1162828001: X-linked lymphoproliferative disease due to SH2D1A deficiency (disorder)

• SNOMED CT Concept\Clinical finding (finding)\Disease\...
• \Genetic disease\Hereditary disease\...
• \Hereditary disorder by system\Hereditary disorder of immune system\X-linked lymphoproliferative syndrome\X-linked lymphoproliferative disease due to SH2D1A deficiency (disorder)
• \Sex-linked hereditary disorder\X-linked hereditary disease\X-linked recessive hereditary disease\X-linked lymphoproliferative syndrome\X-linked lymphoproliferative disease due to SH2D1A deficiency (disorder)
• \Disorder of immune function (disorder)\Hereditary disorder of immune system\X-linked lymphoproliferative syndrome\X-linked lymphoproliferative disease due to SH2D1A deficiency (disorder)
• \Disorder of immune function (disorder)\Immunodeficiency disorder\Primary immune deficiency disorder\X-linked lymphoproliferative syndrome\X-linked lymphoproliferative disease due to SH2D1A deficiency (disorder)
• \Disorder of hematopoietic cell proliferation (disorder)\Lymphoproliferative disorder\Atypical lymphoproliferative disorder\X-linked lymphoproliferative syndrome\X-linked lymphoproliferative disease due to SH2D1A deficiency (disorder)
• \Disorder of body system\Disorder of immune structure (disorder)\X-linked lymphoproliferative syndrome\X-linked lymphoproliferative disease due to SH2D1A deficiency (disorder)
• \Disorder of body system\Hereditary disorder by system\Hereditary disorder of immune system\X-linked lymphoproliferative syndrome\X-linked lymphoproliferative disease due to SH2D1A deficiency (disorder)

Status: current, Not sufficiently defined by necessary conditions definition status (core metadata concept). Date: 30-Sep 2021. Module: SNOMED CT core

Descriptions:

Id	Description	Lang	Type	Status	Case?	Module
4591662013	X-linked lymphoproliferative disease due to SH2D1A deficiency (disorder)	en	Fully specified name	Active	Entire term case sensitive (core metadata concept)	SNOMED CT core
4591663015	X-linked lymphoproliferative syndrome type 1	en	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT core
4591664014	SH2D1A/SLAM-associated protein deficiency	en	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT core
4591665010	X-linked lymphoproliferative disease due to SH2D1A deficiency	en	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT core
4591669016	A rare, genetic, primary immunodeficiency disorder characterised by an abnormal immune response to Epstein-Barr virus (EBV) infection, caused by hemizygous mutations in the X-linked SH2D1A gene, resulting in B cell lymphoproliferation and manifesting with various phenotypes which include EBV-driven severe or fulminant mononucleosis, haemophagocytic lymphohistiocytosis (presenting with fulminant hepatitis, hepatic necrosis, bone marrow hypoplasia, and neurological involvement), hypogammaglobulinaemia, and B-cell lymphoma. Additional variable manifestations include vasculitis, lymphomatoid granulomatosis, aplastic anaemia, and chronic gastritis. Occasionally, T-cell lymphoma may be observed. Laboratory findings include normal or increased activated T cells and reduced memory B cells.	en	Definition	Active	Entire term case sensitive (core metadata concept)	SNOMED CT core
4591670015	A rare, genetic, primary immunodeficiency disorder characterized by an abnormal immune response to Epstein-Barr virus (EBV) infection, caused by hemizygous mutations in the X-linked SH2D1A gene, resulting in B cell lymphoproliferation and manifesting with various phenotypes which include EBV-driven severe or fulminant mononucleosis, hemophagocytic lymphohistiocytosis (presenting with fulminant hepatitis, hepatic necrosis, bone marrow hypoplasia, and neurological involvement), hypogammaglobulinemia, and B-cell lymphoma. Additional variable manifestations include vasculitis, lymphomatoid granulomatosis, aplastic anemia, and chronic gastritis. Occasionally, T-cell lymphoma may be observed. Laboratory findings include normal or increased activated T cells and reduced memory B cells.	en	Definition	Active	Entire term case sensitive (core metadata concept)	SNOMED CT core

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