70887009: Skin structure of palmar area of hand (body structure)

SNOMED CT Concept\Body structure (body structure)\Anatomical or acquired body structure (body structure)\Anatomical structure\...

\An anatomical structure that consists of the maximal set of organ parts so connected to one another that together they constitute a self-contained unit of macroscopic anatomy, distinct both morphologically and functionally from other such units. Together with other organs, an organ constitutes an organ system or a body part. An organ is divisible into organ parts but not organs (examples: femur, biceps, liver, heart, aorta, sciatic nerve, ovary).\Organ part\Skin part\Structure of skin region\Skin structure of limb\Skin structure of upper limb (body structure)\Skin of part of upper limb\Skin structure of free upper limb (body structure)\Skin structure of wrist and/or hand (body structure)\Skin of part of wrist and hand\Skin structure of hand\Skin of part of hand\Skin structure of palmar area of hand
\An anatomical structure that consists of the maximal set of organ parts so connected to one another that together they constitute a self-contained unit of macroscopic anatomy, distinct both morphologically and functionally from other such units. Together with other organs, an organ constitutes an organ system or a body part. An organ is divisible into organ parts but not organs (examples: femur, biceps, liver, heart, aorta, sciatic nerve, ovary).\Organ part\Skin part\Structure of skin region\Skin structure of limb\Skin of part of limb (body structure)\Skin of part of upper limb\Skin structure of free upper limb (body structure)\Skin structure of wrist and/or hand (body structure)\Skin of part of wrist and hand\Skin structure of hand\Skin of part of hand\Skin structure of palmar area of hand
\An anatomical structure that consists of the maximal set of organ parts so connected to one another that together they constitute a self-contained unit of macroscopic anatomy, distinct both morphologically and functionally from other such units. Together with other organs, an organ constitutes an organ system or a body part. An organ is divisible into organ parts but not organs (examples: femur, biceps, liver, heart, aorta, sciatic nerve, ovary).\Skin structure\Skin part\Structure of skin region\Skin structure of limb\Skin structure of upper limb (body structure)\Skin of part of upper limb\Skin structure of free upper limb (body structure)\Skin structure of wrist and/or hand (body structure)\Skin of part of wrist and hand\Skin structure of hand\Skin of part of hand\Skin structure of palmar area of hand
\An anatomical structure that consists of the maximal set of organ parts so connected to one another that together they constitute a self-contained unit of macroscopic anatomy, distinct both morphologically and functionally from other such units. Together with other organs, an organ constitutes an organ system or a body part. An organ is divisible into organ parts but not organs (examples: femur, biceps, liver, heart, aorta, sciatic nerve, ovary).\Skin structure\Skin part\Structure of skin region\Skin structure of limb\Skin of part of limb (body structure)\Skin of part of upper limb\Skin structure of free upper limb (body structure)\Skin structure of wrist and/or hand (body structure)\Skin of part of wrist and hand\Skin structure of hand\Skin of part of hand\Skin structure of palmar area of hand

\Body tissue structure\Structure of soft tissue (body structure)\...

Status: current, Not sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jan 2002. Module: SNOMED CT core

Descriptions:

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
Skin structure of palmar area of hand	Is a	Skin of surface of hand	false	Inferred relationship	Some
Skin structure of palmar area of hand	Is a	Palm (region) structure	false	Inferred relationship	Some
Skin structure of palmar area of hand	partie de	Entire skin	false	Inferred relationship	Some
Skin structure of palmar area of hand	partie de	Structure of surface region of palm of hand (body structure)	false	Inferred relationship	Some
Skin structure of palmar area of hand	partie de	Entire skin of hand	false	Additional relationship	Some
Skin structure of palmar area of hand	Is a	Skin of part of hand	true	Inferred relationship	Some
Skin structure of palmar area of hand	Is a	Skin and/or subcutaneous tissue structure of palmar area of hand (body structure)	true	Inferred relationship	Some
Skin structure of palmar area of hand	Laterality	Side (qualifier value)	true	Inferred relationship	Some

