373513008: Indometacin (substance)

SNOMED CT Concept\Substance\...

\Substance categorized by disposition\Substance with effector mechanism of action (substance)\Enzyme inhibitor\Substance with prostaglandin-endoperoxide synthase inhibitor mechanism of action (substance)\Indometacin

\A grouper concept for substances that are used in medicinal products for medical treatment, and also psychoactive substances that have few or no legitimate medical uses or that are not legally available to the person using them.\Substance with prostaglandin-endoperoxide synthase inhibitor mechanism of action (substance)\Indometacin
\A grouper concept for substances that are used in medicinal products for medical treatment, and also psychoactive substances that have few or no legitimate medical uses or that are not legally available to the person using them.\Analgesic (substance)\Non-opioid analgesic (substance)\Non-steroidal anti-inflammatory agent (substance)\Indometacin

\Substance categorised by structure\Chemical\Chemical categorized by structure (substance)\...

\Organic compound\Substance with ether structure\Indometacin
\Organic compound\Organic chloride compound\Chlorinated hydrocarbon\Chlorobenzene\Indometacin
\Organic compound\Hydrocarbon\Halogenated hydrocarbon\Chlorinated hydrocarbon\Chlorobenzene\Indometacin

Status: current, Not sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jul 2002. Module: SNOMED CT core

Descriptions:

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
Indometacin	Is a	Non-steroidal anti-inflammatory agent (substance)	true	Inferred relationship	Some
Indometacin	Is a	Chlorobenzene	true	Inferred relationship	Some
Indometacin	Is a	éther	false	Inferred relationship	Some
Indometacin	Is a	Substance with prostaglandin-endoperoxide synthase inhibitor mechanism of action (substance)	true	Inferred relationship	Some
Indometacin	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	Prostaglandin-endoperoxide synthase inhibitor (disposition)	true	Inferred relationship	Some
Indometacin	Is a	Substance with ether structure	true	Inferred relationship	Some

