75777003: Cytokine (substance)

SNOMED CT Concept\Substance\...

\Substance categorized by disposition\Immunomodulator\Mediator of immune response and inflammation (substance)\Mediator of immune response\Cytokine

\Substance categorised by structure\Chemical\Chemical categorized by structure (substance)\...

\Nitrogen and/or nitrogen compound (substance)\Nitrogen compound\Organic nitrogen compound\Amide and/or amide derivative (substance)\Substituted amide (substance)\Polypeptide\Protein\Glycoprotein\Cytokine

\Organic compound\Organic nitrogen compound\Amide and/or amide derivative (substance)\Substituted amide (substance)\Polypeptide\Protein\Glycoprotein\Cytokine

\Biological substance\Protein and/or protein derivative\Protein\Glycoprotein\Cytokine
\Biological substance\Immunologic substance\Mediator of immune response and inflammation (substance)\Mediator of immune response\Cytokine
\Biological substance\Polypeptide\Protein\Glycoprotein\Cytokine

Status: current, Not sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jan 2002. Module: SNOMED CT core

Descriptions:

Id Description Lang Type Status Case? Module

125852012 Cytokine en Synonym (core metadata concept) Active Entire term case insensitive (core metadata concept) SNOMED CT core

816424012 Cytokine (substance) en Fully specified name Active Entire term case insensitive (core metadata concept) SNOMED CT core

7109781000241114 cytokine fr Synonym (core metadata concept) Active Entire term case insensitive (core metadata concept) SNOMED CT Switzerland NRC maintained Module

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
Cytokine	Is a	analyte immunologique	false	Inferred relationship	Some
Cytokine	Is a	Mediator of immune response	true	Inferred relationship	Some
Cytokine	Is a	Glycoprotein	true	Inferred relationship	Some
Cytokine	This attribute specifies the behavior that a substance will exhibit or participate in, given the appropriate context.	A substance that modifies the immune response or the functioning of the immune system.	true	Inferred relationship	Some

