387080000: Valproic acid (substance)

SNOMED CT Concept\Substance\...

\Substance categorized by disposition\Substance with effector mechanism of action (substance)\Enzyme inhibitor\Hydrolase inhibitor\Histone deacetylase inhibitor\Valproic acid (substance)

\A grouper concept for substances that are used in medicinal products for medical treatment, and also psychoactive substances that have few or no legitimate medical uses or that are not legally available to the person using them.\Central nervous system agent (substance)\...

\Psychoactive substance (substance)\Psychotropic agent (substance)\Valproate\Valproic acid (substance)

\Anticonvulsant\Valproate\Valproic acid (substance)

\Substance categorised by structure\Chemical\Chemical categorized by structure (substance)\Organic compound\...

\Organic acid and/or organic acid derivative\Carboxylic acid and/or carboxylic acid derivative (substance)\Carboxylic acid\Fatty acid\Unesterified fatty acid\Saturated fatty acid\Valproate\Valproic acid (substance)

\Lipid\Fatty acid\Unesterified fatty acid\Saturated fatty acid\Valproate\Valproic acid (substance)

Status: current, Not sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jan 2003. Module: SNOMED CT core

Descriptions:

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
Valproic acid (substance)	Is a	Valproate	false	Inferred relationship	Some
Valproic acid (substance)	Is a	Mood stabilizing agent	false	Inferred relationship	Some
Valproic acid (substance)	Is a	Anticonvulsant	false	Inferred relationship	Some
Valproic acid (substance)	Is a	allergène médicamenteux	false	Inferred relationship	Some
Valproic acid (substance)	Is a	Valproic acid or valproic acid derivative	false	Inferred relationship	Some
Valproic acid (substance)	Is a	Valproate	true	Inferred relationship	Some
Valproic acid (substance)	Is a	Enzyme inhibitor	false	Inferred relationship	Some
Valproic acid (substance)	Is a	Histone deacetylase inhibitor	true	Inferred relationship	Some
Valproic acid (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	Histone deacetylase inhibitor (disposition)	true	Inferred relationship	Some

