387381009: Methotrexate (substance)

SNOMED CT Concept\Substance\...

\Substance categorized by disposition\Immunomodulator\Antimetabolite (substance)\Antifolate (substance)\Methotrexate (substance)

\Drug or medicament (substance)\Immunologic agent (substance)\Antifolate (substance)\Methotrexate (substance)
\Drug or medicament (substance)\Antineoplastic agent (substance)\Antimetabolite (substance)\Antifolate (substance)\Methotrexate (substance)

\Substance categorised by structure\Chemical\Chemical categorized by structure\Organic compound\Organic cyclic compound\Heterocyclic compound (substance)\Pteridine\Methotrexate (substance)

Status: current, Not sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jan 2003. Module: SNOMED CT core

Descriptions:

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
Methotrexate (substance)	Is a	Antimetabolite (substance)	false	Inferred relationship	Existential restriction modifier (core metadata concept)
Methotrexate (substance)	Is a	Methotrexate and derivative	false	Inferred relationship	Existential restriction modifier (core metadata concept)
Methotrexate (substance)	Is a	agent antirhumatismal	false	Inferred relationship	Existential restriction modifier (core metadata concept)
Methotrexate (substance)	Has disposition	Antimetabolite	true	Inferred relationship	Existential restriction modifier (core metadata concept)
Methotrexate (substance)	Is a	Antifolate (substance)	true	Inferred relationship	Existential restriction modifier (core metadata concept)
Methotrexate (substance)	Is a	allergène médicamenteux	false	Inferred relationship	Existential restriction modifier (core metadata concept)
Methotrexate (substance)	Is a	Pteridine	true	Inferred relationship	Existential restriction modifier (core metadata concept)

