418143002: Cerebral degeneration (disorder)

SNOMED CT Concept\Clinical finding (finding)\...

\Head finding (finding)\Finding of brain\Disorder of brain\Degenerative brain disorder\Cerebral degeneration (disorder)
\Head finding (finding)\Disorder of head (disorder)\Disorder of brain\Degenerative brain disorder\Cerebral degeneration (disorder)

\Central nervous system finding\Finding of brain\Disorder of brain\Degenerative brain disorder\Cerebral degeneration (disorder)
\Central nervous system finding\Disorder of the central nervous system (disorder)\Disorder of brain\Degenerative brain disorder\Cerebral degeneration (disorder)
\Central nervous system finding\Disorder of the central nervous system (disorder)\Degenerative disease of the central nervous system\Degenerative brain disorder\Cerebral degeneration (disorder)

\Disease\Degenerative disorder\Degenerative disease of the central nervous system\Degenerative brain disorder\Cerebral degeneration (disorder)
\Disease\Disorder of body system\Disease of nervous system (disorder)\Disorder of the central nervous system (disorder)\Disorder of brain\Degenerative brain disorder\Cerebral degeneration (disorder)
\Disease\Disorder of body system\Disease of nervous system (disorder)\Disorder of the central nervous system (disorder)\Degenerative disease of the central nervous system\Degenerative brain disorder\Cerebral degeneration (disorder)
\Disease\Disorder of head (disorder)\Disorder of brain\Degenerative brain disorder\Cerebral degeneration (disorder)

Status: current, Sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jan 2006. Module: SNOMED CT core

Descriptions:

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
Cerebral degeneration (disorder)	Is a	Degenerative brain disorder	true	Inferred relationship	Existential restriction modifier (core metadata concept)
Cerebral degeneration (disorder)	Associated morphology	dégénérescence	false	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Cerebral degeneration (disorder)	Finding site	The cerebrum is the regional structure of the brain, which is the adult equivalent of the forebrain or prosencephalon. It is constituted by the structural derivatives of the telencephalon and diencephalon including the cerebral hemispheres, epithalamus, thalamus, hypothalamus, lateral ventricles and third ventricle. This definition is harmonious with the Federation of Association of Anatomist Second Edition (2019) Part V Terminologia Anatomica.	false	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Cerebral degeneration (disorder)	Associated morphology	dégénérescence	false	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Cerebral degeneration (disorder)	Finding site	The cerebrum is the regional structure of the brain, which is the adult equivalent of the forebrain or prosencephalon. It is constituted by the structural derivatives of the telencephalon and diencephalon including the cerebral hemispheres, epithalamus, thalamus, hypothalamus, lateral ventricles and third ventricle. This definition is harmonious with the Federation of Association of Anatomist Second Edition (2019) Part V Terminologia Anatomica.	true	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Cerebral degeneration (disorder)	Associated morphology	Degenerative abnormality (morphologic abnormality)	true	Inferred relationship	Existential restriction modifier (core metadata concept)	1

