281300000: Below reference range (qualifier value)

SNOMED CT Concept\Qualifier value (qualifier value)\Finding value (qualifier value)\...

\Interpretation value\Reference range interpretation value\Outside reference range (qualifier value)\Below reference range

\Finding status values\Change values\Changed status\Decreased\Below reference range

\Degree findings\Decreased\Below reference range

Status: current, Not sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jan 2002. Module: SNOMED CT core

Descriptions:

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
Below reference range	Is a	Reference range comments	false	Inferred relationship	Some
Below reference range	Is a	Outside reference range (qualifier value)	true	Inferred relationship	Some
Below reference range	Is a	Decreased	true	Inferred relationship	Some

Inbound Relationships	Type	Active	Source	Characteristic	Refinability	Group
Nephrotic syndrome, diffuse mesangial proliferative glomerulonephritis	Has interpretation	True	Below reference range	Inferred relationship	Some	2
Nephrotic syndrome with proliferative glomerulonephritis	Has interpretation	True	Below reference range	Inferred relationship	Some	2
Nephrotic syndrome with membranous glomerulonephritis	Has interpretation	True	Below reference range	Inferred relationship	Some	2
Congenital nephrotic syndrome with evidence of an underlying congenital infection (e.g. syphilis, toxoplasmosis, rubella, hepatitis B).	Has interpretation	True	Below reference range	Inferred relationship	Some	3
Nephrotic syndrome with membranoproliferative glomerulonephritis	Has interpretation	True	Below reference range	Inferred relationship	Some	2
Congenital nephrotic syndrome, interstitial lung disease, epidermolysis bullosa syndrome	Has interpretation	True	Below reference range	Inferred relationship	Some	4
Steroid-sensitive nephrotic syndrome	Has interpretation	True	Below reference range	Inferred relationship	Some	2
Steroid-resistant nephrotic syndrome	Has interpretation	True	Below reference range	Inferred relationship	Some	2
Nephrotic syndrome, minor glomerular abnormality	Has interpretation	True	Below reference range	Inferred relationship	Some	2
Steroid-dependent nephrotic syndrome	Has interpretation	True	Below reference range	Inferred relationship	Some	2
Nephrotic syndrome, diffuse membranous glomerulonephritis	Has interpretation	True	Below reference range	Inferred relationship	Some	2
Congenital nephrotic syndrome with focal glomerulosclerosis	Has interpretation	True	Below reference range	Inferred relationship	Some	1
Drash syndrome	Has interpretation	True	Below reference range	Inferred relationship	Some	3
Nephrotic syndrome, diffuse endocapillary proliferative glomerulonephritis	Has interpretation	True	Below reference range	Inferred relationship	Some	2
Nephrotic syndrome due to type 2 diabetes mellitus	Has interpretation	True	Below reference range	Inferred relationship	Some	2
Nephrotic syndrome, diffuse mesangiocapillary glomerulonephritis	Has interpretation	True	Below reference range	Inferred relationship	Some	2
Nephrotic syndrome in amyloidosis	Has interpretation	True	Below reference range	Inferred relationship	Some	2
Nephrotic syndrome, diffuse crescentic glomerulonephritis	Has interpretation	True	Below reference range	Inferred relationship	Some	2
Finnish congenital nephrotic syndrome	Has interpretation	True	Below reference range	Inferred relationship	Some	2
syndrome néphrotique associé à un autre trouble	Has interpretation	False	Below reference range	Inferred relationship	Some	2
A rare, hereditary nephrotic syndrome characterized by proteinuria, hypoalbuminemia, edema, and hyperlipidemia, with an absence of response to an initial trial of corticosteroids (i.e. steroid-resistant nephrotic syndrome; SRNS) and a generally complicated course.	Has interpretation	True	Below reference range	Inferred relationship	Some	2
Nephrotic syndrome due to diabetes mellitus (disorder)	Has interpretation	True	Below reference range	Inferred relationship	Some	2
Nephrotic syndrome in malaria	Has interpretation	True	Below reference range	Inferred relationship	Some	3