Inbound Relationships	Type	Active	Source	Characteristic	Refinability	Group
Indometacin sodium trihydrate	Is a	False	Indometacin	Inferred relationship	Some
Indomethacin measurement	Component	True	Indometacin	Inferred relationship	Some	1
Accidental indomethacin poisoning	Causative agent (attribute)	False	Indometacin	Inferred relationship	Some
Intentional indomethacin poisoning	Causative agent (attribute)	False	Indometacin	Inferred relationship	Some
Indomethacin poisoning of undetermined intent	Causative agent (attribute)	False	Indometacin	Inferred relationship	Some	1
Indomethacin adverse reaction	Causative agent (attribute)	True	Indometacin	Inferred relationship	Some	1
Allergy to indometacin	Causative agent (attribute)	False	Indometacin	Inferred relationship	Some
Indomethacin overdose	Causative agent (attribute)	True	Indometacin	Inferred relationship	Some	1
Accidental indomethacin overdose	Causative agent (attribute)	True	Indometacin	Inferred relationship	Some	1
Intentional indomethacin overdose	Causative agent (attribute)	True	Indometacin	Inferred relationship	Some	1
Indomethacin overdose of undetermined intent	Causative agent (attribute)	False	Indometacin	Inferred relationship	Some	1
Indometacin 25 mg oral capsule	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Indometacin	Inferred relationship	Some
Indometacin 50 mg oral capsule	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Indometacin	Inferred relationship	Some
Product containing precisely indometacin 100 milligram/1 each conventional release rectal suppository (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Indometacin	Inferred relationship	Some
Indomethacin 75mg m/r tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Indometacin	Inferred relationship	Some
Indomethacin 50mg m/r tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Indometacin	Inferred relationship	Some
Indomethacin 25mg m/r tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Indometacin	Inferred relationship	Some
Product containing precisely indometacin (as indometacin sodium trihydrate) 1 milligram/1 vial powder for conventional release solution for injection	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Indometacin	Inferred relationship	Some
Indomethacin 75mg m/r capsule	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Indometacin	Inferred relationship	Some
Indomethacin 25mg m/r capsule	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Indometacin	Inferred relationship	Some
Indometacin 50 mg rectal suppository	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Indometacin	Inferred relationship	Some
Product containing precisely indometacin 75 milligram/1 each conventional release oral capsule (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Indometacin	Inferred relationship	Some
Product containing precisely indometacin 5 milligram/1 milliliter conventional release oral suspension (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Indometacin	Inferred relationship	Some
Indomethacin sodium 1.0mg/vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Indometacin	Inferred relationship	Some
Poisoning by indomethacin	Causative agent (attribute)	True	Indometacin	Inferred relationship	Some	1
Product containing indometacin (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Indometacin	Inferred relationship	Some	1
Product containing indometacin in oral dose form (medicinal product form)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Indometacin	Inferred relationship	Some	1
Intentional indomethacin poisoning	Causative agent (attribute)	True	Indometacin	Inferred relationship	Some	1
Product containing indometacin in rectal dose form (medicinal product form)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Indometacin	Inferred relationship	Some	1
Indometacin-containing product in parenteral dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Indometacin	Inferred relationship	Some	1
Accidental poisoning by indomethacin	Causative agent (attribute)	True	Indometacin	Inferred relationship	Some	1
Allergy to indometacin	Causative agent (attribute)	True	Indometacin	Inferred relationship	Some	1
Indomethacin embryofetopathy refers to the manifestations that may be observed in a fetus or newborn when the mother has taken indomethacin, a potent prostaglandin inhibitor and tocolytic agent that can cross placenta, during pregnancy. Reported adverse fetal/neonatal effects include decreased renal function resulting in oligohydramnios, closure of the ductus arteriosus, and delayed cardiovascular adaptation at birth. These effects are usually transient and reversible. Indomethacin may also be a risk factor for cerebral injury (periventricular leukomalacia) and necrotizing enterocolitis in preterm infants.	Causative agent (attribute)	True	Indometacin	Inferred relationship	Some	1
Indometacin 25 mg oral capsule	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Indometacin	Inferred relationship	Some	1
Indometacin 25 mg oral capsule	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Indometacin	Inferred relationship	Some	1
Indometacin 50 mg oral capsule	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Indometacin	Inferred relationship	Some	1
Indometacin 50 mg oral capsule	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Indometacin	Inferred relationship	Some	1
Product containing precisely indometacin 75 milligram/1 each conventional release oral capsule (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Indometacin	Inferred relationship	Some	1
Product containing precisely indometacin 75 milligram/1 each conventional release oral capsule (clinical drug)	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Indometacin	Inferred relationship	Some	1
Indometacin 25 mg prolonged-release oral capsule	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Indometacin	Inferred relationship	Some	1
Indometacin 25 mg prolonged-release oral capsule	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Indometacin	Inferred relationship	Some	1
Product containing precisely indometacin 100 milligram/1 each conventional release rectal suppository (clinical drug)	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Indometacin	Inferred relationship	Some	1
Product containing precisely indometacin 100 milligram/1 each conventional release rectal suppository (clinical drug)	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Indometacin	Inferred relationship	Some	1
Product containing precisely indometacin 75 milligram/1 each prolonged-release oral capsule (clinical drug)	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Indometacin	Inferred relationship	Some	1
Product containing precisely indometacin 75 milligram/1 each prolonged-release oral capsule (clinical drug)	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Indometacin	Inferred relationship	Some	1
Indometacin 25 mg oral capsule	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Indometacin	Inferred relationship	Some	1
Indometacin 50 mg oral capsule	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Indometacin	Inferred relationship	Some	1
Product containing precisely indometacin 75 milligram/1 each conventional release oral capsule (clinical drug)	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Indometacin	Inferred relationship	Some	1
Product containing precisely indometacin 5 milligram/1 milliliter conventional release oral suspension (clinical drug)	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Indometacin	Inferred relationship	Some	1
Product containing precisely indometacin 5 milligram/1 milliliter conventional release oral suspension (clinical drug)	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Indometacin	Inferred relationship	Some	1
Product containing precisely indometacin (as indometacin sodium trihydrate) 1 milligram/1 vial powder for conventional release solution for injection	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	False	Indometacin	Inferred relationship	Some	1
Indometacin sodium trihydrate	This attribute indicates that the concept is a structural modification of another concept, and that the substance's intrinsic physicochemical properties remain unchanged.	False	Indometacin	Inferred relationship	Some
Indometacin only product	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Indometacin	Inferred relationship	Some	1
Product containing only indometacin in oral dose form (medicinal product form)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Indometacin	Inferred relationship	Some	1
Product containing only indometacin in rectal dose form (medicinal product form)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Indometacin	Inferred relationship	Some	1
Product containing only indometacin in parenteral dose form (medicinal product form)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Indometacin	Inferred relationship	Some	1
Indometacin sodium (substance)	This attribute indicates that the concept is a structural modification of another concept, and that the substance's intrinsic physicochemical properties remain unchanged.	True	Indometacin	Inferred relationship	Some
Indometacin 50 mg rectal suppository	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Indometacin	Inferred relationship	Some	1
Indometacin 50 mg rectal suppository	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Indometacin	Inferred relationship	Some	1
Indometacin (as indometacin sodium) 1 mg powder for solution for injection vial	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Indometacin	Inferred relationship	Some	1

This concept is not in any reference sets

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Id	Description	Lang	Type	Status	Case?	Module
1211982017	Indomethacin	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
2476726013	Indometacin	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
3475271013	Indometacin (substance)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
53021000195110	indometacina	it	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
817741000172112	indométacine	fr	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
67891000195116	Indometacin	de	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module