387381009: Methotrexate (substance)

SNOMED CT Concept\Substance\...

\Substance categorized by disposition\Immunomodulator\Antimetabolite (substance)\Antifolate (substance)\Methotrexate (substance)

\A grouper concept for substances that are used in medicinal products for medical treatment, and also psychoactive substances that have few or no legitimate medical uses or that are not legally available to the person using them.\Immunologic agent (substance)\Antifolate (substance)\Methotrexate (substance)
\A grouper concept for substances that are used in medicinal products for medical treatment, and also psychoactive substances that have few or no legitimate medical uses or that are not legally available to the person using them.\Antineoplastic agent (substance)\Antimetabolite (substance)\Antifolate (substance)\Methotrexate (substance)

\Substance categorised by structure\Chemical\Chemical categorized by structure (substance)\Organic compound\Organic cyclic compound\Heterocyclic compound\Pteridine\Methotrexate (substance)

Status: current, Not sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jan 2003. Module: SNOMED CT core

Descriptions:

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
Methotrexate (substance)	Is a	Antimetabolite (substance)	false	Inferred relationship	Some
Methotrexate (substance)	Is a	Methotrexate and derivative	false	Inferred relationship	Some
Methotrexate (substance)	Is a	agent antirhumatismal	false	Inferred relationship	Some
Methotrexate (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	A substance that competes with, replaces or inhibits a specific metabolite of a cell and thereby interferes with the cell's normal metabolic functioning.	true	Inferred relationship	Some
Methotrexate (substance)	Is a	Antifolate (substance)	true	Inferred relationship	Some
Methotrexate (substance)	Is a	allergène médicamenteux	false	Inferred relationship	Some
Methotrexate (substance)	Is a	Pteridine	true	Inferred relationship	Some