Sporadic idiopathic steroid-resistant nephrotic syndrome (disorder)	Has interpretation	True	Below reference range	Inferred relationship	Some	2
Nephrotic syndrome in polyarteritis nodosa (disorder)	Has interpretation	True	Below reference range	Inferred relationship	Some	2
X-linked dyserythropoietic anemia with abnormal platelets and neutropenia is a rare, genetic, constitutional dyserythropoietic anemia disorder characterized by moderate to severe anemia without thrombocytopenia, variable degrees of neutropenia, and bone marrow biopsy findings of trilineage dysplasia and hypocellularity of erythroid and granulocytic lineages. Peripheral blood findings include anisocytosis, macrocytosis, poikilocytosis, elliptocytes, and fragmented erythrocytes.	Has interpretation	True	Below reference range	Inferred relationship	Some	4
X-linked dyserythropoietic anemia with abnormal platelets and neutropenia is a rare, genetic, constitutional dyserythropoietic anemia disorder characterized by moderate to severe anemia without thrombocytopenia, variable degrees of neutropenia, and bone marrow biopsy findings of trilineage dysplasia and hypocellularity of erythroid and granulocytic lineages. Peripheral blood findings include anisocytosis, macrocytosis, poikilocytosis, elliptocytes, and fragmented erythrocytes.	Has interpretation	True	Below reference range	Inferred relationship	Some	3
A rare hemolytic anemia characterized by combination of neurologic features, such as psychomotor delay, seizures, variable movement disorders, and hemolytic anemia with stomatocytosis, resulting in cation-leaky erythrocytes, pseudohyperkalemia, hemolytic crises and hepatosplenomegaly. Cataracts are also a presenting feature.	Has interpretation	True	Below reference range	Inferred relationship	Some	2
A rare hemolytic anemia characterized by combination of neurologic features, such as psychomotor delay, seizures, variable movement disorders, and hemolytic anemia with stomatocytosis, resulting in cation-leaky erythrocytes, pseudohyperkalemia, hemolytic crises and hepatosplenomegaly. Cataracts are also a presenting feature.	Has interpretation	True	Below reference range	Inferred relationship	Some	1
Autosomal recessive severe congenital neutropenia due to G6PC3 deficiency is a rare, genetic, primary immunodeficiency disorder characterized by increased susceptibility to recurrent, life-threatening bacterial infections, in association with typically severe neutropenia in peripheral blood and bone marrow and a prominent ectatic superficial vein pattern, resulting from recessively inherited mutations in the G6PC3 gene. Cardiac malformations (e.g. atrial septal defects, patent ductus arteriosus, valvular defects), urogenital anomalies (including cryptorchidism), growth and developmental delay, facial dysmorphism (e.g. frontal bossing, upturned nose, malar hypoplasia), and intermittent thrombocytopenia are frequently associated.	Has interpretation	True	Below reference range	Inferred relationship	Some	1
Leigh-Syndrom mit nephrotischem Syndrom	Has interpretation	False	Below reference range	Inferred relationship	Some	2
A rare syndrome with combined immunodeficiency characterized by a variable clinical presentation ranging from asymptomatic individuals to potentially life-threatening, recurrent bacterial infections associated with progressive loss of serum immunoglobulins and B cells.	Has interpretation	True	Below reference range	Inferred relationship	Some	1
A rare syndrome with combined immunodeficiency characterized by a variable clinical presentation ranging from asymptomatic individuals to potentially life-threatening, recurrent bacterial infections associated with progressive loss of serum immunoglobulins and B cells.	Has interpretation	True	Below reference range	Inferred relationship	Some	3
A rare syndrome with combined immunodeficiency characterized by a variable clinical presentation ranging from asymptomatic individuals to potentially life-threatening, recurrent bacterial infections associated with progressive loss of serum immunoglobulins and B cells.	Has interpretation	True	Below reference range	Inferred relationship	Some	2
