116003000: Structure of immune system (body structure)

SNOMED CT Concept\Body structure (body structure)\Anatomical or acquired body structure (body structure)\Anatomical structure\Body system structure\Structure of immune system (body structure)

Status: current, Not sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jan 2002. Module: SNOMED CT core

Descriptions:

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
Structure of immune system (body structure)	Is a	Body system structure	true	Inferred relationship	Some
Structure of immune system (body structure)	partie de	Entire body as a whole	false	Additional relationship	Some

Inbound Relationships	Type	Active	Source	Characteristic	Refinability	Group
Retinal vascular changes with AIDS (acquired immunodeficiency syndrome)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
Intestinal malabsorption with AIDS (acquired immunodeficiency syndrome)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
Hematopoietic system disease with acquired immunodeficiency syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
Acute endocarditis with AIDS (acquired immunodeficiency syndrome)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	3
Pneumocystosis with acquired immunodeficiency syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	2
Myelopathy with acquired immunodeficiency syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
Kaposi's sarcoma with AIDS (acquired immunodeficiency syndrome)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
Bacterial pneumonia with AIDS (acquired immunodeficiency syndrome)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	2
Salivary gland disease with acquired immunodeficiency syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
Progressive multifocal leucoencephalopathy with AIDS (acquired immunodeficiency syndrome)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	2
Organic dementia with acquired immunodeficiency syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	4
Radiculitis with acquired immunodeficiency syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	2
Nutritional deficiency with acquired immunodeficiency syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
Central nervous system demyelinating disease with acquired immunodeficiency syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	3
Salmonella infection with acquired immunodeficiency syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	2
Organic brain syndrome with AIDS (acquired immunodeficiency syndrome)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
Pneumococcal pneumonia with acquired immunodeficiency syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	2
Malaise with acquired immunodeficiency syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
Mycobacteriosis with acquired immunodeficiency syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	2
Dermatomycosis with AIDS (acquired immunodeficiency syndrome)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	2
Fatigue with acquired immunodeficiency syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
Subacute endocarditis with AIDS (acquired immunodeficiency syndrome)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	4
Histoplasmosis with acquired immunodeficiency syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	2
Presenile dementia with AIDS (acquired immunodeficiency syndrome)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	4
Candidiasis of lung with AIDS (acquired immunodeficiency syndrome)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	2
Disseminated candidiasis with AIDS (acquired immunodeficiency syndrome)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	2
Aplastic anemia with AIDS (acquired immunodeficiency syndrome)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	7
Hepatomegaly with acquired immunodeficiency syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
Subacute myocarditis with acquired immunodeficiency syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	4
Primary lymphoma of brain with AIDS (acquired immunodeficiency syndrome)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	3
Agranulocytosis with acquired immunodeficiency syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
Myelitis with acquired immunodeficiency syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
Skin disorder with AIDS (acquired immunodeficiency syndrome)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
Cryptococcosis with acquired immunodeficiency syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
Subacute adenoviral encephalitis with acquired immunodeficiency syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	2
Nocardiosis with acquired immunodeficiency syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	2
Infectious gastroenteritis with acquired immunodeficiency syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
Retinopathy with acquired immunodeficiency syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	2
Viral pneumonia with acquired immunodeficiency syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	2
Dementia with acquired immunodeficiency syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	4
Tuberculosis with acquired immunodeficiency syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
Polyneuropathy with AIDS (acquired immunodeficiency syndrome)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
Failure to thrive in infant with AIDS (acquired immunodeficiency syndrome)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	2
Pneumonia with acquired immunodeficiency syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
Blindness with AIDS (acquired immunodeficiency syndrome)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
Infective arthritis with acquired immunodeficiency syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
Candidiasis of mouth with acquired immunodeficiency syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	2
Thrombocytopenia with acquired immunodeficiency syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	5
Encephalopathy with acquired immunodeficiency syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
Respiratory disorder with AIDS (acquired immunodeficiency syndrome)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
Strongyloidiasis with AIDS (acquired immunodeficiency syndrome)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	2
Myocarditis with acquired immunodeficiency syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
Noninfectious gastroenteritis with acquired immunodeficiency syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	3
