91861009: Acute myeloid leukemia (disorder)

SNOMED CT Concept\Clinical finding (finding)\...

\Mass of body structure\Mass of lymphoreticular structure\Neoplasm of bone marrow (disorder)\Myeloid leukaemia\Acute myeloid leukemia, disease
\Mass of body structure\Mass of lymphoreticular structure\Neoplasm of bone marrow (disorder)\Acute leukemia\Acute myeloid leukemia, disease
\Mass of body structure\Hematologic neoplasm\Neoplasm affecting hematopoietic structure (disorder)\Leukaemia\Myeloid leukaemia\Acute myeloid leukemia, disease
\Mass of body structure\Hematologic neoplasm\Neoplasm affecting hematopoietic structure (disorder)\Leukaemia\Acute leukemia\Acute myeloid leukemia, disease

\Disease\Disorder of hematopoietic cell proliferation (disorder)\Myeloproliferative disorder (disorder)\Myeloid leukaemia\Acute myeloid leukemia, disease
\Disease\Neoplasm and/or hamartoma (disorder)\Neoplastic disease\Neoplasm of hematopoietic cell type (disorder)\Malignant neoplasm of lymphoid, hematopoietic and/or related tissue (disorder)\Leukaemia\Myeloid leukaemia\Acute myeloid leukemia, disease
\Disease\Neoplasm and/or hamartoma (disorder)\Neoplastic disease\Neoplasm of hematopoietic cell type (disorder)\Malignant neoplasm of lymphoid, hematopoietic and/or related tissue (disorder)\Leukaemia\Acute leukemia\Acute myeloid leukemia, disease
\Disease\Neoplasm and/or hamartoma (disorder)\Neoplastic disease\Malignant neoplastic disease (disorder)\Malignant neoplasm of lymphoid, hematopoietic and/or related tissue (disorder)\Leukaemia\Myeloid leukaemia\Acute myeloid leukemia, disease
\Disease\Neoplasm and/or hamartoma (disorder)\Neoplastic disease\Malignant neoplastic disease (disorder)\Malignant neoplasm of lymphoid, hematopoietic and/or related tissue (disorder)\Leukaemia\Acute leukemia\Acute myeloid leukemia, disease
\Disease\Neoplasm and/or hamartoma (disorder)\Neoplastic disease\Hematologic neoplasm\Neoplasm affecting hematopoietic structure (disorder)\Leukaemia\Myeloid leukaemia\Acute myeloid leukemia, disease
\Disease\Neoplasm and/or hamartoma (disorder)\Neoplastic disease\Hematologic neoplasm\Neoplasm affecting hematopoietic structure (disorder)\Leukaemia\Acute leukemia\Acute myeloid leukemia, disease
\Disease\Disorder of body system\Disorder of hematopoietic structure (disorder)\Neoplasm affecting hematopoietic structure (disorder)\Leukaemia\Myeloid leukaemia\Acute myeloid leukemia, disease
\Disease\Disorder of body system\Disorder of hematopoietic structure (disorder)\Neoplasm affecting hematopoietic structure (disorder)\Leukaemia\Acute leukemia\Acute myeloid leukemia, disease
\Disease\Disorder of body system\Disorder of hematopoietic structure (disorder)\Bone marrow disorder\Myeloproliferative disorder (disorder)\Myeloid leukaemia\Acute myeloid leukemia, disease
\Disease\Disorder of body system\Disorder of hematopoietic structure (disorder)\Bone marrow disorder\Neoplasm of bone marrow (disorder)\Myeloid leukaemia\Acute myeloid leukemia, disease
\Disease\Disorder of body system\Disorder of hematopoietic structure (disorder)\Bone marrow disorder\Neoplasm of bone marrow (disorder)\Acute leukemia\Acute myeloid leukemia, disease
\Disease\Disorder of body system\Hematologic neoplasm\Neoplasm affecting hematopoietic structure (disorder)\Leukaemia\Myeloid leukaemia\Acute myeloid leukemia, disease
\Disease\Disorder of body system\Hematologic neoplasm\Neoplasm affecting hematopoietic structure (disorder)\Leukaemia\Acute leukemia\Acute myeloid leukemia, disease

