| Inbound Relationships |
Type |
Active |
Source |
Characteristic |
Refinability |
Group |
| Crohn's disease of small and large intestines |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
2 |
| Crohn's disease of rectum |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Crohn's disease of jejunum |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Crohn's disease of colon (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Crohn disease of appendix (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Crohn's disease of terminal ileum |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Exacerbation of Crohn's disease of large intestine (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Exacerbation of Crohn's disease of small intestine (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Stenosis of small intestine co-occurrent and due to Crohn's disease (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Arthritis co-occurrent and due to Crohn's disease (disorder) |
Pathological process (attribute) |
False |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Metastatic Crohn's disease of skin (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Crohn's disease of vulva (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Crohn's disease of penis (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Crohn's disease of scrotum (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Perianal Crohn's disease |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Iritis with Crohn's disease (disorder) |
Pathological process (attribute) |
False |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Crohn's disease of skin (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Abscess of intestine co-occurrent and due to Crohn's disease of large intestine (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Abscess of intestine co-occurrent and due to Crohn's disease of small and large intestine (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Abscess of intestine co-occurrent and due to Crohn's disease of small and large intestine (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
2 |
| Abscess of intestine co-occurrent and due to Crohn's disease of small intestine (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Abscess of intestine co-occurrent and due to Crohn's disease (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Chronic ulcerative rectosigmoiditis |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Chronic ulcerative rectosigmoiditis |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
2 |
| Chronic ulcerative pancolitis |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Abscess of intestine co-occurrent and due to chronic ulcerative pancolitis (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
4 |
| Abscess of intestine co-occurrent and due to chronic ulcerative rectosigmoiditis (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
3 |
| Abscess of intestine co-occurrent and due to chronic ulcerative rectosigmoiditis (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
5 |
| A rare autosomal recessive primary immunodeficiency characterised by infancy onset of severe inflammatory bowel disease with life-threatening diarrhoea and failure to thrive, oral aphthous ulcers, and recurrent severe upper and lower respiratory tract infections with finger clubbing. Laboratory examination reveals increased IgE and decreased IgG levels, as well as reduced numbers of circulating CD19+ B-cells including IgM+ naive and class-switched IgG memory B-cells, with a concomitant increase in transitional B-cells, while T-cell numbers and function are normal. |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| A rare immune dysregulation disease with immunodeficiency characterized by infantile or childhood onset of a variable phenotype including recurrent/persistent bacterial, fungal, and viral infections with involvement of the skin, lower respiratory tract, and gastrointestinal tract, eczema, allergies, and inflammatory bowel disease, among others. EBV-related smooth muscle tumors have also been reported. Immunophenotyping shows decreased Treg counts, as well as a deficient CD3/CD28 co-stimulation response in CD4+ and CD8+ T-cells. |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
2 |
| A rare autosomal recessive primary immunodeficiency characterized by susceptibility to Epstein-Barr virus (EBV)-associated lymphoproliferative disorders such as malignant B-cell proliferation, Hodgkin lymphoma, B-cell lymphoma, lymphoid granulomatosis, hemophagocytic lymphohistiocytosis, and smooth muscle tumor. Patients present persistent symptoms of infectious mononucleosis including recurrent febrile episodes, lymphadenopathies, and hepatosplenomegaly, accompanied by high EBV viral load in the blood. Additional manifestations are autoimmune diseases like hemolytic anemia or renal disease. |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
2 |
| A rare autosomal recessive primary immunodeficiency characterized by susceptibility to Epstein-Barr virus (EBV)-related disorders (B-cell lymphoproliferative disorders including Hodgkin lymphoma) as well as dysgammaglobulinemia and recurrent infections. Patients can present with recurrent fever, lymphadenopathy, hepatosplenomegaly, Behçet-like stomatitis, pharyngitis, tonsillitis, adenitis, and viral encephalitis. |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
2 |
| A rare genetic disease characterized by infantile onset of severe inflammatory bowel disease manifesting with bloody diarrhea and failure to thrive, and central nervous system disease with global developmental delay and regression, impaired speech, hypotonia, hyperreflexia, and epilepsy. Brain imaging shows global cerebral atrophy, thin corpus callosum, delayed myelination, and posterior leukoencephalopathy. Cases with recurrent infections and impaired T-cell responses to stimulation, as well as decreased T-cell subsets, have been reported. |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
2 |
| A rare genetic disease characterized by multiple intestinal atresia in association with combined immunodeficiency and inflammatory bowel disease. Clinical features include widespread atresia extending from the stomach to the rectum, homogenous calcifications in the abdominal cavity, hepatic cholestasis, cirrhosis, and chronic liver failure, hypoplastic thymus, and increased susceptibility to mainly bacteria and viruses. The immunological phenotype consists of profound generalized T-cell lymphopenia and milder natural killer cell and B-cell lymphopenia, as well as low serum levels of IgG, IgA, and IgM, with elevated serum IgE. The disease is mostly fatal in infancy or childhood. |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Crohn disease of colon and rectum (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Crohn disease of colon and rectum (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
2 |
| Crohn disease of jejunum and ileum (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Crohn disease of jejunum and ileum (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
