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397343002: Therapy-related acute myeloid leukemia and myelodysplastic syndrome, alkylating agent-related type (morphologic abnormality)

    Status: retired, Not sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Mar 2023. Module: SNOMED CT core

    Descriptions:

    Id Description Lang Type Status Case? Module
    1765261016 Therapy-related acute myeloid leukemia and myelodysplastic syndrome, alkylating agent-related type (morphologic abnormality) en Fully specified name Active Entire term case insensitive (core metadata concept) SNOMED CT core
    1773086019 Therapy-related acute myeloid leukaemia and myelodysplastic syndrome, alkylating agent-related type en Synonym (core metadata concept) Active Entire term case insensitive (core metadata concept) SNOMED CT core
    1774372017 Therapy-related acute myeloid leukemia and myelodysplastic syndrome, alkylating agent-related type en Synonym (core metadata concept) Active Entire term case insensitive (core metadata concept) SNOMED CT core
    1785803015 Therapy-related AML and myelodysplastic syndrome, alkylating agent-related type en Synonym (core metadata concept) Active Only initial character case insensitive (core metadata concept) SNOMED CT core

    0 descendants.

    Expanded Value Set

    Outbound Relationships Type Target Active Characteristic Refinability Group Values
    Therapy-related acute myeloid leukemia and myelodysplastic syndrome, alkylating agent-related type Is a Therapy-related acute myeloid leukemia and myelodysplastic syndrome false Inferred relationship Some
    Inbound Relationships Type Active Source Characteristic Refinability Group
    A subgroup of therapy-related myeloid neoplasms (t-MN), associated with a treatment of an unrelated neoplastic or autoimmune disease with cytotoxic agents, like cyclophosphamid, platins, melphalan and others. The neoplastic cells typically harbour unbalanced aberrations of chromosomes 5 and 7 (monosomy 5/del(5q) and monosomy 7/del(7q)) or a complex karyotype. It usually presents with multilineage dysplasia and cytopenias 5-10 years after exposure, with symptoms related to the degree of bone marrow failure and the corresponding cytopenia (fatigue, bleeding and bruising, recurrent infections, bone pain). Associated morphology False Therapy-related acute myeloid leukemia and myelodysplastic syndrome, alkylating agent-related type Inferred relationship Some 1

    Reference Sets

    Concept inactivation indicator reference set

    REPLACED BY association reference set (foundation metadata concept)

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