702806008: Ruxolitinib (substance)

SNOMED CT Concept\Substance\...

\Substance categorized by disposition\Substance with effector mechanism of action (substance)\Enzyme inhibitor\Transferase inhibitor\Phosphotransferase inhibitor\Protein kinase inhibitor\Protein-tyrosine kinase inhibitor\Janus kinase inhibitor\Ruxolitinib

\Drug or medicament (substance)\Antineoplastic agent (substance)\Ruxolitinib
\Drug or medicament (substance)\Pyrazole derivative\Ruxolitinib

\Substance categorised by structure\Chemical\Chemical categorized by structure\...

\Nitrogen and/or nitrogen compound (substance)\Nitrogen compound\Organic nitrogen compound\...

\Azole (substance)\Pyrazole and/or pyrazole derivative (substance)\Pyrazole derivative\Ruxolitinib

\Nitrile\Ruxolitinib

\Organic compound\Organic cyclic compound\Heterocyclic compound (substance)\Azole (substance)\Pyrazole and/or pyrazole derivative (substance)\Pyrazole derivative\Ruxolitinib
\Organic compound\Organic nitrogen compound\Azole (substance)\Pyrazole and/or pyrazole derivative (substance)\Pyrazole derivative\Ruxolitinib
\Organic compound\Organic nitrogen compound\Nitrile\Ruxolitinib
\Organic compound\Hydrocarbon\Pyrazole and/or pyrazole derivative (substance)\Pyrazole derivative\Ruxolitinib

Status: current, Not sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jul 2014. Module: SNOMED CT core

Descriptions:

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
Ruxolitinib	Is a	Protein-tyrosine kinase inhibitor	false	Inferred relationship	Existential restriction modifier (core metadata concept)
Ruxolitinib	Is a	Antineoplastic agent (substance)	true	Inferred relationship	Existential restriction modifier (core metadata concept)
Ruxolitinib	Is a	Janus kinase inhibitor	true	Inferred relationship	Existential restriction modifier (core metadata concept)
Ruxolitinib	Has disposition	Janus kinase inhibitor (disposition)	true	Inferred relationship	Existential restriction modifier (core metadata concept)
Ruxolitinib	Is a	produit chimique catégorisé selon sa fonction	false	Inferred relationship	Existential restriction modifier (core metadata concept)
Ruxolitinib	Is a	Enzyme inhibitor	false	Inferred relationship	Existential restriction modifier (core metadata concept)
Ruxolitinib	Is a	Nitrile	true	Inferred relationship	Existential restriction modifier (core metadata concept)
Ruxolitinib	Is a	Pyrazole derivative	true	Inferred relationship	Existential restriction modifier (core metadata concept)

Inbound Relationships	Type	Active	Source	Characteristic	Refinability	Group
Product containing ruxolitinib (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Ruxolitinib	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely ruxolitinib 5 milligram/1 each conventional release oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Ruxolitinib	Inferred relationship	Existential restriction modifier (core metadata concept)
Product containing precisely ruxolitinib 10 milligram/1 each conventional release oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Ruxolitinib	Inferred relationship	Existential restriction modifier (core metadata concept)
Product containing precisely ruxolitinib 20 milligram/1 each conventional release oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Ruxolitinib	Inferred relationship	Existential restriction modifier (core metadata concept)
Product containing precisely ruxolitinib 15 milligram/1 each conventional release oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Ruxolitinib	Inferred relationship	Existential restriction modifier (core metadata concept)
Product containing precisely ruxolitinib 25 milligram/1 each conventional release oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Ruxolitinib	Inferred relationship	Existential restriction modifier (core metadata concept)
Product containing precisely ruxolitinib 5 milligram/1 each conventional release oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Ruxolitinib	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely ruxolitinib 5 milligram/1 each conventional release oral tablet	Has basis of strength substance (attribute)	False	Ruxolitinib	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely ruxolitinib 10 milligram/1 each conventional release oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Ruxolitinib	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely ruxolitinib 10 milligram/1 each conventional release oral tablet	Has basis of strength substance (attribute)	False	Ruxolitinib	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely ruxolitinib 20 milligram/1 each conventional release oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Ruxolitinib	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely ruxolitinib 20 milligram/1 each conventional release oral tablet	Has basis of strength substance (attribute)	False	Ruxolitinib	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely ruxolitinib 15 milligram/1 each conventional release oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Ruxolitinib	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely ruxolitinib 15 milligram/1 each conventional release oral tablet	Has basis of strength substance (attribute)	False	Ruxolitinib	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely ruxolitinib 25 milligram/1 each conventional release oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Ruxolitinib	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely ruxolitinib 25 milligram/1 each conventional release oral tablet	Has basis of strength substance (attribute)	False	Ruxolitinib	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Ruxolitinib phosphate (substance)	Is a	False	Ruxolitinib	Inferred relationship	Existential restriction modifier (core metadata concept)
Product containing precisely ruxolitinib 5 milligram/1 each conventional release oral tablet	Has precise active ingredient	False	Ruxolitinib	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely ruxolitinib 10 milligram/1 each conventional release oral tablet	Has precise active ingredient	False	Ruxolitinib	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely ruxolitinib 20 milligram/1 each conventional release oral tablet	Has precise active ingredient	False	Ruxolitinib	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely ruxolitinib 15 milligram/1 each conventional release oral tablet	Has precise active ingredient	False	Ruxolitinib	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely ruxolitinib 25 milligram/1 each conventional release oral tablet	Has precise active ingredient	False	Ruxolitinib	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Ruxolitinib-containing product in oral dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Ruxolitinib	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Ruxolitinib phosphate (substance)	Is modification of (attribute)	True	Ruxolitinib	Inferred relationship	Existential restriction modifier (core metadata concept)
Product containing only ruxolitinib (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Ruxolitinib	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Ruxolitinib only product in oral dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Ruxolitinib	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely ruxolitinib (as ruxolitinib phosphate) 5 milligram/1 each conventional release oral tablet (clinical drug)	Has basis of strength substance (attribute)	True	Ruxolitinib	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Ruxolitinib (as ruxolitinib phosphate) 10 mg oral tablet	Has basis of strength substance (attribute)	True	Ruxolitinib	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Ruxolitinib (as ruxolitinib phosphate) 20 mg oral tablet	Has basis of strength substance (attribute)	True	Ruxolitinib	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Ruxolitinib (as ruxolitinib phosphate) 15 mg oral tablet	Has basis of strength substance (attribute)	True	Ruxolitinib	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Product containing precisely ruxolitinib (as ruxolitinib phosphate) 25 milligram/1 each conventional release oral tablet (clinical drug)	Has basis of strength substance (attribute)	True	Ruxolitinib	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Ruxolitinib withdrawal syndrome (disorder)	Associated with	False	Ruxolitinib	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Ruxolitinib dependence (disorder)	Causative agent (attribute)	True	Ruxolitinib	Inferred relationship	Existential restriction modifier (core metadata concept)	1

This concept is not in any reference sets

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Id	Description	Lang	Type	Status	Case?	Module
3006149011	Ruxolitinib	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
3006175010	Ruxolitinib (substance)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
3006149011	Ruxolitinib	en	Synonym (core metadata concept)	Active	Only initial character case insensitive (core metadata concept)	SNOMED CT core
3006149011	Ruxolitinib	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
3006175010	Ruxolitinib (substance)	en	Fully specified name	Active	Only initial character case insensitive (core metadata concept)	SNOMED CT core
3006175010	Ruxolitinib (substance)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
839091000172115	ruxolitinib	fr	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
839091000172115	ruxolitinib	fr	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module