Inbound Relationships	Type	Active	Source	Characteristic	Refinability	Group
Methotrexate measurement	Component	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Methotrexate injection into tubal pregnancy	Direct substance	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Methotrexate poisoning (disorder)	Causative agent (attribute)	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Accidental methotrexate poisoning	Causative agent (attribute)	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)
Intentional methotrexate poisoning	Causative agent (attribute)	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)
intoxication par le méthotrexate d'intention indéterminée	Causative agent (attribute)	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Methotrexate adverse reaction	Causative agent (attribute)	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Allergy to methotrexate (finding)	Causative agent (attribute)	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)
Methotrexate overdose	Causative agent (attribute)	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Accidental methotrexate overdose (disorder)	Causative agent (attribute)	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Intentional methotrexate overdose	Causative agent (attribute)	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
surdose de méthotrexate d'intention indéterminée	Causative agent (attribute)	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Plasma methotrexate measurement	Component	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Serum methotrexate measurement	Component	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Product containing precisely methotrexate 2.5 milligram/1 each conventional release oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)
Product containing precisely methotrexate 10 milligram/1 each conventional release oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)
Methotrexate 5mg/2mL injection	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)
Methotrexate 50mg/2mL injection (product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)
Methotrexate 200mg/8mL injection (product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)
Methotrexate 500mg/20mL injection (substance)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)
Methotrexate 25mg/mL injection solution 40mL vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)
Methotrexate 25mg/mL injection solution 200mL vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)
Methotrexate 1g/10mL injection (product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)
Methotrexate 5g/50mL injection (substance)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)
Methotrexate 375mg/30mL infusion (substance)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)
Methotrexate 750mg/60mL infusion (substance)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)
Methotrexate excretion measurement (procedure)	Component	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely methotrexate 5 milligram/1 each conventional release oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)
Product containing precisely methotrexate 7.5 milligram/1 each conventional release oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)
Product containing precisely methotrexate 15 milligram/1 each conventional release oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)
Methotrexate lpf 25mg/mL preservative free injection	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)
Product containing methotrexate (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Methotrexate sodium	Is a	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)
Methotrexate 25mg/mL injection solution 10mL vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)
Neurotoxicity caused by methotrexate (disorder)	Causative agent (attribute)	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Accidental methotrexate poisoning	Causative agent (attribute)	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Intentional methotrexate poisoning	Causative agent (attribute)	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Intravenous injection of methotrexate (procedure)	Direct substance	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Methotrexate skin ulceration (disorder)	Causative agent (attribute)	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)
Intramuscular injection of methotrexate	Direct substance	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Intravenous injection of methotrexate (procedure)	Direct substance	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Intravenous injection of methotrexate (procedure)	Direct substance	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Intramuscular injection of methotrexate	Direct substance	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Methotrexate injection into tubal pregnancy	Direct substance	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Measurement of methotrexate in cerebrospinal fluid (procedure)	Component	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Subcutaneous injection of methotrexate (procedure)	Direct substance	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Subcutaneous injection of methotrexate (procedure)	Direct substance	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Allergy to methotrexate (finding)	Causative agent (attribute)	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing methotrexate in parenteral dose form (medicinal product form)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Methotrexate-containing product in oral dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Cirrhosis of liver caused by methotrexate	Causative agent (attribute)	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	3
Product containing precisely methotrexate 2.5 milligram/1 each conventional release oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely methotrexate 2.5 milligram/1 each conventional release oral tablet	Has basis of strength substance (attribute)	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely methotrexate 10 milligram/1 each conventional release oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely methotrexate 10 milligram/1 each conventional release oral tablet	Has basis of strength substance (attribute)	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely methotrexate 5 milligram/1 each conventional release oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely methotrexate 5 milligram/1 each conventional release oral tablet	Has basis of strength substance (attribute)	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely methotrexate 7.5 milligram/1 each conventional release oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely methotrexate 7.5 milligram/1 each conventional release oral tablet	Has basis of strength substance (attribute)	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely methotrexate 15 milligram/1 each conventional release oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely methotrexate 15 milligram/1 each conventional release oral tablet	Has basis of strength substance (attribute)	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Methotrexate 25mg/mL conventional release solution for injection	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)
Product containing precisely methotrexate 5 milligram/1 each conventional release oral tablet	Has precise active ingredient	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely methotrexate 2.5 milligram/1 each conventional release oral tablet	Has precise active ingredient	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely methotrexate 7.5 milligram/1 each conventional release oral tablet	Has precise active ingredient	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely methotrexate 10 milligram/1 each conventional release oral tablet	Has precise active ingredient	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely methotrexate 15 milligram/1 each conventional release oral tablet	Has precise active ingredient	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely methotrexate (as methotrexate sodium) 5 milligram/2 milliliter conventional release solution for injection vial	Has basis of strength substance (attribute)	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely methotrexate (as methotrexate sodium) 500 milligram/20 milliliter conventional release solution for injection vial	Has basis of strength substance (attribute)	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely methotrexate (as methotrexate sodium) 1 gram/40 milliliter conventional release solution for injection vial	Has basis of strength substance (attribute)	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely methotrexate (as methotrexate sodium) 1 gram/10 milliliter conventional release solution for injection vial	Has basis of strength substance (attribute)	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely methotrexate (as methotrexate sodium) 5 gram/50 milliliter conventional release solution for injection vial	Has basis of strength substance (attribute)	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely methotrexate (as methotrexate sodium) 50 milligram/2 milliliter conventional release solution for injection vial	Has basis of strength substance (attribute)	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely methotrexate (as methotrexate sodium) 200 milligram/8 milliliter conventional release solution for injection vial	Has basis of strength substance (attribute)	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely methotrexate (as methotrexate sodium) 5 gram/200 milliliter conventional release solution for injection vial	Has basis of strength substance (attribute)	False	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Methotrexate sodium	Is modification of (attribute)	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)
Lymphoproliferative disorder caused by methotrexate	Causative agent (attribute)	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing only methotrexate (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Methotrexate only product in oral dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Methotrexate only product in parenteral dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Methotrexate (as methotrexate sodium) 100 mg/mL solution for injection	Has basis of strength substance (attribute)	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely methotrexate (as methotrexate sodium) 25 milligram/1 milliliter conventional release solution for injection (clinical drug)	Has basis of strength substance (attribute)	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Methotrexate (as methotrexate sodium) 2.5 mg/mL solution for injection	Has basis of strength substance (attribute)	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Methotrexate skin ulceration (disorder)	Causative agent (attribute)	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Cirrhosis of liver caused by methotrexate	Causative agent (attribute)	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Cirrhosis of liver caused by methotrexate	Causative agent (attribute)	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Accelerated rheumatoid nodulosis caused by methotrexate (disorder)	Causative agent (attribute)	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Methotrexate (as methotrexate sodium) 2.5 mg oral tablet	Has basis of strength substance (attribute)	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Methotrexate (as methotrexate sodium) 5 mg oral tablet	Has basis of strength substance (attribute)	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely methotrexate (as methotrexate sodium) 10 milligram/1 each conventional release oral tablet (clinical drug)	Has basis of strength substance (attribute)	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Methotrexate (as methotrexate sodium) 15 mg oral tablet	Has basis of strength substance (attribute)	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely methotrexate (as methotrexate sodium) 7.5 milligram/1 each conventional release oral tablet (clinical drug)	Has basis of strength substance (attribute)	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Methotrexate (as methotrexate sodium) 20 mg/mL solution for injection	Has basis of strength substance (attribute)	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely methotrexate (as methotrexate sodium) 50 milligram/1 milliliter conventional release solution for injection (clinical drug)	Has basis of strength substance (attribute)	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Methotrexate 25 mg/mL solution for injection	Has precise active ingredient	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Methotrexate 25 mg/mL solution for injection	Has basis of strength substance (attribute)	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Methotrexate 50 mg/mL solution for injection	Has precise active ingredient	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Methotrexate 50 mg/mL solution for injection	Has basis of strength substance (attribute)	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Methotrexate therapy (procedure)	Direct substance	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Measurement of methotrexate in cerebrospinal fluid (procedure)	Component	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Serum methotrexate measurement	Component	True	Methotrexate (substance)	Inferred relationship	Existential restriction modifier (core metadata concept)	1

