68594002: Adrenal cortex structure (body structure)

SNOMED CT Concept\Body structure (body structure)\Anatomical or acquired body structure (body structure)\Anatomical structure\...

\Anatomical structure which has as its parts a heterogeneous collection of organs, organ parts, cells, cell parts or body part subdivisions that are adjacent to, or continuous with one another; does not constitute a cell part, cell, tissue, organ, or body part subdivision.\Structure of anatomical compartment (body structure)\Structure of body cavity and/or content\This structure comprises the space and content within the boundaries of the abdominopelvic cavity but excludes the walls that define and enclose the space. Previously SNOMED CT used the word 'compartment' to describe structures comprising the cavity and content but FMA has used the same word to include cavity, content and wall. As a consequence, the preferred notation is intra-abdominopelvic structure as this more clearly excludes the 'wall' structures. The intra-abdominopelvic structure is bounded by, but excludes the following 'wall' structures: superiorly the thoracic diaphragm; inferiorly the pelvic diaphragm; anteriorly the anterior abdominal wall (including the lateral abdominal wall); and posteriorly the wall of the abdominal proper segment of trunk. The pelvic component consists of the cavity and content of the true pelvis, which is bounded by the pelvic wall. Note, the structures that form the boundaries are excluded.\...

\Any organ (viscera) contained within the abdominopelvic cavity. The abdominopelvic viscera includes stomach, small intestine, large intestine, spleen, kidneys, adrenal glands, pancreas, liver and gallbladder and the viscera within the true pelvic cavity including ovaries, uterus, prostate, urinary bladder and anal canal.\Structure of organ within abdomen proper cavity (body structure)\Adrenal structure\Adrenal part\Layer of adrenal gland\Adrenal cortex structure

\This structure comprises the space and content within the boundaries of the abdominal proper cavity but excludes the walls that define and enclose the space. Previously SNOMED CT used the word 'compartment' to describe structures comprising the cavity and content but FMA has used the same word to include cavity, content and wall. As a consequence, the preferred notation is intra-abdominopelvic proper structure as this more clearly excludes the 'wall' structures. The intra-abdominopelvic proper structure is bounded by, but excludes the following 'wall' structures: superiorly the thoracic diaphragm; inferiorly the superior pelvic aperture; anteriorly the anterior abdominal (including the lateral abdominal wall); and posteriorly the posterior wall of abdomen proper. Note, the structures that form the boundaries are excluded.\Structure of organ within abdomen proper cavity (body structure)\Adrenal structure\Adrenal part\Layer of adrenal gland\Adrenal cortex structure

\Retroperitoneal compartment structure (body structure)\Adrenal structure\Adrenal part\Layer of adrenal gland\Adrenal cortex structure

\Gland structure\Endocrine gland structure (body structure)\...

\Endocrine gland part (body structure)\Adrenal part\Layer of adrenal gland\Adrenal cortex structure

\Adrenal structure\Adrenal part\Layer of adrenal gland\Adrenal cortex structure

\Body system structure\Structure of breast and/or endocrine system (body structure)\Structure of endocrine system (body structure)\Endocrine gland structure (body structure)\...

\Endocrine gland part (body structure)\Adrenal part\Layer of adrenal gland\Adrenal cortex structure

\Adrenal structure\Adrenal part\Layer of adrenal gland\Adrenal cortex structure

Status: current, Not sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jan 2002. Module: SNOMED CT core

Descriptions:

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
Adrenal cortex structure	Is a	Layer of adrenal gland	true	Inferred relationship	Some
Adrenal cortex structure	partie de	Entire adrenal gland	false	Additional relationship	Some
Adrenal cortex structure	Laterality	Side (qualifier value)	true	Inferred relationship	Some