Central nervous disorder with AIDS (acquired immunodeficiency syndrome)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
Neuritis with AIDS (acquired immunodeficiency syndrome)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	2
Encephalomyelitis with acquired immunodeficiency syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
Herpes zoster with acquired immunodeficiency syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	2
Neuralgia with AIDS (acquired immunodeficiency syndrome)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
Dyspnea with acquired immunodeficiency syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
Low vision with acquired immunodeficiency syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
Hyperhidrosis with AIDS (acquired immunodeficiency syndrome)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	4
Malignant neoplasm with acquired immunodeficiency syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
Coccidioidomycosis with acquired immunodeficiency syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	2
Neutropenia with acquired immunodeficiency syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	2
Cholangitis with AIDS (acquired immunodeficiency syndrome)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
Sepsis with acquired immunodeficiency syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
Infectious disease with acquired immune deficiency syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
Complement component 8 deficiency	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
A rare, genetic, primary immunodeficiency disorder characterised by an abnormal immune response to Epstein-Barr virus (EBV) infection, caused by hemizygous mutations in the X-linked SH2D1A gene, resulting in B cell lymphoproliferation and manifesting with various phenotypes which include EBV-driven severe or fulminant mononucleosis, haemophagocytic lymphohistiocytosis (presenting with fulminant hepatitis, hepatic necrosis, bone marrow hypoplasia, and neurological involvement), hypogammaglobulinaemia, and B-cell lymphoma. Additional variable manifestations include vasculitis, lymphomatoid granulomatosis, aplastic anaemia, and chronic gastritis. Occasionally, T-cell lymphoma may be observed. Laboratory findings include normal or increased activated T cells and reduced memory B cells.	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
A rare, genetic, primary immunodeficiency disorder characterized by an abnormal immune response to Epstein-Barr virus (EBV) infection, caused by hemizygous mutations in the X-linked XIAP gene, resulting in B cell lymphoproliferation and manifesting with various phenotypes which include EBV-driven hemophagocytic lymphohistiocytosis, hypogammaglobulinemia, recurrent splenomegaly, hepatitis, colitis, and intestinal bowel disease with features of Crohn's disease. Additional manifestations include variable auto-inflammatory symptoms such as uveitis, arthritis, skin abscesses, erythema nodosum, and nephritis. Neurological involvement is rare, and lymphoma is never observed. Laboratory findings include normal or increased activated T cells, low or normal iNKT cells, and normal or reduced memory B cells.	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
X-linked immunoneurologic disorder is characterized by immune deficiency and neurological disorders in females, and by neonatal death in males.	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
Primary cerebral lymphoma co-occurrent with human immunodeficiency virus infection	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	2
Leukocyte adhesion deficiency	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
Leucocyte adhesion deficiency - type 2	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
A rare functional neutrophil defect characterized by increased susceptibility to aggressive periodontitis in otherwise young, healthy individuals, due to impaired polymorphonuclear leukocyte chemotaxis toward bacterial formylpeptides. The periodontitis is rapidly progressive with progredient destruction of periodontal tissue and attachment loss.	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
Functional disorder of polymorphonuclear neutrophil (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
A rare systemic condition affecting patients undergoing chimeric antigen receptor (CAR) T-cell therapy and characterized by a systemic inflammatory response due to massive activation of leukocytes with subsequent cytokine release. It can present with a variety of signs and symptoms ranging from mild, flu-like symptoms (such as fever, fatigue, headache, rash, arthralgia, and myalgia) to severe life-threatening manifestations including vascular leakage, disseminated intravascular coagulation, shock, and multiple organ failure. Respiratory manifestations are common and range from cough and tachypnea to acute respiratory distress syndrome (ARDS).	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
Immune effector cell-associated neurotoxicity syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	2
Autoinflammatory disease (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
Familial Mediterranean fever	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	4
Familial amyloid nephropathy with urticaria AND deafness	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	7
Familial cold urticaria	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
Chronic infantile neurological, cutaneous and articular syndrome	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	4
Hereditary periodic fever (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
TNF receptor-associated periodic fever syndrome (TRAPS)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
A rare autoinflammatory disease and form of mevalonate kinase deficiency (MKD), characterised by periodic attacks of fever and a systemic inflammatory reaction (cervical lymphadenopathy, abdominal pain, vomiting, diarrhoea, arthralgia and skin manifestations). The disease usually begins in the first year of life and rarely after 5 years of age. HIDS is an inherited syndrome caused by mutations in the mevalonate kinase (MVK) gene (12q24). These MVK mutations lead to reduced, but not abolished enzyme activity. This in turn leads to impaired control of the production of inflammatory mediators, which in turn cause inflammatory (fever) attacks. The disease follows an autosomal recessive pattern of inheritance.	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
