112674009: Fibrosis (morphologic abnormality)

SNOMED CT Concept\Body structure (body structure)\Morphologically altered structure\Morphologically abnormal structure\Lesion (morphologic abnormality)\Fibrosis AND/OR repair abnormality\Fibrosis

Status: current, Not sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jan 2002. Module: SNOMED CT core

Descriptions:

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
Fibrosis	Is a	Fibrosis AND/OR repair abnormality	true	Inferred relationship	Some

Inbound Relationships	Type	Active	Source	Characteristic	Refinability	Group
Idiopathic retroperitoneal fibrosis	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Fibrosis of subcutaneous tissue (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Aortic valve fibrosis	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Cirrhosis of liver due to chronic hepatitis C	Associated morphology	False	Fibrosis	Inferred relationship	Some	2
infection au VIH causant une pneumopathie lymphoïde interstitielle	Associated morphology	False	Fibrosis	Inferred relationship	Some	4
Severe autosomal recessive intrahepatic cholestasis described in aboriginal children from northwestern Quebec. First manifestation as neonatal jaundice, progresses to periportal fibrosis and cirrhosis.	Associated morphology	False	Fibrosis	Inferred relationship	Some	2
Fibrosis of external urethral sphincter (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Malignant frozen pelvis	Associated morphology	True	Fibrosis	Inferred relationship	Some	2
Parametrial fibrosis	Associated morphology	False	Fibrosis	Inferred relationship	Some	4
Non-malignant frozen pelvis	Associated morphology	True	Fibrosis	Inferred relationship	Some	2
Non-malignant male frozen pelvis	Associated morphology	True	Fibrosis	Inferred relationship	Some	2
Frozen pelvis syndrome (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	2
Non-malignant female frozen pelvis	Associated morphology	True	Fibrosis	Inferred relationship	Some	4
Fibrosis of capsule of temporomandibular joint (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Vertical retraction syndrome	Associated morphology	False	Fibrosis	Inferred relationship	Some	3
Congenital fibrosis of inferior rectus muscle (disorder)	Associated morphology	False	Fibrosis	Inferred relationship	Some	3
Strabismus fixus	Associated morphology	False	Fibrosis	Inferred relationship	Some	3
A rare syndromic disorder with strabismus with characteristics of congenital non-progressive ophthalmoplegia affecting the oculomotor and/or trochlear nucleus/nerve and their innervated muscles. Patients present with abnormal resting position of the eyes (in most cases infraducted and exotropic), limitation of vertical and horizontal gaze, impaired binocular vision, amblyopia, unilateral or bilateral blepharoptosis, and compensatory abnormal head posture. Extraocular manifestations include intellectual disability, peripheral neuropathy, and skeletal abnormalities among others.	Associated morphology	False	Fibrosis	Inferred relationship	Some	3
Acute idiopathic pulmonary fibrosis	Associated morphology	False	Fibrosis	Inferred relationship	Some	4
Cirrhosis of liver due to hepatitis B	Associated morphology	False	Fibrosis	Inferred relationship	Some	2
Pulmonary fibrosis due to Hermansky-Pudlak syndrome (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	2
Idiopathic pulmonary fibrosis (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Subacute idiopathic pulmonary fibrosis	Associated morphology	False	Fibrosis	Inferred relationship	Some	1
Pulmonary emphysema co-occurrent with fibrosis of lung (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	6
Congenital fibrosis of inferior rectus muscle (disorder)	Associated morphology	False	Fibrosis	Inferred relationship	Some	5
Familial fibrous mediastinitis	Associated morphology	False	Fibrosis	Inferred relationship	Some	2
Fibrous mediastinitis caused by radiation	Associated morphology	False	Fibrosis	Inferred relationship	Some	2
Ainhum	Associated morphology	False	Fibrosis	Inferred relationship	Some	4
Chronic hepatitis C with stage 2 fibrosis	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Drug induced pulmonary fibrosis (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Reynolds syndrome (RS) is an autoimmune disorder characterized by the association of primary biliary cirrhosis (PBC) with limited cutaneous systemic sclerosis (lcSSc).	Associated morphology	False	Fibrosis	Inferred relationship	Some	4
Reynolds syndrome (RS) is an autoimmune disorder characterized by the association of primary biliary cirrhosis (PBC) with limited cutaneous systemic sclerosis (lcSSc).	Associated morphology	False	Fibrosis	Inferred relationship	Some	5