Inbound Relationships	Type	Active	Source	Characteristic	Refinability	Group
Methotrexate measurement	Component	True	Methotrexate (substance)	Inferred relationship	Some	1
Methotrexate injection into tubal pregnancy	Direct substance	False	Methotrexate (substance)	Inferred relationship	Some	1
Methotrexate poisoning	Causative agent (attribute)	True	Methotrexate (substance)	Inferred relationship	Some	1
Accidental methotrexate poisoning	Causative agent (attribute)	False	Methotrexate (substance)	Inferred relationship	Some
Intentional methotrexate poisoning (disorder)	Causative agent (attribute)	False	Methotrexate (substance)	Inferred relationship	Some
intoxication par le méthotrexate d'intention indéterminée	Causative agent (attribute)	False	Methotrexate (substance)	Inferred relationship	Some	1
Methotrexate adverse reaction	Causative agent (attribute)	True	Methotrexate (substance)	Inferred relationship	Some	1
Allergy to methotrexate	Causative agent (attribute)	False	Methotrexate (substance)	Inferred relationship	Some
Methotrexate overdose	Causative agent (attribute)	True	Methotrexate (substance)	Inferred relationship	Some	1
Accidental methotrexate overdose	Causative agent (attribute)	True	Methotrexate (substance)	Inferred relationship	Some	1
Intentional methotrexate overdose	Causative agent (attribute)	True	Methotrexate (substance)	Inferred relationship	Some	1
surdose de méthotrexate d'intention indéterminée	Causative agent (attribute)	False	Methotrexate (substance)	Inferred relationship	Some	1
Plasma methotrexate measurement	Component	False	Methotrexate (substance)	Inferred relationship	Some	2
Serum methotrexate measurement	Component	False	Methotrexate (substance)	Inferred relationship	Some	2
Product containing precisely methotrexate 2.5 milligram/1 each conventional release oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Some
Methotrexate 10 mg oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Some
Methotrexate 2.5mg/mL injection solution 2mL vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Some
Methotrexate 25mg/mL injection solution 2mL vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Some
Methotrexate 25mg/mL injection solution 8mL vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Some
Methotrexate 25mg/mL injection solution 20mL vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Some
Methotrexate 25mg/mL injection solution 40mL vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Some
Methotrexate 25mg/mL injection solution 200mL vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Some
Methotrexate 100mg/mL injection solution 10mL vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Some
Methotrexate 100mg/mL injection solution 50mL vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Some
Methotrexate 12.5mg/mL infusion solution 30mL vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Some
Methotrexate 12.5mg/mL infusion solution 60mL vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Some
Methotrexate excretion measurement (procedure)	Component	True	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate 5 milligram/1 each conventional release oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Some
Product containing precisely methotrexate 7.5 milligram/1 each conventional release oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Some
Product containing precisely methotrexate 15 milligram/1 each conventional release oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Some
Methotrexate lpf 25mg/mL preservative free injection	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Some
Product containing methotrexate (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Methotrexate (substance)	Inferred relationship	Some	1
Methotrexate sodium (substance)	Is a	False	Methotrexate (substance)	Inferred relationship	Some
Methotrexate 25mg/mL injection solution 10mL vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Some
Neurotoxicity caused by methotrexate (disorder)	Causative agent (attribute)	True	Methotrexate (substance)	Inferred relationship	Some	1
Accidental methotrexate poisoning	Causative agent (attribute)	True	Methotrexate (substance)	Inferred relationship	Some	1
Intentional methotrexate poisoning (disorder)	Causative agent (attribute)	True	Methotrexate (substance)	Inferred relationship	Some	1
Intravenous injection of methotrexate (procedure)	Direct substance	False	Methotrexate (substance)	Inferred relationship	Some	1
Methotrexate skin ulceration (disorder)	Causative agent (attribute)	False	Methotrexate (substance)	Inferred relationship	Some
Intramuscular injection of methotrexate (procedure)	Direct substance	False	Methotrexate (substance)	Inferred relationship	Some	1
Intravenous injection of methotrexate (procedure)	Direct substance	False	Methotrexate (substance)	Inferred relationship	Some	1
Intravenous injection of methotrexate (procedure)	Direct substance	True	Methotrexate (substance)	Inferred relationship	Some	1
Intramuscular injection of methotrexate (procedure)	Direct substance	True	Methotrexate (substance)	Inferred relationship	Some	1
Methotrexate injection into tubal pregnancy	Direct substance	True	Methotrexate (substance)	Inferred relationship	Some	1
Measurement of methotrexate in cerebrospinal fluid (procedure)	Component	False	Methotrexate (substance)	Inferred relationship	Some	2
Subcutaneous injection of methotrexate (procedure)	Direct substance	False	Methotrexate (substance)	Inferred relationship	Some	1
Subcutaneous injection of methotrexate (procedure)	Direct substance	True	Methotrexate (substance)	Inferred relationship	Some	1
Allergy to methotrexate	Causative agent (attribute)	True	Methotrexate (substance)	Inferred relationship	Some	1
Product containing methotrexate in parenteral dose form (medicinal product form)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Methotrexate (substance)	Inferred relationship	Some	1
Methotrexate-containing product in oral dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Methotrexate (substance)	Inferred relationship	Some	1
Cirrhosis of liver caused by methotrexate (disorder)	Causative agent (attribute)	False	Methotrexate (substance)	Inferred relationship	Some	3
Product containing precisely methotrexate 2.5 milligram/1 each conventional release oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate 2.5 milligram/1 each conventional release oral tablet	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	False	Methotrexate (substance)	Inferred relationship	Some	1
Methotrexate 10 mg oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Some	1
Methotrexate 10 mg oral tablet	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate 5 milligram/1 each conventional release oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate 5 milligram/1 each conventional release oral tablet	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	False	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate 7.5 milligram/1 each conventional release oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate 7.5 milligram/1 each conventional release oral tablet	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	False	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate 15 milligram/1 each conventional release oral tablet	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate 15 milligram/1 each conventional release oral tablet	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	False	Methotrexate (substance)	Inferred relationship	Some	1
Methotrexate 25mg/mL conventional release solution for injection	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Methotrexate (substance)	Inferred relationship	Some