Cryopyrin associated periodic syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
A rare, hereditary, immune deficiency with skin involvement characterised by early-onset cold urticaria after generalised exposure to cold air or evaporative cooling and not after contact with cold objects. Additional immunologic abnormalities are often present - antibody deficiency, recurrent infections, autoimmune disease and symptomatic allergic disease.	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	2
Monogenic autoinflammatory syndrome (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
A rare autoinflammatory syndrome characterized by episodic and recurrent periods of fever combined with various systemic manifestations such as myalgia, arthralgia, joint swelling, urticaria, headache and skin rash. Common trigger of these episodes is cold.	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
A rare genetic autoinflammatory syndrome with immune deficiency characterized by a combination of autoinflammation, immunodeficiency, and neutrophil dysfunction, as well as mild bleeding diathesis. Patients present recurrent attacks of abdominal pain, high fever, and systemic inflammation lasting four to five days and occurring every few weeks. Attacks may be accompanied by nailbed, tongue, submandibular, and gluteal abscesses, intra-abdominal granulomas, pyoderma gangrenosum, and buccal ulcerations. Frequent episodes of purulent paronychia, superficial skin and mucosal infections, and purulent upper respiratory tract infections have also been reported.	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
A rare genetic systemic or rheumatologic disease characterized by neonatal or infantile onset of enterocolitis (which resolves with age), periodic fever, and episodes of severe systemic inflammation, which may be precipitated by infections, stress, or fatigue. Signs and symptoms include splenomegaly, urticaria-like rashes, arthralgia, and myalgia. Associated laboratory findings are elevated inflammatory markers (such as ferritin, C-reactive protein), pancytopenia, and elevated transaminases. If left untreated, flares can progress to coagulopathy, organ failure, and death.	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	7
A chronic autoinflammatory disease in which innate immune response is activated abnormally causing fever and inflammation-related damage to tissues and organs. The episodes can last for several days and occur weeks to months apart, manifestations include erythematous plaques on the skin, abdominal pain, dry eyes, dry mouth, mouth sores, chest pain and gland enlargement. This condition likely results from a combination of genetic and environmental factors. Variations in the NOD2 gene increase risk and it is suspected that environmental factors such as infections may also play a role in triggering the disease in people with genetic variants that increase their risk. The syndrome appears to be a complex disease without a single genetic cause.	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
A rare, genetic, mixed autoinflammatory and autoimmune syndrome characterized by chronic systemic autoinflammation (presenting as recurrent fever in the neonatal or infantile period) and combined immunodeficiency (manifesting as recurrent viral and invasive bacterial infections). Muscular amylopectinosis may be subclinical or be complicated by myopathy/cardiomyopathy.	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
A rare, mixed autoinflammatory and autoimmune syndrome disorder characterized by recurrent neutrophilic blistering skin lesions, arthralgia, ocular inflammation, inflammatory bowel disease, absence of autoantibodies, and mild immunodeficiency manifested by recurrent sinopulmonary infections and deficiency of circulating antibodies. Inflammatory phenotype is not provoked by cold temperatures.	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1
A rare skin disease belonging to the spectrum of autoinflammatory syndromes characterized by the triad of pyoderma gangrenosum (PG), suppurative hidradenitis (SH) and acne.	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	5
A rare granulomatous autoinflammatory syndrome characterized by infantile-onset, widespread, chronic, recurrent, progressive, lobular panniculitis associated with panuveitis, arthritis and severe systemic granulomatous inflammation.	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	4
Neonatal inflammatory skin and bowel disease is a rare, life-threatening, autoinflammatory syndrome with immune deficiency disorder characterized by early-onset, life-long inflammation, affecting the skin and bowel, associated with recurrent infections. Patients present perioral and perianal psoriasiform erythema and papular eruption with pustules, failure to thrive associated with chronic malabsorptive diarrhea, intercurrent gastrointestinal infections and feeding troubles, as well as absent, short or broken hair and trichomegaly. Recurrent cutaneous and pulmonary infections lead to recurrent blepharitis, otitis externa and bronchiolitis.	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	4
A rare, genetic, autoinflammatory syndrome with immune deficiency disease characterized by recurrent and severe flares of generalized pustular psoriasis associated with high fever, asthenia, and systemic inflammation, due to IL36R antagonist deficiency. Psoriatic nail changes (e.g. pitting and onychomadesis) and ichthyosis may occasionally be associated.	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	4
Pyogenic arthritis-pyoderma gangrenosum-acne syndrome is a rare pleiotropic autoinflammatory disorder of childhood, primarily affecting the joints and skin.	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	2
Cytokine-associated toxicity (disorder)	Finding site	True	Structure of immune system (body structure)	Inferred relationship	Some	1

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Reference Sets

Anatomy structure and entire association reference set (foundation metadata concept)

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Id	Description	Lang	Type	Status	Case?	Module
187178010	Immune system	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
418218019	Immune system structure	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
2638100019	Structure of immune system (body structure)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
2642200018	Structure of immune system	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
195981000077112	structure du système immunitaire	fr	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module