A rare syndrome with combined immunodeficiency characterized by a variable clinical presentation ranging from asymptomatic individuals to potentially life-threatening, recurrent bacterial infections associated with progressive loss of serum immunoglobulins and B cells.	Has interpretation	True	Below reference range	Inferred relationship	Some	4
A rare, genetic, primary immunodeficiency disorder characterized by predisposition to recurrent, life-threatening bacterial infections associated with decreased peripheral neutrophil granulocytes (absolute neutrophil count less than 500 cells/microliter), resulting from recessively inherited loss-of-function mutations in the CSF3R gene. Full maturation of all three lineages in the bone marrow and refractoriness to in vivo rhG-CSF treatment are associated.	Has interpretation	True	Below reference range	Inferred relationship	Some	1
Autosomal recessive severe congenital neutropenia due to JAGN1 deficiency is a rare, genetic, primary immunodeficiency disorder characterized by early-onset, recurrent, severe bacterial infections, granulopoiesis maturation arrest at the promyelocyte/myelocyte stage and markedly reduced absolute neutrophil counts, resulting from recessively inherited mutations in the JAGN1 gene. Mild facial dysmorphism (i.e. triangular face), short stature, failure to thrive, hypothyroidism, developmental delay, pancreatic insufficiency and coarctation of aorta, as well as bone and urogenital abnormalities, may also be associated.	Has interpretation	True	Below reference range	Inferred relationship	Some	1
A rare, genetic, isolated constitutional thrombocytopenia disease characterized by impaired platelet aggregation resulting from a defect in thromboxane synthesis or signaling, manifesting with mild to moderate mucocutaneous, gastrointestinal or surgical bleeding (e.g. easy bruising, prolonged epistaxis, excessive bleeding after a tooth extraction).	Has interpretation	True	Below reference range	Inferred relationship	Some	1
A rare, genetic, primary immunodeficiency disorder characterized by recurrent bacterial infections (including septic thrombophlebitis and subacute bacterial endocarditis) and neutropenia without lymphopenia or warts, resulting from recessively inherited mutations in CXCR2.	Has interpretation	True	Below reference range	Inferred relationship	Some	1
A rare, genetic, isolated constitutional thrombocytopenia disease characterized by decreased platelet counts, not associated with platelet morphology or function impairment, in multiple members of a family. Manifestations are variable, typically ranging from asymptomatic to mild bleeding diathesis (e.g. easy bruising, epistaxis, petechiae). Occasionally, a more severe bleeding tendency has been associated and a mild predisposition to infection and eczema has been reported.	Has interpretation	True	Below reference range	Inferred relationship	Some	1
Hereditary isolated aplastic anemia is a rare, genetic, constitutional aplastic anemia disorder characterized by severe peripheral blood pancytopenia and bone marrow hypoplasia in multiple individuals of a family, in the absence of any somatic symptoms. Abnormal bleeding, as well as erythrocyte macrocytosis, is reported and patients usually become transfusion dependent.	Has interpretation	True	Below reference range	Inferred relationship	Some	2
Hereditary isolated aplastic anemia is a rare, genetic, constitutional aplastic anemia disorder characterized by severe peripheral blood pancytopenia and bone marrow hypoplasia in multiple individuals of a family, in the absence of any somatic symptoms. Abnormal bleeding, as well as erythrocyte macrocytosis, is reported and patients usually become transfusion dependent.	Has interpretation	True	Below reference range	Inferred relationship	Some	5
Hereditary isolated aplastic anemia is a rare, genetic, constitutional aplastic anemia disorder characterized by severe peripheral blood pancytopenia and bone marrow hypoplasia in multiple individuals of a family, in the absence of any somatic symptoms. Abnormal bleeding, as well as erythrocyte macrocytosis, is reported and patients usually become transfusion dependent.	Has interpretation	True	Below reference range	Inferred relationship	Some	4
