36176003: Thrombin (substance)

\Nitrogen and/or nitrogen compound (substance)\Nitrogen compound\Organic nitrogen compound\Amide and/or amide derivative\Substituted amide (substance)\Polypeptide\Protein\Plasma protein (substance)\Coagulation protein (substance)\Thrombin

\Organic compound\Organic nitrogen compound\Amide and/or amide derivative\Substituted amide (substance)\Polypeptide\Protein\Plasma protein (substance)\Coagulation protein (substance)\Thrombin

Status: current, Not sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jan 2002. Module: SNOMED CT core

Descriptions:

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
Thrombin	Is a	Coagulation protein (substance)	true	Inferred relationship	Existential restriction modifier (core metadata concept)
Thrombin	Is a	Activated coagulation factor (substance)	true	Inferred relationship	Existential restriction modifier (core metadata concept)
Thrombin	Is a	Serine protease	true	Inferred relationship	Existential restriction modifier (core metadata concept)
Thrombin	Is a	Fibrinolytic system factor	true	Inferred relationship	Existential restriction modifier (core metadata concept)
Thrombin	Is a	Hemostatic agent (substance)	true	Inferred relationship	Existential restriction modifier (core metadata concept)
Thrombin	Has disposition	Activated coagulation factor (disposition)	true	Inferred relationship	Existential restriction modifier (core metadata concept)
Thrombin	Has disposition	Serine protease (disposition)	true	Inferred relationship	Existential restriction modifier (core metadata concept)
Thrombin	Is a	Substance with hydrolase mechanism of action (substance)	false	Inferred relationship	Existential restriction modifier (core metadata concept)

Inbound Relationships	Type	Active	Source	Characteristic	Refinability	Group
Thrombin time ratio (procedure)	Component	True	Thrombin	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Bovine thrombin (substance)	Is a	True	Thrombin	Inferred relationship	Existential restriction modifier (core metadata concept)
Product containing human fibrinogen and thrombin (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Thrombin	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing thrombin (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Thrombin	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Biological active component+thrombin sealant solution	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Thrombin	Inferred relationship	Existential restriction modifier (core metadata concept)
Biological active component 5mL vial/thrombin sealant solution 5mL vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Thrombin	Inferred relationship	Existential restriction modifier (core metadata concept)
Biological active component 1mL vial/thrombin sealant solution 1mL vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Thrombin	Inferred relationship	Existential restriction modifier (core metadata concept)
Biological active component 2mL vial/thrombin sealant solution 2mL vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Thrombin	Inferred relationship	Existential restriction modifier (core metadata concept)
Human thrombin topical solution 5mL vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Thrombin	Inferred relationship	Existential restriction modifier (core metadata concept)
Human thrombin topical solution 20mL vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Thrombin	Inferred relationship	Existential restriction modifier (core metadata concept)
Repair of pesudoaneurysm by injection of thrombin (procedure)	Direct substance	False	Thrombin	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Human thrombin topical solution 2mL vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Thrombin	Inferred relationship	Existential restriction modifier (core metadata concept)
Recombinant thrombin (substance)	Is a	False	Thrombin	Inferred relationship	Existential restriction modifier (core metadata concept)
Percutaneous injection of thrombin using fluoroscopic guidance (procedure)	Direct substance	False	Thrombin	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Sealer protein concentrate/thrombin solution 2mL pack	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Thrombin	Inferred relationship	Existential restriction modifier (core metadata concept)
Sealer protein concentrate/thrombin solution 4mL pack	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Thrombin	Inferred relationship	Existential restriction modifier (core metadata concept)
Sealer protein concentrate/thrombin solution 10mL pack	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Thrombin	Inferred relationship	Existential restriction modifier (core metadata concept)
Repair of pesudoaneurysm by injection of thrombin (procedure)	Direct substance	True	Thrombin	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Injection of thrombin using ultrasound guidance (procedure)	Direct substance	False	Thrombin	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Percutaneous injection of thrombin using fluoroscopic guidance (procedure)	Direct substance	True	Thrombin	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Injection of thrombin using ultrasound guidance (procedure)	Direct substance	True	Thrombin	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Injection of thrombin into pseudoaneurysm of limb	Direct substance	False	Thrombin	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Repair of pesudoaneurysm by injection of thrombin (procedure)	Direct substance	False	Thrombin	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Injection of thrombin into pseudoaneurysm of limb	Direct substance	True	Thrombin	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Injection of thrombin for femoral artery pseudoaneurysm using imaging guidance (procedure)	Direct substance	True	Thrombin	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Injection of thrombin using fluoroscopic guidance (procedure)	Direct substance	True	Thrombin	Inferred relationship	Existential restriction modifier (core metadata concept)	3
Injection of thrombin into pseudoaneurysm of extremity using fluoroscopic guidance (procedure)	Direct substance	True	Thrombin	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Injection of thrombin	Direct substance	True	Thrombin	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Thrombin only product	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Thrombin	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Human fibrinogen and thrombin only product	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Thrombin	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Thrombin only product in cutaneous dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Thrombin	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing thrombin in cutaneous dose form (medicinal product form)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Thrombin	Inferred relationship	Existential restriction modifier (core metadata concept)	1

Reference Sets

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US English

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Id	Description	Lang	Type	Status	Case?	Module
60365011	Thrombin	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
60366012	Fibrinogenase	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
767897014	Thrombin (substance)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
60365011	Thrombin	en	Synonym (core metadata concept)	Active	Only initial character case insensitive (core metadata concept)	SNOMED CT core
60365011	Thrombin	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
60366012	Fibrinogenase	en	Synonym (core metadata concept)	Active	Only initial character case insensitive (core metadata concept)	SNOMED CT core
60366012	Fibrinogenase	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
767897014	Thrombin (substance)	en	Fully specified name	Active	Only initial character case insensitive (core metadata concept)	SNOMED CT core
767897014	Thrombin (substance)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
920101000195119	trombina	it	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
11871000188116	thrombine humaine	fr	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
11871000188116	thrombine humaine	fr	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
920101000195119	trombina	it	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module