Inbound Relationships |
Type |
Active |
Source |
Characteristic |
Refinability |
Group |
Acquired hypermelanotic disorder |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Inherited cutaneous hyperpigmentation |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Mercury pigmentation of skin |
Is a |
False |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Acquired lentiginosis |
Is a |
False |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Traumatic hemorrhage into heel that persists as black dots. |
Is a |
False |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Carotene pigmentation of skin |
Is a |
False |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Pigmented hairy epidermal nevus |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Chrysoderma |
Is a |
False |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Inflammatory hyperkeratotic dermatosis |
Is a |
False |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Inflammatory hyperkeratotic dermatosis, chronic |
Is a |
False |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Inflammatory hyperkeratotic dermatosis, isomorphous |
Is a |
False |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Inflammatory hyperkeratotic dermatosis, intertriginous |
Is a |
False |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Inflammatory hyperkeratotic dermatosis, annular |
Is a |
False |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Inflammatory hyperkeratotic dermatosis, plaque |
Is a |
False |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Inflammatory hyperkeratotic dermatosis, rupial |
Is a |
False |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Inflammatory hyperkeratotic dermatosis, guttate |
Is a |
False |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Inflammatory hyperkeratotic dermatosis, generalized exfoliative |
Is a |
False |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Lentigo simplex (disorder) |
Is a |
False |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Arsenic-induced skin pigmentation (disorder) |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Hereditary hypermelanosis (disorder) |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Zosteriform reticulate hyperpigmentation |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Lichen planus (LP) pigmentosus is a rare variant of cutaneous lichen planus characterized by the presence of hyperpigmented lichenoid lesions in sun-exposed or flexural areas of the body. |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
A rare genetic neurological disease characterized by silvery hair, profound dysfunction of central nervous system, abnormal melanocytes and melanosomes and abnormal inclusion bodies in fibroblast and other cells. |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
A rare, syndromic, hyperpigmentation of the skin characterized by multiple lentigines and café-au-lait spots associated with hiatal hernia and peptic ulcer, hypertelorism and myopia. There have been no further descriptions in the literature since 1982. |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Riehl's melanosis |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Benign acanthosis nigricans |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Solar lentiginosis |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Cantu's syndrome |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Reticulate acropigmentation of Kitamura |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Hypotrichosis with keratosis pilaris and lentiginosis |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Post-inflammatory hyperpigmentation |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Drug-induced hypermelanosis |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Eruptive lentiginosis |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Genital lentiginosis |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Diabetic dermopathy |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Circumscribed hypermelanosis (disorder) |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Lentiginosis due to PUVA |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Nevoid lentiginosis (disorder) |
Is a |
False |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Hyperchromic lesions of pinta |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Solar lentigo |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Vulval melanotic macule (disorder) |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Melanotic macule of penis (disorder) |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Acquired acanthosis nigricans |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
A rare endocrine disease characterized by lentigines with a specific peri-orifical distribution, blue nevus, myxomas, various endocrine tumors including primary pigmented nodular adrenocortical disease (PPNAD), acromegaly, thyroid tumors, and a wide range of other tumors. |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Pseudoleprechaunism syndrome, Patterson type is a rare, genetic, adrenal disorder characterized by congenital bronzed hyperpigmentation, cutis laxa of the hands and feet, body disproportion (comprising large hands, feet, nose and ears), hirsutism and severe intellectual disability. Patients additionally present hyperadrenocorticism, cushingoid features, premature adrenarche and diabetes mellitus, as well as skeletal deformities (not present at birth and which progress with age). There have been no further descriptions in the literature since 1981. |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Carney complex-trismus-pseudocamptodactyly syndrome is a rare genetic heart-hand syndrome characterized by typical manifestations of the Carney complex (spotty pigmentation of the skin, familial cardiac and cutaneous myxomas and endocrinopathy) associated with trismus and distal arthrogryposis (presenting as involuntary contraction of distal and proximal interphalangeal joints of hands evident only on dorsiflexion of wrist and similar lower-limb contractures producing foot deformities). |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Erythromelanosis follicularis of face AND/OR neck |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Zosteriform lentiginosis (disorder) |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Hyperpigmentation of eyelid |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Progressive cribriform and zosteriform hyperpigmentation (disorder) |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Palmoplantar hyperkeratosis-hyperpigmentation syndrome of Cantu (disorder) |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Legius syndrome |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
X-linked reticulate pigmentary disorder is an extremely rare skin disease described in only four families to date and characterized in males by diffuse reticulate brown hyperpigmented skin lesions developing in early childhood and a variety of systemic manifestations (recurrent pneumonia, corneal opacification, gastrointestinal inflammation, urethral stricture, failure to thrive, hypohidrosis, digital clubbing, and unruly hair and flared eyebrows), while in females, there is only cutaneous involvement with the development in early childhood of localized brown hyperpigmented skin lesions following the lines of Blaschko. This disease was first considered as a cutaneous amyloidosis, but amyloid deposits are an inconstant feature. |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
A rare multiple congenital anomalies/dysmorphic syndrome with intellectual disability characterized by infantile onset of global developmental delay, severe intellectual disability, growth deficiency, microcephaly, strabismus, blue-gray sclerae, and extensive Mongolian spots. Some patients also present with epilepsy. Brain imaging may demonstrate variable abnormalities including cerebral atrophy, thin corpus callosum, ventriculomegaly, or arachnoid cysts. |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Neurofibromatosis type 6 (NF6), also referred as café-au-lait spots syndrome, is a cutaneous disorder characterized by the presence of several café-au-lait (CAL) macules without any other manifestations of neurofibromatosis or any other systemic disorder. |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Skin graft hyperpigmentation (disorder) |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Hyperpigmentation of right eyelid and periocular area (disorder) |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Hyperpigmentation of left eyelid and periocular area (disorder) |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Hypermelanosis caused by photodynamic agent (disorder) |
Is a |
False |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
A combination of congenital hyperpigmented and hypopigmented skin lesions coexisting in the same individual. |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Nevus spilus (disorder) |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Dermal melanocytic hamartoma (disorder) |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Linear atrophoderma of Moulin (disorder) |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
A rare mosaic form of Legius syndrome with findings typical of Legius syndrome, namely multiple cafe-au-lait macules (CALMs) with or without axillary or inguinal freckling. Mosaic form is caused by postzygotic pathogenic variants in SPRED1 gene. In mosaic Legius syndrome the allelic/tissue distribution of the pathogenic SPRED1-variant clearly suggests mosaicism and/or the distribution of CALMs is segmental. The phenotype can be milder than in Legius syndrome. |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Hypermelanosis due to neoplasia (disorder) |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|
Acanthosis palmaris |
Is a |
True |
Hyperpigmentation of skin |
Inferred relationship |
Some |
|