Status: current, Sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jan 2002. Module: SNOMED CT core

Descriptions:

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
Acute myeloid leukemia, disease	Is a	Acute leukemia	true	Inferred relationship	Some
Acute myeloid leukemia, disease	Is a	Myeloid leukemia, disease (disorder)	false	Inferred relationship	Some
Acute myeloid leukemia, disease	Finding site	Bone marrow structure	false	Inferred relationship	Some	2
Acute myeloid leukemia, disease	Course	Acute	false	Inferred relationship	Some
Acute myeloid leukemia, disease	Associated morphology	Acute myeloid leukemia, no International Classification of Diseases for Oncology subtype	false	Inferred relationship	Some	3
Acute myeloid leukemia, disease	Pathological process	Malignant neoplastic process	false	Inferred relationship	Some	1
Acute myeloid leukemia, disease	Associated morphology	Myeloid leukemia - category	false	Inferred relationship	Some	4
Acute myeloid leukemia, disease	Finding site	Lymphoid system consists of lymph nodes, lymphatic vessels and organs that contain lymphoid tissue, e.g. thymus, spleen.	false	Inferred relationship	Some	1
Acute myeloid leukemia, disease	Associated morphology	Acute leukemia	false	Inferred relationship	Some	2
Acute myeloid leukemia, disease	Associated morphology	néoplasie maligne (morphologie)	false	Inferred relationship	Some	3
Acute myeloid leukemia, disease	Finding site	Bone marrow structure	false	Inferred relationship	Some	4
Acute myeloid leukemia, disease	Finding site	Bone marrow structure	false	Inferred relationship	Some	1
Acute myeloid leukemia, disease	Finding site	Hematopoietic system structure	false	Inferred relationship	Some	3
Acute myeloid leukemia, disease	Finding site	Bone marrow structure	false	Inferred relationship	Some	2
Acute myeloid leukemia, disease	Finding site	Bone marrow structure	false	Inferred relationship	Some	1
Acute myeloid leukemia, disease	Is a	Myeloid leukaemia	true	Inferred relationship	Some
Acute myeloid leukemia, disease	Finding site	Bone marrow structure	false	Inferred relationship	Some	2
Acute myeloid leukemia, disease	Finding site	Bone marrow structure	false	Inferred relationship	Some	3
Acute myeloid leukemia, disease	Associated morphology	néoplasie maligne (morphologie)	false	Inferred relationship	Some	1
Acute myeloid leukemia, disease	Finding site	Hematopoietic system structure	false	Inferred relationship	Some	1
Acute myeloid leukemia, disease	Finding site	Bone marrow structure	false	Inferred relationship	Some	1
Acute myeloid leukemia, disease	Finding site	Bone marrow structure	false	Inferred relationship	Some	2
Acute myeloid leukemia, disease	Associated morphology	Acute myeloid leukemia - category	false	Inferred relationship	Some	1
Acute myeloid leukemia, disease	Finding site	Bone marrow structure	false	Inferred relationship	Some	1
Acute myeloid leukemia, disease	Finding site	Bone marrow structure	false	Inferred relationship	Some	2
Acute myeloid leukemia, disease	Finding site	Bone marrow structure	false	Inferred relationship	Some	1
Acute myeloid leukemia, disease	Finding site	Bone marrow structure	false	Inferred relationship	Some	2
Acute myeloid leukemia, disease	Finding site	Bone marrow structure	false	Inferred relationship	Some	1
Acute myeloid leukemia, disease	Finding site	Bone marrow structure	false	Inferred relationship	Some	2
Acute myeloid leukemia, disease	Associated morphology	Acute myeloid leukemia - category	false	Inferred relationship	Some	1
Acute myeloid leukemia, disease	Finding site	Bone marrow structure	true	Inferred relationship	Some	1
Acute myeloid leukemia, disease	Associated morphology	Acute myeloid leukemia (morphologic abnormality)	true	Inferred relationship	Some	1