Inbound Relationships	Type	Active	Source	Characteristic	Refinability	Group
A rare genetic disease characterised by thickening of the skin on palms and soles restricted to areas of weight bearing and/or friction (focal, non-epidermolytic palmoplantar keratoderma) and oral and oesophageal leucokeratosis, associated with a very high lifetime risk of developing squamous cell carcinoma of the oesophagus. The skin lesions appear in childhood and can be complicated by fissuring and infection.	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	2
Keratoderma areata	Finding site	False	Skin structure of palmar area of hand	Inferred relationship	Some	2
Symmetrical keratoderma	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	2
Keratoderma climactericum	Finding site	False	Skin structure of palmar area of hand	Inferred relationship	Some	2
Mutilating keratoderma	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	2
Palmoplantar keratoderma transgrediens	Finding site	False	Skin structure of palmar area of hand	Inferred relationship	Some	2
Autosomal dominant mutilating keratoderma	Finding site	False	Skin structure of palmar area of hand	Inferred relationship	Some	2
Acroerythrokeratoderma (disorder)	Finding site	False	Skin structure of palmar area of hand	Inferred relationship	Some	2
Progressive palmoplantar keratoderma of Greither	Finding site	False	Skin structure of palmar area of hand	Inferred relationship	Some	2
Epidermolytic palmoplantar keratoderma of Vorner	Finding site	False	Skin structure of palmar area of hand	Inferred relationship	Some	2
A hereditary palmoplantar keratoderma with characteristics of the combination of bilateral mutilating transgredient palmoplantar keratoderma and periorificial keratotic plaques.	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	2
Papuloverrucous palmoplantar keratoderma of Jakac-Wolf	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	2
Hereditary palmoplantar keratoderma	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	2
Palmoplantar keratoderma with leukoplakia	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	2
Papillon-Lefèvre syndrome	Finding site	False	Skin structure of palmar area of hand	Inferred relationship	Some	3
Diffuse palmoplantar keratoderma of Thost-Unna (disorder)	Finding site	False	Skin structure of palmar area of hand	Inferred relationship	Some	2
Hereditary diffuse palmoplantar keratoderma (disorder)	Finding site	False	Skin structure of palmar area of hand	Inferred relationship	Some	2
Punctate palmoplantar keratoderma (disorder)	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	2
Palmoplantar hyperkeratosis-hyperpigmentation syndrome of Cantu (disorder)	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	2
Acquired palmoplantar keratoderma (disorder)	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	2
Focal acral hyperkeratosis (disorder)	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	2
Follicular atrophoderma with palmoplantar hyperkeratosis (disorder)	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	3
Hidrotic ectodermal dysplasia syndrome	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	3
Cole disease	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	2
Palmoplantar keratoderma	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	2
Autosomal recessive palmoplantar hyperkeratosis and congenital alopecia (PPK-CA) is a rare genetic skin disorder characterized by congenital alopecia and palmoplantar hyperkeratosis. It is usually associated with cataracts, progressive sclerodactyly and pseudo-ainhum.	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	4
A rare genetic skin disorder characterized by absence of scalp and body hair and palmoplantar keratoderma, without other hand complications.	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	5
A rare genetic ectodermal dysplasia syndrome characterised by woolly hair (presenting at birth), palmoplantar keratoderma (developing in the first year of life) and dilated cardiomyopathy with predominant left ventricle involvement (developing in childhood) which can lead to life-threatening heart failure in childhood or adolescence.	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	1
Haim-Munk syndrome (HMS) is characterized by palmoplantar hyperkeratosis, severe early-onset periodontitis, onychogryposis, pes planus, arachnodactyly and acroosteolysis.	Finding site	False	Skin structure of palmar area of hand	Inferred relationship	Some	5
A rare dysostosis with predominant vertebral involvement characterized by paraspinal ligament ossification (most pronounced in the lower thoracic region), osteophytosis, marginal sacroiliac joint sclerosis, and punctate hyperkeratosis on the soles and palms. Patients may be asymptomatic or present mild to moderate back pain. There have been no further descriptions in the literature since 1969.	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	5
Diffuse palmoplantar keratoderma-acrocyanosis syndrome is characterized by the association of diffuse palmoplantar keratoderma and acrocyanosis. It has been described in eight members of one family and in two sporadic cases. The mode of inheritance in the familial cases was autosomal dominant.	Finding site	False	Skin structure of palmar area of hand	Inferred relationship	Some	1