Reynolds syndrome (RS) is an autoimmune disorder characterized by the association of primary biliary cirrhosis (PBC) with limited cutaneous systemic sclerosis (lcSSc).	Associated morphology	False	Fibrosis	Inferred relationship	Some	6
A rare ciliopathy characterized by the association of nephronophthisis and liver fibrosis. Renal manifestations include chronic renal failure, polyuria, polydipsia, anemia, as well as increased echogenicity on renal ultrasound and interstitial fibrosis and tubular dilation on biopsy. Hepatic involvement manifests as hepatosplenomegaly with extensive fibrosis, destruction of the bile ducts, and cholestasis. Mild psychomotor retardation and ocular symptoms, such as strabismus, nystagmus, retinal degeneration, and anisocoria, have been reported in some patients.	Associated morphology	False	Fibrosis	Inferred relationship	Some	3
Decompensated cirrhosis of liver (disorder)	Associated morphology	False	Fibrosis	Inferred relationship	Some	1
Idiopathic copper-associated cirrhosis is a rare copper-overload liver disease characterized by a rapidly progressive liver cirrhosis from the first few years of life leading to hepatic insufficiency and harboring a specific pathological aspect: pericellular fibrosis, inflammatory infiltration, hepatocyte necrosis, absence of steatosis, poor regeneration and histochemical copper staining.	Associated morphology	False	Fibrosis	Inferred relationship	Some	4
Glomerulonephritis co-occurrent and due to scleroderma (disorder)	Associated morphology	False	Fibrosis	Inferred relationship	Some
Cryptogenic organizing pneumonia (disorder)	Associated morphology	False	Fibrosis	Inferred relationship	Some	4
Congenital hepatic fibrosis	Associated morphology	False	Fibrosis	Inferred relationship	Some	2
Fibrosis of liver caused by alcohol (disorder)	Associated morphology	False	Fibrosis	Inferred relationship	Some	2
Joubert syndrome with hepatic defect is a very rare subtype of Joubert syndrome and related disorders characterized by the neurological features of JS associated with congenital hepatic fibrosis (CHF).	Associated morphology	False	Fibrosis	Inferred relationship	Some	3
Lung fibrosis-immunodeficiency-46,XX gonadal dysgenesis syndrome is characterized by immune deficiency, gonadal dysgenesis and fatal lung fibrosis. So far, it has been described in two sisters born to consanguineous parents. Both karyotypes were normal female (46,XX). No genetic anomalies could be identified by comparative genome hybridization analysis of their genomes or by analysis of genes known to be associated with these types of anomalies.	Associated morphology	False	Fibrosis	Inferred relationship	Some	3
Joubert syndrome with hepatic defect is a very rare subtype of Joubert syndrome and related disorders characterized by the neurological features of JS associated with congenital hepatic fibrosis (CHF).	Associated morphology	True	Fibrosis	Inferred relationship	Some	2
Morton's neuroma (morphologic abnormality)	Is a	True	Fibrosis	Inferred relationship	Some
Classical histoplasmosis mediastinal fibrosis	Associated morphology	True	Fibrosis	Inferred relationship	Some	2
A rare disease, manifesting with idiopathic pulmonary fibrosis, hepatic nodular regenerative hyperplasia leading to portal hypertension and thrombocytopenia due to bone marrow hypoplasia. The condition was associated with 100% mortality.	Associated morphology	True	Fibrosis	Inferred relationship	Some	5
Cirrhotic cardiomyopathy is the term used to describe a constellation of features indicative of abnormal heart structure and function in patients with cirrhosis. These include systolic and diastolic dysfunction, electrophysiological changes, and macroscopic and microscopic structural changes.	Associated morphology	False	Fibrosis	Inferred relationship	Some	4
Pediatric onset systemic sclerosis (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Diabetic mastopathy	Associated morphology	True	Fibrosis	Inferred relationship	Some	5
External iliac artery endofibrosis (disorder)	Associated morphology	False	Fibrosis	Inferred relationship	Some	2
Cirrhosis of liver caused by methotrexate (disorder)	Associated morphology	False	Fibrosis	Inferred relationship	Some	2
Cirrhosis of liver caused by methotrexate (disorder)	Associated morphology	False	Fibrosis	Inferred relationship	Some	3
Cirrhosis of liver caused by amiodarone (disorder)	Associated morphology	False	Fibrosis	Inferred relationship	Some	2
Cirrhosis of liver caused by amiodarone (disorder)	Associated morphology	False	Fibrosis	Inferred relationship	Some	3
Cirrhosis of liver caused by methyldopa (disorder)	Associated morphology	False	Fibrosis	Inferred relationship	Some	2
Cirrhosis of liver caused by methyldopa (disorder)	Associated morphology	False	Fibrosis	Inferred relationship	Some	3
