56448008: Kallidin I (substance)

SNOMED CT Concept\Substance\...

\Substance categorized by disposition\Immunomodulator\Mediator of immune response and inflammation (substance)\Mediator of immune response\Kallidin I

\Biological substance\Immunologic substance\Mediator of immune response and inflammation (substance)\Mediator of immune response\Kallidin I

Status: current, Not sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jan 2002. Module: SNOMED CT core

Descriptions:

Id Description Lang Type Status Case? Module

93868013 Kallidin I en Synonym (core metadata concept) Active Only initial character case insensitive (core metadata concept) SNOMED CT core

93869017 Bradykinin en Synonym (core metadata concept) Active Entire term case insensitive (core metadata concept) SNOMED CT core

794961016 Kallidin I (substance) en Fully specified name Active Only initial character case insensitive (core metadata concept) SNOMED CT core

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
Kallidin I	Is a	Immunochemistry analyte	false	Inferred relationship	Some
Kallidin I	Is a	Mediator of immune response	true	Inferred relationship	Some
Kallidin I	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	A substance that modifies the immune response or the functioning of the immune system.	true	Inferred relationship	Some

Inbound Relationships	Type	Active	Source	Characteristic	Refinability	Group
Bradykinin measurement	Has measured component (attribute)	False	Kallidin I	Inferred relationship	Some
Bradykinin measurement	Component	True	Kallidin I	Inferred relationship	Some	1
ACE inhibitor-aggravated angioedema	Causative agent (attribute)	True	Kallidin I	Inferred relationship	Some	2
A rare non-histaminic angioedema characterised by potentially life-threatening episodes of oedema of subcutaneous and/or mucosal tissues without urticaria, caused by excessive consumption of C1 esterase inhibitor (C1-INH) in the context of lymphoproliferative or autoimmune diseases. Patients typically present in the fourth decade of life or later and without a family history of angioedema. Clinical manifestation includes nonpitting oedema of the skin predominantly involving the face, but also the limbs or genitals, as well as abdominal pain due to involvement of the gastrointestinal mucosa and severe oedema of the upper airway and oral mucosa. Laboratory examination shows low C1-INH activity and low C3, C4, and C1q levels. Autoantibodies to C1-INH are frequently detectable.	Causative agent (attribute)	True	Kallidin I	Inferred relationship	Some	1
Angioedema caused by angiotensin-converting-enzyme inhibitor (disorder)	Causative agent (attribute)	True	Kallidin I	Inferred relationship	Some	2
Intestinal angioedema caused by angiotensin-converting enzyme inhibitor (disorder)	Causative agent (attribute)	True	Kallidin I	Inferred relationship	Some	2
Angioedema due to disorder of kinin metabolism	Causative agent (attribute)	True	Kallidin I	Inferred relationship	Some	1
Acquired angio-oedema due to the presence of neutralising antibodies against C1 inhibitor.	Causative agent (attribute)	True	Kallidin I	Inferred relationship	Some	1
Acquired angioedema due to activation of the classical complement pathway related to an underlying lymphoreticular disorder particularly lymphoma or monoclonal gammopathy of unknown significance (MGUS)	Causative agent (attribute)	True	Kallidin I	Inferred relationship	Some	1
Hereditary C1 esterase inhibitor deficiency - deficient factor	Causative agent (attribute)	True	Kallidin I	Inferred relationship	Some	1
Hereditary C1 esterase inhibitor deficiency - dysfunctional factor	Causative agent (attribute)	True	Kallidin I	Inferred relationship	Some	1
Angioedema of gingiva due to deficiency of C1 esterase inhibitor	Causative agent (attribute)	True	Kallidin I	Inferred relationship	Some	1

This concept is not in any reference sets