Inbound Relationships	Type	Active	Source	Characteristic	Refinability	Group
Product containing precisely valproic acid (as valproate semisodium) 500 milligram/1 each gastro-resistant oral tablet (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Valproic acid (substance)	Inferred relationship	Some
Product containing precisely valproic acid (as valproate semisodium) 250 milligram/1 each gastro-resistant oral tablet (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Valproic acid (substance)	Inferred relationship	Some
Product containing valproic acid (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Valproic acid (substance)	Inferred relationship	Some	1
Valproic acid 150 mg gastro-resistant oral capsule	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Valproic acid (substance)	Inferred relationship	Some
Product containing precisely valproic acid 300 milligram/1 each gastro-resistant oral capsule (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Valproic acid (substance)	Inferred relationship	Some
Product containing precisely valproic acid 500 milligram/1 each gastro-resistant oral capsule (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Valproic acid (substance)	Inferred relationship	Some
Product containing precisely valproic acid 250 milligram/1 each conventional release oral capsule (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Valproic acid (substance)	Inferred relationship	Some
Sodium valproate	Is a	False	Valproic acid (substance)	Inferred relationship	Some
Valproic acid measurement	Component	True	Valproic acid (substance)	Inferred relationship	Some	1
Sodium valproate blood measurement	Component	False	Valproic acid (substance)	Inferred relationship	Some
Serum sodium valproate measurement (procedure)	Component	False	Valproic acid (substance)	Inferred relationship	Some
Valproate	Is a	False	Valproic acid (substance)	Inferred relationship	Some
Valproic acid 250mg/5mL syrup	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Valproic acid (substance)	Inferred relationship	Some
Measurement of free valproic acid (procedure)	Component	True	Valproic acid (substance)	Inferred relationship	Some	1
Product containing precisely valproic acid 125 milligram/1 each gastro-resistant oral capsule (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Valproic acid (substance)	Inferred relationship	Some
Product containing precisely valproic acid 250 milligram/1 each gastro-resistant oral capsule (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Valproic acid (substance)	Inferred relationship	Some
Valproic acid 500mg delayed release capsule	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Valproic acid (substance)	Inferred relationship	Some
Product containing valproic acid in oral dose form (medicinal product form)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Valproic acid (substance)	Inferred relationship	Some	1
Product containing valproic acid in parenteral dose form (medicinal product form)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Valproic acid (substance)	Inferred relationship	Some	1
Product containing precisely valproic acid 250 milligram/1 each conventional release oral capsule (clinical drug)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Valproic acid (substance)	Inferred relationship	Some	1
Product containing precisely valproic acid 250 milligram/1 each conventional release oral capsule (clinical drug)	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Valproic acid (substance)	Inferred relationship	Some	1
Valproate sodium 100mg/mL solution for injection	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Valproic acid (substance)	Inferred relationship	Some
Valproate semisodium	This attribute indicates that the concept is a structural modification of another concept, and that the substance's intrinsic physicochemical properties remain unchanged.	True	Valproic acid (substance)	Inferred relationship	Some
Sodium valproate	This attribute indicates that the concept is a structural modification of another concept, and that the substance's intrinsic physicochemical properties remain unchanged.	True	Valproic acid (substance)	Inferred relationship	Some
Valpromide	This attribute indicates that the concept is a structural modification of another concept, and that the substance's intrinsic physicochemical properties remain unchanged.	True	Valproic acid (substance)	Inferred relationship	Some
Product containing precisely valproic acid 500 milligram/1 each gastro-resistant oral capsule (clinical drug)	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Valproic acid (substance)	Inferred relationship	Some	1
Product containing precisely valproic acid 500 milligram/1 each gastro-resistant oral capsule (clinical drug)	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Valproic acid (substance)	Inferred relationship	Some	1
Valproic acid 150 mg gastro-resistant oral capsule	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Valproic acid (substance)	Inferred relationship	Some	1
Valproic acid 150 mg gastro-resistant oral capsule	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Valproic acid (substance)	Inferred relationship	Some	1
Product containing precisely valproic acid 300 milligram/1 each gastro-resistant oral capsule (clinical drug)	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Valproic acid (substance)	Inferred relationship	Some	1
Product containing precisely valproic acid 300 milligram/1 each gastro-resistant oral capsule (clinical drug)	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Valproic acid (substance)	Inferred relationship	Some	1
Product containing precisely valproic acid (as valproate semisodium) 500 milligram/1 each gastro-resistant oral tablet (clinical drug)	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Valproic acid (substance)	Inferred relationship	Some	1
Product containing precisely valproic acid (as valproate semisodium) 250 milligram/1 each gastro-resistant oral tablet (clinical drug)	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Valproic acid (substance)	Inferred relationship	Some	1
Product containing precisely valproic acid 250 milligram/1 each conventional release oral capsule (clinical drug)	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Valproic acid (substance)	Inferred relationship	Some	1
Allergy to valproic acid	Causative agent (attribute)	True	Valproic acid (substance)	Inferred relationship	Some	1
