Inbound Relationships |
Type |
Active |
Source |
Characteristic |
Refinability |
Group |
Tubulointerstitial nephritis with uveitis syndrome (disorder) |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
2 |
Drug-induced tubulointerstitial nephritis (disorder) |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
2 |
Heavy-metal-induced tubulointerstitial nephritis (disorder) |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
2 |
Idiopathic interstitial tubulonephritis (disorder) |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
2 |
Chronic tubulointerstitial nephritis |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
2 |
Infantile nephropathic cystinosis |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
2 |
Cis-platinum nephropathy |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
2 |
Hypokalemic nephropathy |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
2 |
Bartter syndrome (disorder) |
Finding site |
False |
Renal tubule structure |
Inferred relationship |
Some |
2 |
tubulopathie familiale avec hypokaliémie et hypomagnésémie |
Finding site |
False |
Renal tubule structure |
Inferred relationship |
Some |
2 |
A rare syndrome characterised by hypokalaemic metabolic alkalosis in combination with significant hypomagnesaemia and low urinary calcium excretion. |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
2 |
Idiopathic acute tubulointerstitial nephritis (disorder) |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
2 |
Analgesic nephropathy |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
2 |
Bartter syndrome antenatal type 1 (disorder) |
Finding site |
False |
Renal tubule structure |
Inferred relationship |
Some |
2 |
Bartter syndrome antenatal type 2 (disorder) |
Finding site |
False |
Renal tubule structure |
Inferred relationship |
Some |
2 |
Bartter syndrome type 3 (disorder) |
Finding site |
False |
Renal tubule structure |
Inferred relationship |
Some |
2 |
Bartter syndrome type 4 |
Finding site |
False |
Renal tubule structure |
Inferred relationship |
Some |
2 |
Epilepsy, ataxia, sensorineural deafness, and tubulopathy syndrome |
Finding site |
False |
Renal tubule structure |
Inferred relationship |
Some |
2 |
Acute on chronic tubulointerstitial nephritis (disorder) |
Finding site |
False |
Renal tubule structure |
Inferred relationship |
Some |
1 |
Bartter syndrome type 4a (disorder) |
Finding site |
False |
Renal tubule structure |
Inferred relationship |
Some |
2 |
A rare, genetic renal disease characterized by slowly progressive, chronic, tubulointerstitial nephritis, leading to end-stage renal disease before the age of 50 years, manifesting with mild proteinuria, glucosuria and, occasionally, urinary sediment abnormalities (mainly hematuria). Mild extrarenal manifestations, such as recurrent upper respiratory tract infections and abnormal liver function tests, may be associated. Renal biopsy reveals severe, chronic, interstitial fibrosis and tubular changes, as well as hallmark karyomegalic tubular epithelial cells which line the proximal and distal tubules and have enlarged, hyperchromatic nuclei. |
Finding site |
False |
Renal tubule structure |
Inferred relationship |
Some |
2 |
Hereditary tubulointerstitial disorder |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
2 |
Lowe syndrome |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
2 |
Idiopathic chronic tubulointerstitial nephritis |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
2 |
Familial interstitial nephritis |
Finding site |
False |
Renal tubule structure |
Inferred relationship |
Some |
3 |
Toxoplasma tubulointerstitial nephropathy |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
2 |
A rare, genetic renal tubular disease characterized by phosphate loss in the proximal tubule, leading to hypercalciuria and recurrent urolithiasis and/or osteoporosis. |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
3 |
Renal tubular dysgenesis due to twin to twin transfusion |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
1 |
Renal tubular dysgenesis caused by drug |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
1 |
Acute tubulo-interstitial nephritis due to immunological disorder |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
2 |
Toxic acute tubular necrosis |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
1 |
Acute tubular necrosis due to ischemia and caused by toxin |
Finding site |
False |
Renal tubule structure |
Inferred relationship |
Some |
1 |
Chronic tubulointerstitial nephritis following renal transplantation (disorder) |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
2 |
Chronic tubulo-interstitial nephritis due to connective tissue disorder |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
2 |
Chronic tubulointerstitial nephritis due to ischaemia |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
2 |
Chronic tubulointerstitial nephritis due to neoplastic disease (disorder) |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
2 |
Chronic tubulointerstitial nephritis due to metabolic disease (disorder) |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
2 |