Inbound Relationships	Type	Active	Source	Characteristic	Refinability	Group
Corticosterone 18-monooxygenase deficiency	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
Salt-losing congenital adrenal hyperplasia	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
Testosterone 17-beta-dehydrogenase deficiency	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
Cholesterol monooxygenase (side-chain cleaving) deficiency	Finding site	False	Adrenal cortex structure	Inferred relationship	Some	3
3 beta-Hydroxysteroid dehydrogenase deficiency	Finding site	False	Adrenal cortex structure	Inferred relationship	Some	2
Congenital adrenal hyperplasia	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
Deficiency of steroid 17-alpha-monooxygenase	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
Deficiency of steroid 11-beta-monooxygenase	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
Steroid 21-monooxygenase deficiency, salt wasting type	Finding site	False	Adrenal cortex structure	Inferred relationship	Some	3
Late onset congenital adrenal hyperplasia	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
Congenital primary adrenocortical hypofunction	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
Familial hyperaldosteronism	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
A rare inherited disorder due to the ectopic expression of the aldosterone synthase in the fascicular zone of the adrenal gland and marked with early severe hypertension (often occurring before the age of 20), biological signs of primary aldosteronism of variable intensity, and an abnormal elevated level of 18-oxo- and 18-hydroxycortisol.	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
A genetic cause of hypertension secondary to primary aldosteronism that is not suppressed with dexamethasone. Patients present with an adrenal adenoma that secretes aldosterone.	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
Familial hyperaldosteronism type 3 (disorder)	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
Primary hyperaldosteronism due to aldosterone-secreting malignant neoplasm of adrenal gland	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	2
Accessory adrenal cortex	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
Steroid 21-monooxygenase deficiency, simple virilizing type	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
17 alpha-Hydroxyprogesterone aldolase deficiency	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
Cholesterol monooxygenase (side-chain cleaving) deficiency	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
Steroid 21-monooxygenase deficiency, salt wasting type	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
Adolescent X-linked adrenoleukodystrophy (disorder)	Finding site	False	Adrenal cortex structure	Inferred relationship	Some
Pseudohermaphrodite, female with adrenocortical disorder	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
Virilisation-adrenogenital syndrome	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
Juxtaglomerular hyperplasia co-occurrent with secondary hyperaldosteronism (disorder)	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	2
Hyperaldosteronism co-occurrent with hyperplasia of the adrenal cortex	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
Childhood cerebral X-linked adrenoleukodystrophy	Finding site	False	Adrenal cortex structure	Inferred relationship	Some
Salt-losing congenital adrenal hyperplasia with virilism	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
Tuberculous Addison's disease	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	3
A rare inherited defect of the final step of aldosterone biosynthesis (conversion of deoxycorticosterone to aldosterone). It is due to mutations of the /CYP11B2/ (aldosterone synthase) gene and usually presents in infancy as a life-threatening electrolyte imbalance.	Finding site	False	Adrenal cortex structure	Inferred relationship	Some
A rare form of congenital adrenal hyperplasia due to P450 oxidoreductase deficiency and characterized by glucocorticoid deficiency, virilization of external genitalia in females, and undervirilization in males. Findings range from severely affected infants with 46,XX and 46,XY disorders/differences of sex development (DSD) and cortisol deficiency to mildly affected women who appear to have polycystic ovary syndrome, or mildly affected men with gonadal insufficiency.	Finding site	False	Adrenal cortex structure	Inferred relationship	Some	2
A severe form of congenital adrenal hyperplasia (CAH) characterized by severe adrenal insufficiency and sex reversal in males.	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
A form of congenital adrenal hyperplasia (CAH) characterized by simple virilizing or salt wasting forms that can manifest with abnormal genital development with variable levels of virilization in females and with adrenal insufficiency in both sexes, and that presents with dehydration and hypoglycemia (which can be lethal if left untreated) in the neonatal period, as well as hyperandrogenism.	Finding site	False	Adrenal cortex structure	Inferred relationship	Some	2
dysplasie micronodulaire pigmentée des surrénales	Finding site	False	Adrenal cortex structure	Inferred relationship	Some	1
Adrenocortical hypofunction following procedure (disorder)	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	2
Severe steroid 21-hydroxylase deficiency	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
Familial adrenocortical hypoplasia	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
Moderate steroid 21-hydroxylase deficiency	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
Adrenoleukodystrophy	Finding site	False	Adrenal cortex structure	Inferred relationship	Some	1
Hereditary adrenal unresponsiveness to corticotropin	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
Pseudohypoaldosteronism, type 1, dominant form	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
Pseudohypoaldosteronism, type 1, recessive form	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
Neonatal adrenoleukodystrophy	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
Acyl-CoA oxidase deficiency	Finding site	False	Adrenal cortex structure	Inferred relationship	Some	1