Hereditary isolated aplastic anemia is a rare, genetic, constitutional aplastic anemia disorder characterized by severe peripheral blood pancytopenia and bone marrow hypoplasia in multiple individuals of a family, in the absence of any somatic symptoms. Abnormal bleeding, as well as erythrocyte macrocytosis, is reported and patients usually become transfusion dependent.	Has interpretation	True	Below reference range	Inferred relationship	Some	3
Osteopetrosis - intermediate type	Has interpretation	True	Below reference range	Inferred relationship	Some	2
A sclerosing disorder of the skeleton characterized by increased bone density that classically displays the radiographic sign of sandwich vertebrae (dense bands of sclerosis parallel to the vertebral endplates).	Has interpretation	True	Below reference range	Inferred relationship	Some	2
Osteopetrosis	Has interpretation	True	Below reference range	Inferred relationship	Some	2
A rare syndrome characterized by sparse hair, osteopenia, intellectual disability, minor facial abnormalities, joint laxity and hypotonia. There have been no further descriptions in the literature since 1992.	Has interpretation	True	Below reference range	Inferred relationship	Some	4
This syndrome is characterized by osteopetrosis, agenesis of the corpus callosum, cerebral atrophy and a small hippocampus.	Has interpretation	True	Below reference range	Inferred relationship	Some	3
Juvenile idiopathic generalised osteoporosis	Has interpretation	False	Below reference range	Inferred relationship	Some	2
Spondyloocular syndrome (disorder)	Has interpretation	True	Below reference range	Inferred relationship	Some	2
Dysplasia with decreased bone density	Has interpretation	True	Below reference range	Inferred relationship	Some	2
Transient infantile osteopetrosis	Has interpretation	True	Below reference range	Inferred relationship	Some	2
A rare, genetic, primary bone dysplasia with decreased bone density disorder characterized by childhood-onset osteoporosis associated with recurrent, multiple, osteoporotic, long bone fractures and/or vertebral compression fractures, significant height loss in adulthood, low bone mineral density scores, and otherwise no other abnormalities. Heterozygote females may be unaffected or have a milder phenotype.	Has interpretation	True	Below reference range	Inferred relationship	Some	2
A rare congenital disorder of bone resorption characterised by generalised skeletal densification.	Has interpretation	True	Below reference range	Inferred relationship	Some	2
A rare, genetic, primary bone dysplasia with increased bone density disorder characterized by benign, isolated, calvarial thickening, presenting with prominent frontoparietal bones, a high forehead with ridging of the metopic and sagittal sutures, lateral frontal prominences, and facial dysmorphism comprising a flat nasal root and short, upturned nose. Increased intracranial pressure and cranial nerve entrapment are not associated. There have been no further descriptions in the literature since 1986.	Has interpretation	True	Below reference range	Inferred relationship	Some	2
A rare primary bone dysplasia with decreased bone density disorder characterized by multiple doughnut-shaped hyperostotic or osteosclerotic calvarial lesions (manifesting with cranial lumps) associated with numerous pathologic fractures, elevated serum alkaline phosphatase levels and osteopenia.	Has interpretation	True	Below reference range	Inferred relationship	Some	3
Benign autosomal dominant osteopetrosis	Has interpretation	False	Below reference range	Inferred relationship	Some	2
A rare skeletal disorder characterized clinically by multiple fractures, wormian bones of the skull, dentinogenesis imperfecta and facial dysmorphism (hypertelorism, periorbital fullness). Although the signs are very similar to osteogenesis imperfecta, characteristic cortical defects in the absence of osteopenia and collagen abnormalities are considered to be distinctive. There have been no further descriptions in the literature since 1999.	Has interpretation	True	Below reference range	Inferred relationship	Some	3
