| Inbound Relationships |
Type |
Active |
Source |
Characteristic |
Refinability |
Group |
| Nicotine 500 microgram/actuation nasal spray |
Is a |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine 2mg sublingual tablet |
Is a |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine 1mg mint lozenge |
Is a |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine chewing gum |
Is a |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine patches |
Is a |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine inhalator |
Is a |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine sulfate poisoning |
Causative agent (attribute) |
False |
Nicotine |
Inferred relationship |
Some |
1 |
| Accidental nicotine poisoning |
Causative agent (attribute) |
False |
Nicotine |
Inferred relationship |
Some |
|
| Intentional nicotine poisoning |
Causative agent (attribute) |
False |
Nicotine |
Inferred relationship |
Some |
|
| intoxication par la nicotine d'intention indéterminée |
Causative agent (attribute) |
False |
Nicotine |
Inferred relationship |
Some |
1 |
| Allergy to nicotine |
Causative agent (attribute) |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine overdose |
Causative agent (attribute) |
True |
Nicotine |
Inferred relationship |
Some |
1 |
| Accidental nicotine overdose |
Causative agent (attribute) |
True |
Nicotine |
Inferred relationship |
Some |
1 |
| Intentional nicotine overdose |
Causative agent (attribute) |
True |
Nicotine |
Inferred relationship |
Some |
1 |
| surdose de nicotine d'intention indéterminée |
Causative agent (attribute) |
False |
Nicotine |
Inferred relationship |
Some |
1 |
| Nicotine-induced organic mental disorder |
Causative agent (attribute) |
True |
Nicotine |
Inferred relationship |
Some |
1 |
| Nicotine measurement |
Has measured component (attribute) |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine dependence |
Causative agent (attribute) |
True |
Nicotine |
Inferred relationship |
Some |
1 |
| Nicotine poisoning |
Causative agent (attribute) |
True |
Nicotine |
Inferred relationship |
Some |
1 |
| Tobacco dependence syndrome |
Causative agent (attribute) |
True |
Nicotine |
Inferred relationship |
Some |
1 |
| Nicotine withdrawal |
Causative agent (attribute) |
True |
Nicotine |
Inferred relationship |
Some |
1 |
| Tobacco dependence, continuous |
Causative agent (attribute) |
True |
Nicotine |
Inferred relationship |
Some |
1 |
| Tobacco dependence, episodic |
Causative agent (attribute) |
True |
Nicotine |
Inferred relationship |
Some |
1 |
| Tobacco dependence in remission |
Causative agent (attribute) |
True |
Nicotine |
Inferred relationship |
Some |
2 |
| Tobacco dependence, unspecified |
Causative agent (attribute) |
False |
Nicotine |
Inferred relationship |
Some |
|
| Tobacco dependence NOS |
Causative agent (attribute) |
False |
Nicotine |
Inferred relationship |
Some |
|
| [X]Mental and behavioral disorders due to use of tobacco: withdrawal state |
Causative agent (attribute) |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine polacrilex |
Is a |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine measurement |
Component |
True |
Nicotine |
Inferred relationship |
Some |
1 |
| Nicotine 2mg fruit chewing gum |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine 4mg fruit chewing gum |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine 2mg citrus chewing gum |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Product containing nicotine (medicinal product) |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
True |
Nicotine |
Inferred relationship |
Some |
1 |
| Nicotine (as nicotine polacrilex) 2 mg oral gum chewing gum |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Product containing precisely nicotine (as nicotine polacrilex) 4 milligram/1 chewing gum prolonged-release oral gum (clinical drug) |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine 7mg/24hours patch |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine 21mg/24hours patch |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine 5mg/16hours patch |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine 10mg/16hours patch |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine 15mg/16hours patch |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine 2mg mint chewing gum |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine 4mg mint chewing gum |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine 10mg inhalator starter pack |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine 10mg inhalator refill pack |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine 2mg sublingual tablet |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine 1mg mint lozenge |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine chewing gum |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine inhalator |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine 10mg/mL spray |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine 14mg/day patch |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine 11mg/24hours patch |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine 22mg/day patch |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine 10mg inhaler |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine polacrilex 2mg gum |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine inhaler |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine m/r transdermal patch |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine nasal spray |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine oral |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine 1mg lozenge |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine 2mg lozenge |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine 4mg lozenge |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine 2 |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine lozenges |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine 14mg/24hours patch |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine 500 microgram/actuation nasal spray |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine patches |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine 4mg liquorice chewing gum |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine 2mg liquorice chewing gum |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Product containing precisely nicotine (as nicotine polacrilex) 1 milligram/1 each conventional release oromucosal lozenge (clinical drug) |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Product containing precisely nicotine (as nicotine polacrilex) 2 milligram/1 each conventional release oromucosal lozenge (clinical drug) |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine (as nicotine polacrilex) 4 mg oromucosal lozenge |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine 1mg mint lozenge |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine polacrilex 4mg gum |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine replacement therapy provided free |
