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372537003: Substance with topoisomerase inhibitor mechanism of action (substance)

Status: current, Sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jan 2018. Module: SNOMED CT core

Descriptions:

Id Description Lang Type Status Case? Module
1211070011 Topoisomerase inhibitor en Synonym (core metadata concept) Active Entire term case insensitive (core metadata concept) SNOMED CT core
3520833018 Substance with topoisomerase inhibitor mechanism of action (substance) en Fully specified name Active Entire term case insensitive (core metadata concept) SNOMED CT core
3559327014 Substance with topoisomerase inhibitor mechanism of action en Synonym (core metadata concept) Active Entire term case insensitive (core metadata concept) SNOMED CT core
189191000077114 inhibiteur de la topoisomérase fr Synonym (core metadata concept) Active Entire term case insensitive (core metadata concept) SNOMED CT Switzerland NRC maintained Module

11 descendants. Search Descendants:

Expanded Value Set

Outbound Relationships Type Target Active Characteristic Refinability Group Values
Topoisomerase inhibitor Is a Antineoplastic agent (substance) false Inferred relationship Some
Topoisomerase inhibitor Is a Enzyme inhibitor true Inferred relationship Some
Topoisomerase inhibitor This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context. Topoisomerase inhibitor (disposition) true Inferred relationship Some
Topoisomerase inhibitor Is a Substance categorized by disposition false Inferred relationship Some
Topoisomerase inhibitor Is a Substance with effector mechanism of action (substance) false Inferred relationship Some
Inbound Relationships Type Active Source Characteristic Refinability Group
Topotecan (substance) Is a True Topoisomerase inhibitor Inferred relationship Some
Irinotecan (substance) Is a True Topoisomerase inhibitor Inferred relationship Some
Product containing topoisomerase inhibitor (product) The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. True Topoisomerase inhibitor Inferred relationship Some 1
A subgroup of therapy-related myeloid neoplasms (t-MN), associated with treatment of an unrelated neoplastic disease with cytotoxic agents, like etoposide, doxorubicin, daunorubicin and others. The neoplastic cells often show rearrangements involving the mixed lineage leukaemia gene at 11q23. This subgroup of t-MN is typically associated with overt leukaemia, without preceding myelodysplastic syndrome, developing 2-3 years after exposure, presenting with non-specific symptoms related to ineffective haematopoesis (fatigue, bleeding and bruising, recurrent infections, bone pain) and/or extramedullary site involvement. Causative agent (attribute) True Topoisomerase inhibitor Inferred relationship Some 1
Irinotecan hydrochloride (substance) Is a True Topoisomerase inhibitor Inferred relationship Some
Irinotecan hydrochloride trihydrate (substance) Is a True Topoisomerase inhibitor Inferred relationship Some
Flumequine (substance) Is a True Topoisomerase inhibitor Inferred relationship Some
Irinotecan liposome (substance) Is a True Topoisomerase inhibitor Inferred relationship Some
Topotecan hydrochloride Is a True Topoisomerase inhibitor Inferred relationship Some
Sacituzumab Is a True Topoisomerase inhibitor Inferred relationship Some
Sacituzumab govitecan Is a True Topoisomerase inhibitor Inferred relationship Some
Irinotecan sucrosofate (substance) Is a True Topoisomerase inhibitor Inferred relationship Some
Irinotecan hydrochloride anhydrous (substance) Is a True Topoisomerase inhibitor Inferred relationship Some

This concept is not in any reference sets

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