Cirrhosis of liver co-occurrent and due to primary sclerosing cholangitis (disorder)	Associated morphology	False	Fibrosis	Inferred relationship	Some	4
Fibropolycystic disease of liver	Associated morphology	True	Fibrosis	Inferred relationship	Some	2
Subacute effusive constrictive pericarditis	Associated morphology	True	Fibrosis	Inferred relationship	Some	3
Chronic constrictive pericarditis	Associated morphology	True	Fibrosis	Inferred relationship	Some	2
Pericarditis secondary to scleroderma	Associated morphology	False	Fibrosis	Inferred relationship	Some
Constrictive pericarditis caused by virus (disorder)	Associated morphology	False	Fibrosis	Inferred relationship	Some	3
Constrictive pericarditis caused by Mycobacterium tuberculosis complex (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Subacute constrictive pericarditis	Associated morphology	True	Fibrosis	Inferred relationship	Some	2
Infective constrictive pericarditis (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	2
Concato's disease (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	5
Constrictive pericarditis caused by bacteria (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	2
Pericarditis secondary to Mulibrey nanism (disorder)	Associated morphology	False	Fibrosis	Inferred relationship	Some	3
Lipodermatosclerosis of lower limb due to varicose veins of lower limb	Associated morphology	False	Fibrosis	Inferred relationship	Some	9
Stiff skin syndrome is a rare, slowly progressive cutaneous disease characterized by rock-hard skin bound firmly to the underlying tissues (mainly on the shoulders, lower back, buttocks and thighs), mild hypertrichosis and hyperpigmentation overlying the affected areas of skin, as well as limited joint mobility (mainly of large joints) with flexion contractures. Cutaneous nodules, affecting mostly distal interphalangeal joints, as well as extracutaneous manifestations, including diffuse entrapment neuropathy, scoliosis, a tiptoe gait and a narrow thorax, may be associated. Restrictive pulmonary changes, muscle weakness, short stature and growth delay have also been reported. No vascular hyperreactivity, immunologic abnormalities nor visceral, muscular or bone involvement has been described.	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Renal-hepatic-pancreatic dysplasia is a rare, genetic, developmental defect during embryogenesis syndrome characterized by the triad of pancreatic fibrosis (and cysts, with a reduction of parenchymal tissue), renal dysplasia (with peripheral cortical cysts, primitive collecting ducts, glomerular cysts and metaplastic cartilage) and hepatic dysgenesis (enlarged portal areas containing numerous elongated binary profiles with a tendency to perilobular fibrosis). Situs abnormalities, skeletal anomalies and anencephaly have also been associated. Patients that survive the neonatal period present renal insufficiency, chronic jaundice and insulin-dependent diabetes.	Associated morphology	True	Fibrosis	Inferred relationship	Some	2
Hepatic fibrosis-renal cysts-intellectual disability syndrome is a rare, syndromic intellectual disability characterized by early developmental delay with failure to thrive, intellectual disability, congenital hepatic fibrosis, renal cystic dysplasia, and dysmorphic facial features (bilateral ptosis, anteverted nostrils, high arched palate, and micrognathia). Variable additional features have been reported, including cerebellar anomalies, postaxial polydactyly, syndactyly, genital anomalies, tachypnea. There have been no further descriptions in the literature since 1987.	Associated morphology	True	Fibrosis	Inferred relationship	Some	3
Hereditary fibrosing poikiloderma-tendon contractures-myopathy-pulmonary fibrosis syndrome is a rare, genetic, hereditary poikiloderma syndrome characterized by early-onset poikiloderma (mainly on the face), hypotrichosis, hypohidrosis, muscle and tendon contractures with varus foot deformity, progressive proximal and distal muscle weakness in all extremities, and progressive pulmonary fibrosis. Mild lymphedema of the extremities, growth retardation, liver impairment, exocrine pancreatic insufficiency and hematologic abnormalities are additional variable features.	Associated morphology	True	Fibrosis	Inferred relationship	Some	2
Pericarditis secondary to Mulibrey nanism (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Lung fibrosis-immunodeficiency-46,XX gonadal dysgenesis syndrome is characterized by immune deficiency, gonadal dysgenesis and fatal lung fibrosis. So far, it has been described in two sisters born to consanguineous parents. Both karyotypes were normal female (46,XX). No genetic anomalies could be identified by comparative genome hybridization analysis of their genomes or by analysis of genes known to be associated with these types of anomalies.	Associated morphology	True	Fibrosis	Inferred relationship	Some	2
