37411004: Tissue plasminogen activator (substance)

SNOMED CT Concept\Substance\...

\Substance categorized by disposition\Substance with effector mechanism of action (substance)\Enzyme activator\Tissue plasminogen activator
\Substance categorized by disposition\Enzyme\Substance with hydrolase mechanism of action (substance)\Peptide hydrolase\Tissue plasminogen activator

\Substance categorised by structure\Chemical\Chemical categorized by structure\...

\Nitrogen and/or nitrogen compound (substance)\Nitrogen compound\Organic nitrogen compound\Amide and/or amide derivative\Substituted amide (substance)\Polypeptide\Protein\Tissue plasminogen activator

\Organic compound\Organic nitrogen compound\Amide and/or amide derivative\Substituted amide (substance)\Polypeptide\Protein\Tissue plasminogen activator

\Biological substance\Protein and/or protein derivative\Protein\Tissue plasminogen activator
\Biological substance\Polypeptide\Protein\Tissue plasminogen activator

Status: current, Not sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jan 2002. Module: SNOMED CT core

Descriptions:

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
Tissue plasminogen activator	Is a	Plasminogen activator	false	Inferred relationship	Existential restriction modifier (core metadata concept)
Tissue plasminogen activator	Is a	Substance with hydrolase mechanism of action (substance)	false	Inferred relationship	Existential restriction modifier (core metadata concept)
Tissue plasminogen activator	Has disposition	Hydrolase	false	Inferred relationship	Existential restriction modifier (core metadata concept)
Tissue plasminogen activator	Has disposition	Plasminogen activator (disposition)	true	Inferred relationship	Existential restriction modifier (core metadata concept)
Tissue plasminogen activator	Is a	Enzyme activator	true	Inferred relationship	Existential restriction modifier (core metadata concept)
Tissue plasminogen activator	Is a	proteasi	false	Inferred relationship	Existential restriction modifier (core metadata concept)
Tissue plasminogen activator	Is a	Protein	true	Inferred relationship	Existential restriction modifier (core metadata concept)
Tissue plasminogen activator	Is a	Peptide hydrolase	true	Inferred relationship	Existential restriction modifier (core metadata concept)

Inbound Relationships	Type	Active	Source	Characteristic	Refinability	Group
tPA-PAI complex assay	Has measured component	False	Tissue plasminogen activator	Inferred relationship	Existential restriction modifier (core metadata concept)
Tissue plasminogen activator assay	Has measured component	False	Tissue plasminogen activator	Inferred relationship	Existential restriction modifier (core metadata concept)
Tissue plasminogen activator activity assay	Has measured component	False	Tissue plasminogen activator	Inferred relationship	Existential restriction modifier (core metadata concept)
Tissue plasminogen activator antigen assay	Has measured component	False	Tissue plasminogen activator	Inferred relationship	Existential restriction modifier (core metadata concept)
Tissue plasminogen activator antigen	Direct substance	False	Tissue plasminogen activator	Inferred relationship	Existential restriction modifier (core metadata concept)
tPA-PAI complex assay	Component	False	Tissue plasminogen activator	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Tissue plasminogen activator assay	Component	True	Tissue plasminogen activator	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Tissue plasminogen activator activity assay	Component	True	Tissue plasminogen activator	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Tissue plasminogen activator antigen assay	Component	True	Tissue plasminogen activator	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Reteplase (substance)	Is a	False	Tissue plasminogen activator	Inferred relationship	Existential restriction modifier (core metadata concept)
Alteplase (substance)	Is a	False	Tissue plasminogen activator	Inferred relationship	Existential restriction modifier (core metadata concept)
Tenecteplase (substance)	Is a	False	Tissue plasminogen activator	Inferred relationship	Existential restriction modifier (core metadata concept)
Product containing tissue plasminogen activator (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Tissue plasminogen activator	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing reteplase (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Tissue plasminogen activator	Inferred relationship	Existential restriction modifier (core metadata concept)
Alteplase 50mg injection (pdr for recon)+diluent (substance)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Tissue plasminogen activator	Inferred relationship	Existential restriction modifier (core metadata concept)
Alteplase 20mg injection (pdr for recon)+diluent (product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Tissue plasminogen activator	Inferred relationship	Existential restriction modifier (core metadata concept)
alteplase 10 mg, fiole de poudre et solvant pour solution pour injection	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Tissue plasminogen activator	Inferred relationship	Existential restriction modifier (core metadata concept)
Reteplase 10units injection (pdr for recon)+diluent pack (substance)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Tissue plasminogen activator	Inferred relationship	Existential restriction modifier (core metadata concept)
Product containing tenecteplase (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Tissue plasminogen activator	Inferred relationship	Existential restriction modifier (core metadata concept)
Product containing alteplase (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Tissue plasminogen activator	Inferred relationship	Existential restriction modifier (core metadata concept)
Tenecteplase 8000iu(40mg) injection (pdr for recon)+solvent (product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Tissue plasminogen activator	Inferred relationship	Existential restriction modifier (core metadata concept)
Tenecteplase 10,000iu(50mg) inj (pdr for recon)+solvent	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Tissue plasminogen activator	Inferred relationship	Existential restriction modifier (core metadata concept)
Alteplase 1mg injection solution 1mL vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Tissue plasminogen activator	Inferred relationship	Existential restriction modifier (core metadata concept)
Reteplase, recombinant 10unt/vial powder	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Tissue plasminogen activator	Inferred relationship	Existential restriction modifier (core metadata concept)
Alteplase 100mg powder	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Tissue plasminogen activator	Inferred relationship	Existential restriction modifier (core metadata concept)
Tissue plasminogen activator only product	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Tissue plasminogen activator	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Fibrinolytic disorder caused by tissue plasminogen activator	Causative agent (attribute)	True	Tissue plasminogen activator	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Intravenous injection of tissue plasminogen activator	Direct substance	True	Tissue plasminogen activator	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Intra-arterial injection of tissue plasminogen activator	Direct substance	True	Tissue plasminogen activator	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Adverse reaction caused by tissue plasminogen activator (disorder)	Causative agent (attribute)	True	Tissue plasminogen activator	Inferred relationship	Existential restriction modifier (core metadata concept)	1
tPA-PAI complex assay	Component	True	Tissue plasminogen activator	Inferred relationship	Existential restriction modifier (core metadata concept)	1

Reference Sets

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US English

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Id	Description	Lang	Type	Status	Case?	Module
62404015	Tissue plasminogen activator	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
62405019	T-PA	en	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT core
769275011	Tissue plasminogen activator (substance)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
62404015	Tissue plasminogen activator	en	Synonym (core metadata concept)	Active	Only initial character case insensitive (core metadata concept)	SNOMED CT core
62404015	Tissue plasminogen activator	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
62405019	T-PA	en	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT core
769275011	Tissue plasminogen activator (substance)	en	Fully specified name	Active	Only initial character case insensitive (core metadata concept)	SNOMED CT core
769275011	Tissue plasminogen activator (substance)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core