A rare inherited defect of the final step of aldosterone biosynthesis (conversion of deoxycorticosterone to aldosterone). It is due to mutations of the /CYP11B2/ (aldosterone synthase) gene and usually presents in infancy as a life-threatening electrolyte imbalance.	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
dysplasie micronodulaire pigmentée des surrénales	Finding site	False	Adrenal cortex structure	Inferred relationship	Some	2
A rare DNA repair defect other than combined T-cell and B-cell immunodeficiencies characterized by intrauterine and postnatal growth retardation resulting in short stature, microcephaly, glucocorticoid deficiency, natural killer cell deficiency, and recurrent viral infections. Patients may also have increased susceptibility to cancer.	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	4
Adolescent X-linked adrenoleukodystrophy (disorder)	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
Childhood cerebral X-linked adrenoleukodystrophy	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
Glucocorticoid deficiency with achalasia	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	3
Adrenal carcinoma	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	2
An extremely rare genetic endocrine disease characterised by primary adrenal insufficiency, dystrophic myopathy, hepatic steatosis, severe psychomotor delay, megalocornea, failure to thrive, chronic constipation, and terminal bladder ectasia which can lead to death. There have been no further descriptions in the literature since 1982.	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
Inherited isolated adrenal insufficiency due to partial CYP11A1 deficiency is a rare, genetic, chronic, primary adrenal insufficiency disorder, due to partial loss-of-function CYP11A1 mutations, characterized by early-onset adrenal insufficiency without associated abnormal external male genitalia. Patients present with signs of adrenal crisis, including electrolyte abnormalities, severe weakness, recurrent vomiting and seizures. Ultrasound reveals absent (or very small) adrenal glands.	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
Familial glucocorticoid deficiency (FGD) is a group of primary adrenal insufficiencies characterized clinically by neonatal hyperpigmentation, hypoglycemia, failure to thrive, and recurrent infections, and biochemically by glucocorticoid deficiency without mineralocorticoid deficiency.	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
A primary adrenal insufficiency caused by a sudden defective production of adrenal steroids (cortisol and aldosterone). It represents an emergency, thus the rapid recognition and prompt therapy are critical for survival even before the diagnosis is made.	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	2
Acquired benign adrenal androgenic overactivity	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
Acquired adrenogenital syndrome	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
A type of primary hyperaldosteronism resulting from a benign neoplasm of the adrenal gland. The adrenal neoplasm increases production of aldosterone. Excess aldosterone causes the kidneys to retain more salt than usual resulting in increases in body fluid levels and blood pressure. The disease is caused by mutations in one of several genes. The most commonly mutated gene is KCNJ5, accounting for an estimated 40 percent of the neoplasms, followed by the CACNA1D and ATP1A1 genes. Changes in other genes cause a small percentage of cases with additional unidentified genes involved in the condition. The disease is generally not inherited but may arise from a mutation occurring after conception.	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
A rare form of congenital adrenal hyperplasia due to P450 oxidoreductase deficiency and characterized by glucocorticoid deficiency, virilization of external genitalia in females, and undervirilization in males. Findings range from severely affected infants with 46,XX and 46,XY disorders/differences of sex development (DSD) and cortisol deficiency to mildly affected women who appear to have polycystic ovary syndrome, or mildly affected men with gonadal insufficiency.	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
A form of congenital adrenal hyperplasia (CAH) characterized by simple virilizing or salt wasting forms that can manifest with abnormal genital development with variable levels of virilization in females and with adrenal insufficiency in both sexes, and that presents with dehydration and hypoglycemia (which can be lethal if left untreated) in the neonatal period, as well as hyperandrogenism.	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
A rare endocrine disease characterized by a miniature adult type of congenital adrenal hypoplasia (residual adrenal cortex is composed of a small amount of permanent adult cortex with normal structural organization), selective absence of pituitary luteinizing hormone in otherwise normal brain, and neonatal demise. Patients present with hypogonadotropic hypogonadism, hypoglycemia, seizures, encephalopathy and diabetes insipidus. There have been no further descriptions in the literature since 1988.	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
A rare, genetic, neurologic disease characterized by primary hyperaldosteronism presenting with early-onset, severe hypertension, hypokalemia and neurological manifestations (including seizures, severe hypotonia, spasticity, cerebral palsy and profound developmental delay/intellectual disability).	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	2
Congenital lipoid adrenal hyperplasia due to steroidogenic acute regulatory protein deficiency non classic form	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
Congenital lipoid adrenal hyperplasia due to steroidogenic acute regulatory protein deficiency classic form (disorder)	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
Precocious puberty with adrenocortical hyperfunction (disorder)	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	3
Congenital adrenal hyperplasia due to 21-hydroxylase deficiency non-classic form (disorder)	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
Nodular hyperplasia of adrenal cortex (disorder)	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