Inbound Relationships	Type	Active	Source	Characteristic	Refinability	Group
Frontotemporal degeneration	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Existential restriction modifier (core metadata concept)
Chronic hepatocerebral degeneration	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Existential restriction modifier (core metadata concept)
Frontal lobe degeneration	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Existential restriction modifier (core metadata concept)
Cerebral degeneration presenting primarily with dementia	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Existential restriction modifier (core metadata concept)
Corticobasal degeneration	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Existential restriction modifier (core metadata concept)
Cerebral degeneration in childhood	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Existential restriction modifier (core metadata concept)
Pigmentary pallidal degeneration	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Existential restriction modifier (core metadata concept)
Cerebral degeneration in diseases EC (disorder)	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Existential restriction modifier (core metadata concept)
Striatonigral degeneration	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Existential restriction modifier (core metadata concept)
Progressive supranuclear ophthalmoplegia (disorder)	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Existential restriction modifier (core metadata concept)
Posterior cortical atrophy syndrome	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Existential restriction modifier (core metadata concept)
Kuru	Is a	False	Cerebral degeneration (disorder)	Inferred relationship	Existential restriction modifier (core metadata concept)
Spongiform encephalopathy	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Existential restriction modifier (core metadata concept)
Autosomal dominant striatal neurodegeneration (disorder)	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Existential restriction modifier (core metadata concept)
A rare late-onset neurodegenerative disease with characteristics of supranuclear gaze palsy, postural instability, progressive rigidity, and mild dementia. Five clinical variants have been described with clinicopathological correlations, with Richardson's syndrome the most common clinical variant. The disease has neuropathological manifestations of neuronal loss, gliosis with astrocytic plaques and accumulation of tau-immunoreactive neurofibrillary tangles in specific brain areas. The differences in the rate and areas of accumulation of phosphorylated tau protein correlate with the five clinical variants. The disease is a 4R tauopathy composed of a preponderance of four-repeat (exon 10 positive) tau isoforms and a characteristic biochemical profile (doublet tau 64 and tau 69). The MAPT H1-clade specific sub-haplotype, H1c, is a risk factor for this disease.	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Existential restriction modifier (core metadata concept)
Huntington disease-like syndrome due to chromosome 9 open reading frame 72 expansions (disorder)	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Existential restriction modifier (core metadata concept)
Progressive myoclonic epilepsy type 3 (disorder)	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Existential restriction modifier (core metadata concept)
A rare genetic human prion disease characterised by adult-onset neurodegenerative manifestations associated with a movement disorder and psychiatric/behavioural disturbances. Patients typically present personality changes, aggressiveness, manias, anxiety and/or depression in conjunction with rapidly progressive cognitive decline (presenting with dysarthria, apraxia, aphasia and eventually leading to dementia) as well as ataxia (manifesting with gait disturbances, unsteadiness, coordination problems), Parkinsonism, myoclonus, and/or chorea. Additional features may include generalised spasticity, seizures, urine incontinence and pyramidal abnormalities. There is evidence the disease is caused by 8 extra octapeptide repeats in the PRNP gene on chromosome 20p13.	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Existential restriction modifier (core metadata concept)
White matter disease (disorder)	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Existential restriction modifier (core metadata concept)
Neuroaxonal leukodystrophy	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Existential restriction modifier (core metadata concept)
Cerebral calcification	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Existential restriction modifier (core metadata concept)
Cerebral atrophy (disorder)	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Existential restriction modifier (core metadata concept)
Parkinson's disease	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Existential restriction modifier (core metadata concept)
Onset of disease between 2 and 5 years of age with characteristics of cerebello-spastic syndrome exacerbated by episodes of fever or head trauma leading to death after 5 to 10 years of disease evolution, diffuse involvement of the white matter on cerebral MRI with a CSF-like signal intensity (cavitation), a recessive autosomal mode of inheritance, neuropathologic findings consistent with a cavitating orthochromatic leukodystrophy with increased number of oligodendrocytes. This disease is linked to mutations in the five EIF2B genes encoding the five subunits of the eukaryotic initiation factor 2B (eIF2B), involved in the protein synthesis and its regulation under cellular stress.	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Existential restriction modifier (core metadata concept)
Leukoencephalopathy with metaphyseal chondrodysplasia syndrome	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Existential restriction modifier (core metadata concept)
Pituitary degeneration	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Existential restriction modifier (core metadata concept)
Cerebral non-neuropathic heredofamilial amyloidosis angiopathy	Is a	False	Cerebral degeneration (disorder)	Inferred relationship	Existential restriction modifier (core metadata concept)
Pineal degeneration	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Existential restriction modifier (core metadata concept)
Corticobasal syndrome (disorder)	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Existential restriction modifier (core metadata concept)
A rare severe neurodegenerative disorder that is considered one of the phenocopies of Huntington Disease (HD) affecting patients of African descent and characterized by a triad of movement (chorea, oculomotor, parkinsonism), psychiatric (prominently sadness, irritability and anxiety), and cognitive abnormalities (early cognitive decline and subcortical-like dementia).	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Existential restriction modifier (core metadata concept)
Parkinsonism with polyneuropathy (disorder)	Is a	True	Cerebral degeneration (disorder)	Inferred relationship	Existential restriction modifier (core metadata concept)

This concept is not in any reference sets

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Id	Description	Lang	Type	Status	Case?	Module
2574464019	Cerebral degeneration (disorder)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
2577820013	Cerebral degeneration	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
2574464019	Cerebral degeneration (disorder)	en	Fully specified name	Active	Only initial character case insensitive (core metadata concept)	SNOMED CT core
2574464019	Cerebral degeneration (disorder)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
2577820013	Cerebral degeneration	en	Synonym (core metadata concept)	Active	Only initial character case insensitive (core metadata concept)	SNOMED CT core
2577820013	Cerebral degeneration	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core