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Id	Description	Lang	Type	Status	Case?	Module
1461559012	Methotrexate (substance)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
1481477014	Methotrexate	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
1492026011	Amethopterin	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
3756239015	MTX - methotrexate	en	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT core
1461559012	Methotrexate (substance)	en	Fully specified name	Active	Only initial character case insensitive (core metadata concept)	SNOMED CT core
1461559012	Methotrexate (substance)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
1481477014	Methotrexate	en	Synonym (core metadata concept)	Active	Only initial character case insensitive (core metadata concept)	SNOMED CT core
1481477014	Methotrexate	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
1492024014	MTX	en	Synonym (core metadata concept)	Active	Only initial character case insensitive (core metadata concept)	SNOMED CT core
1492024014	MTX	en	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT core
1492025010	Methotrexate sodium	en	Synonym (core metadata concept)	Active	Only initial character case insensitive (core metadata concept)	SNOMED CT core
1492026011	Amethopterin	en	Synonym (core metadata concept)	Active	Only initial character case insensitive (core metadata concept)	SNOMED CT core
1492026011	Amethopterin	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
3010969015	MTX - Methotrexate	en	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT core
3756239015	MTX - methotrexate	en	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT core
59901000195117	metotrexato	it	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
75541000195111	Methotrexat	de	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
28901000188118	méthotréxate	fr	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
824651000172117	méthotrexate	fr	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
28901000188118	méthotréxate	fr	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
824651000172117	méthotrexate	fr	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
59901000195117	metotrexato	it	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
75541000195111	Methotrexat	de	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module