Osteopetrosis with renal tubular acidosis	Has interpretation	True	Below reference range	Inferred relationship	Some	2
Singleton-Merten syndrome	Has interpretation	True	Below reference range	Inferred relationship	Some	2
Osteopetrosis - delayed type	Has interpretation	True	Below reference range	Inferred relationship	Some	2
Menkes kinky-hair syndrome	Has interpretation	True	Below reference range	Inferred relationship	Some	3
A rare genetic disease characterized by congenital oculocutaneous hypopigmentation, visual impairment, generalized osteoporosis with skeletal anomalies such as short stature, short neck and trunk, kyphosis, scoliosis, and platyspondyly, and dysmorphic facial features (including long philtrum, small mouth, micrognathia, and prominent ears). Moderate joint hyperelasticity and muscular hypotrophy have also been reported.	Has interpretation	True	Below reference range	Inferred relationship	Some	4
A rare, hereditary, developmental defect with connective tissue involvement characterized by cutis laxa of variable severity, in utero growth restriction, congenital hip dislocation and joint hyperlaxity, wrinkling of the skin, in particular the dorsum of hands and feet, and progeroid facial features. Hypotonia, developmental delay, and intellectual disability are common. In addition, cataracts, corneal clouding, wormian bones, lipodystrophy and osteopenia have been reported.	Has interpretation	True	Below reference range	Inferred relationship	Some	4
A rare, genetic coenzyme Q10 deficiency characterized by sensorineural deafness and severe, progressive nephrotic syndrome not responding to steroid treatment. Clinical manifestations include early onset proteinuria, hypoalbuminemia and edema, leading to end-stage renal disease. The renal biopsy reveals focal segmental glomerulosclerosis and diffuse mesangial sclerosis. Rarely, seizures, ataxia and dysmorphic features have been described.	Has interpretation	True	Below reference range	Inferred relationship	Some	1
Majeed syndrome is a rare genetic multisystemic disorder characterised by chronic recurrent multifocal osteomyelitis, congenital dyserythropoietic anaemia, which may be accompanied by neutrophilic dermatosis.	Has interpretation	True	Below reference range	Inferred relationship	Some	4
Majeed syndrome is a rare genetic multisystemic disorder characterised by chronic recurrent multifocal osteomyelitis, congenital dyserythropoietic anaemia, which may be accompanied by neutrophilic dermatosis.	Has interpretation	True	Below reference range	Inferred relationship	Some	5
A rare, acquired immunodeficiency disease characterized by adult-onset absolute neutrophil counts less than 1.5 x 10^9/L on at least 3 occasions in a 3 month period that cannot be attributable to drugs or a specific genetic, infectious, inflammatory, autoimmune or malignant cause. Recurrent apthous stomatitis and a history of mild bacterial infections are typically associated. A benign outcome with a low rate of severe infections and no secondary malignancies is observed.	Has interpretation	True	Below reference range	Inferred relationship	Some	1
Acute nephrotic syndrome (disorder)	Has interpretation	True	Below reference range	Inferred relationship	Some	1
Neutropenic sepsis (disorder)	Has interpretation	True	Below reference range	Inferred relationship	Some	2
Pancytopenia caused by immunosuppressant	Has interpretation	True	Below reference range	Inferred relationship	Some	3
Pancytopenia caused by immunosuppressant	Has interpretation	True	Below reference range	Inferred relationship	Some	1
Pancytopenia caused by immunosuppressant	Has interpretation	True	Below reference range	Inferred relationship	Some	4
Pancytopenia caused by immunosuppressant	Has interpretation	True	Below reference range	Inferred relationship	Some	2
Loss of hypoglycemic warning due to diabetes mellitus	Has interpretation	True	Below reference range	Inferred relationship	Some	1
Somogyi phenomenon	Has interpretation	False	Below reference range	Inferred relationship	Some	1
Hypoglycaemic unawareness due to type 1 diabetes mellitus	Has interpretation	True	Below reference range	Inferred relationship	Some	1
