372623002: Substance with central alpha adrenergic receptor agonist mechanism of action (substance)

Status: retired, Not sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jan 2020. Module: SNOMED CT core

Descriptions:

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
Substance with central alpha adrenergic receptor agonist mechanism of action	Is a	Sympathomimetic agent (substance)	false	Inferred relationship	Existential restriction modifier (core metadata concept)
Substance with central alpha adrenergic receptor agonist mechanism of action	Is a	Substance with alpha adrenergic receptor agonist mechanism of action (substance)	false	Inferred relationship	Existential restriction modifier (core metadata concept)
Substance with central alpha adrenergic receptor agonist mechanism of action	Has disposition	Alpha adrenergic receptor agonist (disposition)	false	Inferred relationship	Existential restriction modifier (core metadata concept)

Inbound Relationships	Type	Active	Source	Characteristic	Refinability	Group
Apraclonidine hydrochloride (substance)	Is a	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Guanfacine (substance)	Is a	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Guanabenz (substance)	Is a	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Methyldopa (substance)	Is a	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Clonidine hydrochloride	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Central alpha-adrenoceptor agonist poisoning	Causative agent (attribute)	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Accidental clonidine poisoning	Causative agent (attribute)	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Intentional clonidine poisoning	Causative agent (attribute)	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
intoxication par la clonidine d'intention indéterminée	Causative agent (attribute)	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Central alpha-adrenoceptor agonist adverse reaction	Causative agent (attribute)	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Apraclonidine adverse reaction	Causative agent (attribute)	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Clonidine adverse reaction (disorder)	Causative agent (attribute)	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Lofexidine adverse reaction	Causative agent (attribute)	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Central alpha-adrenoceptor agonist allergy	Causative agent (attribute)	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Apraclonidine allergy	Causative agent (attribute)	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Allergy to clonidine (finding)	Causative agent (attribute)	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Allergy to lofexidine (finding)	Causative agent (attribute)	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Central alpha-adrenoceptor agonist overdose	Causative agent (attribute)	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Clonidine overdose	Causative agent (attribute)	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Accidental clonidine overdose	Causative agent (attribute)	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Intentional clonidine overdose (disorder)	Causative agent (attribute)	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
surdose de clonidine d'intention indéterminée	Causative agent (attribute)	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Clonidine hydrochloride [antihypertensive]	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Clonidine hydrochloride 250micrograms m/r capsule	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Clonidine hydrochloride 150micrograms/1mL injection (substance)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Clonidine HCl [migraine]	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Product containing precisely clonidine hydrochloride 25 microgram/1 each conventional release oral tablet (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Lofexidine hydrochloride	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Product containing precisely lofexidine hydrochloride 200 microgram/1 each conventional release oral tablet (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Apraclonidine-containing product	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Product containing central alpha-adrenoceptor agonist	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing lofexidine (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Clonidine hydrochloride 0.1mg tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Clonidine hydrochloride 0.2mg tablet (product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Clonidine hydrochloride 0.3mg tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Clonidine 2.5mg/unt	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Clonidine 7.5mg/unt	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Clonidine hydrochloride 100mcg/mL injection	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Clonidine 4mg/patch	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Clonidine 0.1mg patch	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Clonidine 5mg patch	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Chlortalidone 15 mg and clonidine hydrochloride 200 microgram oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Chlorthalidone + clonidine hydrochloride 15mg/0.3mg tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Clonidine-containing product in oral dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Clonidine-containing product in transdermal dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Product containing clonidine in parenteral dose form (medicinal product form)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Clonidine m/r	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Poisoning by clonidine	Causative agent (attribute)	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Product containing clonidine (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Apraclonidine hydrochloride 1%/mL solution	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Apraclonidine hydrochloride 0.5% solution	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Product containing chlortalidone and clonidine hydrochloride	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Clonidine hydrochloride 100mcg/mL injection solution 10mL vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Clonidine hydrochloride 100 microgram oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Clonidine hydrochloride 300micrograms tablet (substance)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Apraclonidine (as apraclonidine hydrochloride) 5 mg/mL eye drops	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Apraclonidine 1% intra-ocular solution	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Apraclonidine hydrochloride	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Clonidine hydrochloride 0.5mg/mL injection solution 10mL vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Clonidine (substance)	Is a	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Lofexidine (substance)	Is a	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Central alpha-adrenoceptor agonist allergy	Causative agent (attribute)	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Lofexidine hydrochloride (substance)	Is a	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Clonidine hydrochloride (substance)	Is a	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Methyldopa anhydrous	Is a	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Guanfacine hydrochloride (substance)	Is a	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)
Guanabenz acetate	Is a	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Existential restriction modifier (core metadata concept)

Reference Sets

Concept inactivation indicator attribute value reference set (foundation metadata concept)

POSSIBLY EQUIVALENT TO association reference set

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Id	Description	Lang	Type	Status	Case?	Module
1211152010	Central alpha-adrenoceptor agonist	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
3646033017	Substance with central alpha adrenergic receptor agonist mechanism of action (substance)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
3646034011	Substance with central alpha adrenergic receptor agonist mechanism of action	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
1197917019	Central alpha-adrenoceptor agonist (substance)	en	Fully specified name	Active	Only initial character case insensitive (core metadata concept)	SNOMED CT core
1197917019	Central alpha-adrenoceptor agonist (substance)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
1211152010	Central alpha-adrenoceptor agonist	en	Synonym (core metadata concept)	Active	Only initial character case insensitive (core metadata concept)	SNOMED CT core
1211152010	Central alpha-adrenoceptor agonist	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
3646033017	Substance with central alpha adrenergic receptor agonist mechanism of action (substance)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
3646034011	Substance with central alpha adrenergic receptor agonist mechanism of action	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core