Product containing only valproic acid (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Valproic acid (substance)	Inferred relationship	Some	1
Valproic acid only product in oral dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Valproic acid (substance)	Inferred relationship	Some	1
Valproic acid only product in parenteral dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Valproic acid (substance)	Inferred relationship	Some	1
Product containing precisely valproic acid 125 milligram/1 each gastro-resistant oral capsule (clinical drug)	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Valproic acid (substance)	Inferred relationship	Some	1
Product containing precisely valproic acid 125 milligram/1 each gastro-resistant oral capsule (clinical drug)	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Valproic acid (substance)	Inferred relationship	Some	1
Product containing precisely valproic acid 250 milligram/1 each gastro-resistant oral capsule (clinical drug)	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Valproic acid (substance)	Inferred relationship	Some	1
Product containing precisely valproic acid 250 milligram/1 each gastro-resistant oral capsule (clinical drug)	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Valproic acid (substance)	Inferred relationship	Some	1
Product containing precisely valproic acid 100 milligram/1 each conventional release oral tablet (clinical drug)	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Valproic acid (substance)	Inferred relationship	Some	1
Product containing precisely valproic acid 100 milligram/1 each conventional release oral tablet (clinical drug)	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Valproic acid (substance)	Inferred relationship	Some	1
Product containing precisely valproic acid (as valproate semisodium) 125 milligram/1 each gastro-resistant oral tablet (clinical drug)	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Valproic acid (substance)	Inferred relationship	Some	1
Product containing precisely valproic acid 100 milligram/1 milliliter conventional release solution for injection (clinical drug)	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Valproic acid (substance)	Inferred relationship	Some	1
Product containing precisely valproic acid 100 milligram/1 milliliter conventional release solution for injection (clinical drug)	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Valproic acid (substance)	Inferred relationship	Some	1
Valproic acid 50 mg/mL oral solution	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Valproic acid (substance)	Inferred relationship	Some	1
Valproic acid 50 mg/mL oral solution	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Valproic acid (substance)	Inferred relationship	Some	1
Congenital malformation caused by valproic acid	Causative agent (attribute)	True	Valproic acid (substance)	Inferred relationship	Some	1
Sodium valproate 133 mg and valproic acid 58 mg prolonged-release oral tablet	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Valproic acid (substance)	Inferred relationship	Some	1
Sodium valproate 133 mg and valproic acid 58 mg prolonged-release oral tablet	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Valproic acid (substance)	Inferred relationship	Some	1
Sodium valproate 333 mg and valproic acid 145 mg prolonged-release oral tablet	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Valproic acid (substance)	Inferred relationship	Some	1
Sodium valproate 333 mg and valproic acid 145 mg prolonged-release oral tablet	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Valproic acid (substance)	Inferred relationship	Some	1
Sodium valproate 200 mg and valproic acid 87 mg prolonged-release oral tablet	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Valproic acid (substance)	Inferred relationship	Some	1
Sodium valproate 200 mg and valproic acid 87 mg prolonged-release oral tablet	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Valproic acid (substance)	Inferred relationship	Some	1
Sodium valproate 66.66 mg and valproic acid 29.03 mg prolonged-release oral granules sachet	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Valproic acid (substance)	Inferred relationship	Some	1
Sodium valproate 66.66 mg and valproic acid 29.03 mg prolonged-release oral granules sachet	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Valproic acid (substance)	Inferred relationship	Some	1
Product containing precisely sodium valproate 166.76 milligram and valproic acid 72.61 milligram/1 sachet prolonged-release oral granules (clinical drug)	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Valproic acid (substance)	Inferred relationship	Some	1
Product containing precisely sodium valproate 166.76 milligram and valproic acid 72.61 milligram/1 sachet prolonged-release oral granules (clinical drug)	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Valproic acid (substance)	Inferred relationship	Some	1
Sodium valproate 333.3 mg and valproic acid 145.14 mg prolonged-release oral granules sachet	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Valproic acid (substance)	Inferred relationship	Some	1
Sodium valproate 333.3 mg and valproic acid 145.14 mg prolonged-release oral granules sachet	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Valproic acid (substance)	Inferred relationship	Some	1
Adverse reaction caused by valproic acid (disorder)	Causative agent (attribute)	True	Valproic acid (substance)	Inferred relationship	Some	1
Poisoning caused by valproic acid (disorder)	Causative agent (attribute)	True	Valproic acid (substance)	Inferred relationship	Some	1

This concept is not in any reference sets

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Id	Description	Lang	Type	Status	Case?	Module
1461258017	Valproic acid (substance)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
1481194018	Valproic acid	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
1491863018	Dipropylacetic acid	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
2957104015	DPA - dipropylacetic acid	en	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT core
3722042015	2-propylpentanoic acid	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
3722043013	2-propylvaleric acid	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
53791000195111	acido valproico	it	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
848761000172116	acide valproïque	fr	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
68731000195114	Valproinsäure	de	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module