Inbound Relationships |
Type |
Active |
Source |
Characteristic |
Refinability |
Group |
Serum cyclosporin measurement (procedure) |
Component |
False |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
2 |
Cyclosporin poisoning |
Causative agent (attribute) |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Accidental cyclosporin poisoning |
Causative agent (attribute) |
False |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
|
Intentional cyclosporin poisoning |
Causative agent (attribute) |
False |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
|
Cyclosporin poisoning of undetermined intent |
Causative agent (attribute) |
False |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Cyclosporin adverse reaction (disorder) |
Causative agent (attribute) |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Allergy to ciclosporin (finding) |
Causative agent (attribute) |
False |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
|
Cyclosporin overdose |
Causative agent (attribute) |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Accidental cyclosporin overdose |
Causative agent (attribute) |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Intentional cyclosporin overdose |
Causative agent (attribute) |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Cyclosporin overdose of undetermined intent |
Causative agent (attribute) |
False |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Blood cyclosporin measurement (procedure) |
Component |
False |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
2 |
Product containing precisely ciclosporin 25 milligram/1 each conventional release oral capsule (clinical drug) |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
|
Product containing precisely ciclosporin 100 milligram/1 each conventional release oral capsule (clinical drug) |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
|
Ciclosporin 50mg capsule |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
|
Ciclosporin 10 mg oral capsule |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
|
Ciclosporin 100mg/mL s/f oral solution |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
|
Cyclosporin 50mg/1mL oily infusion concentrate |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
|
Ciclosporin 250mg/5mL oily infusion concentrate |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
|
Cyclosporine measurement |
Component |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Cyclosporine 250mg/amp |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
|
Cyclosporine 100mg/mL solution |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
|
Cyclosporine 250mg/5mL |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
|
Cyclosporine 100mg/5mL solution |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
|
Cyclosporine 25mg gel |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
|
Cyclosporine 100mg gel capsule |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
|
Cyclosporine 50mg gel |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
|
Product containing ciclosporin (medicinal product) |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Ciclosporin metabolites |
Is a |
False |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
|
Cyclosporine ophthalmic emulsion 0.05% |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
|
Restasis ophthalmic emulsion 0.05% |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
|
Ciclosporin measurement, polyclonal (procedure) |
Component |
False |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
2 |
Ciclosporin measurement, monoclonal (procedure) |
Component |
False |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
2 |
Ciclosporin measurement, high performance liquid chromatography equivalent (procedure) |
Component |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Cyclosporine 50mg gel |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
|
Cyclosporine 250mg/amp |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
|
Accidental cyclosporin poisoning |
Causative agent (attribute) |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Intentional cyclosporin poisoning |
Causative agent (attribute) |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Ciclosporin modified immediate release |
Is a |
False |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
|
Ciclosporin-containing product in parenteral dose form |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Product containing ciclosporin in ophthalmic dosage form |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
|
Ciclosporin-containing product in oral dose form |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Plasma cyclosporin level (procedure) |
Component |
False |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
2 |
Measurement of ciclosporin 2 hours after dosing |
Component |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Measurement of ciclosporin trough concentration |
Component |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Quantitative measurement of mass concentration of ciclosporin in serum or plasma specimen using enzyme immunoassay technique (procedure) |
Component |
False |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
2 |
Allergy to ciclosporin (finding) |
Causative agent (attribute) |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Cyclosporin A poisoning |
Causative agent (attribute) |
False |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Nephropathy induced by ciclosporin |
Causative agent (attribute) |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Cyclosporine therapy (procedure) |
Direct substance |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
2 |
Product containing precisely ciclosporin 25 milligram/1 each conventional release oral capsule (clinical drug) |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Product containing precisely ciclosporin 25 milligram/1 each conventional release oral capsule (clinical drug) |
Has basis of strength substance (attribute) |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Product containing precisely ciclosporin 100 milligram/1 each conventional release oral capsule (clinical drug) |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Product containing precisely ciclosporin 100 milligram/1 each conventional release oral capsule (clinical drug) |
