387094004: Proguanil (substance)

SNOMED CT Concept\Substance\...

\Substance categorized by disposition\Antiprotozoal\Substance with antimalarial mechanism of action (substance)\Biguanide antimalarial agent\Proguanil

\A grouper concept for substances that are used in medicinal products for medical treatment, and also psychoactive substances that have few or no legitimate medical uses or that are not legally available to the person using them.\Anti-infective agent (substance)\Antiprotozoal\Substance with antimalarial mechanism of action (substance)\Biguanide antimalarial agent\Proguanil

\Substance categorised by structure\Chemical\Chemical categorized by structure (substance)\Nitrogen and/or nitrogen compound (substance)\Nitrogen compound\Biguanide (substance)\Biguanide antimalarial agent\Proguanil

Status: current, Not sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jan 2003. Module: SNOMED CT core

Descriptions:

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
Proguanil	Is a	Substance with antimalarial mechanism of action (substance)	false	Inferred relationship	Some
Proguanil	Is a	Biguanide antimalarial agent	true	Inferred relationship	Some
Proguanil	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	Antimalarial (disposition)	true	Inferred relationship	Some

Inbound Relationships	Type	Active	Source	Characteristic	Refinability	Group
Product containing proguanil (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Proguanil	Inferred relationship	Some	1
Accidental proguanil poisoning	Causative agent (attribute)	False	Proguanil	Inferred relationship	Some
Intentional proguanil poisoning	Causative agent (attribute)	False	Proguanil	Inferred relationship	Some
intoxication par le proguanil d'intention indéterminée	Causative agent (attribute)	False	Proguanil	Inferred relationship	Some	1
Proguanil adverse reaction	Causative agent (attribute)	True	Proguanil	Inferred relationship	Some	1
Allergy to proguanil (finding)	Causative agent (attribute)	False	Proguanil	Inferred relationship	Some
Proguanil overdose	Causative agent (attribute)	True	Proguanil	Inferred relationship	Some	1
Accidental proguanil overdose	Causative agent (attribute)	True	Proguanil	Inferred relationship	Some	1
Intentional proguanil overdose	Causative agent (attribute)	True	Proguanil	Inferred relationship	Some	1
surdose de proguanil d'intention indéterminée	Causative agent (attribute)	False	Proguanil	Inferred relationship	Some	1
Proguanil hydrochloride (substance)	Is a	False	Proguanil	Inferred relationship	Some
Poisoning by proguanil	Causative agent (attribute)	True	Proguanil	Inferred relationship	Some	1
Accidental proguanil poisoning	Causative agent (attribute)	True	Proguanil	Inferred relationship	Some	1
Intentional proguanil poisoning	Causative agent (attribute)	True	Proguanil	Inferred relationship	Some	1
Proguanil hydrochloride 100 mg oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Proguanil	Inferred relationship	Some
Atovaquone+proguanil hydrochloride	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Proguanil	Inferred relationship	Some
Product containing precisely atovaquone 250 milligram and proguanil 100 milligram/1 each conventional release oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Proguanil	Inferred relationship	Some
Proguanil hydrochloride+chloroquine phosphate	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Proguanil	Inferred relationship	Some
Proguanil hydrochloride 100mg tablet and chloroquine phosphate 250mg tablet pack	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Proguanil	Inferred relationship	Some
Product containing proguanil hydrochloride	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Proguanil	Inferred relationship	Some
Product containing precisely atovaquone 62.5 milligram and proguanil 25 milligram/1 each conventional release oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Proguanil	Inferred relationship	Some
Proguanil	Is a	False	Proguanil	Inferred relationship	Some
Proguanil hydrochloride (substance)	Is a	False	Proguanil	Inferred relationship	Some
Product containing atovaquone and proguanil (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Proguanil	Inferred relationship	Some	2
Allergy to proguanil (finding)	Causative agent (attribute)	True	Proguanil	Inferred relationship	Some	1
Proguanil-containing product in oral dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Proguanil	Inferred relationship	Some	1
Product containing precisely atovaquone 62.5 milligram and proguanil 25 milligram/1 each conventional release oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Proguanil	Inferred relationship	Some	1
Product containing precisely atovaquone 62.5 milligram and proguanil 25 milligram/1 each conventional release oral tablet	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	False	Proguanil	Inferred relationship	Some	1
Product containing precisely atovaquone 250 milligram and proguanil 100 milligram/1 each conventional release oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Proguanil	Inferred relationship	Some	1
Product containing precisely atovaquone 250 milligram and proguanil 100 milligram/1 each conventional release oral tablet	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	False	Proguanil	Inferred relationship	Some	1
Proguanil hydrochloride (substance)	This attribute indicates that the concept is a structural modification of another concept, and that the substance's intrinsic physicochemical properties remain unchanged.	True	Proguanil	Inferred relationship	Some
Atovaquone- and proguanil-containing product in oral dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Proguanil	Inferred relationship	Some	2
Product containing precisely atovaquone 250 milligram and proguanil 100 milligram/1 each conventional release oral tablet	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	False	Proguanil	Inferred relationship	Some	1
Product containing precisely atovaquone 62.5 milligram and proguanil 25 milligram/1 each conventional release oral tablet	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	False	Proguanil	Inferred relationship	Some	1
Product containing only atovaquone and proguanil (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Proguanil	Inferred relationship	Some	2
Product containing only proguanil (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Proguanil	Inferred relationship	Some	1
Atovaquone and proguanil only product in oral dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Proguanil	Inferred relationship	Some	2
Proguanil only product in oral dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Proguanil	Inferred relationship	Some	1

Reference Sets

Description inactivation indicator reference set

GB English

US English

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Id	Description	Lang	Type	Status	Case?	Module
1481207012	Chlorguanide	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
1491867017	Chloroguanide	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
1491868010	Proguanil	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
3482664011	Proguanil (substance)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
52611000195119	proguanil	it	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
835931000172117	proguanil	fr	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
66991000195112	Proguanil	de	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module