14016003: Bone marrow structure (body structure)

SNOMED CT Concept\Body structure (body structure)\Anatomical or acquired body structure (body structure)\Anatomical structure\...

\An anatomical structure that consists of the maximal set of organ parts so connected to one another that together they constitute a self-contained unit of macroscopic anatomy, distinct both morphologically and functionally from other such units. Together with other organs, an organ constitutes an organ system or a body part. An organ is divisible into organ parts but not organs (examples: femur, biceps, liver, heart, aorta, sciatic nerve, ovary).\Structure of bone organ\Bone marrow structure

\Body system structure\Structure of hematological system (body structure)\Hematopoietic system structure\Bone marrow structure
\Body system structure\Structure of lymphoreticular system (body structure)\Bone marrow structure

\Body tissue structure\Bone marrow structure

Status: current, Not sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jan 2002. Module: SNOMED CT core

Descriptions:

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
Bone marrow structure	Is a	An anatomical structure that consists of the maximal set of organ parts so connected to one another that together they constitute a self-contained unit of macroscopic anatomy, distinct both morphologically and functionally from other such units. Together with other organs, an organ constitutes an organ system or a body part. An organ is divisible into organ parts but not organs (examples: femur, biceps, liver, heart, aorta, sciatic nerve, ovary).	false	Inferred relationship	Some
Bone marrow structure	Is a	Structure of lymphoreticular system (body structure)	true	Inferred relationship	Some
Bone marrow structure	Is a	Hematopoietic system structure	true	Inferred relationship	Some
Bone marrow structure	partie de	Entire hematopoietic system	false	Additional relationship	Some
Bone marrow structure	Is a	Body tissue structure	true	Inferred relationship	Some
Bone marrow structure	Is a	Structure of bone organ	true	Inferred relationship	Some