Product containing precisely methotrexate 5 milligram/1 each conventional release oral tablet	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	False	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate 2.5 milligram/1 each conventional release oral tablet	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	False	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate 7.5 milligram/1 each conventional release oral tablet	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	False	Methotrexate (substance)	Inferred relationship	Some	1
Methotrexate 10 mg oral tablet	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate 15 milligram/1 each conventional release oral tablet	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	False	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate (as methotrexate sodium) 5 milligram/2 milliliter conventional release solution for injection vial	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	False	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate (as methotrexate sodium) 500 milligram/20 milliliter conventional release solution for injection vial	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	False	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate (as methotrexate sodium) 1 gram/40 milliliter conventional release solution for injection vial	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	False	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate (as methotrexate sodium) 1 gram/10 milliliter conventional release solution for injection vial	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	False	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate (as methotrexate sodium) 5 gram/50 milliliter conventional release solution for injection vial	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	False	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate (as methotrexate sodium) 50 milligram/2 milliliter conventional release solution for injection vial	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	False	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate (as methotrexate sodium) 200 milligram/8 milliliter conventional release solution for injection vial	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	False	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate (as methotrexate sodium) 5 gram/200 milliliter conventional release solution for injection vial	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	False	Methotrexate (substance)	Inferred relationship	Some	1
Methotrexate sodium (substance)	This attribute indicates that the concept is a structural modification of another concept, and that the substance's intrinsic physicochemical properties remain unchanged.	True	Methotrexate (substance)	Inferred relationship	Some
Methotrexate-associated lymphoproliferative disorders are rare immunodeficiency-associated lymphoproliferative diseases characterized by lymphoid proliferation or lymphomas (large B-cell lymphoma, T-cell lymphoma, Hodgkin lymphoma, reactive lymphadenitis and a polymorphic post-transplant lymphoproliferative disorder) that develop in patients with different autoimmune diseases treated with methotrexate. Swelling is the predominant manifestation of the disease and regression after methotrexate withdrawal is observed in a significant proportion of patients.	Causative agent (attribute)	True	Methotrexate (substance)	Inferred relationship	Some	1
Product containing only methotrexate (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Methotrexate (substance)	Inferred relationship	Some	1
Methotrexate only product in oral dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Methotrexate (substance)	Inferred relationship	Some	1
Product containing only methotrexate in parenteral dose form (medicinal product form)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Methotrexate (substance)	Inferred relationship	Some	1
Methotrexate (as methotrexate sodium) 100 mg/mL solution for injection	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate (as methotrexate sodium) 25 milligram/1 milliliter conventional release solution for injection (clinical drug)	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Methotrexate (substance)	Inferred relationship	Some	1
Methotrexate (as methotrexate sodium) 2.5 mg/mL solution for injection	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Methotrexate (substance)	Inferred relationship	Some	1
Methotrexate skin ulceration (disorder)	Causative agent (attribute)	True	Methotrexate (substance)	Inferred relationship	Some	1
Cirrhosis of liver caused by methotrexate (disorder)	Causative agent (attribute)	True	Methotrexate (substance)	Inferred relationship	Some	1
Cirrhosis of liver caused by methotrexate (disorder)	Causative agent (attribute)	True	Methotrexate (substance)	Inferred relationship	Some	2
Accelerated rheumatoid nodulosis caused by methotrexate (disorder)	Causative agent (attribute)	True	Methotrexate (substance)	Inferred relationship	Some	2
Methotrexate (as methotrexate sodium) 2.5 mg oral tablet	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate (as methotrexate sodium) 5 milligram/1 each conventional release oral tablet (clinical drug)	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate (as methotrexate sodium) 10 milligram/1 each conventional release oral tablet (clinical drug)	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate (as methotrexate sodium) 15 milligram/1 each conventional release oral tablet (clinical drug)	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate (as methotrexate sodium) 7.5 milligram/1 each conventional release oral tablet (clinical drug)	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Methotrexate (substance)	Inferred relationship	Some	1
Methotrexate (as methotrexate sodium) 20 mg/mL solution for injection	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate (as methotrexate sodium) 50 milligram/1 milliliter conventional release solution for injection (clinical drug)	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate 25 milligram/1 milliliter conventional release solution for injection (clinical drug)	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Methotrexate (substance)	Inferred relationship	Some	1
Product containing precisely methotrexate 25 milligram/1 milliliter conventional release solution for injection (clinical drug)	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Methotrexate (substance)	Inferred relationship	Some	1
Methotrexate 50 mg/mL solution for injection	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Methotrexate (substance)	Inferred relationship	Some	1
Methotrexate 50 mg/mL solution for injection	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Methotrexate (substance)	Inferred relationship	Some	1
Methotrexate therapy (procedure)	Direct substance	True	Methotrexate (substance)	Inferred relationship	Some	1
Measurement of methotrexate in cerebrospinal fluid (procedure)	Component	True	Methotrexate (substance)	Inferred relationship	Some	1
Serum methotrexate measurement	Component	True	Methotrexate (substance)	Inferred relationship	Some	1

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Id	Description	Lang	Type	Status	Case?	Module
1461559012	Methotrexate (substance)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
1481477014	Methotrexate	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
1492026011	Amethopterin	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
3756239015	MTX - methotrexate	en	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT core
59901000195117	metotrexato	it	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
28901000188118	méthotréxate	fr	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
824651000172117	méthotrexate	fr	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
75541000195111	Methotrexat	de	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module