126172005: Estradiol (substance)

SNOMED CT Concept\Substance\...

\Substance categorized by disposition\Substance with molecular messenger mechanism of action (substance)\Hormone\Sex hormone (substance)\Substance with estrogen receptor agonist mechanism of action (substance)\Estradiol
\Substance categorized by disposition\Substance with molecular messenger mechanism of action (substance)\Hormone\Steroid hormone\Estradiol
\Substance categorized by disposition\Receptor agonist\Substance with estrogen receptor agonist mechanism of action (substance)\Estradiol

\A grouper concept for substances that are used in medicinal products for medical treatment, and also psychoactive substances that have few or no legitimate medical uses or that are not legally available to the person using them.\Hormone\...

\Sex hormone (substance)\Substance with estrogen receptor agonist mechanism of action (substance)\Estradiol

\Steroid hormone\Estradiol

\Substance categorised by structure\Chemical\Chemical categorized by structure (substance)\Organic compound\Organic cyclic compound\Polycyclic compound (substance)\Steroid\...

\Estrane\Estradiol and/or estradiol derivative\Estradiol

\Steroid hormone\Estradiol

Status: current, Not sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jan 2002. Module: SNOMED CT core

Descriptions:

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
Estradiol	Is a	Estrane	false	Inferred relationship	Some
Estradiol	Is a	Estradiol and/or estradiol derivative	true	Inferred relationship	Some
Estradiol	Is a	estrogeno	false	Inferred relationship	Some
Estradiol	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	Estrogen	false	Inferred relationship	Some
Estradiol	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	Gonadal hormone	false	Inferred relationship	Some
Estradiol	Is a	Substance with estrogen receptor agonist mechanism of action (substance)	true	Inferred relationship	Some
Estradiol	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	Estrogen receptor agonist	true	Inferred relationship	Some
Estradiol	Is a	Steroid hormone	true	Inferred relationship	Some

