734581006: Protein-tyrosine kinase inhibitor (disposition)

SNOMED CT Concept\Qualifier value (qualifier value)\Disposition\A substance that alters biochemical processes in a cell by decreasing or increasing the activity of an enzyme.\Compound or agent that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction US Library of Medicine MESH Descriptor data Accessed 20/01/2017\Transferase inhibitor (disposition)\Phosphotransferase inhibitor (disposition)\Protein kinase inhibitor (disposition)\Protein-tyrosine kinase inhibitor (disposition)

Status: current, Not sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jan 2018. Module: SNOMED CT core

Descriptions:

Id Description Lang Type Status Case? Module

3510319012 Protein-tyrosine kinase inhibitor (disposition) en Fully specified name Active Entire term case insensitive (core metadata concept) SNOMED CT core

3510320018 Protein-tyrosine kinase inhibitor en Synonym (core metadata concept) Active Entire term case insensitive (core metadata concept) SNOMED CT core

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
Protein-tyrosine kinase inhibitor (disposition)	Is a	Protein kinase inhibitor (disposition)	true	Inferred relationship	Some

Inbound Relationships	Type	Active	Source	Characteristic	Refinability	Group
Janus kinase inhibitor (disposition)	Is a	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Non-specific protein-tyrosine kinase inhibitor (disposition)	Is a	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Neratinib (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Neratinib maleate (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Brigatinib (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Tivozanib (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Imatinib mesilate	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Protein-tyrosine kinase inhibitor	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Gefitinib (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Erlotinib (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Imatinib (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Vandetanib (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Sunitinib (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Sorafenib (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Dasatinib (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Lapatinib (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Lapatinib ditosylate (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Sunitinib malate (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Erlotinib hydrochloride (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Axitinib (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Nilotinib (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Sorafenib tosylate (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Nilotinib hydrochloride monohydrate (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Pazopanib (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Toceranib (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Toceranib phosphate (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Regorafenib	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Bosutinib (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Ceritinib	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Afatinib (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Afatinib dimaleate	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Bosutinib monohydrate (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Crizotinib (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Ponatinib	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Ponatinib hydrochloride (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Lenvatinib	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Cobimetinib (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Alectinib (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Alectinib hydrochloride (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Cabozantinib (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Lapatinib ditosylate monohydrate (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Cobimetinib fumarate (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Lenvatinib mesilate	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Pazopanib hydrochloride (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Midostaurin	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Fostamatinib (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Rho-associated protein kinase inhibitor	Is a	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Dacomitinib	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Gilteritinib (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Lorlatinib	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Larotrectinib (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Nilotinib hydrochloride (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Human epidermal growth factor receptor 2 inhibitor	Is a	False	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Erdafitinib	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Pexidartinib	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Entrectinib	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Cabozantinib s-malate	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Tucatinib (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Pemigatinib	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Capmatinib (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	False	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Selpercatinib	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Ripretinib (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Pralsetinib (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Tirbanibulin	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Tepotinib	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	False	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Tepotinib hydrochloride	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	False	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Dacomitinib monohydrate (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Mesenchymal epithelial transition inhibitor	Is a	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Tivozanib hydrochloride	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Tivozanib hydrochloride monohydrate (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Gilteritinib fumarate (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Larotrectinib sulfate	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Dasatinib monohydrate (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Dacomitinib anhydrous (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Dasatinib anhydrous	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Tivozanib hydrochloride anhydrous (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Nilotinib hydrochloride anhydrous (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Lapatinib ditosylate anhydrous	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Asciminib hydrochloride	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Fostamatinib disodium hexahydrate	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Asciminib	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Fruquintinib (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some
Dasatinib (S)-propylene glycol (substance)	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	True	Protein-tyrosine kinase inhibitor (disposition)	Inferred relationship	Some

This concept is not in any reference sets

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Id	Description	Lang	Type	Status	Case?	Module
3510319012	Protein-tyrosine kinase inhibitor (disposition)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
3510320018	Protein-tyrosine kinase inhibitor	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core