Palmoplantar keratoderma-XX sex reversal-predisposition to squamous cell carcinoma syndrome is characterised by sex reversal in males with a 46, XX (SRY-negative) karyotype, palmoplantar hyperkeratosis and a predisposition to squamous cell carcinoma. To date, five cases (four of whom were brothers) have been described. The aetiology is unknown.	Finding site	False	Skin structure of palmar area of hand	Inferred relationship	Some	4
Palmoplantar keratoderma-deafness syndrome is a keratinization disorder characterized by focal or diffuse palmoplantar keratoderma. A patchy distribution is observed with accentuation on the thenars, hypothenars and the arches of the feet. The disease becomes apparent in infancy and is associated with sensorineural hearing loss that shows a variable age of onset. Due to genetic and clinical similarities, it has been proposed that palmoplantar keratoderma-deafness syndrome, knuckle pads-leukonychia-sensorineural deafness-palmoplantar hyperkeratosis syndrome and keratoderma hereditarium mutilans may represent variants of one broad disorder of syndromic deafness with heterogeneous phenotype. The disease is transmitted in an autosomal dominant manner with incomplete penetrance.	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	5
A rare autosomal recessive, isolated diffuse palmoplantar keratoderma characterized by transgressive and nonprogressive palmoplantar keratoderma resembling a mild form of mal de Meleda.	Finding site	False	Skin structure of palmar area of hand	Inferred relationship	Some	1
A rare X-linked syndromic intellectual disability characterized by intellectual impairment of variable severity, progressive lower limb spasticity, and diffuse palmoplantar hyperkeratosis. Additional manifestations include pes cavus, extensor plantar responses, hand tremor, and mild dysmorphic facial features.	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	2
A rare, genetic, neurocutaneous disease characterized by severe developmental abnormalities of the nervous system and aberrant differentiation of the epidermis. Patients present with a unique constellation of clinical signs described with the acronym CEDNIK: CErebral Dysgenesis, Neuropathy, Ichthyosis, and palmoplantar Keratoderma.	Finding site	False	Skin structure of palmar area of hand	Inferred relationship	Some	5
Keratosis palmaris et plantaris-clinodactyly syndrome is characterized by the association of palmoplantar keratosis with clinodactyly of the fifth finger. Less than 20 cases have been described in the literature so far, and the majority of reported patients were of Mexican origin. Transmission is autosomal dominant.	Finding site	False	Skin structure of palmar area of hand	Inferred relationship	Some	4
A rare arrhythmogenic right ventricular cardiomyopathy (ARVC) and a cutaneous phenotype, characterized by peculiar wooly hair and palmoplantar keratoderma.	Finding site	False	Skin structure of palmar area of hand	Inferred relationship	Some	6
A rare isolated diffuse palmoplantar keratoderma characterized by diffuse, homogeneous, mild to thick, brown-to-yellowish palmoplantar hyperkeratosis (sometimes spreading over the dorsal aspect of fingers). Skin biopsy shows non-epidermolytic changes. There are no changes in hair, teeth or nails, and no syndromic involvement of other organs.	Finding site	False	Skin structure of palmar area of hand	Inferred relationship	Some	2
A rare hereditary skin disease characterized by irregularly distributed epidermal papular/punctate hyperkeratosis of the palms and soles with wide variation among patients.	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	2
Hereditary palmoplantar keratoderma, Gamborg-Nielsen type is characterized by the presence of diffuse palmoplantar keratoderma without associated symptoms. The syndrome has been described in multiple families from the northernmost county of Sweden (Norrbotten). The palmoplantar keratoderma found in the Gamborg-Nielsen type disease is milder than that found in Mal de Meleda but more severe than that found in Thost-Unna palmoplantar keratoderma. Transmission is autosomal recessive.	Finding site	False	Skin structure of palmar area of hand	Inferred relationship	Some	2
A rare, genetic, ectodermal dysplasia syndrome characterized by persistent skin fragility which manifests with blistering and erosions due to minimal trauma, wooly hair with variable alopecia, hyperkeratotic nail dysplasia, diffuse or focal palmoplantar keratoderma with painful fissuring, and no cardiac abnormalities. Perioral hyperkeratosis may also be associated.	Finding site	False	Skin structure of palmar area of hand	Inferred relationship	Some	6
A rare, genetic, isolated palmoplantar keratoderma characterized by focal hyperkeratotic lesions affecting the pressure- and mechanical trauma-bearing areas of the palms and soles, as well as hyperkeratotic plaques involving joints, including knees, elbows, ankles and dorsa of interphalangeal joints.	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	3