Inbound Relationships	Type	Active	Source	Characteristic	Refinability	Group
Topical estradiol allergy	Causative agent (attribute)	False	Estradiol	Inferred relationship	Some	1
Allergy to estradiol (finding)	Causative agent (attribute)	True	Estradiol	Inferred relationship	Some	1
Oral estradiol allergy	Causative agent (attribute)	False	Estradiol	Inferred relationship	Some	1
Estradiol implant allergy	Causative agent (attribute)	False	Estradiol	Inferred relationship	Some	1
Estradiol enanthate (substance)	Is a	False	Estradiol	Inferred relationship	Some
Albumin bound estradiol (substance)	Is a	False	Estradiol	Inferred relationship	Some
Bioavailable estradiol	Is a	False	Estradiol	Inferred relationship	Some
Estradiol 1 mg oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Estradiol	Inferred relationship	Some	1
Estradiol 1 mg oral tablet	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Estradiol	Inferred relationship	Some	1
Estradiol 2 mg oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Estradiol	Inferred relationship	Some	1
Estradiol 2 mg oral tablet	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Estradiol	Inferred relationship	Some	1
Estradiol 2 mg and norethisterone acetate 1 mg oral tablet	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Estradiol	Inferred relationship	Some	2
Product containing precisely estradiol 1 milligram and norethisterone acetate 500 microgram/1 each conventional release oral tablet (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Estradiol	Inferred relationship	Some	1
Product containing precisely estradiol 1 milligram and norethisterone acetate 500 microgram/1 each conventional release oral tablet (clinical drug)	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	False	Estradiol	Inferred relationship	Some	1
Estradiol 1.5 mg oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Estradiol	Inferred relationship	Some	1
Estradiol 1.5 mg oral tablet	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Estradiol	Inferred relationship	Some	1
Estradiol 500 microgram oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Estradiol	Inferred relationship	Some	1
Estradiol 500 microgram oral tablet	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Estradiol	Inferred relationship	Some	1
Estradiol 4 mg oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Estradiol	Inferred relationship	Some	1
Estradiol 4 mg oral tablet	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Estradiol	Inferred relationship	Some	1
Drospirenone 500 microgram and estradiol 1 mg oral tablet	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	False	Estradiol	Inferred relationship	Some	2
Estradiol 2 mg and norethisterone acetate 1 mg oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Estradiol	Inferred relationship	Some	1
Estradiol 2 mg and norethisterone acetate 1 mg oral tablet	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	False	Estradiol	Inferred relationship	Some	1
Drospirenone 2 mg and estradiol 1 mg oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Estradiol	Inferred relationship	Some	1
Drospirenone 2 mg and estradiol 1 mg oral tablet	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Estradiol	Inferred relationship	Some	1
Estradiol 500 microgram and norethisterone acetate 100 microgram oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Estradiol	Inferred relationship	Some	1
Estradiol 500 microgram and norethisterone acetate 100 microgram oral tablet	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	False	Estradiol	Inferred relationship	Some	1
Drospirenone 500 microgram and estradiol 1 mg oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Estradiol	Inferred relationship	Some	1
Drospirenone 500 microgram and estradiol 1 mg oral tablet	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Estradiol	Inferred relationship	Some	1
Albumin bound estradiol (substance)	This attribute indicates that the concept is a structural modification of another concept, and that the substance's intrinsic physicochemical properties remain unchanged.	False	Estradiol	Inferred relationship	Some
Estradiol cypionate	This attribute indicates that the concept is a structural modification of another concept, and that the substance's intrinsic physicochemical properties remain unchanged.	True	Estradiol	Inferred relationship	Some
Estradiol acetate (substance)	This attribute indicates that the concept is a structural modification of another concept, and that the substance's intrinsic physicochemical properties remain unchanged.	True	Estradiol	Inferred relationship	Some
Estradiol hemihydrate	This attribute indicates that the concept is a structural modification of another concept, and that the substance's intrinsic physicochemical properties remain unchanged.	True	Estradiol	Inferred relationship	Some
Estradiol enanthate (substance)	This attribute indicates that the concept is a structural modification of another concept, and that the substance's intrinsic physicochemical properties remain unchanged.	True	Estradiol	Inferred relationship	Some
Free estradiol	This attribute indicates that the concept is a structural modification of another concept, and that the substance's intrinsic physicochemical properties remain unchanged.	False	Estradiol	Inferred relationship	Some
Bioavailable estradiol	This attribute indicates that the concept is a structural modification of another concept, and that the substance's intrinsic physicochemical properties remain unchanged.	False	Estradiol	Inferred relationship	Some
Estradiol benzoate	This attribute indicates that the concept is a structural modification of another concept, and that the substance's intrinsic physicochemical properties remain unchanged.	True	Estradiol	Inferred relationship	Some
Estradiol valerate	This attribute indicates that the concept is a structural modification of another concept, and that the substance's intrinsic physicochemical properties remain unchanged.	True	Estradiol	Inferred relationship	Some
Ethinylestradiol	This attribute indicates that the concept is a structural modification of another concept, and that the substance's intrinsic physicochemical properties remain unchanged.	False	Estradiol	Inferred relationship	Some
Estradiol 4 mg oral tablet	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Estradiol	Inferred relationship	Some	1
Estradiol 500 microgram and norethisterone acetate 100 microgram oral tablet	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	False	Estradiol	Inferred relationship	Some	1
Estradiol 1.5 mg oral tablet	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Estradiol	Inferred relationship	Some	1
Estradiol 1 mg oral tablet	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Estradiol	Inferred relationship	Some	1
Estradiol 2 mg oral tablet	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Estradiol	Inferred relationship	Some	1
Estradiol 500 microgram oral tablet	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Estradiol	Inferred relationship	Some	1
Product containing precisely estradiol 1 milligram and norethisterone acetate 500 microgram/1 each conventional release oral tablet (clinical drug)	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	False	Estradiol	Inferred relationship	Some	1
Drospirenone- and estradiol-containing product in oral dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Some	1
Drospirenone 2 mg and estradiol 1 mg oral tablet	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Estradiol	Inferred relationship	Some	1
Drospirenone 500 microgram and estradiol 1 mg oral tablet	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	False	Estradiol	Inferred relationship	Some	2
Estradiol 2 mg and norethisterone acetate 1 mg oral tablet	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Estradiol	Inferred relationship	Some	2
Estradiol-containing product in transdermal dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Some	1
Estradiol 2.083 microgram/hour and norethisterone acetate 10.417 microgram/hour prolonged-release transdermal patch	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	False	Estradiol	Inferred relationship	Some	1
Estradiol 2.083 microgram/hour and norethisterone acetate 10.417 microgram/hour prolonged-release transdermal patch	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	False	Estradiol	Inferred relationship	Some	1
Estradiol 3.125 microgram/hour prolonged-release transdermal patch	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Estradiol	Inferred relationship	Some	1
Estradiol 3.125 microgram/hour prolonged-release transdermal patch	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Estradiol	Inferred relationship	Some	1
Estradiol 1.042 microgram/hour prolonged-release transdermal patch	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Estradiol	Inferred relationship	Some	1
Estradiol 1.042 microgram/hour prolonged-release transdermal patch	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Estradiol	Inferred relationship	Some	1
Estradiol 1.563 microgram/hour prolonged-release transdermal patch	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Estradiol	Inferred relationship	Some	1
Estradiol 1.563 microgram/hour prolonged-release transdermal patch	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Estradiol	Inferred relationship	Some	1
Product containing precisely estradiol 1.667 microgram/1 hour prolonged-release transdermal patch (clinical drug)	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Estradiol	Inferred relationship	Some	1
Product containing precisely estradiol 1.667 microgram/1 hour prolonged-release transdermal patch (clinical drug)	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Estradiol	Inferred relationship	Some	1
Product containing precisely estradiol 2.083 microgram/1 hour prolonged-release transdermal patch (clinical drug)	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Estradiol	Inferred relationship	Some	1
Product containing precisely estradiol 2.083 microgram/1 hour prolonged-release transdermal patch (clinical drug)	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Estradiol	Inferred relationship	Some	1
Product containing precisely estradiol 3.333 microgram/1 hour prolonged-release transdermal patch (clinical drug)	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Estradiol	Inferred relationship	Some	1
Product containing precisely estradiol 3.333 microgram/1 hour prolonged-release transdermal patch (clinical drug)	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Estradiol	Inferred relationship	Some	1
Product containing precisely estradiol 4.167 microgram/1 hour prolonged-release transdermal patch (clinical drug)	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Estradiol	Inferred relationship	Some	1
Product containing precisely estradiol 4.167 microgram/1 hour prolonged-release transdermal patch (clinical drug)	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Estradiol	Inferred relationship	Some	1
Estradiol 2.083 microgram/hour and norethindrone acetate 7.083 microgram/hour prolonged-release transdermal patch	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	False	Estradiol	Inferred relationship	Some	1
Estradiol 2.083 microgram/hour and norethindrone acetate 7.083 microgram/hour prolonged-release transdermal patch	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	False	Estradiol	Inferred relationship	Some	1
Product containing estradiol and medroxyprogesterone (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Some	2
Estradiol-containing product in cutaneous dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Some	1
Product containing estradiol and levonorgestrel in transdermal dose form (medicinal product form)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Some	2
Estradiol- and medroxyprogesterone-containing product in oral dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Some	2
Product containing estradiol and norethisterone in oral dose form (medicinal product form)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Some	2
Product containing estradiol and norethisterone in transdermal dose form (medicinal product form)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Some	2
Product containing only drospirenone and estradiol (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Some	1
Product containing only estradiol (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Some	1
Product containing only estradiol and levonorgestrel (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Some	2
Estradiol and medroxyprogesterone only product	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Some	2
Product containing only estradiol and norethisterone (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Some	2
Product containing only estradiol and norgestrel (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Some	2
Product containing only dydrogesterone and estradiol (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Some	2
Estradiol and levonorgestrel only product in transdermal dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Some	2
Product containing only estradiol and medroxyprogesterone in oral dose form (medicinal product form)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Some	2
Product containing only estradiol and norethisterone in transdermal dose form (medicinal product form)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Some	2
Product containing only estradiol in cutaneous dose form (medicinal product form)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Some	1
Product containing only estradiol in nasal dose form (medicinal product form)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Some	1
Estradiol only product in oral dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Some	1
Estradiol only product in parenteral dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Some	1
Estradiol only product in transdermal dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Some	1
Estradiol and norethisterone only product in oral dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Some	2
Drospirenone and estradiol only product in oral dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Some	1
Product containing only estradiol in vaginal dose form (medicinal product form)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Estradiol	Inferred relationship	Some	1
Product containing precisely estradiol 25 microgram/1 each conventional release vaginal tablet (clinical drug)	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Estradiol	Inferred relationship	Some	1
Product containing precisely estradiol 25 microgram/1 each conventional release vaginal tablet (clinical drug)	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Estradiol	Inferred relationship	Some	1
Product containing precisely estradiol 312.5 nanogram/1 hour prolonged-release vaginal ring (clinical drug)	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Estradiol	Inferred relationship	Some	1
Product containing precisely estradiol 312.5 nanogram/1 hour prolonged-release vaginal ring (clinical drug)	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Estradiol	Inferred relationship	Some	1
Product containing precisely estradiol 2.083 microgram/1 hour prolonged-release vaginal ring (clinical drug)	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Estradiol	Inferred relationship	Some	1
Product containing precisely estradiol 2.083 microgram/1 hour prolonged-release vaginal ring (clinical drug)	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Estradiol	Inferred relationship	Some	1
Estradiol 4.167 microgram/hour prolonged-release vaginal ring	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Estradiol	Inferred relationship	Some	1
Estradiol 4.167 microgram/hour prolonged-release vaginal ring	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Estradiol	Inferred relationship	Some	1

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Id	Description	Lang	Type	Status	Case?	Module
24201011	Estradiol	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
730100013	Estradiol (substance)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
3721927018	17-beta estradiol	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
3722984013	E2 - estradiol	en	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT core
49321000195112	estradiolo	it	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
32701000188116	estradiol	fr	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
861191000172113	oestradiol	fr	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
63461000195117	Estradiol	de	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
234641000195118	Östradiol	de	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
234651000195115	E2 - Estradiol	de	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
234661000195117	E>2< - Estradiol	de	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module