414629003: Lymphoproliferative disorder (morphologic abnormality)

SNOMED CT Concept\Body structure (body structure)\Morphologically altered structure\Morphologically abnormal structure\Growth alteration\Proliferation\Proliferation of hematopoietic cell type (morphologic abnormality)\Lymphoproliferative disorder (morphologic abnormality)

Status: current, Not sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jan 2005. Module: SNOMED CT core

Descriptions:

Id Description Lang Type Status Case? Module

2530829017 Lymphoproliferative disorder (morphologic abnormality) en Fully specified name Active Entire term case insensitive (core metadata concept) SNOMED CT core

2534293012 Lymphoproliferative disorder en Synonym (core metadata concept) Active Entire term case insensitive (core metadata concept) SNOMED CT core

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
Lymphoproliferative disorder (morphologic abnormality)	Is a	Proliferation of hematopoietic cell type (morphologic abnormality)	true	Inferred relationship	Some

Inbound Relationships	Type	Active	Source	Characteristic	Refinability	Group
Lymphoid neoplasm (morphologic abnormality)	Is a	True	Lymphoproliferative disorder (morphologic abnormality)	Inferred relationship	Some
Immunoproliferative morphology	Is a	True	Lymphoproliferative disorder (morphologic abnormality)	Inferred relationship	Some
Lymphoproliferative disorder following transplantation	Associated morphology	False	Lymphoproliferative disorder (morphologic abnormality)	Inferred relationship	Some
Lymphoproliferative disorder	Associated morphology	True	Lymphoproliferative disorder (morphologic abnormality)	Inferred relationship	Some	1
Histiocytic necrotizing lymphadenitis	Associated morphology	False	Lymphoproliferative disorder (morphologic abnormality)	Inferred relationship	Some
Reactive follicular hyperplasia in the elderly	Associated morphology	False	Lymphoproliferative disorder (morphologic abnormality)	Inferred relationship	Some	2
Post-transplantation lymphoproliferative syndrome	Associated morphology	False	Lymphoproliferative disorder (morphologic abnormality)	Inferred relationship	Some
Virus-associated atypical lymphoproliferative disorder	Associated morphology	True	Lymphoproliferative disorder (morphologic abnormality)	Inferred relationship	Some	2
Atypical lymphoproliferative disorder	Associated morphology	True	Lymphoproliferative disorder (morphologic abnormality)	Inferred relationship	Some	1
Rosai-Dorfman disease	Associated morphology	True	Lymphoproliferative disorder (morphologic abnormality)	Inferred relationship	Some	2
Lymphoid interstitial pneumonitis	Associated morphology	True	Lymphoproliferative disorder (morphologic abnormality)	Inferred relationship	Some	2
X-linked lymphoproliferative syndrome	Associated morphology	True	Lymphoproliferative disorder (morphologic abnormality)	Inferred relationship	Some	1
Hemophagocytic lymphohistiocytosis due to infection (disorder)	Associated morphology	False	Lymphoproliferative disorder (morphologic abnormality)	Inferred relationship	Some	5
Familial hemophagocytic lymphohistiocytosis (disorder)	Associated morphology	False	Lymphoproliferative disorder (morphologic abnormality)	Inferred relationship	Some	4
Primary cutaneous CD30 antigen positive T-cell lymphoproliferative disorder (morphologic abnormality)	Is a	True	Lymphoproliferative disorder (morphologic abnormality)	Inferred relationship	Some
Monomorphic posttransplant lymphoproliferative disorder (disorder)	Associated morphology	False	Lymphoproliferative disorder (morphologic abnormality)	Inferred relationship	Some
infection au VIH causant une pneumopathie lymphoïde interstitielle	Associated morphology	False	Lymphoproliferative disorder (morphologic abnormality)	Inferred relationship	Some
X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia	Associated morphology	True	Lymphoproliferative disorder (morphologic abnormality)	Inferred relationship	Some	1
Lymphoproliferative disorder after transplantation of bone marrow (disorder)	Associated morphology	False	Lymphoproliferative disorder (morphologic abnormality)	Inferred relationship	Some	1
Dianzani autoimmune lymphoproliferative disease (DALD) is a very rare disorder characterized by autoimmunity, lymphadenopathy and/or splenomegaly.	Associated morphology	False	Lymphoproliferative disorder (morphologic abnormality)	Inferred relationship	Some
Dianzani autoimmune lymphoproliferative disease (DALD) is a very rare disorder characterized by autoimmunity, lymphadenopathy and/or splenomegaly.	Associated morphology	True	Lymphoproliferative disorder (morphologic abnormality)	Inferred relationship	Some	1