A rare, genetic, isolated palmoplantar keratoderma characterized by non-epidermolytic, diffuse hyperkeratotic lesions affecting both the palms and the soles, associated with a tendency of painful fissuring. Contrary to the clinical findings, histologic examination reveals findings suggestive of keratosis palmoplantaris striata, with orthohyperkeratosis featuring widening of the intercellular spaces and disadhesion of keratocytes in the upper epidermal layers.	Finding site	False	Skin structure of palmar area of hand	Inferred relationship	Some	3
A rare, genetic, isolated, focal palmoplantar keratoderma disease characterized by focal thickening of the skin of the soles, and often of the palms, associated with minimal or no nail involvement. Patients frequently present non-epidermolytic painful plantar blistering and, occasionally, subtle oral leukokeratosis or plantar hyperhidrosis.	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	3
Leukoencephalopathy-palmoplantar keratoderma syndrome is a rare, genetic epidermal disease characterized by early childhood-onset of punctate palmoplantar keratoderma in association with adult-onset leukoencephalopathy manifested by progressive tetrapyramidal syndrome and cognitive deterioration.	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	4
Hypotrichosis-osteolysis-periodontitis-palmoplantar keratoderma syndrome is an extremely rare ectodermal dysplasia syndrome characterized by hypotrichosis universalis with mild to severe scarring alopecia, acro-osteolysis, onychogryphosis, thin and tapered fingertips, periodontitis and caries leading to premature teeth loss, linear or reticular palmoplantar keratoderma and erythematous, scaling, psoriasis-like skin lesions on arms and legs. Lingua plicata and ventricular tachycardia have also been observed.	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	8
Curly hair-acral keratoderma-caries syndrome is an extremely rare ectodermal dysplasia syndrome characterized by premature loss of curly, brittle, dry hair, premature loss of teeth due to caries, nail dystrophy with thickening of the finger- and toenails, acral keratoderma and hypohidrosis. Additionally, sparse eyebrows and eyelashes, receding frontal hairline and flattened malar region are associated. The severity of features appears to increase with age.	Finding site	False	Skin structure of palmar area of hand	Inferred relationship	Some	8
Keratosis linearis-ichthyosis congenita-sclerosing keratoderma syndrome is an inherited epidermal disorder characterized by palmoplantar keratoderma, linear hyperkeratotic papules on the flexural side of large joints (cord-like distribution around wrists, in antecubital and popliteal folds), hyperkeratotic plaques (on neck, axillae, elbows, wrists, and knees), mild ichthyosiform scaling, and sclerotic constrictions around fingers that present flexural deformities.	Finding site	False	Skin structure of palmar area of hand	Inferred relationship	Some	2
Wooly hair-palmoplantar keratoderma syndrome is a very rare, hereditary epidermal disorder characterized by hypotrichosis/wooly scalp hair, sparse body hair, eyelashes and eyebrows, leukonychia, and striate palmoplantar keratoderma (more severe on the soles than the palms), which progressively worsens with age. Pseudo ainhum of the fifth toes was also reported. Although wooly hair-palmoplantar keratoderma syndrome shares clinical similarities with both Naxos disease and Carvajal syndrome, cardiomyopathy is notably absent.	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	4
Striate palmoplantar keratoderma is an isolated, focal, hereditary palmoplantar keratoderma characterized by linear hyperkeratosis along the flexor aspect of the fingers and on palms, as well as focal hyperkeratosis of the plantar skin. Patients present with painful thickening of the skin on palms and soles, with occasional fissuring, blistering and hyperhidrosis. Rarely, hyperkeratosis on other areas may be seen (knees, dorsal aspects of the digits). Histopathologically, widened intercellular spaces between keratinocytes are observed.	Finding site	False	Skin structure of palmar area of hand	Inferred relationship	Some	3
Focal palmoplantar and gingival keratoderma is a very rare form of focal palmoplantar keratoderma characterized by painful circumscribed hyperkeratotic lesions on weight-bearing areas of soles, moderate focal hyperkeratosis of palmar pressure-related areas and an asymptomatic leukokeratosis confined to labial- and lingual- attached gingiva. Additional occasional features may include hyperhidrosis, follicular keratosis and extended oral mucosa involvement.	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	2
Nail and teeth abnormalities-marginal palmoplantar keratoderma-oral hyperpigmentation syndrome is a rare genetic ectodermal dysplasia syndrome characterized by short stature, nail dystrophy and/or nail loss, oral mucosa and/or tongue hyperpigmentation, dentition abnormalities (delayed teeth eruption, hypodontia, enamel hypoplasia), keratoderma on the margins of the palms and soles and focal hyperkeratosis on the dorsum of the hands and feet. Additionally, dysphagia with esophageal strictures, sensorineural deafness, bronchial asthma and severe iron-deficiency anemia have been observed.	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	8
