Inbound Relationships |
Type |
Active |
Source |
Characteristic |
Refinability |
Group |
Familial non-obstructive reflux-associated chronic pyelonephritis |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |
Unilateral reflux nephropathy due to vesicoureteral reflux |
Clinical course |
False |
Chronic |
Inferred relationship |
Some |
|
Intractable diarrhea-choanal atresia-eye anomalies syndrome is characterized by the association of intractable diarrhea of infancy with choanal atresia. Short stature, a prominent and broad nasal bridge, micrognathia, single palmar creases, chronic corneal inflammation, cytopenia, and abnormal hair texture were also reported. So far, the syndrome has been described in three children from the same family. The absence of intellectual deficit and immune deficiency allow this syndrome to be distinguished from other forms of intractable diarrhea of infancy described previously. |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
6 |
Chronic total occlusion of coronary artery (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |
Chronic thrombosis of splenic vein (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
1 |
Chronic deep venous thrombosis (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
1 |
A rare, syndromic, genetic respiratory disease characterized by cataracts, otitis media, intestinal malabsorption, chronic respiratory infections, and failure to thrive. Recurrent pneumonia and progressive azotemia, leading to end-stage renal disease and early death, are additionally observed. There have been no further descriptions in the literature since 1992. |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
3 |
Chronic primary gouty arthritis (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
1 |
A rare genetic disease characterized by co-occurrence of sick sinus syndrome (manifesting as sinus bradycardia, often requiring pacemaker implantation) and chronic intestinal pseudo-obstruction (which may be of myogenic or neurogenic origin and usually requires total parenteral nutrition), with an age of onset within the first four decades of life. Other cardiac features, such as atrial flutter or fibrillation and valve anomalies, may also be present. |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |
Follicular urethritis |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
1 |
A very rare genetic gastroenterological disease characterized by severe malabsorptive diarrhea (requiring parenteral nutrition and disappearing at fasting) due to a lack of intestinal enteroendocrine cells. It is associated with early-onset (within the first weeks of life) dehydration, metabolic acidosis and diabetes mellitus (that can develop until late childhood). Patient may display various degrees of pancreatic insufficiency that does not explain diarrhea, as it is not reduced with pancreatic enzyme supplementation. Central hypogonadism (developing in the second decade), as well as an association with celiac disease have been reported. |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
4 |
Chronic necrotizing ulcerative gingivitis (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |
Glomerulonephritis with electron dense deposits in the glomerular baseement membrane in a patient with cancer, after exclusion of other possible causes of membranous glomerulonephritis. |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |
Chronic kidney disease developing de novo in a person who has previously donated a kidney for the purposes of kidney transplanataion. |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |
A rare glomerular disease, histologically characterized by thickening of the capillary wall, with immune deposits predominantly containing IgG4 and C3 on the sub-epithelial side, and typically manifesting with nephrotic syndrome. |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
1 |
Glomerulonephritis with electron dense deposits in the glomerular baseement membrane, associated with treatment with a drug known to be associated with membranous nephropathy and after exclusion of alternative causes. |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |
Focal and segmental glomerulosclerosis in association with long-term treatment with lithium carbonate, after exclusion of alternative causes. |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |
Focal and segmental glomerulosclerosis in a patient with sickle cell disease. |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |
Chronic kidney disease developing as a result of removal of kidney tissue (including partial nephrectomy and radical nephrectomy) for the treatment of renal tumor. |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |
Chronic kidney disease associated with chronic infection. |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
4 |
Glomerulonephritis with electron dense deposits in the glomerular baseement membrane, associated with an infection known to cause membranous nephropath and after exclusion of alternative causes. |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |
Chronic kidney disease due to traumatic loss of kidney (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
4 |
A rare multiple congenital anomalies syndrome characterized by cutaneous mastocytosis, microcephaly, microtia and/or hearing loss, hypotonia and skeletal anomalies (e.g. clinodactyly, camptodactyly, scoliosis). Additional common features are short stature, intellectual disability and difficulties. Facial dysmorphism may include upslanted palpebral fissures, highly arched palate and micrognathia. Rarely, seizures and asymmetrically small feet have been reported. |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
3 |
Secondary chronic intestinal pseudo-obstruction (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
1 |
Chronic non-specific multiple ulcers of small intestine (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
1 |
Chronic Chagas disease with heart involvement |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |
Chronic bilateral vestibulopathy (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
1 |
Chronic lymphoproliferative disorder of natural killer cells (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |
Chronic venous infarction of spinal cord (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
1 |
Groove pancreatitis (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |
Chronic renal insufficiency (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
3 |
Chronic poisoning caused by benzene (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |
Complement component 3 glomerulopathy (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |
A histological subtype of C3 glomerulopathy characterized by C3 deposition in renal tissue in the absence or near-absence of immunoglobulin deposits, in a patient with the classic clinical features of glomerulonephritis and electron microscopic findings of highly electron-dense intra-membranous, osmiophilic deposits. |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |
Complement component 3 glomerulonephritis (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |
Chronic disseminated classical histoplasmosis |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |
Chronic pulmonary African histoplasmosis |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |
Chronic rupture of medial collateral ligament of right knee (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
1 |
Chronic rupture of anterior cruciate ligament of right knee (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
1 |
Chronic rupture of posterior cruciate ligament of right knee (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
1 |
Chronic rupture of medial collateral ligament of left knee (disorder) |
Clinical course |
False |
Chronic |
Inferred relationship |
Some |
1 |
Chronic rupture of anterior cruciate ligament of left knee (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
1 |
Chronic rupture of posterior cruciate ligament of left knee (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
1 |
Chronic osteomyelitis of right foot (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
1 |
Chronic osteomyelitis of left foot (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
1 |
Chronic pain following bilateral total knee arthroplasty (finding) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |
Chronic pain following left total hip arthroplasty (finding) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |
Chronic pain following left total knee arthroplasty (finding) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |
Chronic pain following right total hip arthroplasty (finding) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |
Chronic pain following right total knee arthroplasty (finding) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |
Chronic pain of right upper limb (finding) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
1 |
Chronic pain of left upper limb (finding) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
1 |
Chronic pain of right foot (finding) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
1 |
Chronic pain of left foot (finding) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
1 |
Chronic ulcerating interstitial cystitis |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |
ulcère de Hunner |
Clinical course |
False |
Chronic |
Inferred relationship |
Some |
2 |
cistite interstiziale cronica |
Clinical course |
False |
Chronic |
Inferred relationship |
Some |
2 |
Tendinosis of right shoulder (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |
Tendinosis of left shoulder (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |
Non-atherosclerotic chronic arterial occlusive disease (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
1 |
Tropical calcific chronic pancreatitis (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
1 |
Chronic degeneration of tendon without inflammation. |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
1 |
Chronic insomnia (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
1 |
Chronic radiodermatitis due to and following radiotherapy caused by ionizing radiation (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
3 |
Chronic hiccups |
Clinical course |
False |
Chronic |
Inferred relationship |
Some |
1 |
Diffuse large B-cell lymphoma co-occurrent with chronic inflammation caused by Epstein-Barr virus (disorder) |
Clinical course |
False |
Chronic |
Inferred relationship |
Some |
3 |
Idiopathic chronic eosinophilic pneumonitis |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |
Chronic aspergillosis of paranasal sinus |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
1 |
Chronic pulmonary aspergillosis |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
1 |
Chronic sacral pain for greater than three months (finding) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
1 |
Chronic diarrhea with villous atrophy is a rare, genetic gastroenterological disease characterized by the early onset of chronic diarrhea, vomiting, anorexia, lactic acidosis, renal insufficiency and hepatic involvement (mild elevation of liver enzymes, steatosis, hepatomegaly). Partial villous atrophy (with eosinophilic infiltration) is observed on intestinal biopsy. Although diarrhea may resolve, the development of neurologic symptoms (cerebellar ataxia, sensorineural deafness, seizures), retinitis pigmentosa and muscle weakness may complicate disease course and lead to death. There have been no further descriptions in the literature since 1994. |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
3 |
Chronic gastrointestinal tract vascular insufficiency (disorder) |
Clinical course |
False |
Chronic |
Inferred relationship |
Some |
1 |
Chronic female pelvic pain syndrome (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
1 |
Painful operation scar |
Clinical course |
False |
Chronic |
Inferred relationship |
Some |
2 |
Persistent pain following procedure |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |
Internal mammary artery syndrome |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |
Chronic idiopathic non-infectious enteritis of intestine |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
1 |
Chronic pain due to malignant neoplastic disease (finding) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
1 |
Chronic neuropathic pain (finding) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
1 |
Chronic nociceptive pain (finding) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
1 |
Pyometra co-occurrent and due to chronic inflammatory disease of uterus (disorder) |
Clinical course |
False |
Chronic |
Inferred relationship |
Some |
4 |
Complex regional pain syndrome |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |
Chronic painful neuropathy due to diabetes mellitus (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
4 |
Chronic painful polyneuropathy due to diabetes mellitus |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
1 |
Chronic pain syndrome (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
1 |
Complex regional pain syndrome, type II, lower limb (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |
Complex regional pain syndrome, type II, upper limb (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |
Complex regional pain syndrome, type II (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |
Complex regional pain syndrome of upper limb (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |
Complex regional pain syndrome type I (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |
Complex regional pain syndrome of lower limb (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |
Complex regional pain syndrome of foot (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |
Complex regional pain syndrome of knee (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |
Complex regional pain syndrome of hand (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |
Chronic infection caused by Hepatitis D virus (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
1 |
Protracted bronchitis caused by bacterium (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
1 |
Chronic edema of penis (disorder) |
Clinical course |
False |
Chronic |
Inferred relationship |
Some |
1 |
Chronic idiopathic pain syndrome (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
1 |
Complex regional pain syndrome type II of left upper limb (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |
Complex regional pain syndrome type II of right upper limb (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |
Complex regional pain syndrome type II of left lower limb (disorder) |
Clinical course |
True |
Chronic |
Inferred relationship |
Some |
2 |