Inbound Relationships	Type	Active	Source	Characteristic	Refinability	Group
Interferon beta-1b 100mcg injection solution	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Interferon beta-1a 30mcg/vial injection	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Interferon alfa-2b 5000000unt/vial powder	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Interferon alfa-2b 25000000unt/vial powder	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Interferon alfa-2b 50000000unt/vial powder	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Interferon alfa-2b 10000000unt/vial powder	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Interferon alfa-2b 3000000unt/vial powder	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Interferon alfa-2b 18,000,000iu/vial powder	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Interferon alfa-2b 25 million iu/vial solution	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Interferon alfa-2b 18 million iu/vial solution	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Interferon alfa-2b 10 million iu/vial solution	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Interferon alfa-2b 3 million iu/vial solution	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Interferon alfa-2b 5 million iu/vial solution	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Injectable interferon	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Product containing peginterferon alfa-2a (medicinal product)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Interferon alfa-n3 human leu 5000000unt/mL injection solution 1mL vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Interferon alfa-2a 6miu/vial injection solution 1mL vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Interferon alfa-2a 9miu/vial injection solution 0.9mL vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Interferon alfa-2a 36000000iu/mL injection solution 1mL vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Interferon alfa-2a 3miu/vial injection solution 1mL vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Interferon alfa-2a 18000000iu/3mL injection solution 3mL vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Interferon alfa-2a 3miu/vial injection solution 0.5mL syringe	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Interferon beta-1a 30mcg/vial injection solution	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Interferon alfa-2a 6miu/vial injection solution 0.5mL syringe	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
PEG-intron redipen	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
PEG-intron redipen 150micrograms powder+sterile water 0.5mL	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
PEG-intron redipen 120micrograms powder+sterile water 0.5mL	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
PEG-intron redipen 50micrograms powder+sterile water 0.5mL	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
PEG-intron redipen 80micrograms powder+sterile water 0.5mL	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Interferon alfa-2b 10million iu/2mL injection solution	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Peginterferon alfa-2b 150micrograms powder+solvent for solution for injection in prefilled pen	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Peginterferon alfa-2b 50micrograms powder+solvent for solution for injection in prefilled pen	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Peginterferon alfa-2b 80micrograms powder+solvent for solution for injection in prefilled pen	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Peginterferon alfa-2b 100micrograms powder+solvent for solution for injection in prefilled pen	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Peginterferon alfa-2b 120micrograms powder+solvent for solution for injection in prefilled pen	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Peginterferon alfa-2a 180micrograms/0.5mL solution for injection prefilled syringe	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Peginterferon alfa-2a 135micrograms/0.5mL solution for injection prefilled syringe	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Interferon alfa-2a 18million iu/0.5mL injection solution prefilled syringe	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Interferons 1million iu injection (pdr for recon)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Interferons 4.5million iu injection	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Interferons 5million units injection (pdr for recon)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Interferons 10million iu injection (pdr for recon)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Interferons 30million iu injection (pdr for recon)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Interferons 3million iu injection (pdr for recon)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Interferons 9million iu injection (pdr for recon)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Interferons 18million iu injection (pdr for recon)	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Interferons 3million iu/1mL solution for injection	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Interferons 10million iu/1mL solution for injection	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Peginterferon alfa-2a 180micrograms/mL injection 1mL vial	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Ribavirin+interferon alpha-2b	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Ribavirin 200mg capsule+interferon alpha-2b 3million iu/vial injection solution	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Interferon beta-1b 0.3mg powder for injection+diluent	The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications.	False	Cytokine	Inferred relationship	Some
Angiogenin (substance)	Is a	True	Cytokine	Inferred relationship	Some
Platelet factor 4	Is a	True	Cytokine	Inferred relationship	Some
Interleukin	Is a	True	Cytokine	Inferred relationship	Some
Interferon	Is a	False	Cytokine	Inferred relationship	Some
Cytokine agent (substance)	Is a	True	Cytokine	Inferred relationship	Some
Lactoferrin	Is a	True	Cytokine	Inferred relationship	Some
Platelet-derived growth factor	Is a	True	Cytokine	Inferred relationship	Some
Tumor necrosis factor alpha	Is a	False	Cytokine	Inferred relationship	Some
Tumor necrosis factor beta	Is a	False	Cytokine	Inferred relationship	Some
Lymphotoxin	Is a	False	Cytokine	Inferred relationship	Some
Tumor necrosis factor	Is a	True	Cytokine	Inferred relationship	Some
Ancestim (substance)	Is a	True	Cytokine	Inferred relationship	Some
Transforming growth factor beta 1	Is a	True	Cytokine	Inferred relationship	Some
Cytokine-associated toxicity (disorder)	Causative agent (attribute)	True	Cytokine	Inferred relationship	Some	1
A rare systemic condition affecting patients undergoing chimeric antigen receptor (CAR) T-cell therapy and characterized by a systemic inflammatory response due to massive activation of leukocytes with subsequent cytokine release. It can present with a variety of signs and symptoms ranging from mild, flu-like symptoms (such as fever, fatigue, headache, rash, arthralgia, and myalgia) to severe life-threatening manifestations including vascular leakage, disseminated intravascular coagulation, shock, and multiple organ failure. Respiratory manifestations are common and range from cough and tachypnea to acute respiratory distress syndrome (ARDS).	Causative agent (attribute)	True	Cytokine	Inferred relationship	Some	1
Protein kinase C activity assay	Component	True	Cytokine	Inferred relationship	Some	2
Lymphokine assay	Component	True	Cytokine	Inferred relationship	Some	2
Mononuclear cell function assay	Component	True	Cytokine	Inferred relationship	Some	1
Intracellular free calcium assay	Component	True	Cytokine	Inferred relationship	Some	1
Cytokine therapy	Direct substance	True	Cytokine	Inferred relationship	Some	1

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Id	Description	Lang	Type	Status	Case?	Module
125852012	Cytokine	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
816424012	Cytokine (substance)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
7109781000241114	cytokine	fr	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module