Inbound Relationships	Type	Active	Source	Characteristic	Refinability	Group
A rare hematological neoplasm characterized by clonal proliferation of myeloid precursors in the bone marrow, blood and other tissues (spleen, liver), with clinical, morphological and molecular features of myeloproliferative neoplasms (MPN), failing to meet criteria of a specific MPN. The presentation is nonspecific and variable and often includes leukocytosis, thrombocytosis and anemia. Splenomegaly, hepatomegaly as well as fatigue, malaise or weight loss may appear in advanced stages.	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Myeloproliferative disorder (disorder)	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
A subtype of acute myeloid leukemia with recurrent genetic abnormalities characterized by clonal proliferation of myeloid blasts in the bone marrow, blood and, rarely, other tissues. Bone marrow typically shows small, hypolobated megakaryocytes and multilineage dysplasia. Patients typically present with leukocytosis, anemia, variable platelet counts and a variety of nonspecific symptoms related to ineffective hematopoesis (fatigue, bleeding, bruising, recurrent infections, bone pain) and/or extramedullary site involvement (gingivitis, splenomegaly). High resistance to conventional chemotherapy is reported.	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Differentiation syndrome due to and following chemotherapy co-occurrent with acute promyelocytic leukemia (disorder)	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Hereditary isolated aplastic anemia is a rare, genetic, constitutional aplastic anemia disorder characterized by severe peripheral blood pancytopenia and bone marrow hypoplasia in multiple individuals of a family, in the absence of any somatic symptoms. Abnormal bleeding, as well as erythrocyte macrocytosis, is reported and patients usually become transfusion dependent.	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Sclerosing osteomyelitis	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Gonococcal osteomyelitis (disorder)	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Q fever osteomyelitis (disorder)	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Drug-induced hypoplasia of bone marrow (disorder)	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Osteomyelitis	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
SAPHO syndrome	Finding site	True	Bone marrow structure	Inferred relationship	Some	5
Bacterial osteomyelitis	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Salmonella osteomyelitis	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Osteomyelitis caused by Pasteurella multocida (disorder)	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Osteomyelitis of multiple sites	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
B-cell prolymphocytic leukemia in remission	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Juvenile myelomonocytic leukaemia in remission	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Refractory acute myeloid leukaemia	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Relapsing acute myeloid leukemia (disorder)	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Leukemic reticuloendotheliosis of intra-abdominal lymph nodes	Finding site	True	Bone marrow structure	Inferred relationship	Some	2
Osteomyelitis due to type 1 diabetes mellitus (disorder)	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Osteomyelitis due to type 2 diabetes mellitus (disorder)	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Acute myeloid leukemia with CBFB::MYH11 fusion (disorder)	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
B lymphoblastic leukemia lymphoma with hyperdiploidy (disorder)	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
B lymphoblastic leukemia lymphoma with t(5;14)(q31;q32); IL3-IGH	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
B lymphoblastic leukemia lymphoma with t(v;11q23); MLL rearranged	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
B lymphoblastic leukemia lymphoma with t(12;21) (p13;q22); TEL/AML1 (ETV6-RUNX1) (disorder)	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
B lymphoblastic leukemia lymphoma with t(1;19)(Q23;P13.3); E2A-PBX1 (TCF3/PBX1) (disorder)	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
B lymphoblastic leukemia lymphoma with hypodiploidy	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Post-polycythaemia vera myelofibrosis	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Myelofibrosis due to and following essential thrombocythemia (disorder)	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Adult T-cell leukaemia/lymphoma in remission	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
T-cell prolymphocytic leukemia in remission	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Emberger syndrome	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Acute myeloid leukemia with t(8;21)(q22;q22) RUNX1-RUNX1T1 (disorder)	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Acute myelofibrosis in remission	Finding site	False	Bone marrow structure	Inferred relationship	Some	1
Myelofibrosis caused by drug (disorder)	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Mixed phenotype acute leukemia with myeloid and B-cell lymphoid phenotypes	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Mixed phenotype acute leukemia with T-cell and myeloid lineage (disorder)	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Mixed phenotype acute leukemia with t(9;22) (q34;q11.2); BCR-ABL1 (disorder)	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Primary familial polycythemia due to erythropoietin receptor mutation	Finding site	True	Bone marrow structure	Inferred relationship	Some	4
Myelodysplastic syndrome with single lineage dysplasia	Finding site	False	Bone marrow structure	Inferred relationship	Some	1
Myeloproliferative hypereosinophilic syndrome (disorder)	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Aase syndrome	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
A rare tumor arising from hematopoietic and lymphoid tissues characterized by abnormal proliferation and differentiation of a clonal population of myeloid stem cells carrying unspecific 11q23 abnormalities. Clinical manifestations result from accumulation of malignant myeloid cells within the bone marrow, peripheral blood and other organs, and include leukocytosis, anemia, thrombocytopenia, fatigue, anorexia and weight loss.	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Acute myeloid leukaemia in complete remission	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Myeloid leukemia associated with Down syndrome (disorder)	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
High-dose chemotherapy with stem cell transplant (procedure)	Procedure site - Indirect (attribute)	True	Bone marrow structure	Inferred relationship	Some	1
Leukemic infiltration of skin in monocytic leukemia (disorder)	Finding site	True	Bone marrow structure	Inferred relationship	Some	2
A rare multiple congenital anomalies/dysmorphic syndrome characterized by early-onset progressive bone marrow failure with anemia, leukopenia, mild thrombopenia, and myelodysplastic features, as well as non-hematologic manifestations, such as developmental delay, cataracts, facial dysmorphism, short stature, and skeletal anomalies. Immunodeficiency primarily affects B-cells and may lead to increased susceptibility to infections. Additional reported features include dry skin and eczema, cardiac anomalies, hearing loss, and reduction of cerebral volume on brain imaging.	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Disorder of central nervous system co-occurrent and due to acute lymphoid leukemia in remission (disorder)	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Aggressive NK-cell leukaemia involving skin	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Osteomyelitis caused by Salmonella enterica enterica serovar Typhi (disorder)	Finding site	True	Bone marrow structure	Inferred relationship	Some	2