Natural killer (NK)-cell enteropathy is a benign NK-cell lymphoproliferative disease characterized by minor abdominal symptoms (abdominal pain, diverticulosis, constipation and reflux) due to NK cell-derived lesions in the mucosal layer of the gastrointestinal tract and often mistaken for NK or T-cell lymphoma.	Associated morphology	True	Lymphoproliferative disorder (morphologic abnormality)	Inferred relationship	Some	1
RAS-associated autoimmune leukoproliferative disease (RALD) is a rare genetic disorder characterized by monocytosis, autoimmune cytopenias, lymphoproliferation, hepatosplenomegaly, and hypergammaglobulinemia.	Associated morphology	True	Lymphoproliferative disorder (morphologic abnormality)	Inferred relationship	Some	4
Chronic cold agglutinin disease associated with B-cell neoplasm	Associated morphology	True	Lymphoproliferative disorder (morphologic abnormality)	Inferred relationship	Some	8
Secondary autoimmune hemolytic anemia co-occurrent and due to lymphoproliferative disorder	Associated morphology	True	Lymphoproliferative disorder (morphologic abnormality)	Inferred relationship	Some	1
Persistent polyclonal B-cell lymphocytosis (PPBL) is a rare, generally benign, lymphoproliferative hematological disease characterized by chronic, stable, persistent, polyclonal lymphocytosis of memory B-cell origin, the presence of binucleated lymphocytes in the peripheral blood, and a polyclonal increase in serum immunoglobulin M (IgM). Patients are most frequently asymptomatic or may present with mild splenomegaly.	Associated morphology	True	Lymphoproliferative disorder (morphologic abnormality)	Inferred relationship	Some	2
Acquired angioedema due to activation of the classical complement pathway related to an underlying lymphoreticular disorder particularly lymphoma or monoclonal gammopathy of unknown significance (MGUS)	Associated morphology	False	Lymphoproliferative disorder (morphologic abnormality)	Inferred relationship	Some	1
Methotrexate-associated lymphoproliferative disorders are rare immunodeficiency-associated lymphoproliferative diseases characterized by lymphoid proliferation or lymphomas (large B-cell lymphoma, T-cell lymphoma, Hodgkin lymphoma, reactive lymphadenitis and a polymorphic post-transplant lymphoproliferative disorder) that develop in patients with different autoimmune diseases treated with methotrexate. Swelling is the predominant manifestation of the disease and regression after methotrexate withdrawal is observed in a significant proportion of patients.	Associated morphology	True	Lymphoproliferative disorder (morphologic abnormality)	Inferred relationship	Some	1
A rare autosomal recessive primary immunodeficiency characterized by Epstein-Barr virus (EBV)-triggered lymphoproliferative disorders such as malignant B-cell proliferation, Hodgkin lymphoma, B-cell lymphoma and EBV-driven hemophagocytic lymphohistiocytosis (HLH). Aplastic anemia and inflammatory disorders such as uveitis and oral ulcers are also observed.	Associated morphology	True	Lymphoproliferative disorder (morphologic abnormality)	Inferred relationship	Some	1
Histiocytic necrotizing lymphadenitis	Associated morphology	True	Lymphoproliferative disorder (morphologic abnormality)	Inferred relationship	Some	2
Iatrogenic immunodeficiency-associated lymphoproliferative disorder (disorder)	Associated morphology	True	Lymphoproliferative disorder (morphologic abnormality)	Inferred relationship	Some	1
Germinotropic lymphoproliferative disorder caused by Human herpesvirus 8	Associated morphology	True	Lymphoproliferative disorder (morphologic abnormality)	Inferred relationship	Some	1
Hydroa vacciniforme-like lymphoproliferative disorder	Is a	True	Lymphoproliferative disorder (morphologic abnormality)	Inferred relationship	Some
Autoimmune lymphoproliferative syndrome	Associated morphology	True	Lymphoproliferative disorder (morphologic abnormality)	Inferred relationship	Some	1
A rare, genetic, primary immunodeficiency disorder characterised by an abnormal immune response to Epstein-Barr virus (EBV) infection, caused by hemizygous mutations in the X-linked SH2D1A gene, resulting in B cell lymphoproliferation and manifesting with various phenotypes which include EBV-driven severe or fulminant mononucleosis, haemophagocytic lymphohistiocytosis (presenting with fulminant hepatitis, hepatic necrosis, bone marrow hypoplasia, and neurological involvement), hypogammaglobulinaemia, and B-cell lymphoma. Additional variable manifestations include vasculitis, lymphomatoid granulomatosis, aplastic anaemia, and chronic gastritis. Occasionally, T-cell lymphoma may be observed. Laboratory findings include normal or increased activated T cells and reduced memory B cells.	Associated morphology	True	Lymphoproliferative disorder (morphologic abnormality)	Inferred relationship	Some	1
