Inbound Relationships |
Type |
Active |
Source |
Characteristic |
Refinability |
Group |
Micronodular adrenal hyperplasia |
Associated morphology |
True |
Micronodular hyperplasia (morphologic abnormality) |
Inferred relationship |
Some |
1 |
dysplasie micronodulaire pigmentée des surrénales |
Associated morphology |
False |
Micronodular hyperplasia (morphologic abnormality) |
Inferred relationship |
Some |
1 |
A rare adrenocortical nodular disease characterized by increased to normal sized adrenal glands containing multiple small (less than 1 cm in diameter) cortical pigmented (lipofuscin) nodules, surrounded by internodular adrenocortical atrophy. It is typically associated with the development of a form of adrenal Cushing syndrome (CS). Rarely, it has been associated with adrenal macronodules. Whilst PRKAR1A variants are associated with CNC (Carney complex), the mutation c.709-7del6 is mostly associated with i-PPNAD. Other mutations associated with i-PPNAD include PRKACA (germline copy-number gains), PDE11A and PDE8B genes, although these are rare. |
Associated morphology |
True |
Micronodular hyperplasia (morphologic abnormality) |
Inferred relationship |
Some |
1 |
Carney complex-associated-primary pigmented nodular adrenocortical disease (disorder) |
Associated morphology |
True |
Micronodular hyperplasia (morphologic abnormality) |
Inferred relationship |
Some |
1 |
A rare adrenocortical nodular disease characterized by bilateral, multiple micronodules (<1 cm), typically associated with endogenous Cushing syndrome, that occurs predominantly in children and young adults (females in majority). Pigmentation and inter-nodular adrenal cortical atrophy (histological findings present in primary pigmented nodular adrenocortical disease) are generally absent. |
Associated morphology |
True |
Micronodular hyperplasia (morphologic abnormality) |
Inferred relationship |
Some |
1 |
A rare adrenocortical nodular disease characterized by bilateral, multiple micronodules (<1 cm), typically associated with endogenous Cushing syndrome, that occurs predominantly in children and young adults (females in majority). Pigmentation and inter-nodular adrenal cortical atrophy (histological findings present in primary pigmented nodular adrenocortical disease) are generally absent. |
Associated morphology |
True |
Micronodular hyperplasia (morphologic abnormality) |
Inferred relationship |
Some |
2 |