385 mg and caffeine 30 mg and orphenadrine citrate 25 mg oral tablet	Has basis of strength substance (attribute)	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	3
Aspirin 428 mg and caffeine 30 mg and orphenadrine citrate 25 mg oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Aspirin 428 mg and caffeine 30 mg and orphenadrine citrate 25 mg oral tablet	Has basis of strength substance (attribute)	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Aspirin 856 mg and caffeine 60 mg and orphenadrine citrate 50 mg oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Aspirin 856 mg and caffeine 60 mg and orphenadrine citrate 50 mg oral tablet	Has basis of strength substance (attribute)	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Caffeine 25 mg and paracetamol 450 mg oral tablet	Has basis of strength substance (attribute)	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Product containing precisely aspirin 356.4 milligram and caffeine 30 milligram and dihydrocodeine tartrate 16 milligram/1 each conventional release oral capsule (clinical drug)	Has basis of strength substance (attribute)	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	3
Aspirin 428 mg and caffeine 30 mg and orphenadrine citrate 25 mg oral tablet	Has basis of strength substance (attribute)	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	3
Product containing precisely aspirin 770 milligram and caffeine 60 milligram and orphenadrine citrate 50 milligram/1 each conventional release oral tablet (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Product containing precisely aspirin 770 milligram and caffeine 60 milligram and orphenadrine citrate 50 milligram/1 each conventional release oral tablet (clinical drug)	Has basis of strength substance (attribute)	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Aspirin 389 mg and caffeine 32.4 mg and dextropropoxyphene hydrochloride 65 mg oral capsule	Has basis of strength substance (attribute)	False	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Acetaminophen+butalbital+caffeine 325mg/50mg/40mg capsule	Has basis of strength substance (attribute)	True	Caffeine	Inferred relationship	Existential restriction modifier (core metadata concept)	1

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Id	Description	Lang	Type	Status	Case?	Module
380891010	Caffeine	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
646709011	Caffeine (substance)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
380891010	Caffeine	en	Synonym (core metadata concept)	Active	Only initial character case insensitive (core metadata concept)	SNOMED CT core
380891010	Caffeine	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
646709011	Caffeine (substance)	en	Fully specified name	Active	Only initial character case insensitive (core metadata concept)	SNOMED CT core
646709011	Caffeine (substance)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
56441000195115	caffeina	it	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
71441000195114	Coffein	de	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
659461000274116	Koffein	de	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
796671000172110	caféine	fr	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
796671000172110	caféine	fr	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
56441000195115	caffeina	it	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
71441000195114	Coffein	de	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
659461000274116	Koffein	de	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module