Inbound Relationships |
Type |
Active |
Source |
Characteristic |
Refinability |
Group |
High-grade neuroendocrine carcinoma of the corpus uteri is an extremely rare, aggressive, primary uterine neoplasm, originating from neuroendocrine cells scattered within the endometrium, characterized, macroscopically, by a bulky, frequently polypoid, mass with abundant necrosis located in the uterus and, histologically, by rosette-like and cord-like structures consisting of small, rounded cells with oval nuclei and scarce cytoplasm. Patients often present with dysfunctional uterine bleeding, pelvic or abdominal mass and, especially in later stages of the disease, abdominal pain. Symptomatic metastatic spread or symptoms related to a paraneoplastic syndrome, such as retinopathy, or Cushing syndrome due to ectopic ACTH production, may be associated. |
Associated morphology |
True |
Neuroendocrine carcinoma |
Inferred relationship |
Some |
1 |
High-grade neuroendocrine carcinoma of the cervix uteri is a rare, aggressive, primary cervical neoplasm, originating from neuroendocrine cells present in the lining epithelium of the cervix, characterized, macroscopically, by usually large lesions, sometimes with a barrel-shaped appearance. Patients often present with abnormal vaginal bleeding or discharge, pelvic/abdominal pain, post-coital spotting and/or dysuria, while symptoms related to carcinoid syndrome are not frequent. |
Associated morphology |
True |
Neuroendocrine carcinoma |
Inferred relationship |
Some |
1 |
Small cell neuroendocrine carcinoma |
Is a |
True |
Neuroendocrine carcinoma |
Inferred relationship |
Some |
|
Large cell neuroendocrine carcinoma |
Is a |
True |
Neuroendocrine carcinoma |
Inferred relationship |
Some |
|
Neuroendocrine carcinoma |
Associated morphology |
True |
Neuroendocrine carcinoma |
Inferred relationship |
Some |
1 |
Neuroendocrine carcinoma of anus |
Associated morphology |
True |
Neuroendocrine carcinoma |
Inferred relationship |
Some |
1 |
Neuroendocrine carcinoma of appendix (disorder) |
Associated morphology |
True |
Neuroendocrine carcinoma |
Inferred relationship |
Some |
1 |
Primary neuroendocrine carcinoma of esophagus (disorder) |
Associated morphology |
True |
Neuroendocrine carcinoma |
Inferred relationship |
Some |
1 |
Primary neuroendocrine carcinoma of stomach (disorder) |
Associated morphology |
True |
Neuroendocrine carcinoma |
Inferred relationship |
Some |
1 |
Primary neuroendocrine carcinoma of cardia of stomach (disorder) |
Associated morphology |
True |
Neuroendocrine carcinoma |
Inferred relationship |
Some |
1 |
Primary neuroendocrine carcinoma of body of stomach (disorder) |
Associated morphology |
True |
Neuroendocrine carcinoma |
Inferred relationship |
Some |
1 |
Primary neuroendocrine carcinoma of pyloric antrum of stomach (disorder) |
Associated morphology |
True |
Neuroendocrine carcinoma |
Inferred relationship |
Some |
1 |
Primary neuroendocrine carcinoma of overlapping sites of stomach (disorder) |
Associated morphology |
True |
Neuroendocrine carcinoma |
Inferred relationship |
Some |
1 |
Primary neuroendocrine carcinoma of duodenum (disorder) |
Associated morphology |
True |
Neuroendocrine carcinoma |
Inferred relationship |
Some |
1 |
Primary neuroendocrine carcinoma of small intestine (disorder) |
Associated morphology |
True |
Neuroendocrine carcinoma |
Inferred relationship |
Some |
1 |
Primary neuroendocrine carcinoma of colon (disorder) |
Associated morphology |
True |
Neuroendocrine carcinoma |
Inferred relationship |
Some |
1 |
Primary neuroendocrine carcinoma of rectum (disorder) |
Associated morphology |
True |
Neuroendocrine carcinoma |
Inferred relationship |
Some |
1 |
Primary hepatic neuroendocrine carcinoma (PHNEC) is a rare hepatic tumor that may manifest with abdominal pain or fullness, as well as diarrhea or weight loss. More than 10% of cases are asymptomatic and in rare cases a carcinoid syndrome may be observed. |
Associated morphology |
True |
Neuroendocrine carcinoma |
Inferred relationship |
Some |
1 |
Neuroendocrine carcinoma of pancreas |
Associated morphology |
True |
Neuroendocrine carcinoma |
Inferred relationship |
Some |
1 |
Primary neuroendocrine carcinoma of gallbladder |
Associated morphology |
True |
Neuroendocrine carcinoma |
Inferred relationship |
Some |
1 |
Merkel cell carcinoma |
Is a |
True |
Neuroendocrine carcinoma |
Inferred relationship |
Some |
|
A rare very aggressive neuroendocrine neoplasm with the presence of nodular mass(es) arising from the neck, fundus or body of the gallbladder or by diffuse thickening of the gallbladder wall. Patients may be asymptomatic (diagnosed incidentally after surgical resection of the gallbladder) or may present epigastric pain, abdominal mass and/or non-specific symptoms, such as nausea, jaundice, flushing, cough, wheezing, ascites. Paraneoplastic syndromes such as Cushing syndrome, acanthosis nigricans, bullous pemphigoid, dermatomyositis and the Leser-Trelat sign may be associated. |
Associated morphology |
True |
Neuroendocrine carcinoma |
Inferred relationship |
Some |
1 |
Primary neuroendocrine carcinoma of cervix uteri (disorder) |
Associated morphology |
True |
Neuroendocrine carcinoma |
Inferred relationship |
Some |
1 |
Thymic neuroendocrine carcinoma is a type of thymic epithelial neoplasm displaying evidence of neuroendocrine differentiation. |
Associated morphology |
True |
Neuroendocrine carcinoma |
Inferred relationship |
Some |
1 |
Metastatic neuroendocrine carcinoma (morphologic abnormality) |
Is a |
True |
Neuroendocrine carcinoma |
Inferred relationship |
Some |
|