446321003: Denosumab (substance)

SNOMED CT Concept\Substance\...

\Substance categorized by disposition\Substance with effector mechanism of action (substance)\Substance with receptor activator of nuclear factor kappa-B ligand inhibitor mechanism of action (substance)\Denosumab (substance)

\A grouper concept for substances that are used in medicinal products for medical treatment, and also psychoactive substances that have few or no legitimate medical uses or that are not legally available to the person using them.\Substance with receptor activator of nuclear factor kappa-B ligand inhibitor mechanism of action (substance)\Denosumab (substance)
\A grouper concept for substances that are used in medicinal products for medical treatment, and also psychoactive substances that have few or no legitimate medical uses or that are not legally available to the person using them.\Monoclonal antibody\Denosumab (substance)

\Substance categorised by structure\Chemical\Chemical categorized by structure (substance)\...

\Nitrogen and/or nitrogen compound (substance)\Nitrogen compound\Organic nitrogen compound\Amide and/or amide derivative (substance)\Substituted amide (substance)\Polypeptide\Protein\Antibody\Monoclonal antibody\Denosumab (substance)

\Organic compound\Organic nitrogen compound\Amide and/or amide derivative (substance)\Substituted amide (substance)\Polypeptide\Protein\Antibody\Monoclonal antibody\Denosumab (substance)

\Biological substance\Protein and/or protein derivative\Protein\Antibody\Monoclonal antibody\Denosumab (substance)
\Biological substance\Immunologic substance\Antibody\Monoclonal antibody\Denosumab (substance)
\Biological substance\Polypeptide\Protein\Antibody\Monoclonal antibody\Denosumab (substance)

Status: current, Not sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jan 2011. Module: SNOMED CT core

Descriptions:

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
Denosumab (substance)	Is a	agent d'anticorps monoclonal	false	Inferred relationship	Some
Denosumab (substance)	Is a	Monoclonal antibody	true	Inferred relationship	Some
Denosumab (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	Receptor activator of nuclear factor kappa-B ligand inhibitor (disposition)	true	Inferred relationship	Some
Denosumab (substance)	Is a	Substance with receptor activator of nuclear factor kappa-B ligand inhibitor mechanism of action (substance)	true	Inferred relationship	Some

Inbound Relationships	Type	Active	Source	Characteristic	Refinability	Group
Denosumab 60 mg/mL solution for injection	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Denosumab (substance)	Inferred relationship	Some
Product containing denosumab (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Denosumab (substance)	Inferred relationship	Some	1
Denosumab therapy	Direct substance	True	Denosumab (substance)	Inferred relationship	Some	2
Allergy to denosumab (finding)	Causative agent (attribute)	True	Denosumab (substance)	Inferred relationship	Some	1
Product containing only denosumab (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Denosumab (substance)	Inferred relationship	Some	1
Denosumab 60 mg/mL solution for injection	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Denosumab (substance)	Inferred relationship	Some	1
Denosumab 60 mg/mL solution for injection	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Denosumab (substance)	Inferred relationship	Some	1
Denosumab-containing product in parenteral dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Denosumab (substance)	Inferred relationship	Some	1
Denosumab only product in parenteral dose form	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	True	Denosumab (substance)	Inferred relationship	Some	1
Denosumab 70 mg/mL solution for injection	The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration).	True	Denosumab (substance)	Inferred relationship	Some	1
Denosumab 70 mg/mL solution for injection	This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon.	True	Denosumab (substance)	Inferred relationship	Some	1

This concept is not in any reference sets

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Id	Description	Lang	Type	Status	Case?	Module
2879834015	Denosumab (substance)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
2881966015	Denosumab	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
52521000195111	denosumab	it	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
804441000172111	dénosumab	fr	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
66871000195118	Denosumab	de	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module