Punctate palmoplantar keratoderma type 2 is a type of isolated, punctate, hereditary palmoplantar keratoderma characterized by multiple, asymptomatic, 1 to 2 mm-long, firm, hyperkeratotic projections (spiny keratosis) on the palms, soles and digits (typically confined to their volar and/or lateral aspects). Histopathologically, compact columnar parakeratosis over hypo- or agranular epidermis is observed.	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	2
Hypohidrosis-enamel hypoplasia-palmoplantar keratoderma-intellectual disability syndrome is a rare, genetic, syndromic intellectual disability disorder characterised by severe intellectual disability with significant speech and language impairment, hypohidrosis (often resulting in hyperthermia) with normal sweat gland appearance, tooth enamel hypoplasia, palmoplantar hyperkeratosis and a high frequency of acquired microcephaly. Mild facial dysmorphism, including lateral flaring of the eyebrows, broad nasal tip, and thick vermilion border, may also be observed.	Finding site	False	Skin structure of palmar area of hand	Inferred relationship	Some	6
A rare ophthalmic disorder characterized by corneal opacification and dyskeratosis (which may cause visual impairment), associated with systemic features including palmoplantar hyperkeratosis, laryngeal dyskeratosis, pruritic hyperkeratotic scars, chronic rhinitis, dyshidrosis and/or nail thickening.	Finding site	False	Skin structure of palmar area of hand	Inferred relationship	Some	5
A rare, genetic punctate palmoplantar keratoderma disease characterized by discrete, focal, punctate keratoderma on the palms and soles and/or slowly progressive spastic paralysis, predominantly affecting the lower limbs. Lesional histology reveals pronounced orthokeratosis, acanthosis, papillomatosis, and regular undulation to the surface keratin. There have been no further descriptions in the literature since 1983.	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	3
A rare diffuse, mutilating, hereditary palmoplantar keratoderma characterized by severe, honeycomb-pattern palmoplantar keratosis and pseudoainhum of the digits leading to autoamputation, associated with mild to moderate congenital sensorineural hearing loss. Additional features include stellate keratosis on the extensor surfaces of the fingers, feet, elbows and knees. Alopecia, onychogryphosis, nail dystrophy or clubbing, spastic paraplegia and myopathy may also be associated.	Finding site	False	Skin structure of palmar area of hand	Inferred relationship	Some	3
A rare diffuse, mutilating, hereditary palmoplantar keratoderma characterized by severe, honeycomb-pattern palmoplantar keratosis and pseudoainhum of the digits leading to autoamputation, associated with mild to moderate congenital sensorineural hearing loss. Additional features include stellate keratosis on the extensor surfaces of the fingers, feet, elbows and knees. Alopecia, onychogryphosis, nail dystrophy or clubbing, spastic paraplegia and myopathy may also be associated.	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	5
Acropustulosis of infancy	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	2
Pustular psoriasis of palms and soles	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	2
A rare arrhythmogenic right ventricular cardiomyopathy (ARVC) and a cutaneous phenotype, characterized by peculiar wooly hair and palmoplantar keratoderma.	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	4
Acral erythema due to cytotoxic therapy (disorder)	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	2
Friction palmar eczema	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	1
Pustular bacterid	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	2
Palmoplantar sarcoidosis (disorder)	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	2
Hyperkeratotic eczema of palms	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	3
Hyperkeratotic fissured eczema of palms	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	3
Hyperkeratotic eczema of palms and soles	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	5
Striate palmoplantar keratoderma is an isolated, focal, hereditary palmoplantar keratoderma characterized by linear hyperkeratosis along the flexor aspect of the fingers and on palms, as well as focal hyperkeratosis of the plantar skin. Patients present with painful thickening of the skin on palms and soles, with occasional fissuring, blistering and hyperhidrosis. Rarely, hyperkeratosis on other areas may be seen (knees, dorsal aspects of the digits). Histopathologically, widened intercellular spaces between keratinocytes are observed.	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	2
Pachyonychia congenita syndrome	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	4
