75777003: Cytokine (substance)

SNOMED CT Concept\Substance\...

\Substance categorized by disposition\Immunomodulator\Mediator of immune response and inflammation (substance)\Mediator of immune response (substance)\Cytokine

\Substance categorised by structure\Chemical\Chemical categorized by structure\...

\Nitrogen and/or nitrogen compound (substance)\Nitrogen compound\Organic nitrogen compound\Amide and/or amide derivative\Substituted amide (substance)\Polypeptide\Protein\Glycoprotein (substance)\Cytokine

\Organic compound\Organic nitrogen compound\Amide and/or amide derivative\Substituted amide (substance)\Polypeptide\Protein\Glycoprotein (substance)\Cytokine

Status: current, Not sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jan 2002. Module: SNOMED CT core

Descriptions:

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
Cytokine	Is a	analyte immunologique	false	Inferred relationship	Existential restriction modifier (core metadata concept)
Cytokine	Is a	Mediator of immune response (substance)	true	Inferred relationship	Existential restriction modifier (core metadata concept)
Cytokine	Is a	Glycoprotein (substance)	true	Inferred relationship	Existential restriction modifier (core metadata concept)
Cytokine	Has disposition	Immunomodulator (disposition)	true	Inferred relationship	Existential restriction modifier (core metadata concept)

Inbound Relationships	Type	Active	Source	Characteristic	Refinability	Group
Interferon beta-1b 100mcg/ solution (product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Interferon beta-1a 30mcg/vial injection	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Interferon alfa-2b 5000000unt/vial powder	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Interferon alfa-2b 25000000unt/vial powder	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Interferon alfa-2b 50000000unt/vial powder	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Interferon alfa-2b 10000000unt/vial powder	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Interferon alfa-2b 3000000unt/vial powder	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Interferon alfa-2b 18,000,000iu/vial powder	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Interferon alfa-2b 25 millioniu/vial solution (product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Interferon alfa-2b 18 millioniu/vial solution	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Interferon alfa-2b 10 million iu/vial solution	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Interferon alfa-2b 3 million iu/vial solution	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Interferon alfa-2b 5 million iu/vial solution	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Injectable interferon	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Peginterferon alfa-2a-containing product	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Interferon alfa-n3 human leu 5000000unt/mL injection solution 1mL vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Interferon alfa-2a 6miu/vial injection solution 1mL vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Interferon alfa-2a 9miu/vial injection solution 0.9mL vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Interferon alfa-2a 36000000iu/mL injection solution 1mL vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Interferon alfa-2a 3miu/vial injection solution 1mL vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Interferon alfa-2a 18000000iu/3mL injection solution 3mL vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Interferon alfa-2a 3miu/vial injection solution 0.5mL syringe	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Interferon beta-1a 30mcg/vial injection solution	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Interferon alfa-2a 6miu/vial injection solution 0.5mL syringe	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
PEG-intron redipen	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
PEG-intron redipen 150micrograms powder+sterile water 0.5mL	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
PEG-intron redipen 120micrograms powder+sterile water 0.5mL	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
PEG-intron redipen 50micrograms powder+sterile water 0.5mL	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
PEG-intron redipen 80micrograms powder+sterile water 0.5mL	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Interferon alfa-2b 10million iu/2mL injection solution	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Peginterferon alfa-2b 150micrograms powder+solvent for solution for injection in prefilled pen	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Peginterferon alfa-2b 50micrograms powder+solvent for solution for injection in prefilled pen	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Peginterferon alfa-2b 80micrograms powder+solvent for solution for injection in prefilled pen	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Peginterferon alfa-2b 100micrograms powder+solvent for solution for injection in prefilled pen	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Peginterferon alfa-2b 120micrograms powder+solvent for solution for injection in prefilled pen	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Peginterferon alfa-2a 180micrograms/0.5mL solution for injection prefilled syringe	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Peginterferon alfa-2a 135micrograms/0.5mL solution for injection prefilled syringe	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Interferon alfa-2a 18million iu/0.5mL injection solution prefilled syringe	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Interferons 1million iu injection (pdr for recon)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Interferons 4.5million iu injection	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Interferons 5million units injection (pdr for recon)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Interferons 10million iu injection (pdr for recon)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Interferons 30million iu injection (pdr for recon)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Interferons 3million iu injection (pdr for recon)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Interferons 9million iu injection (pdr for recon)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Interferons 18million iu injection (pdr for recon)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Interferons 3million iu/1mL solution for injection	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Interferons 10million iu/1mL solution for injection	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Peginterferon alfa-2a 180micrograms/mL injection 1mL vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Ribavirin+interferon alpha-2b	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Ribavirin 200mg capsule+interferon alpha-2b 3million iu/vial injection solution	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Interferon beta-1b 0.3mg powder for injection+diluent	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Angiogenin	Is a	True	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Platelet factor 4	Is a	True	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Interleukin	Is a	True	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Interferon	Is a	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Cytokine agent (substance)	Is a	True	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Lactoferrin	Is a	True	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Platelet-derived growth factor (substance)	Is a	True	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Tumour necrosis factor alpha	Is a	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Tumor necrosis factor beta	Is a	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Lymphotoxin	Is a	False	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Tumour necrosis factor	Is a	True	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Ancestim	Is a	True	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Transforming growth factor beta 1	Is a	True	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)
Cytokine-associated toxicity (disorder)	Causative agent (attribute)	True	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)	1
A rare systemic condition affecting patients undergoing chimeric antigen receptor (CAR) T-cell therapy and characterized by a systemic inflammatory response due to massive activation of leukocytes with subsequent cytokine release. It can present with a variety of signs and symptoms ranging from mild, flu-like symptoms (such as fever, fatigue, headache, rash, arthralgia, and myalgia) to severe life-threatening manifestations including vascular leakage, disseminated intravascular coagulation, shock, and multiple organ failure. Respiratory manifestations are common and range from cough and tachypnea to acute respiratory distress syndrome (ARDS).	Causative agent (attribute)	True	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Protein kinase C activity assay (procedure)	Component	True	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Lymphokine assay	Component	True	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)	2
Mononuclear cell function assay (procedure)	Component	True	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Intracellular free calcium assay (procedure)	Component	True	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)	1
Cytokine therapy	Direct substance	True	Cytokine	Inferred relationship	Existential restriction modifier (core metadata concept)	1

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Reference Sets

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Id	Description	Lang	Type	Status	Case?	Module
125852012	Cytokine	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
816424012	Cytokine (substance)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
125852012	Cytokine	en	Synonym (core metadata concept)	Active	Only initial character case insensitive (core metadata concept)	SNOMED CT core
125852012	Cytokine	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
816424012	Cytokine (substance)	en	Fully specified name	Active	Only initial character case insensitive (core metadata concept)	SNOMED CT core
816424012	Cytokine (substance)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core