372623002: Substance with central alpha adrenergic receptor agonist mechanism of action (substance)

Status: retired, Not sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jan 2020. Module: SNOMED CT core

Descriptions:

Id Description Lang Type Status Case? Module

1211152010 Central alpha-adrenoceptor agonist en Synonym (core metadata concept) Active Entire term case insensitive (core metadata concept) SNOMED CT core

3646033017 Substance with central alpha adrenergic receptor agonist mechanism of action (substance) en Fully specified name Active Entire term case insensitive (core metadata concept) SNOMED CT core

3646034011 Substance with central alpha adrenergic receptor agonist mechanism of action en Synonym (core metadata concept) Active Entire term case insensitive (core metadata concept) SNOMED CT core

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
Substance with central alpha adrenergic receptor agonist mechanism of action	Is a	Sympathomimetic agent (substance)	false	Inferred relationship	Some
Substance with central alpha adrenergic receptor agonist mechanism of action	Is a	Alpha adrenergic receptor agonist	false	Inferred relationship	Some
Substance with central alpha adrenergic receptor agonist mechanism of action	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	Alpha adrenergic receptor agonist (disposition)	false	Inferred relationship	Some

Inbound Relationships	Type	Active	Source	Characteristic	Refinability	Group
Apraclonidine hydrochloride	Is a	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Guanfacine (substance)	Is a	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Guanabenz (substance)	Is a	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Methyldopa (substance)	Is a	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Clonidine hydrochloride	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Central alpha-adrenoceptor agonist poisoning	Causative agent (attribute)	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some	1
Accidental clonidine poisoning	Causative agent (attribute)	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Intentional clonidine poisoning (disorder)	Causative agent (attribute)	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
intoxication par la clonidine d'intention indéterminée	Causative agent (attribute)	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Central alpha-adrenoceptor agonist adverse reaction	Causative agent (attribute)	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Apraclonidine adverse reaction	Causative agent (attribute)	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Clonidine adverse reaction	Causative agent (attribute)	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Lofexidine adverse reaction	Causative agent (attribute)	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Central alpha-adrenoceptor agonist allergy	Causative agent (attribute)	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Allergy to apraclonidine (finding)	Causative agent (attribute)	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Allergy to clonidine (finding)	Causative agent (attribute)	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Allergy to lofexidine (finding)	Causative agent (attribute)	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Central alpha-adrenoceptor agonist overdose	Causative agent (attribute)	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some	1
Clonidine overdose	Causative agent (attribute)	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Accidental clonidine overdose	Causative agent (attribute)	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Intentional clonidine overdose	Causative agent (attribute)	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
surdose de clonidine d'intention indéterminée	Causative agent (attribute)	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Clonidine hydrochloride [antihypertensive]	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Clonidine hydrochloride 250micrograms m/r capsule	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
chlorhydrate de clonidine 150 microgrammes/mL, ampoule de 1 mL de solution pour injection	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Clonidine HCl [migraine]	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Product containing precisely clonidine hydrochloride 25 microgram/1 each conventional release oral tablet (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Lofexidine hydrochloride	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Lofexidine hydrochloride 200 microgram oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Product containing apraclonidine (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Product containing central alpha-adrenoceptor agonist	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some	1
Product containing lofexidine (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Clonidine hydrochloride 0.1mg tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Clonidine hydrochloride 200 microgram oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Clonidine hydrochloride 0.3mg tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Clonidine 2.5mg/unt	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Clonidine 7.5mg/unt	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Clonidine hydrochloride 100mcg/mL injection	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Clonidine 4mg/patch	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Clonidine 0.1mg patch	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Clonidine 5mg patch	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Chlortalidone 15 mg and clonidine hydrochloride 200 microgram oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Product containing precisely chlortalidone 15 milligram and clonidine hydrochloride 300 microgram/1 each conventional release oral tablet (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Clonidine-containing product in oral dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Clonidine-containing product in transdermal dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Product containing clonidine in parenteral dose form (medicinal product form)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Clonidine m/r	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Poisoning by clonidine	Causative agent (attribute)	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Product containing clonidine (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Apraclonidine hydrochloride 1%/mL solution	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Apraclonidine hydrochloride 0.5% solution	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Product containing chlortalidone and clonidine hydrochloride	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Clonidine hydrochloride 100mcg/mL injection solution 10mL vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Clonidine hydrochloride 100 microgram oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Product containing precisely clonidine hydrochloride 300 microgram/1 each conventional release oral tablet (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Apraclonidine (as apraclonidine hydrochloride) 5 mg/mL eye drops	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Apraclonidine 1% intra-ocular solution	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Apraclonidine hydrochloride	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Clonidine hydrochloride 0.5mg/mL injection solution 10mL vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Clonidine (substance)	Is a	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Lofexidine (substance)	Is a	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Central alpha-adrenoceptor agonist allergy	Causative agent (attribute)	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some	1
Lofexidine hydrochloride (substance)	Is a	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Clonidine hydrochloride (substance)	Is a	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Methyldopa anhydrous	Is a	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Guanfacine hydrochloride	Is a	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some
Guanabenz acetate	Is a	False	Substance with central alpha adrenergic receptor agonist mechanism of action	Inferred relationship	Some

Reference Sets

Concept inactivation indicator reference set

POSSIBLY EQUIVALENT TO association reference set (foundation metadata concept)

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Id	Description	Lang	Type	Status	Case?	Module
1211152010	Central alpha-adrenoceptor agonist	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
3646033017	Substance with central alpha adrenergic receptor agonist mechanism of action (substance)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
3646034011	Substance with central alpha adrenergic receptor agonist mechanism of action	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core