A group of rare acute leukemias of ambiguous lineage characterized by the presence of separate populations of blasts of more than one lineage (bilineal), a single population of blasts coexpressing antigens of more than one lineage (biphenotypic), or a combination thereof. The diagnosis relies on immunophenotyping, the T-cell component being characterized by strong expression of cytoplasmic CD3, usually in the absence of surface CD3, the B-cell component expressing CD19, almost always together with CD10, cCD79a, CD22, or PAX5, while the most specific hallmark of the myeloid component is the presence of myeloperoxidase in the blast cytoplasm.	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Chronic nonbacterial osteomyelitis (CNO), also known as chronic recurrent multifocal osteomyelitis (CRMO), is a chronic autoinflammatory syndrome that is characterised by multiple foci of painful swelling of bones, mainly in the metaphyses of the long bones, in addition to the pelvis, the shoulder girdle and the spine.	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
A rare subtype of indolent systemic mastocytosis characterized by isolated bone marrow involvement without skin lesions, low burden of neoplastic mast cells, and often normal or near normal serum tryptase levels. The KIT D816V mutation is present in the majority of cases.	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
A rare acute myeloid leukemia (AML) with recurrent genetic anomaly characterized by the presence of bone marrow and peripheral blood myeloblasts with features ranging from those of minimal differentiation to granulocytic maturation, demonstrating t(9;22)(q34.1;q11.2) or molecular genetic evidence of BCR-ABL1 fusion. Evidence of chronic myeloid leukemia (CML) is absent. Patients most commonly present with leukocytosis with blast predominance and variable anemia and thrombocytopenia. Splenomegaly is less frequent and peripheral blood basophilia lower than in patients with myeloid blast transformation of CML. The disease occurs primarily in adults, and response to traditional AML therapy or tyrosine kinase inhibitor therapy alone is typically poor.	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Aspiration of bone marrow from donor for transplant	Procedure site - Direct (attribute)	True	Bone marrow structure	Inferred relationship	Some	2
Multiple bone marrow aspiration	Procedure site - Direct (attribute)	True	Bone marrow structure	Inferred relationship	Some	1
Percutaneous fine needle aspiration biopsy of bone marrow using imaging guidance (procedure)	Procedure site - Direct (attribute)	True	Bone marrow structure	Inferred relationship	Some	1
A rare radiation-induced disorder resulting from whole body exposure to large doses of penetrating radiation (>0.7 Gray) within a very short period of time (usually minutes) and characterized by bone marrow syndrome with pancytopenia (mild symptoms of which may occur already at 0.3 Gray), gastrointestinal syndrome resulting in mostly fatal infection, dehydration, and electrolyte imbalance (occurring at doses >10 Gray), and cardiovascular/central nervous system syndrome with watery diarrhea, convulsions, coma, and death within three days of exposure (occurring at doses >50 Gray). The syndrome develops in four clinical stages (prodromal/latent/manifest illness/recovery or death) of variable duration.	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Hematopoietic subsyndrome of acute radiation syndrome (disorder)	Finding site	True	Bone marrow structure	Inferred relationship	Some	10
Myelodysplastic neoplasm with low blasts and SF3B1 mutation	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Myelodysplastic syndrome with low blasts (disorder)	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Hypoplastic myelodysplastic syndrome (disorder)	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Myelodysplastic neoplasm with biallelic TP53 inactivation (disorder)	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Unclassified myelodysplastic syndrome (MDS-U) is a subtype of myelodysplastic syndrome with atypical features of uncertain clinical significance.	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
A rare acute leukemia of ambiguous lineage characterized by clonal proliferation of primitive hematopoietic cells, primarily in the bone marrow and blood, lacking lineage-specific markers and detectable genotypic alterations. The patients present with leukocytosis, anemia, variable platelet count and a variety of nonspecific symptoms related to ineffective hematopoesis (fatigue, bleeding and bruising, recurrent infections, bone pain) and/or extramedullary site involvement (lymphadenopathy, splenomegaly, hepatomegaly).	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Transient abnormal myelopoiesis co-occurrent with Down syndrome (disorder)	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Fanconi anemia of complementation group C	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Polycythaemia vera in remission	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Ventricular shunt to bone marrow	Procedure site - Direct (attribute)	True	Bone marrow structure	Inferred relationship	Some	1
Syngeneic peripheral blood stem cell transplantation (procedure)	Procedure site - Indirect (attribute)	True	Bone marrow structure	Inferred relationship	Some	1
Transplantation of allogeneic hematopoietic stem cell (procedure)	Procedure site - Indirect (attribute)	True	Bone marrow structure	Inferred relationship	Some	1
Chronic osteomyelitis	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Chronic hematogenous osteomyelitis (disorder)	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Chronic osteomyelitis of multiple sites	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
A rare constitutional aplastic anaemia characterised by aplastic anaemia, intellectual disability, short stature, and microcephaly. Skin pigmentation or cafe au lait spots are often present. Majority of the patients present global developmental delay with impaired motor skills, learning disabilities, speech delay whereas some patients also may have behavioural problems including autistic features. Patients often develop premalignant myelodysplastic syndromes or leukaemia.	Finding site	True	Bone marrow structure	Inferred relationship	Some	2
Disorder of bone marrow caused by ionising radiation	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Bone marrow suppression using irradiation	Procedure site - Direct (attribute)	True	Bone marrow structure	Inferred relationship	Some	1
Finding of bone marrow erythropoiesis (finding)	Finding site	True	Bone marrow structure	Inferred relationship	Some	1
Bone marrow normoblastic	Finding site	True	Bone marrow structure	Inferred relationship	Some	2
Bone marrow megaloblastic	Finding site	True	Bone marrow structure	Inferred relationship	Some	2
Bone marrow erythropoiesis hyperplasia (finding)	Finding site	True	Bone marrow structure	Inferred relationship	Some	2
Erythroid hypoplasia of bone marrow (finding)	Finding site	True	Bone marrow structure	Inferred relationship	Some	2
Immature red blood cells (erythroid cells) in the bone marrow are abnormal in size, shape, organization, and/or number.	Finding site	True	Bone marrow structure	Inferred relationship	Some	2

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Reference Sets

Anatomy structure and entire association reference set (foundation metadata concept)

Anatomy structure and part association reference set (foundation metadata concept)

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Id	Description	Lang	Type	Status	Case?	Module
23879014	Bone marrow	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
23881011	Hematopoietic tissue	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
23882016	Hemopoietic tissue	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
23884015	Haematopoietic tissue	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
23885019	Hematopoietic marrow	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
23886018	Haematopoietic marrow	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
476013012	Haemopoietic tissue	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
476014018	Bone marrow structure	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
739892017	Bone marrow structure (body structure)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core