Inbound Relationships |
Type |
Active |
Source |
Characteristic |
Refinability |
Group |
Cerebral infarction due to embolism of middle cerebral artery |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Cerebral infarction due to cerebral venous thrombosis, non-pyogenic |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Disorder due to and following injury of thoracic spinal cord (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Arteritic anterior ischemic optic neuropathy due to giant cell arteritis (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Acute seizure due to infection of central nervous system (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Hydrocephalus due to Dandy-Walker malformation (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Epilepsy due to scarring of brain (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Cerebral infarction due to embolism of cerebral arteries |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Hypertrophic pachymeningitis due to disorder of immune function |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Ex-vacuo hydrocephalus due to infection |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Hydrocephalus due to tuberculosis of brain (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Intracranial hypotension due to cerebrospinal fluid fistula |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Encephalopathy due to COVID-19 |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Top of basilar syndrome |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Retrobulbar neuritis due to late syphilis (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Pachymeningitis due to inflammatory disorder |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Pachymeningitis due to secondary malignant neoplastic disease (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Optic atrophy due to late syphilis (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Traumatic spinal subarachnoid hemorrhage |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Ischemic stroke (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Post infectious grand mal epilepsy (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Post-cerebrovascular accident epilepsy |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Posttraumatic porencephalic cyst of brain |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Benign intracranial hypertension due to hypervitaminosis A (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Meningoencephalitis due to Blastomyces dermatitidis |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Postinflammatory optic atrophy |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Spastic spinal syphilitic paralysis |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Brain disorder resulting from a period of impaired oxygen delivery to the brain (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Intraventricular haemorrhage of prematurity |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Encephalopathy-hypertrophic cardiomyopathy-renal tubular disease syndrome is a rare mitochondrial disease due to a defect in coenzyme Q10 biosynthesis that manifests with a broad spectrum of signs and symptoms which may include: neonatal lactic acidosis, global developmental delay, tonus disorder, seizures, reduced spontaneous movements, ventricular hypertrophy, bradycardia, renal tubular dysfunction with massive lactic acid excretion in urine, severe biochemical defect of respiratory chain complexes II/III when assayed together and deficiency of coenzyme Q10 in skeletal muscle. Cerebral and cerebellar atrophy can be seen on magnetic resonance imaging and multiple choroid plexus cysts and symmetrical hyperechoic signal alterations in basal ganglia have been observed on ultrasound. |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Deafness-encephaloneuropathy-obesity-valvulopathy syndrome is a rare mitochondrial disease with marked clinical variability typically characterized by encephalomyopathy, kidney disease (nephrotic syndrome), optic atrophy, early-onset deafness, pancytopenia, obesity, and cardiac disease (valvulopathy). Additionally, macrocephaly, intellectual disability, hyperlactatemia, elevated lactate/pyruvate ratio, insulin-dependent diabetes, livedo reticularis, liver dysfunction and seizures have also been associated. |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Hypermethioninemia encephalopathy due to adenosine kinase deficiency is a rare inborn error of metabolism disorder characterized by persistent hypermethioninemia with increased levels of S-adenosylmethionine and S-adenosylhomocysteine which manifests with encephalopathy, severe global developmental delay, mild to severe liver dysfunction, hypotonia and facial dysmorphism (most significant is frontal bossing, macrocephaly, hypertelorism and depressed nasal bridge). Epileptic seizures, hypoglycemia and/or cardiac defects (pulmonary stenosis, atrial and/or ventricular septal defect, coarctation of the aorta) may be associated. Clinical picture may range from neurological symptoms only to multi-organ involvement. |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Childhood encephalopathy due to thiamine pyrophosphokinase deficiency is a rare inborn error of metabolism disorder characterized by early-onset, acute, encephalopathic episodes (frequently triggered by viral infections), associated with lactic acidosis and alpha-ketoglutaric aciduria, which typically manifest with variable degrees of ataxia, generalized developmental regression (which deteriorates with each episode) and dystonia. Other manifestations include spasticity, seizures, truncal hypotonia, limb hypertonia, brisk tendon reflexes and reversible coma. |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
A rare neuroinflammatory disease characterized by the onset of ataxia, dysarthria and cerebral white matter changes which are triggered by viral infection. Episodic progressive neurodegeneration (manifesting with loss of motor and verbal skills, muscle weakness, further cerebral white matter degeneration and, eventually, death) is observed in the absence of hematopathology, cytokine overproduction, fever, hypertriglyceridemia, hypofibrinogenemia and hyperferritinemia. |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Kernicterus due to isoimmunization |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Pituitary dwarfism |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Periventricular hemorrhagic venous infarct (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Cerebral ischemic stroke due to dissection of artery (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Cerebral ischemic stroke due to subarachnoid hemorrhage |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Hypersomatotropic gigantism |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Woodhouse-Sakati syndrome is a multisystemic disorder characterized by hypogonadism, alopecia, diabetes mellitus, intellectual deficit and extrapyramidal signs with choreoathetoid movements and dystonia. |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Hypoglycaemic coma |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Optic neuropathy due to folate deficiency (disorder) |
Is a |
False |
Central nervous system complication |
Inferred relationship |
Some |
|
Disease with characteristics of delayed motor development, hypotonia and progressive neurodegeneration. To date, it has been described in four boys. The syndrome is caused by mutations affecting the two alleles of the HIBCH gene, encoding 3-hydroxyisobutyryl-CoA hydrolase which is caused by homozygous or compound heterozygous mutation in the HIBCH gene on chromosome 2q32. |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Parkinsonism co-occurrent and due to acute infection (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Parkinsonism following infection (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Non-infective meningitis due to inflammatory disorder (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Parkinsonism due to heredodegenerative disorder (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Late-onset central hypoventilation co-occurrent and due to hypothalamic dysfunction (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Epilepsy due to infectious disease of central nervous system (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Encephalopathy due to nutritional deficiency (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Perceptual disturbances co-occurrent and due to psychoactive substance withdrawal (disorder) |