Nodule of adrenal cortex (disorder)	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
Structure of left adrenal cortex	Is a	True	Adrenal cortex structure	Inferred relationship	Some
Structure of right adrenal cortex (body structure)	Is a	True	Adrenal cortex structure	Inferred relationship	Some
Adrenocorticotropic hormone resistance syndrome	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	2
Adrenal cortical hypofunction due to interruption of corticosteroid therapy (disorder)	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
Familial hyperreninemic hypoaldosteronism type 2 (disorder)	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
A rare disorder with multisystemic involvement and glomerulopathy characterized by progressive steroid-resistant nephrotic syndrome typically associated with focal segmental glomerulosclerosis, as well as primary adrenal insufficiency with adrenal calcifications. Age of onset and disease course are variable, with some cases presenting as severe fetal hydrops, while most patients present in infancy or early childhood and progress to end-stage renal disease within a few years. Additional features include ichthyosis, primary hypothyroidism, hypogonadism, immunodeficiency, and neurological manifestations (such as cognitive impairment, ataxia, sensorineural hearing loss, or seizures).	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
Atrophy of adrenal cortex (disorder)	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
Familial hyperreninemic hypoaldosteronism type 1A	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
Familial hyperreninemic hypoaldosteronism type 1B	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
Female adrenal virilization	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
A rare genetic disease characterized by pre- and postnatal growth restriction, developmental delay, adrenal hypoplasia, genital abnormalities (such as microphallus, hypospadias, or cryptorchidism), thrombocytopenia and/or anemia, recurrent severe invasive infections, and enteropathy with chronic diarrhea. Myelodysplastic syndrome and dysmorphic features (including downslanting palpebral fissures, low-set and posteriorly rotated ears, anteverted nares, camptodactyly, and arachnodactyly, among others) may also be observed.	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	2
Primary adrenal cortical carcinoma (disorder)	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
Adrenoleukodystrophy	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	3
Adrenomyeloneuropathy (disorder)	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	3
A rare chromosomal anomaly with characteristics of complex glycerol kinase deficiency, congenital adrenal hypoplasia, intellectual disability and/or Duchenne muscular dystrophy that usually affect males. The clinical features depend on the deletion size and the number and type of involved genes.	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
A rare adrenocortical nodular disease characterized by increased to normal sized adrenal glands containing multiple small (less than 1 cm in diameter) cortical pigmented (lipofuscin) nodules, surrounded by internodular adrenocortical atrophy. It is typically associated with the development of a form of adrenal Cushing syndrome (CS). Rarely, it has been associated with adrenal macronodules. Whilst PRKAR1A variants are associated with CNC (Carney complex), the mutation c.709-7del6 is mostly associated with i-PPNAD. Other mutations associated with i-PPNAD include PRKACA (germline copy-number gains), PDE11A and PDE8B genes, although these are rare.	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
Carney complex-associated-primary pigmented nodular adrenocortical disease (disorder)	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
A rare familial hyperaldosteronism characterised by elevated aldosterone levels and low plasma renin activity, early-onset hypertension, and hypokalaemia. Developmental delay, learning disabilities, behavioural abnormalities, and attention deficit disorder are observed in some patients.	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
A form of adrenal Cushing syndrome, an endogenous Cushing syndrome (CS), characterized by chronic over-secretion of cortisol due to a benign adrenal tumor that arises from the adrenal cortex. Most adenomas arise in a sporadic setting, with somatic variants in PRKACA gene (around 40% of cases), or other genes such CTNNB1, GNAS, and PRKAR1A, PRKACB. Germline mutations are rare (MEN1).	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1
Inadequate corticosteroid production relative to the severity of a critical illness, leading to an impaired stress response. Adrenal insufficiency is due to impaired functioning of the hypothalamic-pituitary-adrenal axis, altered cortisol metabolism, and tissue corticosteroid resistance. It is commonly associated with sepsis, septic shock, and other severe critical illnesses.	Finding site	True	Adrenal cortex structure	Inferred relationship	Some	1

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Reference Sets

Lateralizable body structure reference set (foundation metadata concept)

Anatomy structure and entire association reference set (foundation metadata concept)

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Id	Description	Lang	Type	Status	Case?	Module
113940017	Adrenal cortex	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
501057011	Adrenal cortex structure	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
808446019	Adrenal cortex structure (body structure)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
880611000172118	cortex de la glande suprarénale	fr	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
896801000172116	cortex glandula suprarenalis	fr	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
903401000172117	structure du cortex surrénalien	fr	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
944591000172118	corticosurrénale	fr	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
1014061000172117	cortex surrénalien	fr	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
7020261000241116	structure du cortex de la glande suprarénale	fr	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module