2 |
| Sepsis caused by Bacteroides (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Bacterial sepsis |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Crohn's disease of parastomal skin |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Sepsis following induced termination of pregnancy (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Sepsis of the newborn |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Bacterial sepsis of newborn |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Sepsis caused by Salmonella (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Miscarriage with sepsis |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
2 |
| Failed attempted abortion with sepsis (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
2 |
| Pyemia |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
3 |
| Intrauterine fetal sepsis |
Pathological process (attribute) |
False |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
3 |
| Postoperative sepsis (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
3 |
| Sepsis in asplenic subject (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
3 |
| Sepsis caused by fungus |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
3 |
| Sepsis with cutaneous manifestations |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
2 |
| Sepsis without septic shock |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
3 |
| Sepsis due to urinary tract infection (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
3 |
| Line sepsis associated with dialysis catheter (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
4 |
| Sepsis caused by Actinomyces (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Sepsis caused by methicillin resistant Staphylococcus aureus (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Recurrent salmonella sepsis co-occurrent with human immunodeficiency virus infection |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
4 |
| Septic shock co-occurrent with acute organ dysfunction caused by anaerobic bacteria |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
5 |
| Septic shock co-occurrent with acute organ dysfunction caused by Haemophilus influenzae (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
5 |
| Septic shock co-occurrent with acute organ dysfunction caused by Meningococcus (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
5 |
| Septic shock co-occurrent with acute organ dysfunction caused by Pseudomonas |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
5 |
| Septic shock co-occurrent with acute organ dysfunction caused by Serratia (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
5 |
| Septic shock co-occurrent with acute organ dysfunction caused by methicillin resistant Staphylococcus aureus (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
2 |
| Sepsis due to oral infection |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
2 |
| Sepsis due to incomplete miscarriage |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
3 |
| Septic shock co-occurrent with acute organ dysfunction due to Chromobacterium (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
5 |
| Septic shock co-occurrent with acute organ dysfunction due to Enterococcus |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
5 |
| Septic shock co-occurrent with acute organ dysfunction due to Gonococcus |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
5 |
| Septic shock co-occurrent with acute organ dysfunction due to Gram-positive coccus |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
5 |
| Sepsis due to ectopic pregnancy |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
3 |
| Neutropenic sepsis (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
5 |
| Gram positive sepsis |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Septic shock co-occurrent with acute organ dysfunction caused by methicillin susceptible Staphylococcus aureus (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
4 |
| Septic shock co-occurrent with acute organ dysfunction caused by Streptococcus |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
3 |
| Septic shock co-occurrent with acute organ dysfunction caused by Pneumococcus |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
4 |
| Septic shock co-occurrent with acute organ dysfunction due to coagulase-negative Staphylococcus (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
4 |
| Septic shock co-occurrent with acute organ dysfunction due to Group A streptococcus (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
4 |
| Septic shock co-occurrent with acute organ dysfunction due to Group B streptococcus (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
4 |
| Septic shock co-occurrent with acute organ dysfunction due to Staphylococcus (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
3 |
| Puerperal sepsis with postnatal complication |
Pathological process (attribute) |
False |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
2 |
| Sepsis caused by virus (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Sepsis during labor with antenatal problem |
Pathological process (attribute) |
False |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
2 |
| Sepsis of newborn caused by Staphylococcus aureus |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Sepsis of newborn caused by Escherichia coli (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Sepsis of newborn caused by anaerobes (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Early-onset neonatal sepsis |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Late-onset neonatal sepsis (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Neonatal sepsis caused by Malassezia (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Sepsis of neonate caused by Streptococcus pyogenes (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Sepsis of newborn caused by group B Streptococcus (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Sepsis with acquired immunodeficiency syndrome (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
3 |
| Right ventricular failure with sepsis |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Transient respiratory distress with sepsis (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
2 |
| Fetal sepsis caused by Streptococcus pyogenes (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Sepsis caused by Erysipelothrix (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Sepsis caused by anaerobic bacteria |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Sepsis caused by Staphylococcus (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Sepsis caused by Staphylococcus aureus (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
| Sepsis caused by Streptococcus (disorder) |
Pathological process (attribute) |
True |
An imbalance between proinflammatory and anti-inflammatory responses to an infection. |
Inferred relationship |
Some |
1 |
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