Inbound Relationships |
Type |
Active |
Source |
Characteristic |
Refinability |
Group |
Acquired hemolytic anemia co-occurrent with human immunodeficiency virus infection (disorder) |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |
A rare X-linked syndromic intellectual disability characterized by profound developmental delay, facial dysmorphism, genital abnormalities and alpha thalassemia. |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
1 |
Dehydrated hereditary stomatocytosis (DHS) is a rare hemolytic anemia characterized by a decreased red cell osmotic fragility due to a defect in cation permeability, resulting in red cell dehydration and mild to moderate compensated hemolysis. Pseudohyperkalemia (loss of potassium ions from red cells on storage at room temperature) is sometimes observed. |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |
Dominant beta-thalassemia is a form of beta-thalassemia resulting in moderate to severe anemia. |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
1 |
Congenital autosomal recessive sideroblastic anemia (ARSA) is a non-syndromic, microcytic/hypochromic sideroblastic anemia, present from early infancy and characterized by severe microcytic anemia, which is not pyridoxine responsive, and increased serum ferritin. |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |
Familial pseudohyperkalemia (FP) is an inherited, mild, non-hemolytic subtype of hereditary stomatocytosis that is associated with a temperature-dependent anomaly in red cell membrane permeability to potassium that leads to high in vitro potassium levels in samples stored below 37°C. FP is not associated with additional hematological abnormalities, although affected individuals may show some mild abnormalities like macrocytosis. |
Interprets |
True |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |
Megaloblastic anemia due to vitamin B12 deficiency secondary to intestinal disease (disorder) |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
5 |
Vitamin B12 deficiency anaemia caused by drug |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
4 |
Acquired iron deficiency anemia due to increased iron requirement (disorder) |
Interprets |
True |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
5 |
Beta-thalassemia - X-linked thrombocytopenia is a form of beta-thalassemia characterized by splenomegaly and petechiae, moderate thrombocytopenia, prolonged bleeding time due to platelet dysfunction, reticulocytosis and mild beta-thalassemia. |
Interprets |
True |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |
A rare genetic disease characterized by lethal non-spherocytic, non-immune hemolytic anemia, in association with abnormalities of the external genitalia (such as micropenis and hypospadias). Reported dysmorphic features include flat occiput, dimpled earlobes, deep plantar creases, and increased space between the first and second toes. There have been no further descriptions in the literature since 1995. |
Interprets |
True |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
7 |
Thalassemia in mother complicating pregnancy |
Interprets |
True |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
1 |
Anemia in mother complicating childbirth |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
1 |
Thalassemia in mother complicating childbirth |
Interprets |
True |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
1 |
Iron deficiency anemia in mother complicating childbirth |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
1 |
Traumatic cardiac haemolytic anaemia |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
1 |
Stomatocytosis |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |
Acquired hemolytic anemia |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
1 |
Hemolytic anemia due to nonlymphoid neoplasm |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
1 |
A rare genetic haematologic disease characterised by mild chronic haemolytic anaemia (due to highly elevated adenosine deaminase activity in red blood cells resulting in their premature destruction), elevated reticulocyte count, splenomegaly and mild hyperbilirubinaemia. Other cells and tissues are not affected. |
Interprets |
True |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
1 |
Coombs negative hemolytic anemia |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
1 |
Haemolytic anaemia caused by Clostridium welchii |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
3 |
Anemia due to mechanical damage |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
1 |
Sickle cell-thalassemia disease |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |
Hereditary haemolytic anaemia |
Interprets |
True |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
1 |
Anemia due to abnormality extrinsic to the red cell |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
1 |
Anemia of chronic renal failure |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |
Hemolytic anemia |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
1 |
Acute megaloblastic anemia caused by nitrous oxide (disorder) |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
1 |
Coombs positive hemolytic anemia |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
1 |
Hemolytic anemia caused by Bartonella |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
3 |
Hemolytic uremic syndrome, adult type |
Interprets |
True |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
3 |
sindrome mielodisplastica: anemia refrattaria, senza sideroblasti ad anello, senza eccesso di blasti |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
3 |
Myelodysplastic syndrome with ring sideroblasts and single lineage dysplasia (disorder) |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
3 |
anémie réfractaire avec excès de blastes en transformation (clinique) |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
3 |
Hemolytic uremic syndrome |
Interprets |
True |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
3 |
Acquired stomatocytosis |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |
Sickle cell-beta-thalassemia |
Interprets |
True |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |
Sickle cell beta plus thalassaemia |
Interprets |
True |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |
Sickle cell-beta^0^-thalassemia |
Interprets |
True |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |
Sickle cell-delta beta^0^-thalassemia |
Interprets |
True |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |
Refractory anemia without sideroblasts, so stated |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
3 |
Hemolytic anemia due to glutathione metabolism disorder |
Interprets |
True |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
1 |
Non-autoimmune hemolytic anemia |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
1 |
Mechanical haemolytic anaemia |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