Adhesive otitis media of right middle ear	Associated morphology	True	Fibrosis	Inferred relationship	Some	3
Adhesive otitis media of left middle ear	Associated morphology	True	Fibrosis	Inferred relationship	Some	2
Adhesive middle ear disease with adhesions of drum head to stapes	Associated morphology	True	Fibrosis	Inferred relationship	Some	3
Adhesive middle ear disease	Associated morphology	True	Fibrosis	Inferred relationship	Some	2
Adhesive middle ear disease with adhesions of drum head to promontorium	Associated morphology	True	Fibrosis	Inferred relationship	Some	3
Adhesive middle ear disease with adhesions of drum head to incus	Associated morphology	True	Fibrosis	Inferred relationship	Some	3
NPHP3-related Meckel-like syndrome is a rare, genetic, syndromic renal malformation characterized by cystic renal dysplasia with or without prenatal oligohydramnios, central nervous system abnormalities (commonly Dandy-Walker malformation), congenital hepatic fibrosis, and absence of polydactyly.	Associated morphology	True	Fibrosis	Inferred relationship	Some	3
A rare secondary neonatal autoimmune disease characterized by neonatal onset of erythematous skin lesions with a linear appearance that gradually become indurated and hyperpigmented and progressively present skin atrophy. Positive serum antibodies (in particular antinuclear antibodies and/or rheumatoid factor) may be associated.	Associated morphology	False	Fibrosis	Inferred relationship	Some	1
Symmer's pipe-stem fibrosis	Associated morphology	False	Fibrosis	Inferred relationship	Some	2
Fibrocystic change	Is a	True	Fibrosis	Inferred relationship	Some
Progressive systemic sclerosis (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Systemic sclerosis caused by chemical (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Systemic sclerosis sine scleroderma	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Occupational scleroderma (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Pericarditis secondary to scleroderma	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Renal involvement in scleroderma	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Acute scleroderma renal crisis	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Reynolds syndrome (RS) is an autoimmune disorder characterized by the association of primary biliary cirrhosis (PBC) with limited cutaneous systemic sclerosis (lcSSc).	Associated morphology	True	Fibrosis	Inferred relationship	Some	3
Lung disease with systemic sclerosis	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Systemic sclerosis with limited cutaneous involvement	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
sclérose systémique due à des médicaments et des produits chimiques	Associated morphology	False	Fibrosis	Inferred relationship	Some	1
Limited systemic sclerosis	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Systemic sclerosis	Associated morphology	True	Fibrosis	Inferred relationship	Some	1
Glomerulonephritis co-occurrent and due to scleroderma (disorder)	Associated morphology	True	Fibrosis	Inferred relationship	Some	2
CREST syndrome	Associated morphology	True	Fibrosis	Inferred relationship	Some	4
A rare, genetic renal disease characterized by slowly progressive, chronic, tubulointerstitial nephritis, leading to end-stage renal disease before the age of 50 years, manifesting with mild proteinuria, glucosuria and, occasionally, urinary sediment abnormalities (mainly hematuria). Mild extrarenal manifestations, such as recurrent upper respiratory tract infections and abnormal liver function tests, may be associated. Renal biopsy reveals severe, chronic, interstitial fibrosis and tubular changes, as well as hallmark karyomegalic tubular epithelial cells which line the proximal and distal tubules and have enlarged, hyperchromatic nuclei.	Associated morphology	True	Fibrosis	Inferred relationship	Some	1

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Id	Description	Lang	Type	Status	Case?	Module
183325015	Fibrosis	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
188609016	Fibrous repair	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
190411019	Fibrous thickening	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
190412014	Fibroplasia	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
199699016	Fibrous replacement	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
642480010	Fibrosis (morphologic abnormality)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core