Encephalopathy-hypertrophic cardiomyopathy-renal tubular disease syndrome is a rare mitochondrial disease due to a defect in coenzyme Q10 biosynthesis that manifests with a broad spectrum of signs and symptoms which may include: neonatal lactic acidosis, global developmental delay, tonus disorder, seizures, reduced spontaneous movements, ventricular hypertrophy, bradycardia, renal tubular dysfunction with massive lactic acid excretion in urine, severe biochemical defect of respiratory chain complexes II/III when assayed together and deficiency of coenzyme Q10 in skeletal muscle. Cerebral and cerebellar atrophy can be seen on magnetic resonance imaging and multiple choroid plexus cysts and symmetrical hyperechoic signal alterations in basal ganglia have been observed on ultrasound. |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
5 |
Diphtheritic renal tubular necrosis |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
3 |
A rare renal disease occurring in the setting of a systemic IgG4 related disease (IgG4-RD). The disorder is characterized by a fibrosing tubulointerstitial nephritis consisting of predominantly IgG4+ plasma cells with/without glomerulonephritis, retroperitoneal fibrosis and hydronephrosis. |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
2 |
Renal tubulo-interstitial disorder due to cystinosis (disorder) |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
2 |
A rare genetic disease characterised by abnormalities in renal ion transport, ectodermal gland homeostasis, and epidermal integrity, resulting in generalised hypohidrosis, heat intolerance, salt-losing nephropathy, electrolyte imbalance, lacrimal gland dysfunction, ichthyosis, and xerostomia. Development of nephrolithiasis and severe enamel wear have also been described. Laboratory findings include hypermagnesaemia, hypokalaemia, hypercalcaemia, and hypocalciuria. |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
7 |
Chronic lead nephropathy (disorder) |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
2 |
Chronic mercury nephropathy |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
2 |
Chronic tubulointerstitial nephritis caused by heavy metal |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
2 |
Chronic cadmium nephropathy |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
2 |
Saturnine nephropathy |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
2 |
A rare genetic disease characterized by the association of Fanconi syndrome and nephrocalcinosis in addition to neonatal hyperinsulinism and macrosomia. Patients display a phenotype of proximal tubulopathy characterized by generalized aminoaciduria, low molecular weight proteinuria, glycosuria, hyperphosphaturia and hypouricemia, and additional features not normally seen in Fanconi syndrome (apart from nephrocalcinosis), namely renal impairment, hypercalciuria with relative hypocalcemia, and hypermagnesemia. |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
3 |
Acute tubular necrosis due to ischemia |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
1 |
Familial interstitial nephritis |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
2 |
Acute on chronic tubulointerstitial nephritis (disorder) |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
3 |
A rare, genetic renal disease characterized by slowly progressive, chronic, tubulointerstitial nephritis, leading to end-stage renal disease before the age of 50 years, manifesting with mild proteinuria, glucosuria and, occasionally, urinary sediment abnormalities (mainly hematuria). Mild extrarenal manifestations, such as recurrent upper respiratory tract infections and abnormal liver function tests, may be associated. Renal biopsy reveals severe, chronic, interstitial fibrosis and tubular changes, as well as hallmark karyomegalic tubular epithelial cells which line the proximal and distal tubules and have enlarged, hyperchromatic nuclei. |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
3 |
Chronic infective interstitial nephritis |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
2 |
A rare renal tubular disease characterised by hypomagnesaemia due to renal magnesium wasting, recurrent generalised seizures, mild to moderate intellectual disability, speech delay and obesity due to CNNM2 mutations. Most patients also manifest motor skill defects and hyperkinesia. Majority of the affected individuals do not exhibit brain anomalies. |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
6 |
A rare disorder of magnesium transport characterised by hypomagnesaemia due to renal wasting, leading to tetany, early-onset seizures, impaired psychomotor development, and moderate intellectual disability. Secondary hypocalcaemia and obesity are absent. |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
3 |
Renal tubulopathy - encephalopathy - liver failure describes a spectrum of phenotypes with manifestations similar but milder than those seen in GRACILE syndrome and that can be associated with encephalopathy and psychiatric disorders. |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
4 |
Atrophy of renal tubule |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
1 |
A rare genetic renal tubular disease characterized by hypomagnesemia (due to renal magnesium wasting), hypokalemia and activation of renin production due to specific mitochondrial DNA mutations. Hypocalciuria, metabolic alkalosis, progressive chronic kidney disease as well as arterial hypertension and hypercholesterolemia have been reported. Tetany, tremor, paresthesia, muscle fatigue, chondrocalcinosis and cerebral seizures can be present. Extrarenal manifestations of mitochondrial dysfunction may not be evident in the patients. |
Finding site |
True |
Renal tubule structure |
Inferred relationship |
Some |
1 |