A rare, genetic, primary immunodeficiency disorder characterized by an abnormal immune response to Epstein-Barr virus (EBV) infection, caused by hemizygous mutations in the X-linked XIAP gene, resulting in B cell lymphoproliferation and manifesting with various phenotypes which include EBV-driven hemophagocytic lymphohistiocytosis, hypogammaglobulinemia, recurrent splenomegaly, hepatitis, colitis, and intestinal bowel disease with features of Crohn's disease. Additional manifestations include variable auto-inflammatory symptoms such as uveitis, arthritis, skin abscesses, erythema nodosum, and nephritis. Neurological involvement is rare, and lymphoma is never observed. Laboratory findings include normal or increased activated T cells, low or normal iNKT cells, and normal or reduced memory B cells.	Associated morphology	True	Lymphoproliferative disorder (morphologic abnormality)	Inferred relationship	Some	1
A rare immune dysregulation disease with immunodeficiency characterized by infantile or childhood onset of a variable phenotype including recurrent/persistent bacterial, fungal, and viral infections with involvement of the skin, lower respiratory tract, and gastrointestinal tract, eczema, allergies, and inflammatory bowel disease, among others. EBV-related smooth muscle tumors have also been reported. Immunophenotyping shows decreased Treg counts, as well as a deficient CD3/CD28 co-stimulation response in CD4+ and CD8+ T-cells.	Associated morphology	True	Lymphoproliferative disorder (morphologic abnormality)	Inferred relationship	Some	1
A rare autosomal recessive primary immunodeficiency characterized by susceptibility to Epstein-Barr virus (EBV)-associated lymphoproliferative disorders such as malignant B-cell proliferation, Hodgkin lymphoma, B-cell lymphoma, lymphoid granulomatosis, hemophagocytic lymphohistiocytosis, and smooth muscle tumor. Patients present persistent symptoms of infectious mononucleosis including recurrent febrile episodes, lymphadenopathies, and hepatosplenomegaly, accompanied by high EBV viral load in the blood. Additional manifestations are autoimmune diseases like hemolytic anemia or renal disease.	Associated morphology	True	Lymphoproliferative disorder (morphologic abnormality)	Inferred relationship	Some	1
A rare autosomal recessive primary immunodeficiency characterized by susceptibility to Epstein-Barr virus (EBV)-related disorders (B-cell lymphoproliferative disorders including Hodgkin lymphoma) as well as dysgammaglobulinemia and recurrent infections. Patients can present with recurrent fever, lymphadenopathy, hepatosplenomegaly, Behçet-like stomatitis, pharyngitis, tonsillitis, adenitis, and viral encephalitis.	Associated morphology	True	Lymphoproliferative disorder (morphologic abnormality)	Inferred relationship	Some	1
A rare, primary immunodeficiency characterized by variable combination of enteropathy, hypogammaglobulinemia, recurrent respiratory infections, granulomatous lymphocytic interstitial lung disease, lymphocytic infiltration of non-lymphoid organs (intestine, lung, brain, bone marrow, kidney), autoimmune thrombocytopenia or neutropenia, autoimmune hemolytic anemia and lymphadenopathy.	Associated morphology	True	Lymphoproliferative disorder (morphologic abnormality)	Inferred relationship	Some	1
A rare, genetic, lymphoproliferative syndrome characterized by early onset recurrent infections, lymphadenopathy with hepatosplenomegaly and variable autoimmune disorders, including hemolytic anemia, thrombocytopenia, neutropenia, enteropathy, type I diabetes, scleroderma, arthritis, atopic dermatitis, and inflammatory lung disease. Patients commonly have failure to thrive. Variable immunologic findings include decreased regulatory T-cells, hypogammaglobulinemia, and reduction in memory B cells.	Associated morphology	True	Lymphoproliferative disorder (morphologic abnormality)	Inferred relationship	Some	1
Post-transplantation lymphoproliferation (morphologic abnormality)	Is a	True	Lymphoproliferative disorder (morphologic abnormality)	Inferred relationship	Some

This concept is not in any reference sets

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Id	Description	Lang	Type	Status	Case?	Module
2530829017	Lymphoproliferative disorder (morphologic abnormality)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
2534293012	Lymphoproliferative disorder	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core