Inbound Relationships	Type	Active	Source	Characteristic	Refinability	Group
A rare unclassified acute myeloid leukemia characterized by an acute panmyeloid proliferation with blasts constituting more than 20% of cells in the bone marrow or peripheral blood, accompanied by fibrosis of the bone marrow. Patients typically present with acute onset of severe constitutional symptoms, bone pain, and pancytopenia. Splenomegaly is minimal or absent. The disease is rapidly progressive with poor therapy response.	Is a	True	Acute myeloid leukemia, disease	Inferred relationship	Some
Acute promyelocytic leukemia, FAB M3	Is a	True	Acute myeloid leukemia, disease	Inferred relationship	Some
Acute myelomonocytic leukemia, FAB M4	Is a	True	Acute myeloid leukemia, disease	Inferred relationship	Some
Acute myeloblastic leukemia	Is a	False	Acute myeloid leukemia, disease	Inferred relationship	Some
leucémie aigüe monoblastique	Is a	False	Acute myeloid leukemia, disease	Inferred relationship	Some
Acute megakaryoblastic leukaemia	Is a	True	Acute myeloid leukemia, disease	Inferred relationship	Some
Malignant myeloid/lymphoid neoplasm	Is a	False	Acute myeloid leukemia, disease	Inferred relationship	Some
Acute myelogenous leukemia without differentiation, FAB M0	Is a	False	Acute myeloid leukemia, disease	Inferred relationship	Some
Acute myeloid leukaemia, minimal differentiation, FAB M0	Is a	True	Acute myeloid leukemia, disease	Inferred relationship	Some
Acute myelogenous leukemia without maturation, FAB M1	Is a	False	Acute myeloid leukemia, disease	Inferred relationship	Some
Acute myeloid leukemia without maturation, FAB M1	Is a	True	Acute myeloid leukemia, disease	Inferred relationship	Some
Acute myeloid leukemia with maturation, FAB M2	Is a	True	Acute myeloid leukemia, disease	Inferred relationship	Some
Acute monocytic leukemia, FAB M5	Is a	False	Acute myeloid leukemia, disease	Inferred relationship	Some
Acute myeloid leukemia in remission	Is a	True	Acute myeloid leukemia, disease	Inferred relationship	Some
Acute megakaryoblastic leukemia, FAB M7	Is a	False	Acute myeloid leukemia, disease	Inferred relationship	Some
Granulocytic sarcoma	Is a	False	Acute myeloid leukemia, disease	Inferred relationship	Some
Leukemic infiltration of skin in acute myeloid leukemia (disorder)	Is a	True	Acute myeloid leukemia, disease	Inferred relationship	Some
Acute biphenotypic leukaemia	Is a	False	Acute myeloid leukemia, disease	Inferred relationship	Some
leucémie monocytaire/monoblastique aigue	Is a	False	Acute myeloid leukemia, disease	Inferred relationship	Some
Basophilic leukemia	Is a	True	Acute myeloid leukemia, disease	Inferred relationship	Some
Erythroleukemia, FAB M6	Is a	True	Acute myeloid leukemia, disease	Inferred relationship	Some
Myeloid sarcoma	Is a	False	Acute myeloid leukemia, disease	Inferred relationship	Some
Acute myeloid leukemia with t(9:11)(p22;q23); MLLT3-MLL (disorder)	Is a	False	Acute myeloid leukemia, disease	Inferred relationship	Some
Acute myeloid leukemia with myelodysplasia-related changes (disorder)	Is a	True	Acute myeloid leukemia, disease	Inferred relationship	Some
Form of acute myeloid leukemia having a shortage of all types of mature blood cells with onset in childhood or young adulthood.	Is a	True	Acute myeloid leukemia, disease	Inferred relationship	Some
Cytogenetically normal acute myeloid leukaemia	Is a	True	Acute myeloid leukemia, disease	Inferred relationship	Some
History of acute myeloid leukaemia	Associated finding	True	Acute myeloid leukemia, disease	Inferred relationship	Some	1
Therapy related acute myeloid leukemia and myelodysplastic syndrome (disorder)	Is a	False	Acute myeloid leukemia, disease	Inferred relationship	Some
Akute myeloblastische Leukämie mit rekurrenter genetischer Anomalie	Is a	False	Acute myeloid leukemia, disease	Inferred relationship	Some