Is a |
False |
Central nervous system complication |
Inferred relationship |
Some |
|
Parkinsonism due to and following injury of head (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Chorea co-occurrent and due to Huntington disease-like condition (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Chorea co-occurrent and due to Wilson disease (disorder) |
Is a |
False |
Central nervous system complication |
Inferred relationship |
Some |
|
Ataxia co-occurrent and due to phytanic acid storage disease (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
White matter disorder co-occurrent and due to cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Demyelination of central nervous system co-occurrent and due to neurosarcoidosis (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Demyelination of central nervous system co-occurrent and due to systemic lupus erythematosus (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Demyelination of central nervous system co-occurrent and due to Sjogren disease (disorder) |
Is a |
False |
Central nervous system complication |
Inferred relationship |
Some |
|
Demyelination of central nervous system co-occurrent and due to mitochondrial disease (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Epilepsy due to perinatal anoxic-ischemic brain injury (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Epilepsy due to cerebrovascular accident (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Epilepsy due to intracranial neoplasm |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Autonomic nervous system disorder co-occurrent and due to neurodegenerative disorder (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Epilepsy co-occurrent and due to degenerative brain disorder (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Epilepsy co-occurrent and due to mesial temporal sclerosis (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Epilepsy due to immune disorder (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Epilepsy co-occurrent and due to demyelinating disorder (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
A rare, potentially fatal, epileptic encephalopathy characterized by explosive-onset of recurrent multifocal and bilateral tonic-clonic seizures following an unspecific febrile illness. The syndrome develops without a clear acute structural, toxic or metabolic cause, in a patient without previous epilepsy. FIRES is a subgroup of new-onset refractory status epilepticus (NORSE) and requires a preceding febrile infection as a mandatory feature. |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
A rare pituitary deficiency characterized by herniation of the subarachnoid space into the sella turcica, resulting in flattening of the pituitary gland and endocrine dysfunction. Most common endocrine abnormalities are hyperprolactinemia and growth hormone deficit. Clinical symptoms are highly variable and include headaches, irregular menstruation, galactorrhea, obesity, and visual disturbances, among others. |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Encephalopathy due to sulfite oxidase deficiency is a rare neurometabolic disorder characterized by seizures, progressive encephalopathy and lens dislocation. |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Cerebrovascular accident due to right carotid artery occlusion |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Cerebrovascular accident due to right carotid artery stenosis |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Cerebrovascular accident due to left carotid artery stenosis |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Amnestic disorder associated with general medical condition (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
CVA - cerebrovascular accident due to cerebral artery occlusion |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Hydrocephalus following traumatic injury (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Seizure co-occurrent and due to drug withdrawal |
Is a |
False |
Central nervous system complication |
Inferred relationship |
Some |
|
This disease is characterized by progressive cerebellar ataxia with pyramidal and spinal cord dysfunction, associated with distinctive MRI anomalies and increased lactate in the abnormal white matter. |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Cupping of optic disc due to open angle glaucoma |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Secondary psychotic syndrome with hallucinations and delusions |
Is a |
False |
Central nervous system complication |
Inferred relationship |
Some |
|
Disorder of central nervous system co-occurrent and due to infection with influenza virus (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Wolfram-like syndrome is a rare endocrine disease characterized by the triad of adult-onset diabetes mellitus, progressive hearing loss (usually presenting in the first decade of life and principally of low to moderate frequencies), and/or juvenile-onset optic atrophy. Psychiatric (i.e. anxiety, depression, hallucinations) and sleep disorders, the only neurologic abnormalities observed in this disease, have been reported in rare cases. Unlike Wolfram syndrome, patients with Wolfram-like syndrome do not report endocrine or cardiac findings. |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Hypertrophic pachymeningitis due to infection (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Status migrainosus co-occurrent and due to migraine without aura (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Cerebrovascular accident due to stenosis of right vertebral artery (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Cerebrovascular accident due to stenosis of left vertebral artery (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Cerebrovascular accident due to occlusion of right vertebral artery (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Cerebrovascular accident due to occlusion of left vertebral artery (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Lacunar ataxic hemiparesis of right dominant side |
Is a |
False |
Central nervous system complication |
Inferred relationship |
Some |
|
Lacunar ataxic hemiparesis of left dominant side |
Is a |
False |
Central nervous system complication |
Inferred relationship |
Some |
|
Lacunar ataxic hemiparesis of left nondominant side |
Is a |
False |
Central nervous system complication |
Inferred relationship |
Some |
|
Lacunar ataxic hemiparesis of right nondominant side |
Is a |
False |
Central nervous system complication |
Inferred relationship |
Some |
|
Cerebrovascular accident due to occlusion of left pontine artery (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Cerebrovascular accident due to occlusion of right pontine artery (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Cerebrovascular accident due to occlusion of left carotid artery (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Cerebrovascular accident due to occlusion of left cerebellar artery (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Cerebrovascular accident due to occlusion of right cerebellar artery (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
Tuberculous abscess of epidural space (disorder) |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|
A disorder characterized by a decline primarily in intellectual function due to disease of the brain caused by a variety of acquired conditions such as cerebrovascular disease, Alzheimer's disease, infections, adverse drug reactions and trauma. |
Is a |
True |
Central nervous system complication |
Inferred relationship |
Some |
|