Inbound Relationships |
Type |
Active |
Source |
Characteristic |
Refinability |
Group |
Product containing precisely nicotine 937.5 microgram/1 hour prolonged-release transdermal patch (clinical drug) |
Has basis of strength substance (attribute) |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Nicotine (as nicotine cyclodextrin complex) 2 mg sublingual tablet |
Has basis of strength substance (attribute) |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Product containing precisely nicotine 500 microgram/1 actuation conventional release nasal spray (clinical drug) |
Has basis of strength substance (attribute) |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Product containing precisely nicotine 500 microgram/1 actuation conventional release nasal spray (clinical drug) |
Has precise active ingredient |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Nicotine resin complex |
Is modification of (attribute) |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
|
Allergy to nicotine |
Causative agent (attribute) |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Nicotine adverse reaction |
Causative agent (attribute) |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Nicotine polacrilex |
Is modification of (attribute) |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
|
Product containing nicotine in pulmonary dose form (medicinal product form) |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Product containing nicotine in cutaneous dose form (medicinal product form) |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Nicotine-containing product in oromucosal dose form |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Nicotine only product |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Nicotine only product in cutaneous dose form |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Nicotine only product in nasal dose form |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Nicotine only product in oromucosal dose form |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Nicotine only product in pulmonary dose form |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Product containing only nicotine in transdermal dose form (medicinal product form) |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Nicotine 2mg chewing gum (substance) |
Has basis of strength substance (attribute) |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Product containing precisely nicotine (as nicotine polacrilex) 2 milligram/1 each conventional release oromucosal lozenge (clinical drug) |
Has basis of strength substance (attribute) |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Product containing precisely nicotine (as nicotine polacrilex) 4 milligram/1 chewing gum prolonged-release oral gum (clinical drug) |
Has basis of strength substance (attribute) |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Product containing precisely nicotine (as nicotine polacrilex) 1 milligram/1 each conventional release oromucosal lozenge (clinical drug) |
Has basis of strength substance (attribute) |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Nicotine (as nicotine polacrilex) 4 mg oromucosal lozenge |
Has basis of strength substance (attribute) |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Product containing precisely nicotine 917 microgram/1 hour prolonged-release transdermal patch (clinical drug) |
Has basis of strength substance (attribute) |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Product containing precisely nicotine 917 microgram/1 hour prolonged-release transdermal patch (clinical drug) |
Has precise active ingredient |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Nicotine 458 microgram/hour prolonged-release transdermal patch |
Has basis of strength substance (attribute) |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Nicotine 458 microgram/hour prolonged-release transdermal patch |
Has precise active ingredient |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Product containing nicotine in oral dose form (medicinal product form) |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Nicotine only product in oral dose form |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Nicotine bitartrate dihydrate |
Is modification of (attribute) |
False |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
|
Nicotine dependence in remission (disorder) |
Causative agent (attribute) |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Tobacco dependence with current use |
Causative agent (attribute) |
False |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Tobacco dependence caused by cigarettes in remission |
Causative agent (attribute) |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Product containing precisely nicotine 1 milligram/1 actuation conventional release oromucosal spray (clinical drug) |
Has precise active ingredient |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Product containing precisely nicotine 1 milligram/1 actuation conventional release oromucosal spray (clinical drug) |
Has basis of strength substance (attribute) |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Nicotine replacement therapy |
Direct substance |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Nondependent harmful pattern of use of tobacco (disorder) |
Causative agent (attribute) |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Nicotine 1.563 mg/hour prolonged-release transdermal patch |
Has precise active ingredient |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Nicotine 1.563 mg/hour prolonged-release transdermal patch |
Has basis of strength substance (attribute) |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Tobacco dependence caused by chewing tobacco in remission |
Causative agent (attribute) |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
2 |
Nicotine (as nicotine polacrilex) 1.5 mg oromucosal lozenge |
Has basis of strength substance (attribute) |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Product containing precisely nicotine (as nicotine bitartrate) 1 milligram/1 each conventional release oromucosal lozenge (clinical drug) |
Has basis of strength substance (attribute) |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Product containing precisely nicotine (as nicotine bitartrate) 2 milligram/1 each conventional release oromucosal lozenge (clinical drug) |
Has basis of strength substance (attribute) |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Nicotine bitartrate (substance) |
Is modification of (attribute) |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
|
Nicotine pouch |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Nicotine use disorder (disorder) |
Causative agent (attribute) |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
An episode of nicotine use that has caused clinically significant harm to a person's physical or mental health. Harm may be caused by the intoxicating effects of caffeine, the direct or secondary toxic effects on body organs and systems, or a harmful route of administration. |
Causative agent (attribute) |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Use of nicotine (observable entity) |
Process acts on |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Qualitative measurement of nicotine in urine (procedure) |
Component |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Maternal harmful pattern of use of tobacco (disorder) |
Causative agent (attribute) |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |
Harmful pattern of use of tobacco |
Causative agent (attribute) |
True |
Nicotine |
Inferred relationship |
Existential restriction modifier (core metadata concept) |
1 |