Has basis of strength substance (attribute) |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Ciclosporin 50mg capsule |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Ciclosporin 50mg capsule |
Has basis of strength substance (attribute) |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Ciclosporin 10 mg oral capsule |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Ciclosporin 10 mg oral capsule |
Has basis of strength substance (attribute) |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Product containing precisely ciclosporin 50 milligram/1 milliliter conventional release solution for injection (clinical drug) |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
|
Ciclosporin 50mg capsule |
Has precise active ingredient |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Product containing precisely ciclosporin 25 milligram/1 each conventional release oral capsule (clinical drug) |
Has precise active ingredient |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Product containing precisely ciclosporin 100 milligram/1 each conventional release oral capsule (clinical drug) |
Has precise active ingredient |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Ciclosporin 10 mg oral capsule |
Has precise active ingredient |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Product containing precisely ciclosporin 100 milligram/1 milliliter conventional release oral solution (clinical drug) |
Has basis of strength substance (attribute) |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Product containing precisely ciclosporin 100 milligram/1 milliliter conventional release oral solution (clinical drug) |
Has precise active ingredient |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Product containing precisely ciclosporin 50 milligram/1 milliliter conventional release solution for infusion ampule |
Has basis of strength substance (attribute) |
False |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Product containing precisely ciclosporin 50 milligram/1 milliliter conventional release solution for infusion ampule |
Has precise active ingredient |
False |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Ciclosporin-containing product in ocular dose form |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Product containing only ciclosporin (medicinal product) |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Ciclosporin only product in ocular dose form |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Product containing only ciclosporin in oral dose form (medicinal product form) |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Product containing only ciclosporin in parenteral dose form (medicinal product form) |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Product containing precisely ciclosporin 50 milligram/1 milliliter conventional release solution for infusion (clinical drug) |
Has basis of strength substance (attribute) |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Product containing precisely ciclosporin 50 milligram/1 milliliter conventional release solution for infusion (clinical drug) |
Has precise active ingredient |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Product containing precisely ciclosporin 50 milligram/1 milliliter conventional release solution for injection (clinical drug) |
Has precise active ingredient |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Product containing precisely ciclosporin 50 milligram/1 milliliter conventional release solution for injection (clinical drug) |
Has basis of strength substance (attribute) |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Product containing precisely ciclosporin 500 microgram/1 milliliter conventional release eye suspension (clinical drug) |
Has precise active ingredient |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Product containing precisely ciclosporin 500 microgram/1 milliliter conventional release eye suspension (clinical drug) |
Has basis of strength substance (attribute) |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Cyclosporin index |
Component |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Chronic cyclosporin A nephrotoxicity |
Causative agent (attribute) |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Product containing precisely ciclosporin 1 milligram/1 milliliter conventional release eye drops (clinical drug) |
Has precise active ingredient |
False |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Product containing precisely ciclosporin 1 milligram/1 milliliter conventional release eye drops (clinical drug) |
Has basis of strength substance (attribute) |
False |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Ciclosporin 50 mg/mL solution for infusion and/or injection |
Has precise active ingredient |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Ciclosporin 50 mg/mL solution for infusion and/or injection |
Has basis of strength substance (attribute) |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Ciclosporin 1 mg/mL eye drops emulsion |
Has precise active ingredient |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Ciclosporin 1 mg/mL eye drops emulsion |
Has basis of strength substance (attribute) |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Ciclosporin 50 mg/mL concentrate for solution for infusion |
Has precise active ingredient |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Ciclosporin 50 mg/mL concentrate for solution for infusion |
Has basis of strength substance (attribute) |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Blood cyclosporin measurement (procedure) |
Component |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Ciclosporin measurement, monoclonal (procedure) |
Component |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Ciclosporin measurement, polyclonal (procedure) |
Component |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Plasma cyclosporin level (procedure) |
Component |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Quantitative measurement of mass concentration of ciclosporin in serum or plasma specimen using enzyme immunoassay technique (procedure) |
Component |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Serum cyclosporin measurement (procedure) |
Component |
True |
Ciclosporin (substance) |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |