Inbound Relationships |
Type |
Active |
Source |
Characteristic |
Refinability |
Group |
Chronic alcoholic brain syndrome |
Is a |
False |
Chronic mental disorder |
Inferred relationship |
Some |
|
toxicomanie chronique |
Is a |
False |
Chronic mental disorder |
Inferred relationship |
Some |
|
Chronic major depressive disorder, single episode |
Is a |
True |
Chronic mental disorder |
Inferred relationship |
Some |
|
Chronic recurrent major depressive disorder |
Is a |
False |
Chronic mental disorder |
Inferred relationship |
Some |
|
Chronic bipolar I disorder, most recent episode depressed |
Is a |
True |
Chronic mental disorder |
Inferred relationship |
Some |
|
Chronic motor tic disorder |
Is a |
True |
Chronic mental disorder |
Inferred relationship |
Some |
|
Chronic schizophrenia |
Is a |
True |
Chronic mental disorder |
Inferred relationship |
Some |
|
Recurrent conversion disorder |
Is a |
False |
Chronic mental disorder |
Inferred relationship |
Some |
|
Intermittent explosive disorder |
Is a |
False |
Chronic mental disorder |
Inferred relationship |
Some |
|
Recurrent major depression |
Is a |
False |
Chronic mental disorder |
Inferred relationship |
Some |
|
poussée évolutive de schizophrénie latente chronique |
Is a |
False |
Chronic mental disorder |
Inferred relationship |
Some |
|
Acute exacerbation of chronic schizoaffective schizophrenia |
Is a |
True |
Chronic mental disorder |
Inferred relationship |
Some |
|
Chronic depression |
Is a |
True |
Chronic mental disorder |
Inferred relationship |
Some |
|
Seasonal affective disorder (disorder) |
Is a |
False |
Chronic mental disorder |
Inferred relationship |
Some |
|
Chronic alcoholic hepatitis |
Is a |
False |
Chronic mental disorder |
Inferred relationship |
Some |
|
Recurrent manic episodes |
Is a |
False |
Chronic mental disorder |
Inferred relationship |
Some |
|
Recurrent depression |
Is a |
False |
Chronic mental disorder |
Inferred relationship |
Some |
|
Chronic organic mental disorder (disorder) |
Is a |
True |
Chronic mental disorder |
Inferred relationship |
Some |
|
Chronic stress disorder (disorder) |
Is a |
True |
Chronic mental disorder |
Inferred relationship |
Some |
|
Chronic psychogenic pain |
Is a |
True |
Chronic mental disorder |
Inferred relationship |
Some |
|
Chronic depressive personality disorder |
Is a |
True |
Chronic mental disorder |
Inferred relationship |
Some |
|
Chronic hypomanic personality disorder |
Is a |
True |
Chronic mental disorder |
Inferred relationship |
Some |
|
Chronic harmful pattern of use of laxatives |
Is a |
False |
Chronic mental disorder |
Inferred relationship |
Some |
|
Continuous chronic alcoholism |
Is a |
True |
Chronic mental disorder |
Inferred relationship |
Some |
|
Episodic chronic alcoholism (disorder) |
Is a |
False |
Chronic mental disorder |
Inferred relationship |
Some |
|
Chronic alcoholism in remission |
Is a |
True |
Chronic mental disorder |
Inferred relationship |
Some |
|
Chronic bipolar II disorder, most recent episode major depressive |
Is a |
True |
Chronic mental disorder |
Inferred relationship |
Some |
|
Recessive intellectual disability-motor dysfunction-multiple joint contractures syndrome is a rare, genetic, syndromic intellectual disability disorder characterized by severe intellectual disability, progressive, postnatal, multiple joint contractures and severe motor dysfunction. Patients present arrest and regression of motor function and speech acquisition, as well as contractures which begin in lower limbs and slowly progress in an ascending manner to include spine and neck, resulting in individuals presenting a specific fixed position. |
Is a |
False |
Chronic mental disorder |
Inferred relationship |
Some |
|
A rare hereditary ataxia characterized by an early onset symptomatic generalized epilepsy, progressive cerebellar ataxia resulting in significant difficulties to walk or wheelchair dependency, and intellectual disability. |
Is a |
False |
Chronic mental disorder |
Inferred relationship |
Some |
|
A rare, genetic, congenital muscular dystrophy due to dystroglycanopathy disorder characterized by a wide phenotypic spectrum which includes hypotonia and muscular weakness present at birth or early infancy and delayed or arrested motor development, associated with mild to severe intellectual disability and variable brain abnormalities on neuroimaging studies. Feeding difficulties, joint and spinal deformities, respiratory insufficiency, and ocular anomalies (e.g. strabismus, retinal dystrophy, oculomotor apraxia) may be associated. Decreased or absent alpha-dystroglycan on immunohistochemical muscle staining and elevated serum creatine kinase are observed. |
Is a |
False |
Chronic mental disorder |
Inferred relationship |
Some |
|
A rare, fatal, inborn error of metabolism disorder characterized by respiratory distress and severe hypotonia at birth, severe global developmental delay, early-onset intractable seizures, myopathic facies with craniofacial dysmorphism (trigonocephaly/progressive microcephaly, low anterior hairline, arched eyebrows, hypotelorism, strabismus, small nose, prominent philtrum, thin upper lip, high-arched palate, micrognathia, malocclusion), severe, congenital flexion joint contractures and elevated serum creatine kinase levels. Scoliosis, optic atrophy, mild hepatomegaly, and hypoplastic genitalia may also be associated. |
Is a |
False |
Chronic mental disorder |
Inferred relationship |
Some |
|
Epiphyseal dysplasia-hearing loss-dysmorphism syndrome is a rare multiple congenital anomalies/dysmorphic syndrome characterized by developmental delay, intellectual disability, short stature, sensorineural hearing impairment, facial dysmorphism (including epicanthus, broad, depressed nasal bridge, broad, fleshy nasal tip, mildly anteverted nares, deep nasolabial folds, broad mouth with thin upper lip) and skeletal anomalies (including abnormally placed thumbs, brachydactyly, scoliosis, dysplastic carpal bones). Patients also present severe behavior disturbances (aggression, hyperactivity), as well as hypopigmented skin lesions and hypoplastic digital patterns. There have been no further descriptions in the literature since 1992. |
Is a |
False |
Chronic mental disorder |
Inferred relationship |
Some |
|
Brachydactyly-mesomelia-intellectual disability-heart defects syndrome is a rare, genetic, multiple congenital anomalies/dysmorphic syndrome characterized by developmental delay, intellectual disability, thin habitus with narrow shoulders, mesomelic shortness of the arms, craniofacial dysmorphism (e.g. long lower face, maxillary hypoplasia, beak nose, short columella, prognathia, high arched palate, obtuse mandibular angle), brachydactyly (mostly involving middle phalanges) and cardiovascular anomalies (i.e. aortic root dilatation, mitral valve prolapse). |
Is a |
False |
Chronic mental disorder |
Inferred relationship |
Some |
|
A rare congenital muscular alpha-dystroglycanopathy with brain and eye anomalies disease characterized by a severe muscle-eye-brain disease-like phenotype associated with intellectual disability, muscular dystrophy, macrocephaly and extended bilateral multicystic white matter disease. |
Is a |
False |
Chronic mental disorder |
Inferred relationship |
Some |
|
Oppositional defiant disorder co-occurrent with chronic irritability-anger (disorder) |
Is a |
True |
Chronic mental disorder |
Inferred relationship |
Some |
|
Neuronal ceroid lipofuscinosis 8 |
Is a |
False |
Chronic mental disorder |
Inferred relationship |
Some |
|
Rett syndrome |
Is a |
True |
Chronic mental disorder |
Inferred relationship |
Some |
|
Chronic post-traumatic stress disorder |
Is a |
True |
Chronic mental disorder |
Inferred relationship |
Some |
|
A rare genetic disease characterized by mild intellectual deficit, congenital cataract, progressive sensorineural hearing impairment, ataxia, peripheral neuropathy, and short stature. There have been no further descriptions in the literature since 1991. |
Is a |
False |
Chronic mental disorder |
Inferred relationship |
Some |
|
Infantile cerebral and cerebellar atrophy with postnatal progressive microcephaly is a rare, central nervous system malformation syndrome characterized by progressive microcephaly with profound motor delay and intellectual disability, associated with hypertonia, spasticity, clonus, and seizures, with brain imaging revealing severe cerebral and cerebellar atrophy, and poor myelination. |
Is a |
False |
Chronic mental disorder |
Inferred relationship |
Some |
|
Persistent depressive disorder is a chronic mood disorder characterized by persistent depressed mood present for a least two years, for most of the day and for more days than not. |
Is a |
True |
Chronic mental disorder |
Inferred relationship |
Some |
|
Recurrent metabolic encephalomyopathic crises-rhabdomyolysis-cardiac arrhythmia-intellectual disability syndrome is a rare, genetic, neurodegenerative disease characterized by episodic metabolic encephalomyopathic crises (of variable frequency and severity which are frequently precipitated by an acute illness) which manifest with profound muscle weakness, ataxia, seizures, cardiac arrhythmias, rhabdomyolysis with myoglobinuria, elevated plasma creatine kinase, hypoglycemia, lactic acidosis, increased acylcarnitines and a disorientated or comatose state. Global developmental delay, intellectual disability and cortical, pyramidal and cerebellar signs develop with subsequent progressive neurodegeneration causing loss of expressive language and varying degrees of cerebral atrophy. |
Is a |
False |
Chronic mental disorder |
Inferred relationship |
Some |
|
A rare, genetic, syndromic intellectual disability characterized by severe intellectual disability, non-inherited, progressive, post-natal microcephaly, hypotonia, hyperkinesia, absence of speech, strabismus, and midline stereotypic hand movements (e.g. hand washing/rubbing). Additional features include developmental delay, seizures and behavioral disturbances, such as self-injury and unexplained crying episodes. |
Is a |
False |
Chronic mental disorder |
Inferred relationship |
Some |
|
A rare genetic multiple congenital anomalies/dysmorphic syndrome characterized by moderate intellectual disability, dysmorphic facial features (such as prominent glabella, synophrys, and prognathism), generalized hirsutism, bilateral single palmar creases, and seizures. Additional reported manifestations include slowly progressive neurological deterioration with muscular weakness and impaired gait and balance, as well as hypogammaglobulinemia with specific absence of plasma and/or secretory IgA, among others. Brain imaging may show mild cerebellar atrophy and thin corpus callosum. |
Is a |
False |
Chronic mental disorder |
Inferred relationship |
Some |
|
Spastic paraplegia-severe developmental delay-epilepsy syndrome is a rare, genetic, complex spastic paraplegia disorder characterized by an infantile-onset of psychomotor developmental delay with severe intellectual disability and poor speech acquisition, associated with seizures (mostly myoclonic), muscular hypotonia which may be noted at birth, and slowly progressive spasticity in the lower limbs leading to severe gait disturbances. Ocular abnormalities and incontinence are commonly associated. Other symptoms may include verbal dyspraxia, hypogenitalism, macrocephaly and sensorineural hearing loss, as well as dystonic movements and ataxia with upper limb involvement. |
Is a |
False |
Chronic mental disorder |
Inferred relationship |
Some |
|
Allan-Herndon-Dudley syndrome |
Is a |
False |
Chronic mental disorder |
Inferred relationship |
Some |
|
Spastic paraplegia-precocious puberty syndrome is a complex form of hereditary spastic paraplegia characterized by the onset of progressive spastic paraplegia associated with precocious puberty (due to Leydig cell hyperplasia) in childhood (at the age of 2 years). Moderate intellectual disability was also reported. There have been no further descriptions in the literature since 1983. |
Is a |
False |
Chronic mental disorder |
Inferred relationship |
Some |
|
Spastic paraplegia-glaucoma-intellectual disability syndrome is characterized by progressive spastic paraplegia, glaucoma and intellectual deficit. It has been described in two families. The second described sibship was born to consanguineous parents. The mode of inheritance is autosomal recessive. |
Is a |
False |
Chronic mental disorder |
Inferred relationship |
Some |
|
A rare complex hereditary spastic paraplegia characterized by an early onset hypotonia that progresses to spasticity, global developmental delay, severe intellectual disability and speech impairment, microcephaly, short stature and dysmorphic features. Patients often become non-ambulatory, and some develop seizures and stereotypic laughter. |
Is a |
False |
Chronic mental disorder |
Inferred relationship |
Some |
|
A rare genetic neurological disorder characterized by postnatal microcephaly, hypotonia during infancy followed in most cases by progressive spasticity mainly affecting the lower limbs, and spastic diplegia or paraplegia, intellectual disability, delayed or absent speech, and dysarthria. Seizures and mildly dysmorphic features have been described in some patients. |
Is a |
False |
Chronic mental disorder |
Inferred relationship |
Some |
|
A rare genetic neurological disorder characterized by progressive spastic paraparesis and delayed gross motor development with an onset in infancy or early childhood. Patients also show variable degrees of intellectual disability, speech delay, and dysarthria. Other reported features include microcephaly, seizures, bifid uvula with or without cleft palate, and ocular anomalies. Brain imaging shows white matter abnormalities in the periventricular and other regions. |
Is a |
False |
Chronic mental disorder |
Inferred relationship |
Some |
|
A rare genetic multiple congenital anomalies/dysmorphic syndrome characterized by global developmental delay and intellectual disability, progressive spondyloepimetaphyseal dysplasia, short stature, short fourth metatarsals, and dysmorphic craniofacial features (including microcephaly, hypertelorism, epicanthal folds, mild ptosis, strabismus, malar hypoplasia, short nose, depressed nasal bridge, full lips, small, low-set ears, and short neck). Craniosynostosis, generalized hypotonia, as well as asymmetry of the cerebral hemispheres and mild thinning of the corpus callosum on brain imaging have also been described. |
Is a |
False |
Chronic mental disorder |
Inferred relationship |
Some |
|
Intellectual disability-spasticity-ectrodactyly syndrome is a rare intellectual disability syndrome characterized by severe intellectual disability, spastic paraplegia (with wasting of the lower limbs) and distal transverse defects of the limbs (e.g. ectrodactyly, syndactyly, clinodactyly of the hands and/or feet). |
Is a |
False |
Chronic mental disorder |
Inferred relationship |
Some |
|
A rare multiple congenital anomalies/dysmorphic syndrome characterized by profound intellectual disability, choreoathetosis, progressive spastic diplegia, progressive tapetoretinal degeneration with loss of retinal vessels, and glomerulopathy resulting in death late in the first or early in the second decade of life. Absence of the cerebellar granular layer has been reported. There have been no further descriptions in the literature since 1982. |
Is a |
False |
Chronic mental disorder |
Inferred relationship |
Some |
|
A rare genetic neurological disorder characterized by postnatal onset of severe global developmental delay, profound mental retardation, progressive microcephaly, progressive spasticity evolving into spastic quadriplegia with joint contractures, generalized seizures, and irritability. Severe choreoathetosis and dysmorphic features are absent. Brain imaging shows progressive cerebellar atrophy followed by cerebral atrophy affecting both white and gray matter, but no pontine involvement. |
Is a |
False |
Chronic mental disorder |
Inferred relationship |
Some |
|
A rare leukodystrophy characterized by a spectrum of progressive neurologic manifestations comprising rapidly progressive early-onset nystagmus, spastic tetraplegia, and visual and hearing impairment, resulting in death in early childhood, as well as later onset of slowly progressive complex spastic ataxia with pyramidal and cerebellar symptoms and loss of developmental milestones. Brain imaging shows diffuse hypomyelination of the subcortical and deep white matter, cerebellar atrophy, and diffuse spinal cord volume loss. |
Is a |
False |
Chronic mental disorder |
Inferred relationship |
Some |
|
A rare genetic, skeletal muscle disease with characteristics of early-onset hypotonia, muscle weakness, global developmental delay with intellectual disability and cardiomyopathy. Congenital structural heart defects and ichthyosiform cutaneous lesions have also been associated. Muscle biopsy shows characteristic enlarged mitochondria located at the periphery of muscle fibres. |
Is a |
False |
Chronic mental disorder |
Inferred relationship |
Some |
|
A rare genetic syndromic intellectual disability characterised by global developmental delay, moderate to severe intellectual disability, motor and language impairment, behavioural abnormalities (with mood instability, aggression, and self-mutilation), and progressive hand tremor. Facial dysmorphism includes narrow palpebral fissures, large ears, long philtrum, and prominent chin. |
Is a |
True |
Chronic mental disorder |
Inferred relationship |
Some |
|
Chronic harmful pattern of substance use |
Is a |
True |
Chronic mental disorder |
Inferred relationship |
Some |
|
Psychosis co-occurrent and due to Parkinson's disease (disorder) |
Is a |
True |
Chronic mental disorder |
Inferred relationship |
Some |
|