Nocturnal hypoglycemia due to diabetes mellitus	Has interpretation	True	Below reference range	Inferred relationship	Some	1
Hypoglycaemia due to diabetes mellitus	Has interpretation	True	Below reference range	Inferred relationship	Some	1
Midpelvic contraction	Has interpretation	True	Below reference range	Inferred relationship	Some	2
Contracted pelvis	Has interpretation	True	Below reference range	Inferred relationship	Some	2
Generally contracted pelvis - delivered	Has interpretation	False	Below reference range	Inferred relationship	Some	2
pelvis généralement rétréci avec problème anténatal	Has interpretation	False	Below reference range	Inferred relationship	Some	2
Inlet contraction of pelvis	Has interpretation	True	Below reference range	Inferred relationship	Some	2
contraction des muscles du détroit inférieur avec problème prénatal	Has interpretation	False	Below reference range	Inferred relationship	Some	2
Congenital contracted pelvis	Has interpretation	True	Below reference range	Inferred relationship	Some	2
Outlet pelvic contraction - delivered	Has interpretation	False	Below reference range	Inferred relationship	Some	2
Geroderma osteodysplastica	Has interpretation	True	Below reference range	Inferred relationship	Some	2
Hyperphosphatasemia tarda	Has interpretation	True	Below reference range	Inferred relationship	Some	4
Pyknodysostosis	Has interpretation	True	Below reference range	Inferred relationship	Some	3
Sclerosteosis	Has interpretation	True	Below reference range	Inferred relationship	Some	3
Outlet contraction of pelvis	Has interpretation	True	Below reference range	Inferred relationship	Some	2
Hypoglycemia unawareness due to type 2 diabetes mellitus	Has interpretation	True	Below reference range	Inferred relationship	Some	2
Endosteal hyperostoses	Has interpretation	True	Below reference range	Inferred relationship	Some	3
Syndrome with characteristics of congenital cerebellar hypoplasia, endosteal sclerosis, hypotonia, ataxia, mild to moderate developmental delay, short stature, hip dislocation, and tooth eruption disturbances. It has been described in four patients. Less common manifestations are microcephaly, strabismus, nystagmus, optic atrophy and dysarthria. It is appears to be transmitted as an autosomal recessive trait.	Has interpretation	True	Below reference range	Inferred relationship	Some	3
Insulin reactive hypoglycemia due to type 2 diabetes mellitus (disorder)	Has interpretation	True	Below reference range	Inferred relationship	Some	3
Lenz-Majewski hyperostosis syndrome	Has interpretation	True	Below reference range	Inferred relationship	Some	3
Worth disease	Has interpretation	True	Below reference range	Inferred relationship	Some	3
Craniometadiaphyseal dysplasia, wormian bone type is an extremely rare craniotubular bone dysplasia syndrome described in fewer than 10 patients to date. Clinical manifestations include macrocephaly, frontal bossing, malar hypoplasia, prominent mandible and dental hypoplasia. Other skeletal anomalies include abnormal bone modeling in tubular bones, multiple wormian bones and deformities of chest, pelvis and elbows. An increased risk of fractures is noted.	Has interpretation	True	Below reference range	Inferred relationship	Some	3
This syndrome is characterized by severe immunodeficiency, osteopetrosis, lymphedema and anhidrotic ectodermal dysplasia.	Has interpretation	True	Below reference range	Inferred relationship	Some	5

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Id	Description	Lang	Type	Status	Case?	Module
419283014	Below reference range	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
674819018	Below reference range (qualifier value)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
149241000077115	au-dessous de l'étendue de référence	fr	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
2343211000195112	Unterhalb Referenzbereich	de	Synonym (core metadata concept)	Active	Only initial character case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
2343221000195119	Unter Referenzbereich	de	Synonym (core metadata concept)	Active	Only initial character case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module