1 |
Toxic hemolytic anemia |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
1 |
Haemoglobinuria due to haemolysis from external causes |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
1 |
Acquired spherocytosis |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
1 |
Infantile pyknocytosis (disorder) |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
1 |
Aplastic anemia due to radiation |
Interprets |
True |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
3 |
Anaemia of renal disease |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
1 |
Megaloblastic anaemia, thiamine-responsive, with diabetes mellitus and sensorineural deafness |
Interprets |
True |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
1 |
Anaemia due to isoimmunisation |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
1 |
Hereditary nonspherocytic haemolytic anaemia |
Interprets |
True |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
1 |
Anaemia secondary to renal failure |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
1 |
Intracorpuscular haemolytic anaemia |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
1 |
Diarrhea-negative hemolytic uremic syndrome (disorder) |
Interprets |
True |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
3 |
A rare disorder characterised by increased bone density (predominantly diaphyseal) and aregenerative corticosteroid-sensitive anaemia. The exact prevalence is unknown. Associated with mutations in the TBXAS1 gene (which encodes thromboxane synthase). Transmitted as an autosomal recessive trait. |
Interprets |
True |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
1 |
Myelodysplastic syndrome with excess blasts (disorder) |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
3 |
Sickle cell-thalassemia disease with crisis (disorder) |
Interprets |
True |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |
Sickle cell-thalassemia disease without crisis (disorder) |
Interprets |
True |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |
A rare genetic disease characterized by cystic fibrosis, gastritis associated with Helicobacter pylori, folate deficiency megaloblastic anemia, and intellectual disability. There have been no further descriptions in the literature since 1991. |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
8 |
A very rare non-syndromic autosomal recessive pyridoxine-refractory sideroblastic anemia due to a splice defect of glutaredoxin-5 (GLRX5) described in a single patient with adult onset microcytic hypochromic anemia with liver iron overload and type 2 diabetes. |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
5 |
Anemia, pre-end stage renal disease on erythropoietin protocol |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |
Autoimmune hemolytic anemia caused by immunoglobulin G (disorder) |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |
Anemia due to radiation |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |
Severe hereditary spherocytosis due to combined deficiency of spectrin AND ankyrin |
Interprets |
True |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
3 |
Autoimmune hemolytic anemia caused by complement |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |
Thiamine-responsive megaloblastic anemia |
Interprets |
True |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |
Goats' milk anemia |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |
Anemia caused by insect venom (disorder) |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |
Anemia of thyroid dysfunction |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |
Anemia of gonadal dysfunction |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |
G-6-PD class I variant anemia |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |
G-6-PD class III variant anemia |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |
Mild hereditary spherocytosis due to combined deficiency of spectrin AND ankyrin |
Interprets |
True |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
3 |
Hereditary spherocytosis due to spectrin deficiency |
Interprets |
True |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
3 |
Acute megaloblastic anaemia due to dialysis |
Interprets |
True |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |
Anaemia caused by oxygen |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |
Anemia of adrenal dysfunction |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |
Mild hereditary spherocytosis due to spectrin deficiency |
Interprets |
True |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
3 |
Autoimmune haemolytic anaemia caused by IgA plus complement |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |
Hereditary spherocytosis due to deficiency of protein 4.2 |
Interprets |
True |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
3 |
G-6-PD class II variant anemia |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |
Megaloblastic anemia due to inborn errors of metabolism |
Interprets |
True |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |
Megaloblastic anemia due to error of folate metabolism |
Interprets |
True |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |
Hemolytic anemia due to infection |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
3 |
Anemia caused by copper |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |
HNSHA due to hexokinase deficiency |
Interprets |
True |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |
Anemia caused by heat (disorder) |
Interprets |
True |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |
Hereditary spherocytosis due to combined deficiency of spectrin AND ankyrin |
Interprets |
True |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
3 |
Juvenile type megaloblastic anemia |
Interprets |
True |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |
Anaemia of pituitary deficiency |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |
Megaloblastic anemia due to congenital deficiency of intrinsic factor |
Interprets |
True |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |
Hemolytic anemia with emphysema AND cutis laxa |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
4 |
Glucose-6-phosphate dehydrogenase deficiency anemia |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |
Autoimmune hemolytic anemia caused by immunoglobulin G plus complement (disorder) |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |
Megaloblastic anemia due to error of cobalamin metabolism |
Interprets |
True |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |
Anemia of parathyroid dysfunction |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |
Hereditary spherocytosis due to beta spectrin defect |
Interprets |
True |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
3 |
Autoimmune hemolytic anemia caused by immunoglobulin M |
Interprets |
False |
Measurement of total haemoglobin concentration |
Inferred relationship |
Some |
2 |