Inherited acute myeloid leukemia (AML) is a rare, malignant hematologic disease characterized by clonal proliferation of myeloid blasts, primarily involving the bone marrow, in association with congenital disorders (e.g. Fanconi anemia, dyskeratosis congenita, Bloom syndrome, Down syndrome, congenital neutropenia, neurofibromatosis, etc.) and genetic defects predisposing to AML. Patients present with signs and symptoms related to ineffective hematopoesis (fatigue, bleeding and bruising, recurrent infections, bone pain) and/or extramedullary site involvement (gingivitis, splenomegaly, etc.). Depending on the underlying genetic defect, there may be additional cancer risks and other health problems present.	Is a	True	Acute myeloid leukemia, disease	Inferred relationship	Some
Refractory acute myeloid leukaemia	Is a	True	Acute myeloid leukemia, disease	Inferred relationship	Some
Relapsing acute myeloid leukemia (disorder)	Is a	True	Acute myeloid leukemia, disease	Inferred relationship	Some
A subtype of acute myeloid leukemia with recurrent genetic abnormalities characterized by leukocytosis, thrombocytosis and nonspecific symptoms related to ineffective hematopoiesis (fatigue, bleeding and bruising, recurrent infections, bone pain), with frequent extramedullary involvement typically presenting as gingival hyperplasia and lymphadenopathy. The disease is characterized by clonal proliferation of myeloid blasts harboring mutations of the NPM1 gene in the bone marrow, blood and other tissues. It is associated with multilineage dysplasia, involving the myeloid, monocytic, erythroid, and megakaryocytic cell lineages.	Is a	True	Acute myeloid leukemia, disease	Inferred relationship	Some
Megakaryoblastic acute myeloid leukemia with t(1;22)(p13;q13) is a rare subtype of acute myeloid leukemia with recurrent cytogenetic abnormalities characterized by clonal proliferation of myeloid blasts with predominantly megakaryoblastic differentiation in the bone marrow and blood, often with extensive infiltration of the abdominal organs. It occurs typically in infants and usually presents with hepatosplenomegaly, anemia, thrombocytopenia and nonspecific symptoms related to ineffective hematopoiesis (fatigue, bleeding and bruising, recurrent infections). Myelofibrosis and fibrosis of other infiltrated organs is also characteristic of this disease.	Is a	True	Acute myeloid leukemia, disease	Inferred relationship	Some
A subtype of acute myeloid leukaemia with recurrent genetic abnormalities, characterised by clonal proliferation of myeloid blasts harbouring somatic mutations of the CEBPA gene in the bone marrow, blood and, rarely, other tissues. It can present with anaemia, thrombocytopenia, and other nonspecific symptoms related to ineffective haematopoesis (fatigue, bleeding and bruising, recurrent infections, bone pain) and/or extramedullary site involvement (gingivitis, splenomegaly).	Is a	True	Acute myeloid leukemia, disease	Inferred relationship	Some
A distinct form of acute myeloid leukemia (AML) in which this chromosomal anomaly is found de novo or in therapy-related AML cases, and is characterized by frequent extramedullary involvement (mainly hepatomegaly, splenomegaly, lymphadenopathies, cutaneous infiltration, but also gum, bone, central nervous system, testicles involvement), severe coagulation disorder (disseminated intravascular coagulopathy or primary fibrinolysis) and poor prognosis. Morphologically, a blast population with a myelomonocytic stage of differentiation is observed.	Is a	True	Acute myeloid leukemia, disease	Inferred relationship	Some
A rare subtype of acute myeloid leukaemia with recurrent genetic abnormalities characterised by clonal proliferation of poorly differentiated myeloid blasts in the bone marrow, blood, or other tissues in patients who present the t(6;9)(p23;q34) translocation. Frequently associated with multilineage bone marrow dysplasia, it usually presents with anaemia, thrombocytopenia (often pancytopenia), and other nonspecific symptoms related to ineffective haematopoesis (fatigue, bleeding and bruising, recurrent infections, bone pain) and/or extramedullary site involvement (gingivitis, splenomegaly). Basophilia, as well as poor response to chemotherapy, has been reported.	Is a	True	Acute myeloid leukemia, disease	Inferred relationship	Some
