414805007: Natalizumab (substance)

SNOMED CT Concept\Substance\...

\Substance categorized by disposition\Substance with receptor antagonist mechanism of action (substance)\Selective adhesion molecule inhibitor\Alpha-4 integrin receptor antagonist\Natalizumab (substance)
\Substance categorized by disposition\Immunomodulator\Immunosuppressant (substance)\Natalizumab (substance)

\A grouper concept for substances that are used in medicinal products for medical treatment, and also psychoactive substances that have few or no legitimate medical uses or that are not legally available to the person using them.\Gastrointestinal agent (substance)\Natalizumab (substance)
\A grouper concept for substances that are used in medicinal products for medical treatment, and also psychoactive substances that have few or no legitimate medical uses or that are not legally available to the person using them.\Immunosuppressant (substance)\Natalizumab (substance)
\A grouper concept for substances that are used in medicinal products for medical treatment, and also psychoactive substances that have few or no legitimate medical uses or that are not legally available to the person using them.\Monoclonal antibody\Natalizumab (substance)

\Substance categorised by structure\Chemical\Chemical categorized by structure (substance)\...

\Nitrogen and/or nitrogen compound (substance)\Nitrogen compound\Organic nitrogen compound\Amide and/or amide derivative (substance)\Substituted amide (substance)\Polypeptide\Protein\Antibody\Monoclonal antibody\Natalizumab (substance)

\Organic compound\Organic nitrogen compound\Amide and/or amide derivative (substance)\Substituted amide (substance)\Polypeptide\Protein\Antibody\Monoclonal antibody\Natalizumab (substance)

\Biological substance\Protein and/or protein derivative\Protein\Antibody\Monoclonal antibody\Natalizumab (substance)
\Biological substance\Immunologic substance\Antibody\Monoclonal antibody\Natalizumab (substance)
\Biological substance\Polypeptide\Protein\Antibody\Monoclonal antibody\Natalizumab (substance)

Status: current, Not sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jan 2005. Module: SNOMED CT core

Descriptions:

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
Natalizumab (substance)	Is a	Alpha-4 integrin receptor antagonist	true	Inferred relationship	Some
Natalizumab (substance)	Is a	Monoclonal antibody	true	Inferred relationship	Some
Natalizumab (substance)	Is a	anticorps monoclonal chimérique souris-humain d'isotype IgG	false	Inferred relationship	Some
Natalizumab (substance)	Is a	agent contre une maladie inflammatoire de l'intestin	false	Inferred relationship	Some
Natalizumab (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	Alpha-4 integrin receptor antagonist (disposition)	true	Inferred relationship	Some
Natalizumab (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	Murine-human monoclonal immunoglobulin G antibody	false	Inferred relationship	Some
Natalizumab (substance)	Is a	Gastrointestinal agent (substance)	true	Inferred relationship	Some
Natalizumab (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	A substance that modifies the immune response or the functioning of the immune system.	true	Inferred relationship	Some
Natalizumab (substance)	Is a	Immunosuppressant (substance)	true	Inferred relationship	Some

Inbound Relationships	Type	Active	Source	Characteristic	Refinability	Group
Product containing natalizumab (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Natalizumab (substance)	Inferred relationship	Some	1
Natalizumab 300mg injection solution 15mL vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Natalizumab (substance)	Inferred relationship	Some
Product containing precisely natalizumab 300 milligram/15 milliliter conventional release solution for injection vial	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	False	Natalizumab (substance)	Inferred relationship	Some	1
Product containing precisely natalizumab 300 milligram/15 milliliter conventional release solution for injection vial	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	False	Natalizumab (substance)	Inferred relationship	Some	1
Natalizumab-containing product in parenteral dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Natalizumab (substance)	Inferred relationship	Some	1
Product containing only natalizumab (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Natalizumab (substance)	Inferred relationship	Some	1
Product containing only natalizumab in parenteral dose form (medicinal product form)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Natalizumab (substance)	Inferred relationship	Some	1
Natalizumab 20 mg/mL solution for injection	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Natalizumab (substance)	Inferred relationship	Some	1
Natalizumab 20 mg/mL solution for injection	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Natalizumab (substance)	Inferred relationship	Some	1
Natalizumab therapy	Direct substance	True	Natalizumab (substance)	Inferred relationship	Some	1
Natalizumab 150 mg/mL solution for injection	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Natalizumab (substance)	Inferred relationship	Some	1
Natalizumab 150 mg/mL solution for injection	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Natalizumab (substance)	Inferred relationship	Some	1

This concept is not in any reference sets

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Id	Description	Lang	Type	Status	Case?	Module
2531793014	Natalizumab (substance)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
2535349018	Natalizumab	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
51821000195115	natalizumab	it	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
827271000172117	natalizumab	fr	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
66101000195116	Natalizumab	de	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module