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450940003: Myeloid-lymphoid neoplasm with PDGFRA rearrangement (morphologic abnormality)

Status: current, Not sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jul 2012. Module: SNOMED CT core

Descriptions:

Id Description Lang Type Status Case? Module
2920674017 Myeloid or lymphoid neoplasm with alpha-type platelet-derived growth factor receptor gene rearrangement en Synonym (core metadata concept) Active Entire term case insensitive (core metadata concept) SNOMED CT core
2920742018 Myeloid or lymphoid neoplasm with PDGFRA rearrangement en Synonym (core metadata concept) Active Only initial character case insensitive (core metadata concept) SNOMED CT core
5143666018 Myeloid-lymphoid neoplasm with PDGFRA rearrangement (morphologic abnormality) en Fully specified name Active Only initial character case insensitive (core metadata concept) SNOMED CT core
5143667010 Myeloid/lymphoid neoplasm with PDGFRA rearrangement en Synonym (core metadata concept) Active Only initial character case insensitive (core metadata concept) SNOMED CT core
5148418015 Myeloid-lymphoid neoplasm with PDGFRA rearrangement en Synonym (core metadata concept) Active Only initial character case insensitive (core metadata concept) SNOMED CT core

0 descendants.

Expanded Value Set

Outbound Relationships Type Target Active Characteristic Refinability Group Values
Myeloid-lymphoid neoplasm with PDGFRA rearrangement (morphologic abnormality) Is a Hematopoietic neoplasm (morphologic abnormality) false Inferred relationship Some
Myeloid-lymphoid neoplasm with PDGFRA rearrangement (morphologic abnormality) Is a Malignant hematopoietic neoplasm (morphologic abnormality) false Inferred relationship Some
Myeloid-lymphoid neoplasm with PDGFRA rearrangement (morphologic abnormality) Is a Myeloid-lymphoid neoplasm (morphologic abnormality) true Inferred relationship Some
Inbound Relationships Type Active Source Characteristic Refinability Group
A rare, malignant, neoplastic disease characterized by clonal proliferation of myeloid and/or lymphoid precursors harboring rearrangements in the PDGFRA gene, in the blood, bone marrow and often other tissues as well (spleen, lymph nodes, skin, etc.). It usually presents as chronic eosinophilic leukemia or, less commonly, as acute myeloid leukemia or T-lymphoblastic leukemia with eosinophilia. Patients usually present with eosinophilia, anemia, thrombocytopenia, neutrophilia, splenomegaly, lymphadenopathy, fever, sweating and/or weight loss. Tissue infiltration by eosinophils can manifest with skin rash, erythema, cough, neurological alterations, gastrointestinal symptoms or, rarely, endomyocardial fibrosis and restrictive cardiomyopathy. Associated morphology True Myeloid-lymphoid neoplasm with PDGFRA rearrangement (morphologic abnormality) Inferred relationship Some 1

This concept is not in any reference sets

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