A subtype of acute myeloid leukemia with recurrent genetic abnormalities characterized by clonal proliferation of myeloid blasts in the bone marrow, blood and, rarely, other tissues. Bone marrow typically shows small, hypolobated megakaryocytes and multilineage dysplasia. Patients typically present with leukocytosis, anemia, variable platelet counts and a variety of nonspecific symptoms related to ineffective hematopoesis (fatigue, bleeding, bruising, recurrent infections, bone pain) and/or extramedullary site involvement (gingivitis, splenomegaly). High resistance to conventional chemotherapy is reported.	Is a	True	Acute myeloid leukemia, disease	Inferred relationship	Some
Acute myeloid leukemia with t(8;21)(q22;q22) RUNX1-RUNX1T1 (disorder)	Is a	True	Acute myeloid leukemia, disease	Inferred relationship	Some
A rare tumor arising from hematopoietic and lymphoid tissues characterized by abnormal proliferation and differentiation of a clonal population of myeloid stem cells carrying unspecific 11q23 abnormalities. Clinical manifestations result from accumulation of malignant myeloid cells within the bone marrow, peripheral blood and other organs, and include leukocytosis, anemia, thrombocytopenia, fatigue, anorexia and weight loss.	Is a	True	Acute myeloid leukemia, disease	Inferred relationship	Some
A rare acute myeloid leukemia (AML) with recurrent genetic anomaly characterized by the presence of bone marrow and peripheral blood myeloblasts with features ranging from those of minimal differentiation to granulocytic maturation, demonstrating t(9;22)(q34.1;q11.2) or molecular genetic evidence of BCR-ABL1 fusion. Evidence of chronic myeloid leukemia (CML) is absent. Patients most commonly present with leukocytosis with blast predominance and variable anemia and thrombocytopenia. Splenomegaly is less frequent and peripheral blood basophilia lower than in patients with myeloid blast transformation of CML. The disease occurs primarily in adults, and response to traditional AML therapy or tyrosine kinase inhibitor therapy alone is typically poor.	Is a	True	Acute myeloid leukemia, disease	Inferred relationship	Some
Acute myeloid leukemia with CBFB::MYH11 fusion (disorder)	Is a	True	Acute myeloid leukemia, disease	Inferred relationship	Some
Acute monocytic leukemia	Is a	True	Acute myeloid leukemia, disease	Inferred relationship	Some
Myeloid leukemia associated with Down syndrome (disorder)	Is a	True	Acute myeloid leukemia, disease	Inferred relationship	Some

This concept is not in any reference sets

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Id	Description	Lang	Type	Status	Case?	Module
152159014	Acute myeloid leukemia	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
201612010	Acute myeloid leukaemia	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
509748011	AML - Acute myeloid leukemia	en	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT core
509749015	Acute myeloid leukemia, disease	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
509750015	AML - Acute myeloid leukaemia	en	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT core
1207830016	Acute myeloid leukaemia, disease	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
2536482014	AML - Acute myeloblastic leukaemia	en	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT core
2536483016	AML - Acute myeloblastic leukemia	en	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT core
2838441019	Acute myelocytic leukaemia	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
2838442014	Acute myelocytic leukemia	en	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
5168461010	Acute myeloid leukemia (disorder)	en	Fully specified name	Active	Entire term case insensitive (core metadata concept)	SNOMED CT core
926531000195117	leucemia mieloide acuta	it	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
3393750011	leucémie myéloïde aiguë	fr	Synonym (core metadata concept)	Active	Entire term case insensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module
3396591001000118	Leukämie, akute myeloische	de	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT Switzerland NRC maintained Module