| Inbound Relationships |
Type |
Active |
Source |
Characteristic |
Refinability |
Group |
| Iron isotope |
Is a |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
|
| Iron |
Is a |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
|
| Secondary pulmonary hemosiderosis is a respiratory disease due to the deposition of hemosiderin-laden macrophages in lungs as a result of repeated alveolar hemorrhage secondary to another disease, especially dysimmunitary disorders (i.e. Heiner syndrome, autoimmune diseases), thrombotic disorders and cardiovascular disorders such as mitral stenosis. It manifests as a triad of hemoptysis, anemia and diffuse parenchymal infiltrates on chest radiography. |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
2 |
| An early-onset and most severe form of rare haemochromatosis characterised by the usual features of haemochromatosis accompanied by cardiomyopathy and hypogonadism. |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| Focal hemosiderosis |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| Bronze diabetes (disorder) |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| Hepatic hemosiderosis |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| Neonatal hemochromatosis |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| Iron overload |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| Idiopathic hemochromatosis (disorder) |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| Autosomal dominant hereditary hemochromatosis (disorder) |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| COASY protein-associated neurodegeneration (CoPAN) is a very rare, slowly progressive form of neurodegeneration with brain iron accumulation (NBIA) characterized by classic NBIA features. The clinical manifestations include early-onset spastic-dystonic paraparesis, oromandibular dystonia, dysarthria, parkinsonism, axonal neuropathy, progressive cognitive impairment, complex motor tics, and obsessive-compulsive disorder. |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| Siderosis of cornea |
Causative agent (attribute) |
False |
Iron and/or iron compound |
Inferred relationship |
Some |
2 |
| Secondary hemochromatosis |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| Transfusion hemosiderosis |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
3 |
| Hemochromatosis (disorder) |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| Erythropoietic hemochromatosis |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| Iron compound |
Is a |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
|
| Bronze cirrhosis |
Causative agent (attribute) |
False |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| Poisoning caused by iron and/or iron compound (disorder) |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| Beta-propeller protein-associated neurodegeneration (BPAN), also known as static encephalopathy of childhood with neurodegeneration in adulthood, is a rare form of neurodegeneration with brain iron accumulation (NBIA) characterized by early-onset developmental delay and further neurological deterioration in early adulthood. |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| Idiopathic pulmonary hemosiderosis |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| Hemosiderosis |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| Milk-induced pulmonary disease in infant |
Causative agent (attribute) |
False |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| African nutritional hemochromatosis |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| Neuroferritinopathy (disorder) |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| A form of rare hemochromatosis (HC) characterized by excessive tissue iron deposition of genetic origin and presenting with liver disease, hypogonadism, arthritis, diabetes and skin pigmentation. |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| Hemochromatosis following repeated red blood cell transfusion |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
2 |
| Secondary hemosiderosis |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| Hereditary hemochromatosis |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| Primary hemochromatosis (disorder) |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| Renal hemosiderosis |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| Product containing iron and/or iron compound (product) |
The clinically relevant part or whole of the substance that is intended to have a therapeutic action on or within the body. It excludes esters, salts or other non-covalent derivatives (such as a complex, chelate etc.), but may include secondary modifications. |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| Shunt hemosiderosis |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| Hemosiderosis, acquired |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| Iron adverse reaction |
Causative agent (attribute) |
False |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| allergie au fer |
Causative agent (attribute) |
False |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| Compound iron preparations adverse reaction |
Causative agent (attribute) |
False |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| Iron and folic acid allergy |
Causative agent (attribute) |
False |
Iron and/or iron compound |
Inferred relationship |
Some |
2 |
| Ferro-cerebro-cutaneous syndrome is a rare, genetic, metabolic liver disease characterized by progressive neurodegeneration, cutaneous abnormalities, including varying degrees of ichthyosis or seborrheic dermatitis, and systemic iron overload. Patients manifest with infantile-onset seizures, encephalopathy, abnormal eye movements, axial hypotonia with peripheral hypertonia, brisk reflexes, cortical blindness and deafness, myoclonus and hepato/splenomegaly, as well as oral manifestations, including microdontia, widely spaced and pointed teeth with delayed eruption, and gingival overgrowth. |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
2 |
| Siderosis of cornea |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| Cirrhosis resulting from accumulation of iron in the liver. |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| Cirrhosis resulting from accumulation of iron in the liver. |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
2 |
| Pigmentary portal cirrhosis |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| Pigmentary portal cirrhosis |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
2 |
| Neonatal iron overload |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| Iron and/or iron compound overdose (disorder) |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| Adverse reaction to iron and/or iron compound (disorder) |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| Haemochromatosis type 1 |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| Type 2A juvenile hereditary hemochromatosis (disorder) |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| Type 2B juvenile hereditary hemochromatosis |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| Milk-induced pulmonary disease in infant |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
2 |
| A rare disorder of iron metabolism and transport characterized by elevated serum ferritin levels, increased serum iron, increased transferrin saturation, and heavy iron deposition in hepatocytes. Iron deposition has also been indicated in heart and bone marrow, while hematological examination of peripheral blood shows no abnormalities. |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| A rare form of hemochromatosis characterized by inappropriately regulated intestinal iron absorption which leads to excessive iron storage in various organs and manifests with a wide range of signs and symptoms, including abdominal pain, weakness, lethargy, weight loss, elevated serum aminotransferase levels, increase in skin pigmentation, and/or arthropathy in the metacarpophalangeal joints. Other commonly associated manifestations include hepatomegaly, cirrhosis, liver fibrosis, hepatocellular carcinoma, restrictive cardiomyopathy and/or diabetes mellitus. |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| A rare subtype of haemochromatosis characterised by the combination of pathogenic variants in two genes involved in iron metabolism (usually a combination of HFE and non-HFE mutations), where the classical HFE-related haemochromatosis is not enough to fully explain the clinical picture of the patient. |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| A form of rare hemochromatosis (HC) with characteristics of increased transferrin saturation and hepatocellular iron deposition with distribution patterns and clinical features indistinguishable from patients with other types of HC. The disease is due to gain-of-function (GOF) mutations of the ferroportin gene (SLC40A1) on chromosome 2. These mutations cause an hepcidin-independent increase in cellular iron export with increased intestinal iron absorption and iron release from spleen macrophages. Transmission is autosomal dominant. |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| A rare disorder of iron metabolism and transport characterised by iron retention in macrophages (particularly of the liver and spleen), with a clinical picture of mild anaemia and elevated of serum ferritin levels. Ferroportin disease is distinct from haemochromatosis as it is not associated with high transferrin saturation or low hepcidin concentrations. |
Causative agent (attribute) |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
1 |
| Iron-based contrast media (substance) |
Is a |
True |
Iron and/or iron compound |
Inferred relationship |
Some |
|
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