710027002: Cytokine-associated toxicity (disorder)

SNOMED CT Concept\Clinical finding (finding)\Disease\...

\Interference in normal bodily functions caused by exposure through ingestion, inhalation, absorption, or injection of a substance (e.g. medicinal product, household product, industrial chemical, or plant or animal derivatives) in quantities that cause diminished control of mental, physiological, or physical functioning.\Acute intoxication\Cytokine-associated toxicity (disorder)
\Interference in normal bodily functions caused by exposure through ingestion, inhalation, absorption, or injection of a substance (e.g. medicinal product, household product, industrial chemical, or plant or animal derivatives) in quantities that cause diminished control of mental, physiological, or physical functioning.\Interference in normal bodily functions caused by exposure through ingestion, inhalation, absorption, or injection of a substance (e.g. medicinal product, household product, industrial chemical, or plant or animal derivatives) in quantities that are harmful to health.\Poisoning caused by biological substance\Cytokine-associated toxicity (disorder)

\Disorder of immune function (disorder)\Cytokine-associated toxicity (disorder)

\Disorder of body system\Disorder of immune structure (disorder)\Cytokine-associated toxicity (disorder)

\Systemic disease\Cytokine-associated toxicity (disorder)

\Any disease of sudden onset AND/OR short duration\Acute intoxication\Cytokine-associated toxicity (disorder)

Status: current, Not sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jul 2015. Module: SNOMED CT core

Descriptions:

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
Cytokine-associated toxicity (disorder)	Is a	Immune system complication of procedure	false	Inferred relationship	Some
Cytokine-associated toxicity (disorder)	Is a	Disorder of immune function (disorder)	true	Inferred relationship	Some
Cytokine-associated toxicity (disorder)	Is a	Interference in normal bodily functions caused by exposure through ingestion, inhalation, absorption, or injection of a substance (e.g. medicinal product, household product, industrial chemical, or plant or animal derivatives) in quantities that are harmful to health.	false	Inferred relationship	Some
Cytokine-associated toxicity (disorder)	Finding site	Structure of immune system (body structure)	false	Inferred relationship	Some	3
Cytokine-associated toxicity (disorder)	Has definitional manifestation	Immune system finding	false	Inferred relationship	Some
Cytokine-associated toxicity (disorder)	Associated with	Procedure	false	Inferred relationship	Some
Cytokine-associated toxicity (disorder)	Due to	Procedure	false	Inferred relationship	Some	2
Cytokine-associated toxicity (disorder)	Pathological process (attribute)	Abnormal immune process (qualifier value)	true	Inferred relationship	Some	1
Cytokine-associated toxicity (disorder)	Is a	Poisoning caused by biological substance	true	Inferred relationship	Some
Cytokine-associated toxicity (disorder)	Is a	Disorder of immune structure (disorder)	true	Inferred relationship	Some
Cytokine-associated toxicity (disorder)	Is a	intoxication par un produit chimique	false	Inferred relationship	Some
Cytokine-associated toxicity (disorder)	Finding site	Structure of immune system (body structure)	true	Inferred relationship	Some	1
Cytokine-associated toxicity (disorder)	Causative agent (attribute)	Cytokine	true	Inferred relationship	Some	1
Cytokine-associated toxicity (disorder)	Is a	Any disease of sudden onset AND/OR short duration	false	Inferred relationship	Some
Cytokine-associated toxicity (disorder)	Is a	Systemic disease	true	Inferred relationship	Some
Cytokine-associated toxicity (disorder)	Clinical course	Sudden onset	true	Inferred relationship	Some	2
Cytokine-associated toxicity (disorder)	Is a	Acute intoxication	true	Inferred relationship	Some

Inbound Relationships	Type	Active	Source	Characteristic	Refinability	Group
A rare systemic condition affecting patients undergoing chimeric antigen receptor (CAR) T-cell therapy and characterized by a systemic inflammatory response due to massive activation of leukocytes with subsequent cytokine release. It can present with a variety of signs and symptoms ranging from mild, flu-like symptoms (such as fever, fatigue, headache, rash, arthralgia, and myalgia) to severe life-threatening manifestations including vascular leakage, disseminated intravascular coagulation, shock, and multiple organ failure. Respiratory manifestations are common and range from cough and tachypnea to acute respiratory distress syndrome (ARDS).	Is a	True	Cytokine-associated toxicity (disorder)	Inferred relationship	Some

Reference Sets

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Id	Description	Lang	Type	Status	Case?	Module
3042801016	Cytokine-associated toxicity (disorder)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
3042829018	CRS - cytokine release syndrome	en	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT core
3042832015	Cytokine release syndrome	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
3042839012	Cytokine-associated toxicity	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
5926201000241112	SLC (syndrome de libération de cytokine)	fr	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
5926211000241114	CRS (cytokine release syndrome)	fr	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
5926221000241119	syndrome de libération de cytokine	fr	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module