Direct substance |
False |
Nicotine |
Inferred relationship |
Some |
2 |
| agent à base de nicotine |
Is a |
False |
Nicotine |
Inferred relationship |
Some |
|
| Accidental nicotine poisoning |
Causative agent (attribute) |
True |
Nicotine |
Inferred relationship |
Some |
1 |
| Intentional nicotine poisoning |
Causative agent (attribute) |
True |
Nicotine |
Inferred relationship |
Some |
1 |
| Product containing nicotine in oropharyngeal dose form (medicinal product form) |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
1 |
| Product containing nicotine in topical dosage form |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Nicotine-containing product in nasal dose form |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
True |
Nicotine |
Inferred relationship |
Some |
1 |
| Product containing nicotine in respiratory dosage form |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
False |
Nicotine |
Inferred relationship |
Some |
|
| Qualitative measurement of nicotine in urine (procedure) |
Component |
False |
Nicotine |
Inferred relationship |
Some |
2 |
| A pattern of nicotine use that has caused damage to a person's physical or mental health. The pattern of nicotine use is observed for a minimum of 12 months for occasional use or at least one month for continuous use (daily or nearly daily). Harm to health results from direct or secondary toxic effects on body organs and systems or a harmful route of administration. |
Causative agent (attribute) |
True |
Nicotine |
Inferred relationship |
Some |
1 |
| Nicotine dependence with current use |
Causative agent (attribute) |
False |
Nicotine |
Inferred relationship |
Some |
1 |
| Sleep disorder caused by nicotine (disorder) |
Causative agent (attribute) |
True |
Nicotine |
Inferred relationship |
Some |
1 |
| Tobacco dependence caused by cigarettes (disorder) |
Causative agent (attribute) |
True |
Nicotine |
Inferred relationship |
Some |
1 |
| Tobacco dependence caused by chewing tobacco (disorder) |
Causative agent (attribute) |
True |
Nicotine |
Inferred relationship |
Some |
1 |
| Nicotine cyclodextrin complex (substance) |
This attribute indicates that the concept is a structural modification of another concept, and that the substance's intrinsic physicochemical properties remain unchanged. |
True |
Nicotine |
Inferred relationship |
Some |
|
| Product containing nicotine in transdermal dose form (medicinal product form) |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
True |
Nicotine |
Inferred relationship |
Some |
1 |
| Nicotine 291.667 microgram/hour prolonged-release transdermal patch |
This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon. |
True |
Nicotine |
Inferred relationship |
Some |
1 |
| Nicotine 291.667 microgram/hour prolonged-release transdermal patch |
The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration). |
True |
Nicotine |
Inferred relationship |
Some |
1 |
| Product containing precisely nicotine 312.5 microgram/1 hour prolonged-release transdermal patch (clinical drug) |
This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon. |
True |
Nicotine |
Inferred relationship |
Some |
1 |
| Product containing precisely nicotine 312.5 microgram/1 hour prolonged-release transdermal patch (clinical drug) |
The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration). |
True |
Nicotine |
Inferred relationship |
Some |
1 |
| Nicotine 583.333 microgram/hour prolonged-release transdermal patch |
The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration). |
True |
Nicotine |
Inferred relationship |
Some |
1 |
| Nicotine 583.333 microgram/hour prolonged-release transdermal patch |
This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon. |
True |
Nicotine |
Inferred relationship |
Some |
1 |
| Nicotine 625 microgram/hour prolonged-release transdermal patch |
This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon. |
True |
Nicotine |
Inferred relationship |
Some |
1 |
| Nicotine 625 microgram/hour prolonged-release transdermal patch |
The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration). |
True |
Nicotine |
Inferred relationship |
Some |
1 |
| Product containing precisely nicotine 875 microgram/1 hour prolonged-release transdermal patch (clinical drug) |
This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon. |
True |
Nicotine |
Inferred relationship |
Some |
1 |
| Product containing precisely nicotine 875 microgram/1 hour prolonged-release transdermal patch (clinical drug) |
The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration). |
True |
Nicotine |
Inferred relationship |
Some |
1 |
| Product containing precisely nicotine 937.5 microgram/1 hour prolonged-release transdermal patch (clinical drug) |
The most specific description of a substance present in the manufactured dose form, before any dilution or transformation. It includes modifiers, such as salts, esters, polymers (e.g. pegylation), and/or solvates (including waters of hydration). |
True |
Nicotine |
Inferred relationship |
Some |
1 |
| Product containing precisely nicotine 937.5 microgram/1 hour prolonged-release transdermal patch (clinical drug) |
This attribute represents an ingredient that is the part of the active ingredient that the strength of a given product is based upon. |
True |
Nicotine |
Inferred relationship |
Some |
1 |
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