Pachyonychia congenita type II of Jackson-Lawler (disorder)	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	2
Pachyonychia congenita type III of Schafer-Brunauer (disorder)	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	2
A rare skin disease characterized by transient wrinkling of the skin, edema, formation of whitish papules, pruritus, burning sensation, or pain, on the palms and/or soles in response to contact with water. Duration of exposure and water temperature affect the rate of development and intensity of the lesions. The condition is more common in females than in males and frequently occurs in patients with cystic fibrosis.	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	2
Palmar pitting due to Darier disease	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	2
A rare, genetic, autosomal dominant hereditary axonal motor and sensory neuropathy disorder characterized by childhood-onset palmoplantar keratoderma associated with motor and sensory polyneuropathy manifesting with late-onset, predominantly distal, lower limb muscle weakness and atrophy (later associating mild proximal weakness and upper limb involvement), moderate sensory impairment (hypoesthesia with stocking-glove distribution), and normal or near-normal nerve conduction velocities. Additional variable manifestations include impaired vibratory sensation, reduced tendon reflexes, paresthesia, pain, talipes equinovarus, pes cavus, and nail dystrophy.	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	2
A rare genetic skin disease characterized by generalized skin peeling or superficial blisters without scarring, leukonychia, acral punctate keratoses coalescing into focal keratoderma on the weight-bearing areas, painful angular cheilitis, and knuckle pads with multiple hyperkeratotic micropapules. The skin appears dry and scaly with superficial exfoliation and underlying erythema. Histopathologic examination of affected skin areas is not specific and shows hyperkeratosis, acanthosis, and occasional intraepidermal clefting with irregular acantholysis.	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	2
A rare epidermal disease characterized by the association of punctate acrokeratoderma with a pigmentary disorder. Patients present skin-colored keratotic papules on the hands and feet and pronounced hyperkeratosis of the palms and soles. Freckle-like pigmentation on the dorsal surfaces of the hands and feet is also reported. Histological examination reveals no fragmentation of dermal elastic tissue. There have been no further descriptions in the literature since 1993.	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	2
Pustular psoriasis of palm and sole caused by drug (disorder)	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	2
Palmar xanthoma	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	1
A rare hereditary palmoplantar keratoderma characterized by focal hyperkeratotic lesions on the palms and soles. Histopathologic examination reveals prominent hyperkeratosis, thickened stratum spinosum with reduced stratum granulosum, disadhesion of cells in the suprabasal layers, elongation of rete ridges, and sparse lymphocyte infiltration in the dermis.	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	2
A rare ectodermal dysplasia syndrome characterized by hypotrichosis, tooth enamel hypoplasia, hypoplastic nails, palmoplantar keratoderma, hyperhidrosis on hands, face, and scalp, bilateral partial cutaneous syndactyly, and dysmorphic facial features with large prominent ear pinnae, pointed nose, and thin upper lips. Association of cardiomegaly has also been reported.	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	3
Palmar fasciectomy with z-plasty	Procedure site - Direct (attribute)	True	Skin structure of palmar area of hand	Inferred relationship	Some	2
Hyperkeratotic fissured eczema of palms	Finding site	True	Skin structure of palmar area of hand	Inferred relationship	Some	4

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Reference Sets

Lateralizable body structure reference set (foundation metadata concept)

Anatomy structure and entire association reference set (foundation metadata concept)

Anatomy structure and part association reference set (foundation metadata concept)

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Id	Description	Lang	Type	Status	Case?	Module
117746018	Skin of palmar area of hand	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
117747010	Skin of palm of hand	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
501713018	Skin structure of palmar area of hand	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
810991012	Skin structure of palmar area of hand (body structure)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
887811000172116	peau de la région palmaire de la main	fr	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
977311000172111	peau de la paume de la main	fr	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
1005861000172111	structure de la peau de la région palmaire de la main	fr	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module