387152000: Alteplase (substance)

SNOMED CT Concept\Substance\...

\Substance categorized by disposition\Substance with effector mechanism of action (substance)\Enzyme activator\Plasminogen activator\Alteplase (substance)
\Substance categorized by disposition\Enzyme\Substance with hydrolase mechanism of action (substance)\Peptide hydrolase\Plasminogen activator\Alteplase (substance)

\Drug or medicament (substance)\Hematologic agent (substance)\Thrombolytic agent (substance)\Plasminogen activator\Alteplase (substance)
\Drug or medicament (substance)\agent cardiovasculaire\Thrombolytic agent (substance)\Plasminogen activator\Alteplase (substance)

\Substance categorised by structure\Chemical\Chemical categorized by structure\...

\Nitrogen and/or nitrogen compound (substance)\Nitrogen compound\Organic nitrogen compound\Amide and/or amide derivative\Substituted amide (substance)\Polypeptide\Protein\Alteplase (substance)

\Organic compound\Organic nitrogen compound\Amide and/or amide derivative\Substituted amide (substance)\Polypeptide\Protein\Alteplase (substance)

\Biological substance\Protein and/or protein derivative\Protein\Alteplase (substance)
\Biological substance\Polypeptide\Protein\Alteplase (substance)

Status: current, Not sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jan 2003. Module: SNOMED CT core

Descriptions:

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
Alteplase (substance)	Is a	Tissue plasminogen activator	false	Inferred relationship	Existential restriction modifier (core metadata concept)
Alteplase (substance)	Is a	agent activateur du plasminogène	false	Inferred relationship	Existential restriction modifier (core metadata concept)
Alteplase (substance)	Has disposition	Plasminogen activator (disposition)	true	Inferred relationship	Existential restriction modifier (core metadata concept)
Alteplase (substance)	Is a	Plasminogen activator	true	Inferred relationship	Existential restriction modifier (core metadata concept)
Alteplase (substance)	Is a	Substance with hydrolase mechanism of action (substance)	false	Inferred relationship	Existential restriction modifier (core metadata concept)
Alteplase (substance)	Is a	Protein	true	Inferred relationship	Existential restriction modifier (core metadata concept)

Inbound Relationships	Type	Active	Source	Characteristic	Refinability	Group
Product containing alteplase (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Alteplase (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Alteplase adverse reaction	Causative agent (attribute)	True	Alteplase (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Allergy to alteplase	Causative agent (attribute)	False	Alteplase (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)
Alteplase 50mg injection (pdr for recon)+diluent (substance)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Alteplase (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)
Alteplase 20mg injection (pdr for recon)+diluent (product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Alteplase (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)
alteplase 10 mg, fiole de poudre et solvant pour solution pour injection	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Alteplase (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)
Alteplase 100mg powder	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Alteplase (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)
Alteplase 1mg injection solution 1mL vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Alteplase (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)
Continuous infusion of alteplase	Direct substance	False	Alteplase (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Continuous infusion of alteplase	Direct substance	True	Alteplase (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Allergy to alteplase	Causative agent (attribute)	True	Alteplase (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely alteplase 50 milligram/1 vial powder for conventional release solution for injection (clinical drug)	Has basis of strength substance (attribute)	True	Alteplase (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely alteplase 50 milligram/1 vial powder for conventional release solution for injection (clinical drug)	Has precise active ingredient	True	Alteplase (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely alteplase 10 milligram/1 vial powder for conventional release solution for injection (clinical drug)	Has precise active ingredient	True	Alteplase (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely alteplase 10 milligram/1 vial powder for conventional release solution for injection (clinical drug)	Has basis of strength substance (attribute)	True	Alteplase (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely alteplase 20 milligram/1 vial powder for conventional release solution for injection (clinical drug)	Has basis of strength substance (attribute)	True	Alteplase (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely alteplase 20 milligram/1 vial powder for conventional release solution for injection (clinical drug)	Has precise active ingredient	True	Alteplase (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing alteplase in parenteral dose form (medicinal product form)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Alteplase (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing only alteplase (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Alteplase (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing only alteplase in parenteral dose form (medicinal product form)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Alteplase (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely alteplase 2 milligram/1 vial powder for conventional release solution for infusion and/or injection (clinical drug)	Has precise active ingredient	True	Alteplase (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely alteplase 2 milligram/1 vial powder for conventional release solution for infusion and/or injection (clinical drug)	Has basis of strength substance (attribute)	True	Alteplase (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1

This concept is not in any reference sets

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Id	Description	Lang	Type	Status	Case?	Module
1461330011	Alteplase (substance)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
1481260011	Alteplase	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
3635509011	Tissue-type plasminogen activator	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
3635514010	rt-PA - Tissue-type plasminogen activator	en	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT core
1461330011	Alteplase (substance)	en	Fully specified name	Active	Only initial character case insensitive (core metadata concept)	SNOMED CT core
1461330011	Alteplase (substance)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
1481260011	Alteplase	en	Synonym (core metadata concept)	Active	Only initial character case insensitive (core metadata concept)	SNOMED CT core
1481260011	Alteplase	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
1491892019	Tissue-type plasminogen activator preparation	en	Synonym (core metadata concept)	Active	Only initial character case insensitive (core metadata concept)	SNOMED CT core
1491892019	Tissue-type plasminogen activator preparation	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
1491893012	t-PA preparation	en	Synonym (core metadata concept)	Active	Only initial character case insensitive (core metadata concept)	SNOMED CT core
1491894018	rt-PA preparation	en	Synonym (core metadata concept)	Active	Only initial character case insensitive (core metadata concept)	SNOMED CT core
3635509011	Tissue-type plasminogen activator	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
3635514010	rt-PA - Tissue-type plasminogen activator	en	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT core
59181000195112	alteplase	it	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
74461000195112	Alteplase	de	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
14861000188111	alteplase	fr	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
790311000172111	altéplase	fr	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
14861000188111	alteplase	fr	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
790311000172111	altéplase	fr	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
59181000195112	alteplase	it	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
74461000195112	Alteplase	de	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module